Savitribai Phule Pune University

(Formerly University of Pune)

Post-Graduate Program in Chemistry

(Faculty of Science and Technology)

New Syllabi (As Per National Education Policy-2020) for

M.Sc. (Chemistry) Part-I

(Physical Chemistry, Inorganic Chemistry and Analytical Chemistry)

(For Colleges Affiliated to Savitribai Phule Pune University)

To be implemented with effect from Academic Year 2023-2024

1|Page
1. Preamble:
The global education development agenda reflected in the Goal 4 (SDG4) of the 2030
Agenda for Sustainable Development, adopted by India in 2015 - seeks to “ensure inclusive
and equitable quality education and promote lifelong learning opportunities for all”. Such a
towering goal will require the entire education system to be redesign to support and foster
learning, so that all of the critical targets for Sustainable Development can be achieved.
National Education Policy 2020 is the first education policy of the 21st century and aims to
address the many growing developmental imperatives of our country. This Policy proposes
the revision and revamping of all aspects of the education structure, including its regulation
and governance, to create a new system that is aligned with the aspirational goals of 21st
century education, including SDG4. The NEP 2020 is based on the principle that education
must develop critical thinking and problem solving abilities along with social, ethical, and
emotional capacities.
The M.Sc. Chemistry syllabi is revised as per the guidelines of UGC, Government of
Maharashtra and Savitribai Phule Pune University, Pune. With NEP-2020 in background, the
revised curricula will articulate the spirit of the policy by emphasizing upon- integrated
approach to learning; innovative pedagogies and assessment strategies; multidisciplinary and
Interdisciplinary education; creative and critical thinking; student-centric participatory
learning; imaginative abilities and flexible curricular structures to enable creative
combination of disciplines for the study. The M.Sc. Chemistry Programme will transmit
advanced knowledge of chemical sciences along with its fundamentals. In this programme,
students will be empowered with assignments in academia and industry to provide the skills
and information necessary for creating employment. The Programme exposes students to
significant advances in chemical sciences as well as related fields through multidisciplinary
and interdisciplinary courses. The design of the syllabi is such a way that it addresses
chemical safety, green chemistry principles and industrial skills. It is intended to bring out the
best in each student's ability, to sharpen their scientific temper, and to keep them up to date
on recent developments in the field.
The Aims of the programme are:
a) To impart basic and advanced knowledge of chemical sciences among students.
b) To provide adequate blend of theory, computation and hands-on experiments.
c) To provide higher education, disciplinary and inter/multi-disciplinary research
oriented knowledge to the students.
2|Page
 d) To provide a learned, skilled and creative pool of graduates who are ready to take up
challenging assignments in different kinds of chemical industries, research institutions
and academia.
e) To foster responsible, proactive individuals who are equipped with rational thinking
and competencies to address local challenges.
The M.Sc. Chemistry course structure consists of a well-balanced mix of Major Core, Major
Electives, Research oriented courses, On-Job training/Internship and Project based learning.
Out of total of 88 credits, 18 credits have been allotted to Research methodology and Project
based learning. For M.Sc. Chemistry Degree, a student has to earn the minimum 88 credits
from their four semesters. If students complete 44 credits in PG first year, he/she can exit
with PG Diploma or continue with PG second year. The M.Sc. Chemistry course structure is
based on following credit framework as per the guidelines of the university and government
of Maharashtra.
Credit Framework for M.Sc. Chemistry Programme
Research Internship Research
Level Semester Credits Related to Major Methodology
On Job Training Project Total
(RM) (OJT) (RP)
I 10 (T) + 4 (P) 2 (T) + 2 (T/P) 4 0 0 22
6.0 II 10 (T) + 4 (P) 2 (T) + 2 (T/P) 0 4 0 22
Exit Option: Award of PG Diploma on Completion of 44 credits at 6.0 level (PG First Year) or Continue with
PG Second Year
III 10 (T) + 4 (P) 2 (T) + 2 (T/P) 0 0 4 22
6.5
IV 8 (T) + 4 (P) 2 (T) + 2 (T/P) 0 0 6 22
Total 4 Years 54 16 4 4 10 88

Abbreviation: T – Theory, P - Practical

Guidelines for conduction of classes:

a) A student has to attend 1-hour classroom teaching per week for one credit of theory
and 2 hours’ lab work/problem-solving session/ related activities per week for one
credit of practical. Practical sessions (lab work/problem-solving session/related
activity) will be conducted in batches. A batch for such sessions will be of size
maximum of 08 students.

3|Page
 b) 4 Credit courses will have 60 lectures (48 L + 12 T) and 2 Credit courses will have 30
lectures (24 L + 6 T)
c) The Department may conduct necessary lectures/workshops as a part of OJT.
d) Each course of 4 credits will carry 100 marks and 2 credit courses will carry 50
marks.
e) There will be Continuous Internal Evaluation (CIE) and Semester End Examination
(SEE) for each course.
Evaluation process:
a) The CIE will be based on minimum two internal tests (IT). In addition, a teacher may
consider one or more of the following. (i) Home Assignments (ii)
Seminar/Presentation (iii) Laboratory assignment (iv) Group Discussions (v) Oral (vi)
Research Paper/Book Review (vi) Technology Demonstration (vi) Case study (vii)
Survey report, etc.
b) Students has to score a minimum of 40 % separately in CIE and SEE, otherwise the
result of such a course will be FAIL.
Eligibility:
B.Sc. Chemistry/B.Sc. (Blended) Chemistry/ B.E./B.Tech. with Chemistry subject (at
least in second year) as per the rules and regulations given by Savitribai Phule Pune
University, Pune.

4|Page
 2. Programme Outcomes (POs)

PO Statement
Knowledge and
PO No. After completing the Master of Science degree
Skill
students are able to
Learn the terms, theories, assumptions,
Disciplinary
PO-1 methods, principles, theorem statements and
knowledge
classification
Fix out the problem and resolve it using Critical thinking and
PO-2
theories and practical knowledge. Problem solving
Inculcate his knowledge for carrying projects
PO-3 Research related skill
and advanced research related skills.
Actively participate in team on case studies Cooperation/Team
PO-4
and field-based situations. work
Analyze and interpret ideas, evidences and
PO-5 Scientific reasoning
experiences with learned scientific reasoning
Aware and implement the subject facts that
PO-6 can be applied for the personal and social Reflective thinking
development
Use digital literacy to retrieve and evaluate Information/Digitally
PO-7
subject related information literacy
Get moral and ethical values for society as Moral and ethical
PO-8
well as in research awareness
Give analytical reasoning to interpret research
PO-9 Analytical Reasoning
data.
Improve their managerial skills and abilities in Leadership
PO-10
subject related activities. readiness/qualities
Inculcate continuous learning habit through all Lifelong
PO-11
available resources. readiness/qualities

5|Page
 3. Programme Specific Outcomes (PSOs)

PO-No. Outcomes Component

Demonstrate a comprehensive knowledge of all Disciplinary
PSO-1
disciplines. knowledge
To assess and evaluate facts, claims and arguments
PSO-2 Critical thinking
using their scientific knowledge
To define a problem, analyse, interpret and draw
Research-related
PSO-3 conclusion by planning, implementing and reporting
skills
the results of an experiment.
To access, evaluate and apply a variety of useful Information/digital
PSO-4
sources literacy
To participate in multicultural society and
Multicultural
PSO-5 communicate the subject knowledge for the
competence
betterment of society
To acquire knowledge and skills including
Lifelong
PSO-6 “Learning how to learn” that are necessary in
learning
learning activities throughout life

6|Page
 4. Course Structure
M. Sc. Chemistry Part-I
(Physical Chemistry, Inorganic Chemistry and Analytical Chemistry)
Semester I
Major Core/
Sr. No. Course Title Course Code Credits
Major elective

