Safety Data Sheet according to (EC) No 1907/2006 as amended

Page 1 of 20

SDS No. : 153498

V008.0
LOCTITE 641 Revision: 13.02.2024
printing date: 27.03.2024
Replaces version from: 30.09.2022

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1. Product identifier
LOCTITE 641

1.2. Relevant identified uses of the substance or mixture and uses advised against
Intended use:
Sealant

1.3. Details of the supplier of the safety data sheet

Henkel Ltd
Adhesives
Wood Lane End
HP2 4RQ Hemel Hempstead

Great Britain

Phone: +44 (1442) 278000

[email protected]
For Safety Data Sheet updates please visit our website https://mysds.henkel.com/index.html#/appSelection or www.henkel-
adhesives.com.

1.4. Emergency telephone number

24 Hours Emergency Tel: +44 (0)1442 278497

SECTION 2: Hazards identification

2.1. Classification of the substance or mixture

Classification (CLP):
Serious eye irritation Category 2
H319 Causes serious eye irritation.
Specific target organ toxicity - single exposure Category 3
H335 May cause respiratory irritation.
Target organ: respiratory tract irritation
Chronic hazards to the aquatic environment Category 3
H412 Harmful to aquatic life with long lasting effects.

2.2. Label elements

Label elements (CLP):

Hazard pictogram:

Contains Cumene hydroperoxide

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Signal word: Warning

Hazard statement: H319 Causes serious eye irritation.

H335 May cause respiratory irritation.
H412 Harmful to aquatic life with long lasting effects.

Supplemental information Contains: methyl methacrylate May produce an allergic reaction.

Precautionary statement: "***" ***For consumer use only: P101 If medical advice is needed, have product
container or label at hand. P102 Keep out of reach of children. P501 Dispose of
contents/container in accordance with national regulation.***

Precautionary statement: P261 Avoid breathing vapors.

Prevention P273 Avoid release to the environment.

Precautionary statement: P337+P313 If eye irritation persists: Get medical advice/attention.

Response

2.3. Other hazards

Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very Bioaccumulative (vPvB) criteria.
None if used properly.

Following substances are present in a concentration ≥ the concentration limit for depiction in Section 3 and fulfill the
criteria for PBT/vPvB, or were identified as endocrine disruptor (ED):

This mixture does not contain any substances in a concentration ≥ the concentration limit for depiction in Section 3 that are
assessed to be a PBT, vPvB or ED.

SECTION 3: Composition/information on ingredients

3.2. Mixtures
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Declaration of the ingredients according to CLP (EC) No 1272/2008:

Hazardous components Concentration Classification Specific Conc. Limits, M- Add.

CAS-No. factors and ATEs Information
EC Number
REACH-Reg No.
Cumene hydroperoxide 1- < 3 % STOT RE 2, H373 Eye Irrit. 2; H319; C 1 - < 3 %
80-15-9 Skin Corr. 1B, H314 Skin Irrit. 2; H315; C 3 - < 10 %
201-254-7 Acute Tox. 2, Inhalation, H330 Eye Dam. 1; H318; C 3 - < 10 %
01-2119475796-19 Aquatic Chronic 2, H411 STOT SE 3; H335; C >= 1 %
Acute Tox. 4, Oral, H302 Skin Corr. 1B; H314; C >= 10 %
Acute Tox. 4, Dermal, H312 =====
Org. Perox. E, H242 dermal:ATE = 1.100 mg/kg
STOT SE 3, H335

N,N-Diethyl-p-toluidine 0,1- < 1 % Acute Tox. 3, Oral, H301 dermal:ATE = 300 mg/kg
613-48-9 Acute Tox. 3, Dermal, H311 oral:ATE = 100 mg/kg
210-345-0 Acute Tox. 3, Inhalation, H331 inhalation:ATE = 3 mg/l;vapour
STOT RE 2, H373
Aquatic Chronic 3, H412
Skin Irrit. 2, H315

N,N-dimethyl-o-toluidine 0,1- < 1 % STOT RE 2, H373 dermal:ATE = 300 mg/kg

609-72-3 Acute Tox. 3, Oral, H301 oral:ATE = 100 mg/kg
210-199-8 Acute Tox. 3, Dermal, H311 inhalation:ATE = 1,5
Acute Tox. 3, Inhalation, H331 mg/l;dust/mist
Aquatic Chronic 3, H412

methacrylic acid 0,1- < 1 % Acute Tox. 4, Oral, H302 STOT SE 3; H335; C >= 1 %
79-41-4 Acute Tox. 3, Dermal, H311 =====
201-204-4 Acute Tox. 4, Inhalation, H332 dermal:ATE = 500 mg/kg
01-2119463884-26 Skin Corr. 1A, H314 inhalation:ATE = 3,61
Eye Dam. 1, H318 mg/l;dust/mist
STOT SE 3, H335

methyl methacrylate 0,1- < 1 % Flam. Liq. 2, H225 EU OEL

80-62-6 STOT SE 3, H335
201-297-1 Skin Irrit. 2, H315
01-2119452498-28 Skin Sens. 1, H317

1,4-Naphthalenedione 0,01- < 0,1 % Acute Tox. 3, Oral, H301 M acute = 10

130-15-4 Skin Corr. 1C, H314 M chronic = 1
204-977-6 Skin Sens. 1, H317
Eye Dam. 1, H318
Acute Tox. 1, Inhalation, H330
STOT SE 3, H335
Aquatic Acute 1, H400
Aquatic Chronic 1, H410

If no ATE values are displayed, please refer to LD/LC50 values in Section 11.
For full text of the H - statements and other abbreviations see section 16 "Other information".

