Proton Therapy: An Overview
Introduction
Proton therapy, also known as proton beam therapy, is an advanced form of radiation
therapy that uses protons instead of X-rays to treat cancer. The unique physical properties
of protons allow precise targeting of tumors, minimizing radiation exposure to surrounding
healthy tissues.
Principles of Proton Therapy
Proton therapy is based on the Bragg peak phenomenon, where protons deposit the
majority of their energy at a specific depth in tissue, corresponding to the tumor location.
This allows radiation oncologists to conform the dose to the tumor while sparing critical
structures and organs.
Techniques of Proton Therapy
Modern proton therapy employs several delivery techniques, including:
• Passive Scattering Proton Therapy: Uses scattering foils to spread the proton beam across
the tumor volume.
• Pencil Beam Scanning (PBS): Uses a narrow proton beam scanned across the tumor in a
spot-by-spot manner, enabling intensity-modulated proton therapy (IMPT).
Clinical Applications
Proton therapy is particularly beneficial in treating cancers located near critical organs or in
pediatric patients where reducing long-term side effects is crucial. Common applications
include brain tumors, head and neck cancers, spinal tumors, lung cancer, liver cancer,
prostate cancer, and pediatric malignancies.
Advantages of Proton Therapy
• Superior dose distribution with minimal exit dose
• Reduced risk of radiation-induced secondary cancers
• Improved quality of life due to lower treatment-related toxicity
• Particularly suitable for re-irradiation cases where conventional radiotherapy is limited
Limitations of Proton Therapy
Despite its advantages, proton therapy has limitations such as high cost, limited availability,
and the need for precise imaging and motion management. Proton therapy centers are
large, complex facilities requiring significant investment.
Role of Medical Physicists
Medical physicists are essential in proton therapy for beam calibration, treatment planning,
quality assurance, and ensuring patient safety. They work alongside oncologists and
radiation therapists to optimize treatment delivery.
Conclusion
Proton therapy represents a major advancement in cancer treatment by providing precise,
effective, and safer radiation delivery. With ongoing technological improvements and wider
availability, proton therapy has the potential to become a standard of care for many cancer
patients.