1 Physical Chemistry-I CHE-501 Major Core 4

2 Inorganic Chemistry-I CHE-502 Major Core 4

3 Organic Chemistry-I CHEPIA-503 Major Core 2

4 Physical Chemistry Practical -I CHE-504 Major Core 2

5 Inorganic Chemistry Practical-I CHE-505 Major Core 2

6 Organic Chemistry Practical-I CHE-506 Major elective 2

Chemical Mathematics CHE-507(A)

Chemistry of Nanomaterials CHE-507(B)

7 Major elective 2
Analytical Chemistry CHE-507(C)

Basic Organic Chemistry CHEPIA-507(D)

8 Research Methodology CHE-508 RM 4

7|Page
 Semester II
Major Core/
Sr. No. Course Title Course Code Credits
Major elective

1 Physical Chemistry-II CHE-551 Major Core 4

2 Inorganic Chemistry-II CHE-552 Major Core 4

3 Organic Chemistry-II CHEPIA-553 Major Core 2

4 Physical Chemistry Practical -II CHE-554 Major Core 2

5 Inorganic Chemistry Practical-II CHE-555 Major Core 2

6 Organic Chemistry Practical-II CHE-556 Major elective 2

Organometallic Compounds and Inorganic

CHE-557(A)
Reaction Mechanism

7 Material Characterization Techniques CHE-557(B) Major elective 2

Green Chemistry CHE-557(C)

Pericyclic Reactions and Photochemistry CHEPIA-557(D)

8 On-Job Training/Internship CHE-558 OJT/Internship 4

8|Page
5. Detailed Syllabus
Semester I
CHE- 501, Physical Chemistry I (4 Credits, 60 L)
Section I [2 Credits, 30 L T]
Chapter 1: Thermodynamics (15 L)
State function, path function, exact and inexact differential, Maxwell's relationship,
temperature and pressure dependence of thermodynamic quantities, Clausius inequality,
chemical potential, variation of chemical potential with temperature and pressure, chemical
potential in a system of ideal gases, Determination of partial molar quantities, Methods for
the determination of molar quantities, Thermodynamics of mixing, Entropy of mixing,
Numerical problems
Chapter 2: Quantum chemistry (15 L)
Recapitulation, Schrodinger wave equation, particle in one dimensional box, particle in three
dimensional box, Degeneracy, Normalization and orthogonality of wave functions, one
dimensional simple harmonic oscillator, operators- Algebra of operators, commutator
operator, linear operators, operator ∇ and ∇2, hydrogen like atom (no deviation), Numerical
problems
Section II [2 Credits, 30 L]
Chapter 1: Chemical kinetics (20 L)
Rate law: Recapitulation, the temp dependent reaction rate, reaction moving towards
equilibrium, consecutive reactions, parallel reactions, pre equilibria, unimolecular reactions.
Numerical problems.
Kinetics of complex reactions: The steady state approximation, chain reactions, free radical
polymerization, reaction between H2 and Br2, explosive reactions, Numerical problems.
Molecular reaction dynamics: Collision theory of bimolecular, gas phase reactions, diffusion
controlled and activation-controlled reaction in solution, activated complex theory of reaction
rate, Eyring equation. Numerical problems.
Enzyme catalysis: Introduction, Michaelis Menten mechanism, effect of pH and temperature
on enzyme catalysed reactions, limiting rate, Lineweaver -Burk, Eadie-Hofstee methods and
plots, competitive and non-competitive inhibition, Numerical problems.

9|Page
Chapter 2: Molecular Thermodynamics (10 L)
Molecular energy levels, Boltzmann distribution law, partition functions and ensembles,
translational, rotational and vibrational partition function of diatomic molecules,
Thermodynamic properties in terms of partition functions (internal energy, heat capacity,
entropy and equilibrium constant), Maxwell-Boltzmann, Fermi- Dirac and Bose -Einstein
statistics.
References:
1. Physical chemistry by Peter Atkins, Julio De Paula, 11th Edition , 2018, Oxford
University Press
2. Principals of Physical chemistry by Puri Sharma Pathania, 48th edition, Vishal
Publishing Co.
3. Physical chemistry by GM borrow, 5th edition , 2006, Mc Graw Hill Education
4. Quantum chemistry by Ira Levine, 6th Edition
5. Quantum chemistry by R.K. Prasad, 4th Edition
6. Physical chemistry by biological sciences by Raymond Chang (Page Number 113,
135, 141)
7. Principles of Physical Chemistry by Marron and Prouton, 4th edition
8. Physical Chemistry: A Molecular Approach by by Donald A. McQuarrie, John D.
Simon (20 August 1997)
Course Outcomes
CO1: Students should be able to remember the concepts of thermodynamic parameters,
quantum mechanical postulates, rate laws of chemical reactions and computation of
macroscopic properties of matter.
CO2: Students should understand the basics like state function and path function,
Schrodinger wave equation, kinetics of fast reactions, partition functions and
ensembles.
CO3: Students should be able to apply the knowledge of various quantum mechanical
methods to determine the different molecular properties and built the concept of the
relation between thermodynamics and quantum mechanics.
CO4: Students should be able to analyze the rates of various chemical reactions both
theoretically and experimentally and also observe the effect of catalyst and
determine energies of activation of such reactions.
CO5: Students should be able to evaluate variation of thermodynamic parameters for multi
component systems and their variation with other extensive properties, Schrodinger
wave equation and its application to hydrogen and hydrogen like atoms.

10 | P a g e
CO6: Students should be able to create the solutions to avoid excess use of energy in
chemical reactions by applying their knowledge of thermodynamics and chemical
kinetics.

11 | P a g e
 CHE-502, Inorganic Chemistry-I (4 credits, 60 L)
Section I-Molecular Symmetry and its applications to Inorganic chemistry
(2 credits, 30 L)
Chapter-1: Molecular Symmetry and Symmetry Groups (12 L)
Symmetry elements and operations, Symmetry planes and reflections, the inversion centre,
proper axes and proper rotations, improper axes and improper rotation, products of symmetry
operations, equivalent symmetry elements and equivalent atoms, general relations among
symmetry elements and symmetry operations, classes of symmetry operations, symmetry
elements and optical isomerism, symmetry point groups, classification of molecular point
groups, defining properties of a group, group multiplication table, some examples of group,
subgroups and classes

Chapter-2. Representations of Groups (08L)

Matrix representation and matrix notation for geometric transformation, The Great
Orthogonality Theorem and its consequence, character tables (No mathematical part), wave
function as basis for irreducible representations

Chapter-3: Symmetry Adapted Linear Combinations (05L)

Projection operators and their use of construct SALC (Construction of SALC for sigma
bonding for molecules belonging point groups D2h, D3h, D4h, C4v, Td, Oh normalization of
SALC, transformation properties of atomic orbital, MO’s for sigma bonding, ABn molecules,
tetrahedral AB4 and Oh AB6 cases.

Chapter-4: Application of Group theory to Infrared Spectroscopy (05L)

Introduction, selection rules, polyatomic molecules, possible vibrations in a linear molecule,
bending modes, symmetry of vibrations and their IR activity, Group vibration concept and its
limitations, IR spectra related to symmetry of some compounds, IR spectra of complex
compounds

References:
1. Chemical Applications of Group Theory by F. A. Cotton
2. Symmetry and Spectroscopy of Molecules by K. Veera Reddy
3. Group Theory and its Chemical Application by P.K. Bhattacharya
4. Symmetry in Chemistry by Jaffe and Orchin