SECTION 4: First aid measures

4.1. Description of first aid measures

Inhalation:
Move to fresh air. If symptoms persist, seek medical advice.

Skin contact:
Rinse with running water and soap.
Obtain medical attention if irritation persists.

Eye contact:
Rinse immediately with plenty of running water (for 10 minutes), seek medical attention from a specialist.
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Ingestion:
Rinse mouth, drink 1-2 glasses of water, do not induce vomiting, consult a doctor.

4.2. Most important symptoms and effects, both acute and delayed
EYE: Irritation, conjunctivitis.

RESPIRATORY: Irritation, coughing, shortness of breath, chest tightness.

Prolonged or repeated contact may cause skin irritation.

4.3. Indication of any immediate medical attention and special treatment needed
See section: Description of first aid measures

SECTION 5: Firefighting measures

5.1. Extinguishing media

Suitable extinguishing media:
water, carbon dioxide, foam, powder

Extinguishing media which must not be used for safety reasons:

High pressure waterjet

5.2. Special hazards arising from the substance or mixture

In the event of a fire, carbon monoxide (CO), carbon dioxide (CO2) and nitrogen oxides (NOx) can be released.
5.3. Advice for firefighters
Wear self-contained breathing apparatus and full protective clothing, such as turn-out gear.

Additional information:
In case of fire, keep containers cool with water spray.

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures

Avoid contact with skin and eyes.
Wear protective equipment.
Ensure adequate ventilation.
Keep away from sources of ignition.

6.2. Environmental precautions

Do not empty into drains / surface water / ground water.

6.3. Methods and material for containment and cleaning up

Dispose of contaminated material as waste according to Section 13.
For small spills wipe up with paper towel and place in container for disposal.
For large spills absorb onto inert absorbent material and place in sealed container for disposal.

6.4. Reference to other sections

See advice in section 8

SECTION 7: Handling and storage

7.1. Precautions for safe handling
Avoid skin and eye contact.
See advice in section 8

Hygiene measures:
Wash hands before work breaks and after finishing work.
Do not eat, drink or smoke while working.
Good industrial hygiene practices should be observed.
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7.2. Conditions for safe storage, including any incompatibilities

Ensure good ventilation/extraction.

Store at room temperature.
Refer to Technical Data Sheet.
Keep container tightly sealed.

7.3. Specific end use(s)

Sealant

SECTION 8: Exposure controls/personal protection

8.1. Control parameters

Occupational Exposure Limits

Valid for
Great Britain

Ingredient [Regulated substance] ppm mg/m3 Value type Short term exposure limit Regulatory list
category / Remarks
Methacrylic acid 20 72 Time Weighted Average EH40 WEL
79-41-4 (TWA):
[METHACRYLIC ACID]
Methacrylic acid 40 143 Short Term Exposure 15 minutes EH40 WEL
79-41-4 Limit (STEL):
[METHACRYLIC ACID]
Methyl methacrylate 50 208 Time Weighted Average EH40 WEL
80-62-6 (TWA):
[METHYL METHACRYLATE]
Methyl methacrylate 100 Short Term Exposure Indicative ECTLV
80-62-6 Limit (STEL):
[METHYL METHACRYLATE]
Methyl methacrylate 50 Time Weighted Average Indicative ECTLV
80-62-6 (TWA):
[METHYL METHACRYLATE]
Methyl methacrylate 100 416 Short Term Exposure 15 minutes EH40 WEL
80-62-6 Limit (STEL):
[METHYL METHACRYLATE]

Occupational Exposure Limits

Valid for
Ireland

Ingredient [Regulated substance] ppm mg/m3 Value type Short term exposure limit Regulatory list
category / Remarks
Methacrylic acid 20 70 Time Weighted Average IR_OEL
79-41-4 (TWA):
[METHACRYLIC ACID]
Methacrylic acid 40 140 Short Term Exposure 15 minutes IR_OEL
79-41-4 Limit (STEL):
[METHACRYLIC ACID]
Methyl methacrylate 50 Time Weighted Average Indicative OELV IR_OEL
80-62-6 (TWA):
[METHYL METHACRYLATE]
Methyl methacrylate 100 Short Term Exposure Indicative ECTLV
80-62-6 Limit (STEL):
[METHYL METHACRYLATE]
Methyl methacrylate 50 Time Weighted Average Indicative ECTLV
80-62-6 (TWA):
[METHYL METHACRYLATE]
Methyl methacrylate 100 Short Term Exposure 15 minutes IR_OEL
80-62-6 Limit (STEL): Indicative OELV
[METHYL METHACRYLATE]
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Predicted No-Effect Concentration (PNEC):