12 | P a g e
Course Outcomes: At the end of course student should able to -
CO-1: Define symmetry elements and symmetry operations, classes, properties of a
group,group multiplication table, etc.
CO-2: Classify symmetry elements, point group, Group, sub-group and classes.
CO-3: Use wave function as basis for determination of irreducible representations and the
Great Orthogonality theorem and its consequence.
CO-4: Solve problem based on point group, matrix representation and character table
CO-5: Construct character table of various point group
CO-6: Justify which can take part in bonding on the basis of SALCs and point group
ofmolecules.
Section-II: Chemistry of Main Group Elements (2 credits, 30 L)
Chapter 1: Hydrogen Compounds (03 L)
Introduction, Classification of Hydrides, electron deficient, electron precise and electron
rich hydrides, Production of dihydrogen (Ref.1 Page number-276-287)
Chapter 2: Alkali and Alkaline Earth Metals (03 L)
Introduction, Solutions in non-aqueous media, application of the elements and their
compounds, Compounds of oxoacids of alkali metals (Ref.1 Page number-297,302-
303,306,313 Ref.3 pages-246-247)
Chapter 3: Boron Group (04 L)
Introduction, Boron Hydrides, preparation, structure and Bonding with reference to
LUMO, HOMO, interconversion of lower and higher boranes,
phosphazenes,metalloboranes, carboranes, organoboranes, and structure of higher
boranes.(Ref.1 Page number- 338344,Ref.3-306-311)
Chapter 4: Carbon Group (04 L)
Introduction, Allotropes of carbon, Diamond, Graphite, Graphene, fullerenes ,carbon
nanotube with synthesis, properties , Structure- single walled and multi walled and its
application, Intercalation compounds of graphite, Silicates classification, use in
technology. Zeolites. (Ref.1 Page number-354358, Ref.2-Pages 432-446)
Chapter 5: Nitrogen Group (04 L)
Nitrogen activation, Hydrides of nitrogen, Oxidation states of nitrogen and their
interconversion, condensed phosphates, Phosphazenes and their Compounds,
Applications. (Ref.1 Page number-381,383-384,387-389,391-394).
Chapter 6: Oxygen Group (03 L)
13 | P a g e
 Introduction, Metal Sulphides ,Selenides and Tellurides, oxyacid’s of Sulphur, hydrogen
peroxide properties and industrial production,Sulphur –nitrogen compounds,. Ring, and
Cluster compounds(Ref.1 Page number-402,409-412,416-417, Ref.2 page number-570-
572)
Chapter 7: Halogen Group (03 L)
Introduction, Interhalogens, pseudohalagen and pseudohalides, Synthesis, Properties and
Applications, Structure, Fluorocarbons, Oxoacids and Oxoanions of Halogens. (Ref.1
Page number-422-423,429,433-34 ,437,Ref.2 page number 621-632)
Chapter 8: Noble Gases (03 L)
Introduction, Occurrence, Compounds of Xenon-with fluorine and Oxygen and its
structures and uses (Ref.1 Page number-442-446,Ref.2 page number 639-648)
Chapter 9: Organometallic Compounds (03 L)
Introduction, Organometallic Compounds of Li, Mg, Si, Al, Sn, Pb, As, with
Classification, Nomenclature, Synthesis, Structure Properties and Uses (Ref.1 Page
number-347,371- 72,394-396, Ref.2-304-308,347-349,446-451.)
Reference:
1. Inorganic Chemistry by Shriver and Atkins, Fifth Edition
2. Concise Inorganic Chemistry by J. D. Lee Fifth Edition
3. Inorganic Chemistry by Principle of Structures and Reactivity by Huheey, Keiter,
Medhi, fourth edition.
4. Inorganic Chemistry by Meissler and Tarr, Third edition.
Course Outcomes: At the end of course student should able to -
CO-1: Define electron deficient, electron precise and electron
richspecies, Pseudohalogens, Oxoacids and Oxidation state.
CO-2: Describe special properties of fluorine, Nitrogen activation, Oxo acids of nitrogen,
sulphur and phosphorous, synthesis and structure of xenon fluorides.
CO-3: Explain term metal sulfides, selenides, tellurides, polonide, inter-halogens, Halogen
oxides, Graphene, fullerenes and carbon nanotube.
CO-4: Determine Oxidation states of nitrogen and their interconversion and application of
crown ether in extraction of alkali and alkaline earth metal.
CO-5: Differentiate between diamond and graphite, Pseudohalogens and interhalogens.
CO-6: Classify the hydrides, borides and oxyacids and draw their structure.

14 | P a g e
 CHEPIA-503, Organic Chemistry-I (2 credits, 30 L)
(Aromaticity, Stereochemistry and Reagents)
Chapter-1: Aromaticity (04 L)
1. Recapitulation: Benzenoid and non-benzenoid compounds, aromaticity and Huckel’s rule
2. Antiaromaticity, Quasiaroamtic and homoaromatic compounds, application to carbocyclic
and heterocyclic systems, annulenes, azulenes and fulvenes, mesoionic compounds,
current concepts of aromaticity, Frost Musulin Diagram
Ref. 1 and 2
Problem solving
1. Recapitulation: Origin of stereochemistry, optical activity, chirality. Projection formulae,
Conformational concepts, conformations of acyclic & cyclic (ethane, propane, butane,
cyclohexane, methylcyclohexane) molecules.
2. Stereoisomerism, enantiomeric relationship, distereomeric relationship, % ee and % de,
D/L, R/S and E/Z nomenclature in C, N, S, P containing compounds, prochiral
relationship, Re/Si faces, Topicity, optical activity in biphenyls, spiranes, allenes, helical
structures, ansa compounds and cyclophanes, stereospecific and stereoselective reactions,
stability and optical activity in cis and trans decalins, stereochemical aspects of
elimination (E2 and Ei) and addition reactions (syn and anti-additions).
Ref. 4, 5 and 6
Problem solving
Chapter 3: Oxidation and Reduction Reactions (12 L)
1. Recapitulation: CrO3 (Jones reagent), KMnO4, O3, OsO4 LiAlH4, LiBH4, NaBH4,
2. Oxidising reagents: PDC, PCC, MnO2, Swern, Pb(OAc)4, RuO4, Woodward and Prevost
dihydroxylation, peracid, HIO4, TEMPO, IBX, CAN, Fetizon's Reagent
3. Reducing reagents: NaBH4/CeCl3, NaBH3CN, Willkinsons catalyst, DIBAL, Clemenson,
Wolff-Kishner reduction, Rosenmund Reduction, Birch, dissolving metal, Lindlar catalyst
Ref. 6, 7, 8, 9
Problem solving
References
Essential books
1. Advanced Organic Chemistry, Reactions Mechanisms and Structure by J. March, 6th
edition, John Wiley

15 | P a g e
 2. Advanced Organic Chemistry Part A: Structure and Mechanism and Part B: Reaction and
synthesis, Francis A. Carey, Richard J. Sundberg, 5th Edition, Springer
3. Stereochemistry of Organic Compounds (Principles and Applications) by D. Nashipuri,
4th edition, New Age International Private Limited.
4. Stereochemistry of Organic Compounds by by Ernest L. Eliel and Samuel H. Wilen, 1 st
edition, Wiley.
5. Stereochemistry: Conformation and Mechanism by P.S. Kalsi, 11th Edition, New Age
International Private Limited.
6. Organic Chemistry, Jonathan Clayden, Nick Geeves, Stuart Warren, 1 st Edition, Oxford
University Press
7. Modern Synthetic Reactions by Herbert O. House, 1st Edition.
8. Advanced Organic Chemistry Part B: Reactions and Synthesis by Francis A. Carey and
Richard J. Sundberg, 5th Edition, Springer.
9. Organic Synthesis by Jagdamba Singh, L.D.S Yadav, Pragati Prakashan.
Course Outcome: Student will able to -
CO1: Understand the concepts of aromaticity, stereochemistry, and oxidation-reduction
reactions
CO2: Learn the concepts of stereochemistry.
CO3: Predict the product and mechanism of the reactions.
CO4: Advance knowledge of various stereochemical aspects.
CO5: Apply the concepts of oxidations and reduction to solve the advance problems.
CO6: Develop problem solving ability.

16 | P a g e
 CHE- 504, Physical Chemistry Practical I [2 Credits, 60 L]
1.Statistical treatment of experimental data (calculation of mean and standard deviation for
given data and least square method for calibration curve method) (compulsory)
Part-I: Chemical Kinetics: (Any three)
2.Kinetic decomposition of diacetone alcohol by dilatometry.
3.Determination of an order of a reaction.
4.Brönsted primary salt effect.
5.To investigate the rate constant of an autocatalytic reaction between potassium
permanganate and oxalic acid.
Part-II: Non-Instrumental (Any three)
6. Partial Molar Volume (Polynometry) Determination of the densities of a series of solutions
and to calculate the molar volumes of the components.
7.Determination of molecular weight by steam distillation.
8. To determine the radius of Glycerol molecule by viscometry.
9.Isotherm for a three-component system: chloroform/acetic acid /water.
Part-III: Colorimetry and Spectrophotometry (Any four)
10.Spectrophotometric determination of the acid dissociation constant of methyl red
11. Simultaneous determination of KMnO4 and K2Cr2O7 by spectrophotometry.
12.To study the adsorption of certain dyes such as methyl violet, picric acid or malachite
green on charcoal.
13.To determine the indicator constant of bromocresol puple by half height method
14. Determination of energy of n to Π* transition in acetone and study of effect of solvent on
energy of this transition by recording absorbance spectra in n-hexane and water.
b) To study the effect of the extended conjugation on the λmax of p-nitro phenol by
recording spectrum in acidic and alkaline medium
Part -IV: Radioactivity
15.Determination of E-max of β radiation and absorption coefficients in Al.
N B.:
1. Use molar concentrations for volumetric /estimations/synthesis experiments.
2. Use optimum concentrations and volumes
3. Two burette method should be used for volumetric analysis (Homogeneous mixtures)
4. Use of microscale technique is recommended wherever possible

17 | P a g e
References:
1. Practical physical chemistry, A. Findlay, T.A. Kitchner (Longmans, Green and Co.)
2. Experiments in Physical Chemistry, J.M. Wilson, K.J. Newcombe, A.r. Denko. R.M.W.
Richett (Pergamon Press)
3. Senior Practical Physical Chemistry, B.D. Khosla and V.S. Garg (R. Chand and Co.,
Delhi.).

Course outcomes:
CO1: Students will grasp the concept of reaction rate and its significance in Chemical
Kinetics.
CO2: Students will learn how to use experimental data to deduce rate laws and rate
constants.
CO3: Students will be familiar with the fundamental principles of colorimetry and
spectrophotometry including Beer's law, Lambert- Beer's law and the relationship
between absorbance and concentration.
CO4: Students will able to operate the instruments like spectrophotometer and colorimeter.
CO5: Students will be able to determine the densities of the solutions and can calculate
molar volumes

18 | P a g e
 CHE-505, Inorganic Chemistry Practical-I (2-Credits; 60 L)
(Inorganic Material analysis, Synthesis and Its Applications)

Part-1: Ore Analysis (Any two) (Ref.1)

1. Determination of silica and manganese from pyrolusite ore.
2. Determination of aluminium and silica from bauxite ore.
3. Determination of silica and iron from hematite ore
4. Determination of copper and sulphide from chalcopyrite ore.

Part-2: Alloy Analysis (Any two) (Ref. 1)

5. Determination of tin and lead from solder alloy.
6. Determination of iron and chromium from stainless steel alloy.
7. Determination of copper and nickel from cupra-nickel alloy
8. Determination of copper and zinc from brass alloy.

Part-3: Synthesis of materials/ nanomaterials and their applications (Any six)

9. Synthesis of ZnO from zinc oxalate precursor method and determine band gap by
absorption spectroscopy (Ref. 2-4, 6).
10. Heterogeneous Photo-Catalysis: Removal and kinetics of photo-catalytic dye degradation
(methylene blue) on synthesized ZnO. (Ref. 5)
11. Synthesis of TiO2 by Sol-Gel method and determine band gap by absorption
spectroscopy (Ref-4)
12. Heterogeneous Photo-Catalysis: Removal and kinetics of photo-catalytic dye degradation
(methylene blue) on synthesized TiO2. (Ref. 5)
13. Synthesis of colloidal silver nanoparticles (suspension) and determine band gap by
absorption spectroscopy. (Ref. 3-4)
14. Synthesis of Cu2O nanoparticles of different colours. (Ref. 7)
15. Synthesis of MnO2 (Ref. 2)
16. Heterogeneous Catalysis: Study on decomposition of H2O2 by non -catalysed and MnO2
catalysed method (Ref. 2, 12)
17. Synthesis of CuxS nano-particles. (Ref. 9-11)
18. Study of non-stoichiometry of synthesised CuxS (Estimation of Cu(II) by colorimetry)
19. Synthesis of Fe2O3 nanoparticles from FeC2O4. (Ref. 2 and 8)
20. Heterogeneous Catalysis: Study on decomposition of H2O2 by non-catalysed and Fe2O3
19 | P a g e
 catalysed method (Ref. 2, 8 and 12).
Part-4: Table Work (compulsory)
1. Study of MnO2 / Fe2O3 / ZnO / TiO2 / Silver – nanoparticles or any other materials:
2. Powder XRD analysis with respect to - 2θ from XRD, miller indices to assigned using
JCPDS or ICDD data and experimentally observed 2θ, inter planar distance, crystal
volume,lattice parameters.
3. SEM: Write surface morphology and calculate grain size.
N B.:
1. Use molar concentrations for volumetric /estimations/synthesis experiments.
2. Use optimum concentrations and volumes
3. Two burette method should be used for volumetric analysis (Homogeneous mixtures)
4. Use of microscale technique is recommended wherever possible

Reference:
1. Text book of Quantitative Analysis, A.I. Vogel 4th Edn. (1964).
2. Experimental Inorganic Chemistry, Mounir A. Malati, HorwoodSeries in Chemical
Science(Harwood publishing, Chichester) 1999
3. A Laboratory Course in Nanoscience and Nanotechnology; Dr. Gérrard Eddy Jai
Poinern;CRC Press Taylor & Francis, 2015
4. Nanotechnology: Principles and Practices, Sulbha Kulkarni, Springer, (2015)
5. Environmental Chemistry Microscale laboratory Experiments, Jorge G. Ibanez Margarita
Hemandez-Esparza, Carmen Doria-Serrano, Arturo Fregoso-Infante, Mono Mohan Singh,
Springer, 2008.
6. Ecofriendly synthesis and solar photocatalytic activity of S-doped ZnO; Journal of
Hazardous Material, Volume 183, Issues 1–3, 15 November 2010, Pages 315-
32310.1016/j.jhazmat.2010.07.026
7. Synthesis of Copper(I) Oxide Particles with Variable Color: Demonstrating Size-
Dependent Optical Properties for High School Students; J. Chem. Educ; DOI:
10.1021/acs.jchemed.5b00563
8. Catalytic Efficiency of Iron(III) Oxides in Decomposition of Hydrogen Peroxide:
Competition between the Surface Area and Crystallinity of Nanoparticles Martin Hermanek,
Radek Zboril, Ivo Medrik, Jiri Pechousek, and Cenek Gregor, J. AM. CHEM. SOC. 2007,
129, 10929-10936,

20 | P a g e
9. CuS Nanoparticles Trigger Sulfite for Fast Degradation of Organic Dyes under Dark
Conditions; CS Omega 2022, 7, 5, 4140-4149; DOI: 10.1021/acsomega.1c05697.
10. A facile chemical route to copper sulfide CuS nano-crystallites – pH effect of the
morphology and the shape of them; journal of optoelectronics and advanced materials; Vol.
8, No. 2, April 2006, p. 597 – 60
11. Facial Grinding Method for Synthesis of High-Purity CuS Nanosheets; Ind. Eng. Chem.
Res. 2018, 57, 8, 2759–2764; https://doi.org/10.1021/acs.iecr.7b04616
12. Practical Physical Chemistry, B. Vishwanathan and P. S. Raghwan, Viva Books (2005)

Course Outcome: Student will able to -

CO-1: Prepare solution of required conc. and handle the laboratory equipment properly.
CO-2: Perform experiment accurately and able to perform calculation.
CO-3: Explain experiment and principal of experiment in detail.
CO-4: Perform calculations and discuss results and write conclusions of the experiment.
CO-5: Apply knowledge to a) design experiment for given aim or modify experiment to
enhance results. b) to find out lacuna in experimental procedure.
CO-6: Solve problem/ numerical depending on given experimental data / information.