Name on list Environmental Exposure Value Remarks

Compartment period
mg/l ppm mg/kg others
.alpha.,.alpha.-Dimethylbenzyl aqua 0,0031
hydroperoxide (freshwater) mg/l
80-15-9
.alpha.,.alpha.-Dimethylbenzyl aqua 0,031 mg/l
hydroperoxide (intermittent
80-15-9 releases)
.alpha.,.alpha.-Dimethylbenzyl aqua (marine 0,00031
hydroperoxide water) mg/l
80-15-9
.alpha.,.alpha.-Dimethylbenzyl sewage 0,35 mg/l
hydroperoxide treatment plant
80-15-9 (STP)
.alpha.,.alpha.-Dimethylbenzyl sediment 0,023
hydroperoxide (freshwater) mg/kg
80-15-9
.alpha.,.alpha.-Dimethylbenzyl sediment 0,0023
hydroperoxide (marine water) mg/kg
80-15-9
.alpha.,.alpha.-Dimethylbenzyl Soil 0,0029
hydroperoxide mg/kg
80-15-9
methacrylic acid aqua 0,82 mg/l
79-41-4 (freshwater)
methacrylic acid Freshwater - 0,45 mg/l
79-41-4 intermittent
methacrylic acid aqua (marine 0,082 mg/l
79-41-4 water)
methacrylic acid sewage 100 mg/l
79-41-4 treatment plant
(STP)
methacrylic acid sediment 3,09 mg/kg
79-41-4 (freshwater)
methacrylic acid sediment 0,309
79-41-4 (marine water) mg/kg
methacrylic acid Soil 0,137
79-41-4 mg/kg
methacrylic acid Predator no potential for
79-41-4 bioaccumulation
methyl methacrylate aqua 0,94 mg/l
80-62-6 (freshwater)
methyl methacrylate aqua (marine 0,94 mg/l
80-62-6 water)
methyl methacrylate aqua 0,94 mg/l
80-62-6 (intermittent
releases)
methyl methacrylate sewage 10 mg/l
80-62-6 treatment plant
(STP)
methyl methacrylate sediment 5,74 mg/kg
80-62-6 (freshwater)
methyl methacrylate Soil 1,47 mg/kg
80-62-6
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Derived No-Effect Level (DNEL):

Name on list Application Route of Health Effect Exposure Value Remarks

Area Exposure Time
.alpha.,.alpha.-Dimethylbenzyl Workers inhalation Long term 6 mg/m3
hydroperoxide exposure -
80-15-9 systemic effects
methacrylic acid Workers Inhalation Long term 88 mg/m3 no potential for
79-41-4 exposure - local bioaccumulation
effects
methacrylic acid Workers Inhalation Long term 29,6 mg/m3 no potential for
79-41-4 exposure - bioaccumulation
systemic effects
methacrylic acid Workers dermal Long term 4,25 mg/kg no potential for
79-41-4 exposure - bioaccumulation
systemic effects
methacrylic acid General Inhalation Long term 6,55 mg/m3 no potential for
79-41-4 population exposure - local bioaccumulation
effects
methacrylic acid General Inhalation Long term 6,3 mg/m3 no potential for
79-41-4 population exposure - bioaccumulation
systemic effects
methacrylic acid General dermal Long term 2,55 mg/kg no potential for
79-41-4 population exposure - bioaccumulation
systemic effects
methyl methacrylate Workers Inhalation Long term 348,4 mg/m3
80-62-6 exposure -
systemic effects
methyl methacrylate Workers Inhalation Long term 208 mg/m3
80-62-6 exposure - local
effects
methyl methacrylate Workers inhalation Acute/short term 416 mg/m3
80-62-6 exposure - local
effects
methyl methacrylate Workers dermal Long term 13,67 mg/kg
80-62-6 exposure -
systemic effects
methyl methacrylate Workers dermal Long term 1,5 mg/cm2
80-62-6 exposure - local
effects
methyl methacrylate Workers dermal Acute/short term 1,5 mg/cm2
80-62-6 exposure - local
effects
methyl methacrylate General Inhalation Long term 74,3 mg/m3
80-62-6 population exposure -
systemic effects
methyl methacrylate General Inhalation Long term 104 mg/m3
80-62-6 population exposure - local
effects
methyl methacrylate General inhalation Acute/short term 208 mg/m3
80-62-6 population exposure - local
effects
methyl methacrylate General dermal Long term 8,2 mg/kg
80-62-6 population exposure -
systemic effects
methyl methacrylate General dermal Long term 1,5 mg/cm2
80-62-6 population exposure - local
effects
methyl methacrylate General dermal Acute/short term 1,5 mg/cm2
80-62-6 population exposure - local
effects
methyl methacrylate General oral Long term
80-62-6 population exposure -
systemic effects
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Biological Exposure Indices:

None

8.2. Exposure controls:

Engineering controls:
Ensure good ventilation/extraction.