21 | P a g e
 CHE-506, Organic Chemistry Practical I (2-Credits; 60 L)
(Single stage preparation and purification techniques)
Single stage preparation and Recrystallization (Any Seven)
1 Reduction of aromatic aldehyde using sodium borohydride.
(Recrystallization)
2 Vilsmeier-Haack reaction of N, N-dimethyl aniline.
(Recrystallization)
3 Bromination of acetanilide using Ceric Ammonium Nitrate
(Recrystallization)
4 Synthesis of dihydropyrimidinone using Biginelli reaction
(Recrystallization)
5 To study the base catalyzed Aldol condensation using LiOH.H2O as catalyst.
(Recrystallization)
7 Synthesis of p-chlorotoulene from p-toluidine by using Sandmeyer reaction.
(Recrystallization)
8 Synthesis of β-naphthyl methyl ether from β-naphthol.
(Chemical Separation and Recrystallization )
9 Reduction of p-nitrotoluene using Sn/HCl.
(Chemical Separation and Crystallization)
Single stage preparation and Simple Distillation (Any Two)
1 Purification of crude aniline by distillation and its conversion to acetanilide
(Simple Distillation)
2 Reduction of acetophenone using hydrazine hydrate.
(Simple Distillation)
3 In situ preparation of sodium hypochlorite (NaOCl) using bleaching powder and NaOH
and its application in the oxidation of cyclohexanol to cyclohexanone.
(Simple Distillation)
Single stage preparation and Other Purification Techniques (Any Three)
1 Synthesis of phthalimide from phthalic acid.
(Sublimation technique)
2 Nitration of Phenol and Purification by Column Chromatography.
(Column Chromatography)

22 | P a g e
 3 Cannizzaro reaction of substituted aromatic aldehyde.
(Chemical Separation)
4 Preparation of Aryloxy derivative of phenolic compound.
(Separation by solvent extraction)
N B.:
1. Use molar concentrations for volumetric /estimations/synthesis experiments.
2. Use optimum concentrations and volumes
3. Two burette method should be used for volumetric analysis (Homogeneous mixtures)
4. Use of microscale technique is recommended wherever possible

References
1. Vogel's Textbook of Practical Organic Chemistry, 5th edition Pearson India.
2. Comprehensive Practical Organic Chemistry by V.K. Ahluwalia and Renu Aggarwal
3. Advanced Practical Organic Chemistry by John Leonard, John Leonard, Barry Lygo,
Garry Procter, 2nd edition, CRC Press.
4. Solvent-free Organic Synthesis by Koichi Tanaka.
5. Practical Organic Chemistry by Mann and Saunders, 4th edition, Pearson Education.
6. Advanced Practical Organic Chemistry by John Leonard, Barry Lygo, Garry Procter, 3rd
Edition.

Course Outcome: Student will able to -

CO1: Understand the theoretical aspects behind separation, purification and synthesis of
organic compounds.
CO2: Acquire the experimental skills for separation, purification, identification and synthesis
of organic compounds.
CO3: Design experimental set up for performing the organic reactions.
CO4: Monitor the organic reactions.
CO5: Describe the mechanistic aspects of organic reactions.
CO6: Develop problem solving ability.

23 | P a g e
 Chemistry electives
(Any one option from the following four courses)
CHE – 507(A), Chemical Mathematics (2 credits, 30)
Chapter 1: Functions (14 L)
Differential and integral calculus, limits, derivatives, physical significance, basic rules of
differentiations, maxima and minima, exact and inexact differentials, partial differentiations,
rules of integrations, substitution, applications to chemistry related problems.
Chapter 2: Differential Equations (08 L)
Separation of variables, homogeneous, exact, linear equations of second order, series solution
method.
Chapter 3: Vectors, Matrices and Determinants (08 L)
Vectors, dots, cross and triple products, Introduction to matrix, algebra, addition and
multiplication of matrices, inverse adjoints and transport of Matrices, unit and diagonal
matrices.
References
1) Chemical maths book, E. Steiner
2) Maths for chemistry vol 1,2 Martin M C R Cockette and G.Doggett.
3) Mathematical preparations for physical chemistry F. Daniels, Mc Graw Hill.
4) Principles of Physical chemistry by Puri Sharma Pathania
Course Outcomes: After studying the chemical mathematics, the students can learn
CO1: Students will able to remember rules of differentiation, integration, vectors, matrices
and determinants.
CO2: Students can understand the various rules to solve problems related to derivatives,
integration, vectors, matrices and determinants.
CO3: Students able to apply mathematical concepts to solve problems related to chemistry.
CO4: Students can analyse the chemical problems using the knowledge of integration,
differentiation, vectors, matrices and determinants.
CO5: Students can evaluate various chemical problems can evaluate by using rules of
integration, differentiation, vectors, matrices and determinants.
CO6: Students will able to create chemical problems with methods of mathematical
background