Respiratory protection:
Ensure adequate ventilation.
An approved mask or respirator fitted with an organic vapour cartridge should be worn if the product is used in a poorly
ventilated area
Filter type: A (EN 14387)

Hand protection:
Chemical-resistant protective gloves (EN 374).
Suitable materials for short-term contact or splashes (recommended: at least protection index 2, corresponding to > 30 minutes
permeation time as per EN 374):
nitrile rubber (NBR; >= 0.4 mm thickness)
Suitable materials for longer, direct contact (recommended: protection index 6, corresponding to > 480 minutes permeation time
as per EN 374):
nitrile rubber (NBR; >= 0.4 mm thickness)
This information is based on literature references and on information provided by glove manufacturers, or is derived by analogy
with similar substances. Please note that in practice the working life of chemical-resistant protective gloves may be considerably
shorter than the permeation time determined in accordance with EN 374 as a result of the many influencing factors (e.g.
temperature). If signs of wear and tear are noticed then the gloves should be replaced.

Eye protection:
Safety glasses with sideshields or chemical safety goggles should be worn if there is a risk of splashing.
Protective eye equipment should conform to EN166.

Skin protection:
Wear suitable protective clothing.
Protective clothing should conform to EN 14605 for liquid splashes or to EN 13982 for dusts.

Advices to personal protection equipment:

The information provided on personal protective equipment is for guidance purposes only. A full risk assessment should be
conducted prior to using this product to determine the appropriate personal protective equipment to suit local conditions.
Personal protective equipment should conform to the relevant EN standard.

SECTION 9: Physical and chemical properties

9.1. Information on basic physical and chemical properties
Delivery form liquid
Colour yellow
Odor mild, Acrylic
Physical state liquid
Melting point Not applicable, Product is a liquid
Solidification temperature < -30 °C (< -22 °F)
Initial boiling point > 150 °C (> 302 °F)
Flammability The product is not flammable.
Explosive limits Not applicable, The product is not flammable.
Flash point > 100 °C (> 212 °F); Tagliabue closed cup
No flash point up to 100 °C
Auto-ignition temperature > 300 °C (> 572 °F)
Decomposition temperature Not applicable, Substance/mixture is not self-reactive, no organic
peroxide and does not decompose under foreseen conditions of use
pH Not applicable, Product is non-polar/aprotic.
Viscosity (kinematic) > 20,5 mm2/s
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(40 °C (104 °F); )

Solubility (qualitative) Slight
(20 °C (68 °F); Solvent: Water)
Solubility (qualitative) Miscible
(Solvent: Acetone)
Partition coefficient: n-octanol/water Not applicable
Mixture
Vapour pressure < 5 mm hg
(27 °C (80.6 °F))
Vapour pressure < 300 mbar;no method / method unknown
(50 °C (122 °F))
Vapour pressure < 0,13 mbar
(20 °C (68 °F))
Density 1,08 g/cm3 None
(20 °C (68 °F))
Relative vapour density: >1
(20 °C)
Particle characteristics Not applicable
Product is a liquid

9.2. Other information

Other information not applicable for this product

SECTION 10: Stability and reactivity

10.1. Reactivity
Reacts with strong oxidants.
Acids.
Reducing agents.
Strong bases.

10.2. Chemical stability

Stable under recommended storage conditions.

10.3. Possibility of hazardous reactions

See section reactivity

10.4. Conditions to avoid

Stable under normal conditions of storage and use.

10.5. Incompatible materials

See section reactivity.

10.6. Hazardous decomposition products

carbon oxides.
Hydrocarbons
nitrogen oxides
Rapid polymerisation may generate excessive heat and pressure.
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SECTION 11: Toxicological information

11.1 Information on hazard classes as defined in Regulation (EC) No 1272/2008

Acute oral toxicity:

The mixture is classified based on calculation method referring to the classified substances present in the mixture.

Hazardous substances Value Value Species Method

CAS-No. type
Cumene hydroperoxide LD50 382 mg/kg rat other guideline:
80-15-9
N,N-Diethyl-p-toluidine Acute 100 mg/kg Expert judgement
613-48-9 toxicity
estimate
(ATE)
N,N-dimethyl-o-toluidine Acute 100 mg/kg Expert judgement
609-72-3 toxicity
estimate
(ATE)
methacrylic acid LD50 1.320 mg/kg rat equivalent or similar to OECD Guideline 401 (Acute Oral
79-41-4 Toxicity)
methyl methacrylate LD50 9.400 mg/kg rat not specified
80-62-6
1,4-Naphthalenedione LD50 124 mg/kg rat equivalent or similar to OECD Guideline 401 (Acute Oral
130-15-4 Toxicity)

Acute dermal toxicity:

The mixture is classified based on calculation method referring to the classified substances present in the mixture.

Hazardous substances Value Value Species Method

CAS-No. type
Cumene hydroperoxide Acute 1.100 mg/kg Expert judgement
80-15-9 toxicity
estimate
(ATE)
N,N-Diethyl-p-toluidine Acute 300 mg/kg Expert judgement
613-48-9 toxicity
estimate
(ATE)
N,N-dimethyl-o-toluidine Acute 300 mg/kg Expert judgement
609-72-3 toxicity
estimate
(ATE)
methacrylic acid LD50 500 - 1.000 rabbit Dermal Toxicity Screening
79-41-4 mg/kg
methacrylic acid Acute 500 mg/kg Expert judgement
79-41-4 toxicity
estimate
(ATE)
methyl methacrylate LD50 > 5.000 mg/kg rabbit equivalent or similar to OECD Guideline 402 (Acute
80-62-6 Dermal Toxicity)
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Acute inhalative toxicity:

The mixture is classified based on calculation method referring to the classified substances present in the mixture.

Hazardous substances Value Value Test atmosphere Exposure Species Method

CAS-No. type time
Cumene hydroperoxide LC50 1,370 mg/l vapour 4h rat not specified
80-15-9
N,N-Diethyl-p-toluidine Acute 3 mg/l vapour Expert judgement
613-48-9 toxicity
estimate
(ATE)
N,N-dimethyl-o-toluidine Acute 1,5 mg/l dust/mist 4h Expert judgement
609-72-3 toxicity
estimate
(ATE)
methacrylic acid LC50 > 3,6 mg/l dust/mist 4h rat OECD Guideline 403 (Acute
79-41-4 Inhalation Toxicity)
methacrylic acid Acute 3,61 mg/l dust/mist Expert judgement
79-41-4 toxicity
estimate
(ATE)
methyl methacrylate LC50 29,8 mg/l vapour 4h rat not specified
80-62-6
1,4-Naphthalenedione LC50 0,046 mg/l dust/mist 4h rat OECD Guideline 403 (Acute
130-15-4 Inhalation Toxicity)

Skin corrosion/irritation:

The mixture is classified based on calculation method referring to the classified substances present in the mixture.

Hazardous substances Result Exposure Species Method

CAS-No. time
Cumene hydroperoxide corrosive rabbit Draize Test
80-15-9
N,N-Diethyl-p-toluidine irritating 4h rabbit OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
613-48-9
methacrylic acid corrosive 3 min rabbit OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
79-41-4
1,4-Naphthalenedione Category 1C rabbit OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
130-15-4 (corrosive)

Serious eye damage/irritation:

The mixture is classified based on calculation method referring to the classified substances present in the mixture.

Hazardous substances Result Exposure Species Method

CAS-No. time
methacrylic acid corrosive rabbit Draize Test
79-41-4

Respiratory or skin sensitization:

The mixture is classified based on threshold limits referring to the classified substances present in the mixture.

Hazardous substances Result Test type Species Method

CAS-No.
methacrylic acid not sensitising Buehler test guinea pig equivalent or similar to OECD Guideline
79-41-4 406 (Skin Sensitisation)
methyl methacrylate sensitising Mouse local lymphnode mouse OECD Guideline 429 (Skin Sensitisation:
80-62-6 assay (LLNA) Local Lymph Node Assay)
1,4-Naphthalenedione sensitising not specified guinea pig not specified
130-15-4
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Germ cell mutagenicity:

The mixture is classified based on threshold limits referring to the classified substances present in the mixture.

Hazardous substances Result Type of study / Metabolic Species Method

CAS-No. Route of activation /
administration Exposure time
Cumene hydroperoxide positive bacterial reverse without OECD Guideline 471
80-15-9 mutation assay (e.g (Bacterial Reverse Mutation
Ames test) Assay)
methacrylic acid negative bacterial reverse with and without equivalent or similar to OECD
79-41-4 mutation assay (e.g Guideline 471 (Bacterial
Ames test) Reverse Mutation Assay)
methyl methacrylate negative bacterial reverse with and without not specified
80-62-6 mutation assay (e.g
Ames test)

Carcinogenicity

The mixture is classified based on threshold limits referring to the classified substances present in the mixture.

Hazardous components Result Route of Exposure Species Sex Method

CAS-No. application time /
Frequency
of treatment
methacrylic acid not carcinogenic inhalation 2y mouse male/female OECD Guideline 451
79-41-4 (Carcinogenicity
Studies)

Reproductive toxicity:

The mixture is classified based on threshold limits referring to the classified substances present in the mixture.

Hazardous substances Result / Value Test type Route of Species Method

CAS-No. application
methacrylic acid NOAEL P 50 mg/kg Two oral: gavage rat OECD Guideline 416 (Two-
79-41-4 generation Generation Reproduction
NOAEL F1 400 mg/kg study Toxicity Study)

NOAEL F2 400 mg/kg

STOT-single exposure:

No data available.

STOT-repeated exposure:

The mixture is classified based on threshold limits referring to the classified substances present in the mixture.