24 | P a g e
 CHE-507(B), Chemistry of Nanomaterials (2 Credits) (30 L)
Chapter-1: The Big World of Nanomaterials (03 L)
History and Scope; Can Small Things Make a Big Difference? Classification of
Nanostructured Materials; Fascinating Nanostructures; Applications of Nanomaterials;
Nature: The Best Nanotechnologist; Challenges and Future Prospects (Ref. 1: 1 to 25)
Chapter-2: Band Theory (04 L)
Metallic Bonding and Band Theory; Band structure of metals; Band structure of insulators;
Band structure of semiconductors: silicon; Band structure of inorganic solids, III–V, II–VI
and
I–VII compounds, Transition metal compounds, Fullerenes and graphite, Bands or Bonds: a
Final Comment
Ref-1-66-100; Ref.-2: 173-186
Chapter-3: Defects in Nano-structure and Properties of Nanomaterials (06 L)
Types of Defect: perfect and imperfect defects, Point Defects, Schottky defect, Frenkel
defect, The Kroger–Vink notation for crystal defects, Colour centres, Vacancies and
interstitials in non-stoichiometric crystals: extrinsic and intrinsic defects, Defect clusters or
aggregates, Interchanged atoms: order–disorder phenomena Extended Defects,
Crystallographic shear structures, Stacking faults, Sub-grain boundaries and antiphase
domains (boundaries).
Ref. 1: 29 to 36; Ref. 2: 83 to 86; 90-95; 108 to 116; 120 to 123;
Chapter-4: Effect of Nano-Dimensions on Materials Behavior (06 L)
Elastic properties; Melting point; Diffusivity; Grain growth characteristics, Enhanced solid
solubility, Magnetic properties, Soft magnetic nanocrystalline alloys, Giant
magnetoresistance (GMR), Electrical properties, Mechanical properties, Hardness and
strength, Tensile ductility and strain hardening, Creep and superplastic behaviour, Fracture
and toughness, Corrosion properties. Ref. 1: 36 to 66). Ref-5: 1-29
Chapter-5: Synthetic Methods of Nanomaterials (06 L)
General Observations; Bottom up and top-down approach (definitions); Solid State Reaction
or Shake ’n Bake Methods: Nucleation and growth, epitaxy and topotaxy, Practical
considerations and some examples of solid state reactions, Combustion synthesis, Mechano-
synthesis; Low Temperature or Chimie Douce Methods: Alkoxide sol–gel method (Synthesis
of MgAl2O4, Synthesis of silica glass, Spinning of alumina fibres, Preparation of indium tin
oxide (ITO) and other coatings), Preparation of indium tin oxide (ITO) and other coatings, Sol–
25 | P a g e
gel method using oxyhydroxides and colloid chemistry (Synthesis of zeolites, Preparation of
alumina-based abrasives and films, Citrate gel and Pechini processes, Use of homogeneous,
single-source precursors, Hydrothermal and solvo-thermal synthesis, Microwave synthesis,
Intercalation and deinter-calation, Graphite intercalation compounds, Pillared clays and
layered double hydroxides, Example of a difficult synthesis made possible by chimie douce
methods: BiFeO3.
Ref-1: 66-106; Ref. 2: 187 to 225.
Chapter-6: Applications of Nanomaterials (05 L)
1. Photocatalysis: Material name, working and principle of Photocatalysis, 2. Gas sensing -
Material name, working and principle of gas sensor, 3. Medical applications, 4. coloured
nanomaterials as inorganic pigments, 5. Nano catalysis- Material, its application and
mechanism 6. Nanomaterials of environmental pollution remediation. 7: Fuel Cell, 8.
Photovoltaic Cell.
Ref. 1. 108 to 148; Ref. 5: 29 to 43, Ref. 6
References
1. Textbook of Nanoscience and Nanotechnology, B S Murty P Shankar Baldev Raj B B
Rath James Murday, Springe/University press, 2013.
2. Solid State Chemistry and its Applications, Anthony R. West, Second Edition Student
Edition; Wiley, 2014
3. Chemistry of Nanomaterials Fundamentals and Applications, Tahir Iqbal Awan, Almas
Bashir, Aqsa Tehseen, Elsevier, 2020.
4. Solution Methods for Metal Oxide Nanostructures, Rajaram S Mane, Vijaykumar V
Jadhav, Abdullah M Al-Enizi; Elsevier, 2023.
5. Advanced Nanomaterials and Their Applications in Renewable Energy Jingbo Louise
Liu, Sajid Bashir; Elsevier (2015).
6. Research Papers: a) Photocatalysis: From Fundamental Principles to Materials and
Applications; ACS Applied Energy Materials 2018 1 (12), 6657-6693; DOI:
10.1021/acsaem.8b01345 b) Photocatalysis for Organic Wastewater Treatment: From the
Basis to Current Challenges for Society; Catalysts 2020, 10, 1260;
doi:10.3390/catal10111260; c) Gas sensing mechanism of metal oxides: The role of
ambient atmosphere, type of semiconductor and gases - A review, Sci. Lett. J. 2015, 4:
126, d) Review: Influences of Semiconductor Metal Oxide Properties on Gas Sensing
Characteristics; https://doi.org/10.3389/fsens.2021.657931 e) An Overview of
26 | P a g e
 Nanomaterials for Water and Wastewater Treatment; Advances in Materials Science and
Engineering Volume 2016, Article ID 4964828, 10 pages
http://dx.doi.org/10.1155/2016/4964828
Course Outcomes: At the end of course student will able to-
CO-1. Define / memories the terms related to - applications of nanomaterials, band theory,
defects in crystal structures, some properties of nanomaterials, synthesis of
nanomaterials.
CO-2. Discuss Applications of nanomaterials, synthesis methods of nanomaterials, some
properties of nanomaterials, defects in nanomaterials.
CO-3. Apply their knowledge to – choose synthesis method for nanomaterial, selection of
nanomaterial for particular application, explain observed properties of nanomaterial,
etc.
CO-4. Differentiate / compare – metals-semiconductors-insulators, Non-stoichiometry and
point defects, different synthetic methods, properties of nanomaterials.
CO-5. Explain the terms related to - applications of nanomaterials, band theory, defects in
crystal structures, some properties of nanomaterials, synthesis of nanomaterials.
CO-6. Propose scope / Applications of nanomaterials to solve real problems.

27 | P a g e
 CHE-507 (C), Analytical Chemistry (2 credits, 30 L)
Chapter 1: Good Laboratory Practice: Quality Assurance of Analytical Measurements
(10 L)
Good Laboratory Practice, Validation of Analytical Methods, Quality Assurance, Laboratory
Accreditation, Electronic Records and Electronic Signatures: 21 CFR, Part 11, Official
Organization.
Chapter 2: Lab Safety (08 L)
Laboratory Emergencies: Spills and Fires I. General Preparation for Emergencies- Handling
the Accidental Release of Hazardous Materials, Notifications, Spill Containment and Clean-
up, Leaking Gas Cylinders, Fires, Classification, Fire Extinguishers (how they work, types),
Risk Assessment, Case Study, Sources of chemical hazards, hazards of organic synthesis,
sulphonating hazard, organic solvent hazard. Control measures for chemical hazards.
Management of combustible gases, toxic gases and oxygen displacing gases, Regulations for
chemical hazards, MSDS, labelling guidelines, management of overexposure to chemicals
and TLV concept, and Disposal of hazardous material.
Chapter 3: Mass Spectrometry (12 L)
Principle, instrumentation, ionization methods- electron bombardment ionization, arc and
spark ionization, Photo-ionization, thermal ionization, Chemical ionization, Mass analyzers-
Magnetic, double focusing, Time of flight, Quadrupolar, Ion cyclotron resonance analyzer,
Correlation of mass spectra with molecular structure and molecular weight, Isotopic
Abundances, Fragmentation patterns, Quantitative analysis, Applications and Problems.
Fourier transform mass spectrometry, Tandem mass spectrometry, inductively coupled
Plasma-mass spectrometry, Secondary ion–mass spectrometry and ion microprobe mass
analyzer.
References
1. Introduction to Instrumental Analysis, R. D. Braun, Mc Graw-Hill. Inc.1987.
2. Instrumental Methods of Chemical analysis, H. H. Willard, L. L. Merritt Jr., J. A. Dean
and F. A. Settle Jr., 6th Edition, Wadsworth Publishing Company, USA,1986
3. Fundamentals of Analytical Chemistry, D. A. Skoog, D. M. West, F. J. Holler, S. R.
Crouch, 7th Edition, Thomson Asia Pte. Ltd, Singapore,2004
4. Instrumental Methods of Chemical Analysis – B. K. Sharma 26th Ed. 2007, pages 286-
307

28 | P a g e
5. Good laboratory practice, regulations, 2nd Edition, Sandy, Wenberg, Vol.69, Marcel,
Dekker series, 1995.
6. Daniel A. Crowl, Joseph F. Louvar, Chemical Process Safety; Fundamentals with
application, 3rd edition, prentice hall, 2011.
7. Quantitative risk assessment in chemical process industries, American institute of
chemical industries, centre for chemical process safety.
Course Outcome: Student will able to –
CO1: Define/memorize GLP, Lab Safety, Quality assurance
CO2: Discuss good laboratory practices, laboratory emergencies, and mass spectrometry
CO3: Apply their knowledge to prepare quality assurance reports, emergencies in the
laboratory
CO4: Differentiate between different ionization technique, compare hazardous and non-
hazardous material handling
CO5: Explain the Quality Assurance, Laboratory Accreditation, Laboratory Emergencies,
different ionization technique
CO6: Applications of GLP, Lab Safety, mass spectrometry

29 | P a g e
 CHEPIA-507 (D), Basic Organic Chemistry (2 credits, 30 L)
Chapter-1: Nature of Bonding in Organic Molecules (12 L)
a) Structure and Bonding:
1. Recapitulation: Various structural and electronic effects and strength of acids and bases
2. Electron Donor–Acceptor (EDA) complexes, crown ether complexes and cryptates,
catenanes and rotaxanes, inclusion compounds, fullerenes
Ref. 1
b) Reactive Intermediates:
1. Recapitulation: Intermediate and transition state, carbocations, carbanions, benzyne, free
radicals
2. Generation, structure, stability and reactivity of carbenes, nitrenes, ketene and isocyanate
Ref. 1, 2 and 3
Problem solving
Chapter 2: Aliphatic Nucleophilic Substitution reactions (08 L)
1. SN1, SN2 and SNi reactions (Mechanism, Reactivity and Stereochemical aspects)
Ref. 1
2. Neighbouring group participation: The neighbouring group mechanism, The Neighbouring
group participation by π and σ bonds, NGP by halogens and heteroatoms (O, N, S),
anchimeric assistance, classical and non-classical carbocations, phenonium ions, norbornyl
system, carbocation rearrangements in neighbouring group participation.
Ref. 4 and 5
Problem solving
Chapter 3: Aromatic electrophilic and nucleophilic substitution reactions (10 L)
1. Recapitulation: Mechanism of aromatic electrophilic substitution reaction.
2. Orientation effects in aromatic electrophilic substitution reactions (Benzene, Naphthalene,
Anthracene, Pyridine, Pyrrole, Furan and Thiophene)
3. Kolbe, Gatterman, Gatterman-Koch, Riemer-Tieman, Vilsemeyer-Haack, Hoesch, Ipso
substitution.
4. Benzyne reaction, Meisenheimer complex, cine and tele substitutions, Chichibabin
reaction, Sandmeyer Reaction
Ref. 1, 2, 3 and 5
Problem solving