Hazardous substances Result / Value Route of Exposure time / Species Method

CAS-No. application Frequency of
treatment
Cumene hydroperoxide inhalation: 6 h/d rat not specified
80-15-9 aerosol 5 d/w
methacrylic acid inhalation 90 d rat OECD Guideline 413
79-41-4 6 h/d, 5 d/w (Subchronic Inhalation
Toxicity: 90-Day)
methyl methacrylate LOAEL 2000 ppm inhalation 14 weeks mouse Dose Range Finding
80-62-6 6 hrs/day, 5 days/wk Study
methyl methacrylate NOAEL 1000 ppm inhalation 14 weeks mouse Dose Range Finding
80-62-6 6 hrs/day, 5 days/wk Study

Aspiration hazard:

No data available.
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11.2 Information on other hazards

not applicable
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SECTION 12: Ecological information

General ecological information:
Do not empty into drains / surface water / ground water.

12.1. Toxicity

Toxicity (Fish):

The mixture is classified based on calculation method referring to the classified substances present in the mixture.

The table below presents the data of the classified substances present in the mixture.

Hazardous substances Value Value Exposure time Species Method

CAS-No. type
Cumene hydroperoxide LC50 3,9 mg/l 96 h Oncorhynchus mykiss OECD Guideline 203 (Fish,
80-15-9 Acute Toxicity Test)
N,N-Diethyl-p-toluidine LC50 78,62 mg/l 96 h Danio rerio OECD Guideline 203 (Fish,
613-48-9 Acute Toxicity Test)
N,N-dimethyl-o-toluidine LC 50 46 mg/l 96 h Fathead minnow (Pimephales
609-72-3 promelas)
methacrylic acid LC50 85 mg/l 96 h Salmo gairdneri (new name: EPA OTS 797.1400 (Fish
79-41-4 Oncorhynchus mykiss) Acute Toxicity Test)
methacrylic acid NOEC 10 mg/l 35 d Danio rerio OECD Guideline 210 (fish
79-41-4 early lite stage toxicity test)
methyl methacrylate LC50 350 mg/l 96 h Leuciscus idus OECD Guideline 203 (Fish,
80-62-6 Acute Toxicity Test)
1,4-Naphthalenedione LC50 0,045 mg/l 96 h Oryzias latipes OECD Guideline 203 (Fish,
130-15-4 Acute Toxicity Test)

Toxicity (aquatic invertebrates):

The mixture is classified based on calculation method referring to the classified substances present in the mixture.

The table below presents the data of the classified substances present in the mixture.

Hazardous substances Value Value Exposure time Species Method

CAS-No. type
Cumene hydroperoxide EC50 18,84 mg/l 48 h Daphnia magna OECD Guideline 202
80-15-9 (Daphnia sp. Acute
Immobilisation Test)
N,N-Diethyl-p-toluidine EC50 10,34 mg/l 48 h Daphnia magna OECD Guideline 202
613-48-9 (Daphnia sp. Acute
Immobilisation Test)
methacrylic acid EC50 > 130 mg/l 48 h Daphnia magna EPA OTS 797.1300
79-41-4 (Aquatic Invertebrate Acute
Toxicity Test, Freshwater
Daphnids)
methyl methacrylate EC50 69 mg/l 48 h Daphnia magna EPA OTS 797.1300
80-62-6 (Aquatic Invertebrate Acute
Toxicity Test, Freshwater
Daphnids)
1,4-Naphthalenedione EC50 0,026 mg/l 48 h Daphnia magna OECD Guideline 202
130-15-4 (Daphnia sp. Acute
Immobilisation Test)

Chronic toxicity (aquatic invertebrates):

The table below presents the data of the classified substances present in the mixture.

Hazardous substances Value Value Exposure time Species Method

CAS-No. type
methacrylic acid NOEC 53 mg/l 21 d Daphnia magna OECD 211 (Daphnia
79-41-4 magna, Reproduction Test)
methyl methacrylate NOEC 37 mg/l 21 d Daphnia magna OECD 211 (Daphnia
80-62-6 magna, Reproduction Test)
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Toxicity (Algae):

The mixture is classified based on calculation method referring to the classified substances present in the mixture.

The table below presents the data of the classified substances present in the mixture.