30 | P a g e
References
Essential books
1. Advanced Organic Chemistry, Reactions Mechanisms and Structure by J. March, 6th
edition, John Wiley
2. Advanced Organic Chemistry Part A: Structure and Mechanism and Part B: Reaction and
synthesis, Francis A. Carey, Richard J. Sundberg, 5th Edition, Springer
3. Advanced organic chemistry, Jagdamba Singh and LDS Yadav, 1st Edition, Pragati
Prakashan.
4. Mechanism and Structure in Organic Chemistry by E.S. Gould, 1st Edition, Holt, Rinehart
and Winston of Canada Ltd.
5. Organic Chemistry, Jonathan Clayden, Nick Geeves, Stuart Warren, 1 st Edition, Oxford
University Press.
Further reading
2. A Guidebook to Mechanism in Organic Chemistry by Peter Sykes, 6th Edition, Pearson
Education.
3. Reaction Mechanism in Organic Chemistry by S. M. Mukherji, 3rd edition, Laxmi
Publications.
4. Organic Reactions and Their Mechanisms by P.S. Kalsi, 5th edition, New Age
International Private Limited.
5. Principles of Organic Synthesis by R.O.C. Norman and J.M. Coxon, 3rd Edition.
Course Outcome: Student will able to –
CO1: Understand the concepts of chemical bonding, various structural effects, acids and
bases, and types of reactions
CO2: Basic knowledge of aliphatic and aromatic substitutions, elimination and addition
reactions
CO3: Understand and identify the types of organic reactions.
CO4: Write the mechanism of aliphatic and aromatic substitutions, elimination and addition
reactions and oxidation-reduction reactions
CO5: Solve the problems involving multiple steps.
CO6: Develop problem solving ability of the students

31 | P a g e
 CHE-508, Research methodology (4 credits, 60 L)
Chapter-1: Introduction to Research methodology (02 L)
Objective of research, motivation in research, types of research, Fundamental research,
applied research, experimental research, and interdisciplinary research.
Chapter-2: Scope of Research and Ethics (05 L)
Steps in scientific research: scientific methods of research, criteria of good research, and
characteristics of a good research, Research problem: Identification, Selection, developing
research title, Criteria for prioritizing topics for research, Prioritizing Topics for Research,
Formulation of research objectives. Types and importance of research ethics, Institutional
ethics committee, Plagiarism, Patenting and intellectual property rights. Publication ethics:
definition, introduction, and importance.
Chapter-3: Literature Survey and Search technique (08L)
Print: Sources of information: Primary, secondary, tertiary sources; Journals: Journal
abbreviations, abstracts, current titles, reviews, monographs, dictionaries, Introduction to
Chemical Abstracts and Beilstein, Subject Index, Substance Index, Author Index, and
Formula Index. Literature Search technique: SCOPUS, Google Scholar, PUBMED, Web of
Science, science direct, Indian Citation Index, Research Gate, and scifinder, Scirus,
ChemIndustry, Wiki- Databases, ChemSpider.
Chapter-4: Overview of the journal article (06 L)
Selection of journals, Data bases and research metrics Databases: i) indexing databases
ii) Citation databases: Web of Science, Scopus, UGC-Care List etc.
Research Metrics: a) Impact Factor of journal as per Journal Citation Report, SNIP, SJR,IPP,
Cite Score b) Metrics: h-index, g index, i10 index.
Chapter-5: Presentation of Scientific findings, Scientific Report Writing (09 L)
Publication Process: Types of technical documents- Full length research paper,
Short/Brief communications, Letters to editor, Book chapter, Review, Conference report,
Patents, dissertation. Components of a research publication: Title/Topic statement,
Abstract/key words, Aims and objectives, Hypothesis building, Rationale of the paper,
Work plan, Materials and methodology, Results and discussion, Key issues, and arguments,
Acknowledgement, Conflict of interest statement, bibliography, Technical Resumes & Cover
Letters. Softwares in Chemistry Data Plotting Structure Drawing, Grammar Checkers and
Sentence Correction Tools.

32 | P a g e
Chapter-6: Data Analysis and interpretation (15 L)
The Investigative Approach: Making and Recording Measurements. SI Units and their uses,
Scientific method and design of experiments, Analysis and Presentation of Data: Descriptive
statistics. Choosing and using statistical tests. Chemometrics. Analysis of variance
(ANOVA), Correlation and regression, Curve fitting, fitting of linear equations, simple
linear cases, weighted linear case, analysis of residuals, General polynomial fitting,
linearizing transformations, exponential function fit, r and its abuse, basic aspects of the
multiple linear regression analysis.
Chapter-7: Presentation and Communication skills (05 L)
Tables, Figures and Pictures using Excel, PowerPoint slide preparation, Preparation of
Posters, Electronic submission of manuscripts, oral and poster, Communication skills.
Chapter-8: Ethical Handling of Chemicals (10 L)
Safe working procedure and protective environment, protective apparel, emergencyprocedure
and first aid, laboratory ventilation. Handling of various chemicals, solvents & glassware.
Fires and fighting with fires. Hazardous substances, Safe storage and use of hazardous
chemicals, procedure for working with substances that pose hazards, flammable or explosive
hazards classification, and handling Safety Data Sheet. Chemical entries, MSDS, CAS
numbers, dead stocks maintenance. Disposal of waste chemicals, recovery, recycling and
reuse of laboratory chemicals.
References
1. C. R. Kothari, Research Methodology: Methods and Techniques, New Age International, 1990
2. B. L. Garg, R. Karadia, F. Agarwal and U. K. Agarwal, An introduction to Research
Methodology, RBSA Publishers, 2002
3. S. M. Coley and C. A. Scheinberg, Proposal Writing, Sage Publications, 1990.
4. Research Methodology by Best and Kahn, PHI Limited.
5. Research Methodology by R. Kumar, A Step-By-Step Guide for
Beginners,Pearson Education, Delhi (2006).
6. Fundamentals of modern statistical methods by Rand R.wilcox.
7. Power Analysis for Experimental Research A Practical Guide for the Biological, Medical
and social Sciences by R. Barker Bausell, Yi-Fang Li Cambridge University Press.
8. Design of Experience: Statistical Principles of Research Design and
Analysis,by Robert O. Kuehl Brooks/cole.
9. Panneerselvam R., Research Methodology, Prentice Hall Of India, New Delhi,2004
33 | P a g e
 10. Design & Analysis of Experiments by D. C. Montgomery, 5th Ed., Wiley India (2007).
Course outcomes:
CO1: Develop a comprehensive understanding of different research methodologies and their
applications in mathematics.
CO2: Cultivate critical thinking and analytical skills necessary for identifying research
problems and formulating research questions.
CO3: Provide practical experience in designing experiments, collecting and analyzing data,
and interpreting research results.
CO4: Foster effective communication skills for presenting research findings orally and in
written form.
CO5: Promote ethical research practices and awareness of responsible conduct in
mathematical research
CO5; Develop problem solving ability.