Hazardous substances Value Value Exposure time Species Method

CAS-No. type
Cumene hydroperoxide EC50 3,1 mg/l 72 h Desmodesmus subspicatus OECD Guideline 201 (Alga,
80-15-9 (reported as Scenedesmus Growth Inhibition Test)
subspicatus)
Cumene hydroperoxide NOEC 1 mg/l 72 h Desmodesmus subspicatus OECD Guideline 201 (Alga,
80-15-9 (reported as Scenedesmus Growth Inhibition Test)
subspicatus)
N,N-Diethyl-p-toluidine EC50 7,42 mg/l 72 h Desmodesmus subspicatus OECD Guideline 201 (Alga,
613-48-9 Growth Inhibition Test)
N,N-Diethyl-p-toluidine EC50 23,69 mg/l 72 h Raphidocelis subcapitata (new OECD Guideline 201 (Alga,
613-48-9 name: Pseudokirchneriella Growth Inhibition Test)
subcapitata)
methacrylic acid NOEC 8,2 mg/l 72 h Selenastrum capricornutum OECD Guideline 201 (Alga,
79-41-4 (new name: Pseudokirchneriella Growth Inhibition Test)
subcapitata)
methacrylic acid EC50 45 mg/l 72 h Selenastrum capricornutum OECD Guideline 201 (Alga,
79-41-4 (new name: Pseudokirchneriella Growth Inhibition Test)
subcapitata)
methyl methacrylate EC50 170 mg/l 96 h Selenastrum capricornutum OECD Guideline 201 (Alga,
80-62-6 (new name: Pseudokirchneriella Growth Inhibition Test)
subcapitata)
methyl methacrylate NOEC 100 mg/l 96 h Selenastrum capricornutum OECD Guideline 201 (Alga,
80-62-6 (new name: Pseudokirchneriella Growth Inhibition Test)
subcapitata)
1,4-Naphthalenedione NOEC 0,07 mg/l 72 h Pseudokirchneriella subcapitata OECD Guideline 201 (Alga,
130-15-4 Growth Inhibition Test)
1,4-Naphthalenedione EC50 0,42 mg/l 72 h Pseudokirchneriella subcapitata OECD Guideline 201 (Alga,
130-15-4 Growth Inhibition Test)

Toxicity (microorganisms):

The mixture is classified based on calculation method referring to the classified substances present in the mixture.

The table below presents the data of the classified substances present in the mixture.

Hazardous substances Value Value Exposure time Species Method

CAS-No. type
Cumene hydroperoxide EC10 70 mg/l 30 min not specified not specified
80-15-9
methacrylic acid EC10 100 mg/l 17 h Pseudomonas putida DIN 38412, part 8
79-41-4 (Pseudomonas
Zellvermehrungshemm-
Test)
methyl methacrylate EC20 > 150 - 200 mg/l 30 min activated sludge, domestic ISO 8192 (Test for
80-62-6 Inhibition of Oxygen
Consumption by Activated
Sludge)
1,4-Naphthalenedione EC50 5,94 mg/l 3h activated sludge of a OECD Guideline 209
130-15-4 predominantly domestic sewage (Activated Sludge,
Respiration Inhibition Test)

12.2. Persistence and degradability

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The table below presents the data of the classified substances present in the mixture.

Hazardous substances Result Test type Degradability Exposure Method

CAS-No. time
Cumene hydroperoxide not readily biodegradable. aerobic 3% 28 d OECD Guideline 301 B (Ready
80-15-9 Biodegradability: CO2 Evolution
Test)
N,N-Diethyl-p-toluidine not readily biodegradable. not specified 1% 28 day OECD Guideline 301 C (Ready
613-48-9 Biodegradability: Modified MITI
Test (I))
N,N-dimethyl-o-toluidine not readily biodegradable. 1% 14 d other guideline:
609-72-3
methacrylic acid readily biodegradable aerobic 86 % 28 d OECD Guideline 301 D (Ready
79-41-4 Biodegradability: Closed Bottle
Test)
methacrylic acid inherently biodegradable aerobic 100 % 14 d OECD Guideline 302 B (Inherent
79-41-4 biodegradability: Zahn-
Wellens/EMPA Test)
methyl methacrylate readily biodegradable aerobic 94 % 14 d OECD Guideline 301 C (Ready
80-62-6 Biodegradability: Modified MITI
Test (I))
1,4-Naphthalenedione not readily biodegradable. aerobic 0% 28 d OECD Guideline 301 F (Ready
130-15-4 Biodegradability: Manometric
Respirometry Test)

12.3. Bioaccumulative potential

The table below presents the data of the classified substances present in the mixture.

Hazardous substances Bioconcentratio Exposure time Temperature Species Method

CAS-No. n factor (BCF)
Cumene hydroperoxide 9,1 calculation OECD Guideline 305
80-15-9 (Bioconcentration: Flow-through
Fish Test)
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12.4. Mobility in soil

The table below presents the data of the classified substances present in the mixture.

Hazardous substances LogPow Temperature Method

CAS-No.
Cumene hydroperoxide 1,6 25 °C OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC
80-15-9 Method)
N,N-Diethyl-p-toluidine 3,7 QSAR (Quantitative Structure Activity Relationship)
613-48-9
methacrylic acid 0,93 22 °C OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake
79-41-4 Flask Method)
methyl methacrylate 1,38 20 °C other guideline:
80-62-6
1,4-Naphthalenedione 1,71 not specified
130-15-4

12.5. Results of PBT and vPvB assessment

The table below presents the data of the classified substances present in the mixture.

Hazardous substances PBT / vPvB

CAS-No.
Cumene hydroperoxide Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very
80-15-9 Bioaccumulative (vPvB) criteria.
methacrylic acid Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very
79-41-4 Bioaccumulative (vPvB) criteria.
methyl methacrylate Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very
80-62-6 Bioaccumulative (vPvB) criteria.
1,4-Naphthalenedione Not fulfilling Persistent, Bioaccumulative and Toxic (PBT), very Persistent and very
130-15-4 Bioaccumulative (vPvB) criteria.

12.6. Endocrine disrupting properties

not applicable

12.7. Other adverse effects

No data available.

SECTION 13: Disposal considerations

13.1. Waste treatment methods
Product disposal:
Dispose of in accordance with local and national regulations.
Do not empty into drains / surface water / ground water.

Disposal of uncleaned packages:

After use, tubes, cartons and bottles containing residual product should be disposed of as chemically contaminated waste in an
authorised legal land fill site or incinerated.

Waste code
08 04 09* waste adhesives and sealants containing organic solvents and other dangerous substances
The valid EWC waste code numbers are source-related. The manufacturer is therefore unable to specify EWC waste codes
for the articles or products used in the various sectors. The EWC codes listed are intended as a recommendation for users. We
will be happy to advise you.
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SECTION 14: Transport information

14.1. UN number or ID number

ADR Not dangerous goods

RID Not dangerous goods
ADN Not dangerous goods
IMDG Not dangerous goods
IATA Not dangerous goods

14.2. UN proper shipping name

ADR Not dangerous goods

RID Not dangerous goods
ADN Not dangerous goods
IMDG Not dangerous goods
IATA Not dangerous goods

14.3. Transport hazard class(es)

ADR Not dangerous goods

RID Not dangerous goods
ADN Not dangerous goods
IMDG Not dangerous goods
IATA Not dangerous goods

14.4. Packing group

ADR Not dangerous goods

RID Not dangerous goods
ADN Not dangerous goods
IMDG Not dangerous goods
IATA Not dangerous goods

14.5. Environmental hazards

ADR not applicable

RID not applicable
ADN not applicable
IMDG not applicable
IATA not applicable

14.6. Special precautions for user

ADR not applicable

RID not applicable
ADN not applicable
IMDG not applicable
IATA not applicable

14.7. Maritime transport in bulk according to IMO instruments

not applicable

SECTION 15: Regulatory information

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
Ozone Depleting Substance (ODS) (Regulation (EC) No 1005/2009): Not applicable
Prior Informed Consent (PIC) (Regulation (EU) No 649/2012): Not applicable
Persistent organic pollutants (Regulation (EU) 2019/1021): Not applicable
VOC content <3%
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(2010/75/EC)
VOC content 0,7 %

15.2. Chemical safety assessment

A chemical safety assessment has not been carried out.

SECTION 16: Other information

The labelling of the product is indicated in Section 2. The full text

of all abbreviations indicated by codes in this safety data sheet are as follows:
H225 Highly flammable liquid and vapour.
H242 Heating may cause a fire.
H301 Toxic if swallowed.
H302 Harmful if swallowed.
H311 Toxic in contact with skin.
H312 Harmful in contact with skin.
H314 Causes severe skin burns and eye damage.
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H318 Causes serious eye damage.
H330 Fatal if inhaled.
H331 Toxic if inhaled.
H332 Harmful if inhaled.
H335 May cause respiratory irritation.
H373 May cause damage to organs through prolonged or repeated exposure.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
H411 Toxic to aquatic life with long lasting effects.
H412 Harmful to aquatic life with long lasting effects.

ED: Substance identified as having endocrine disrupting properties

EU OEL: Substance with a Union workplace exposure limit
EU EXPLD 1: Substance listed in Annex I, Reg (EC) No. 2019/1148
EU EXPLD 2 Substance listed in Annex II, Reg (EC) No. 2019/1148
SVHC: Substance of very high concern (REACH Candidate List)
PBT: Substance fulfilling persistent, bioaccumulative and toxic criteria
PBT/vPvB: Substance fulfilling persistent, bioaccumulative and toxic plus very persistent and very
bioaccumulative criteria
vPvB: Substance fulfilling very persistent and very bioaccumulative criteria

Further information:
This Safety Data Sheet has been produced for sales from Henkel to parties purchasing from Henkel, is based on Regulation
(EC) No 1907/2006 and provides information in accordance with applicable regulations of the European Union only. In that
respect, no statement, warranty or representation of any kind is given as to compliance with any statutory laws or regulations
of any other jurisdiction or territory other than the European Union. When exporting to territories other than the European
Union, please consult with the respective Safety Data Sheet of the concerned territory to ensure compliance or liaise with
Henkel´s Product Safety and Regulatory Affairs Department ([email protected]) prior to export to other
territories than the European Union.

This information is based on our current level of knowledge and relates to the product in the state in which it is delivered. It is
intended to describe our products from the point of view of safety requirements and is not intended to guarantee any
particular properties.

Dear Customer,
Henkel is committed to creating a sustainable future by promoting opportunities along the entire value chain. If you would
like to contribute by switching from a paper to the electronic version of SDS, please contact the local Customer Service
representative. We recommend to use a non-personal email address (e.g. SDS@your_company.com).

Relevant changes in this safety data sheet are indicated by vertical lines at the left margin in the body of this document.
Corresponding text is displayed in a different color on shadowed fields.
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