34 | P a g e
 Semester II
CHE- 551, Physical Chemistry-II (4 Credits, 60 L)
Section I- Molecular Spectroscopy (2 Credits, 30 L)
Chapter 1: Microwave Spectroscopy (06 L)
Rotation of molecules, Rotational spectra of diatomic molecules- rigid diatomic molecule,
intensities of spectral lines, effect of isotopic substitution, non-rigid rotator, spectrum of non-
rigid rotator, polyatomic molecules, linear molecules, symmetric top molecules, Asymmetric
top molecules, Applications. Ref. 1 Pages 33-58
Chapter 2: Infra-Red Spectroscopy (06 L)
Vibrating diatomic molecule, diatomic vibrating rotator, vibration rotation spectrum of
carbon monoxide, Breakdown of the Born-Oppenheimer approximation, vibration of
polyatomic molecules, Fourier transform spectroscopy (FTIR) and its advantages, carbon
dioxide laser and its advantages. Ref. 1 Pages 60-81, 102-110.
Chapter 3: Raman Spectroscopy (05 L)
Quantum theory of Raman effect, classical theory of Raman effect, pure rotational Raman
spectra, vibrational Raman spectra, structure determination from Raman and IR spectroscopy.
Ref. 1 Pages 111-128, 131-133, 138-141
Chapter 4: Electronic spectroscopy of molecules (08 L)
Electronic spectra of diatomic molecules. The Born Oppenheimer approximation, vibrational
course structure, The Franck Condon principle, dissociation energy and dissociation products,
rotational fine structure of electronic-vibration transitions, the Fortrat diagram, pre
dissociation, ultraviolet photo electron spectroscopy, x-ray photoelectron spectroscopy.
Ref. 1 Pages 181-195, 227-231
Chapter 5: Mossbauer Spectroscopy (05 L)
Principle, instrumentation, Applications- chemical shift, quadrupole effect, effect of magnetic
field. Ref:-1 Pages 323-332
References:
1. Fundamentals of molecular spectroscopy by Colin N. Banwell and Elain M. McCash. 5th
Editon.
2. Physical chemistry by G.M. Barrow, 5th edition , 2006, Mc Graw Hill Education
3. Principals of Physical chemistry by Puri Sharma Pathania, 48th edition, Vishal Publishing
Co.

35 | P a g e
4. Physical chemistry by Peter Atkins, Julio De Paula, 11th Edition , 2018, Oxford
University Press
Section II: Nuclear and Radiation Chemistry [2 Credits, 30 L]
Chapter 1: Radioactivity (06 L)
Types of radioactive decay, general characteristics of radioactive decay, decay kinetics
general expression for the activity of a daughter nuclide, Geiger- Nuttalls law, α- decay, A
problem in classical physics, Internal conversion and the Auger effect. Ref:-1 Pages 101-109,
122-126, 151-154
Chapter 2: Elements of radiation chemistry (06 L)
Interaction of radiation with matter, interaction of Gamma radiation with matter, units for
measuring radiation absorption, radiation dosimetry, radiolysis of water, free radicals in
water, radiolysis of some aqueous solutions.
Ref 1: Pages 368-371, 377-384
Chapter 3: Nuclear fission (08 L)
The discovery of nuclear fission, the process of nuclear fission, fission fragments and their
mass distribution, charge distribution, ionic charge of fission fragments, fission energy,
fission cross section and threshold, fission neutrons, theory of nuclear fission, neutron
evaporation and spallation.
Ref 1: 209-224, 228-229
Chapter 4: Application of Radioactivity (10 L)
Typical reaction involved in preparation of radio isotopes- Szillard – Chalmer reaction,
Radiochemical principles in the use of tracers, isotopes in elucidation reaction mechanism
and structure determination, solubility of sparingly soluble substances, surface area of a
powder or precipitate, rates of diffusion, analytical applications- isotope dilution analysis,
neutron activation analysis, radiometric titrations, medical applications- thyroiditis, assessing
the volume of blood in a patient, Industrial applications- thickness measurement and control,
friction and wear out, Gamma radiography
Ref 1: Pages 313-318, 320-334, 338-342, 350-352, 357-359
References:
1) Elements of nuclear chemistry by H. J. Arnikar (revised 4th edition)
2) Chemical applications of radioisotopes by H.J.M. Brown. (1 June 1969)
3) Source book of atomic energy by S. Glasshone Krieger Publishing Company; 3rd edition
(1 January 2012)
36 | P a g e
Course Outcomes:
CO1: Remember basic concepts of molecular spectroscopy, selection rules, intensity of
spectral lines, radioactive decay and decay kinetics.
CO2: Understand principles and applications of rotational, vibrational, Raman, electronic and
Mossbauer spectroscopy. Understand concepts of nuclear and radiation Chemistry.
Applications of Radioisotopes
CO3: Apply various spectroscopic techniques for gaining insights into molecular structure
CO4: Analyse vibrating diatomic molecule, simple harmonic and anharmonic oscillator,
Scattering of light, Raman Spectrum, interaction of γ radiation with matter and radiation
dosimetry.
CO5: Evaluate bond length, vibrational frequency, force constant and dissociation energy
using spectral data.
CO6: Able to create theoretical rotational and vibrational spectra of simple molecules.
Identify and define various types of nuclear changes or processes including fission, fusion
and decay reactions.

37 | P a g e
 CHE-552: Inorganic Chemistry-II (4 Credits, 60 L)
(Coordination and Bioinorganic Chemistry)
SECTION-I: Coordination Chemistry (2 Credits, 30 L)
Chapter-1. Concept and Scope of Ligand Fields (06 L)
Quantum numbers, Free ion Configuration, Terms and States, Energy levels of transition
metal ions, free ion terms, microstates, term wave functions, spin-orbits coupling.
Chapter-2. Ligand Field Theory of Coordination Complexes (08 L)
Effect of ligand field on energy levels of transition metal ions, weak cubic ligand field effect
on Russell- Saunders terms, Orgel diagrams, strong field effect, correlation diagrams,
Tanabe- Sugano Diagrams, Spin-Pairing energies.
Chapter-3: Electronic spectra of Transition Metal Complexes (08 L)
Introduction, band intensities, band energies, band width and shapes, transition metal spectra
of 1st, 2ndand 3rd row ions and complexes, electronic spectra of Lanthanide and Actinide,
spectrochemical and nephelauxetic series, charge transfer and luminescence spectra,
calculations of Dq, B, β parameters, percentage of covalent character for metal complexes.
Chapter-4: Magnetic Properties of Coordination Complexes (08 L)
Origin magnetism, types of magnetism, Curie law, Curie-Weiss Law, Magnetic properties of
Complexes-Para magnetism, 1stand 2nd Ordered Zeeman effect, quenching of orbital angular
momentum by Ligand fields, Magnetic properties of A, E and T ground terms in complexes,
spin free and spin paired equilibria, temperature dependence of magnetism.
Reference
1. Ligand Field Theory and Its Applications by B.N. Figgis and M.A. Hitachman (Wiley
India Pvt Ltd, 12 October 2010)
2. Symmetry and Spectroscopy of Molecules by K. Veera Reddy, Second Edition 2009:
(New Age International Publication)
3. Elements of Magnetochemistry by R. L. Datta and A. Syamal, Second Edition
Course Outcomes: At the end of course student should able to –
CO-1: Define R. S. term, configuration, microstate, paramagnetic, diamagnetic ferromagnetic,
antiferromagnetic, Curie and Neel temperature.
CO-2: Identify complex ions showing same R.S. terms, degeneracy of ground state terms
ofmetal ions, and spin multiplicities of different configurations.
CO-3: Interpret electronic spectra for spin allowed Oh and Td complexes using Orgel
diagram,Magnetic properties of A, E and T ground terms in complexes and selection rules.
38 | P a g e
CO-4: Calculate frequencies of absorption spectrum, 10Dq, Racah and nepholauxetic
parameter for a complex, and magnetic moments of complexes
CO-5: Construct microstate table for various configuration and prepare correlations diagram
and Tanabe-Sugano diagram for various configurations in Td an Oh ligand field.
CO-6: Assess appropriate full spectroscopic terms for various configuration/ion/term.
SECTION-II: Bioinorganic Chemistry (2 Credits, 30 L)
Chapter-1: Introduction of Bioinorganic Chemistry (04 L)
Historical Background and current relevance, role of Cu, Fe, Mn and Mo in metalloprotein,
and metalloenzymes, Metals in medicine. Ref-1 page No.1-19.
Chapter-2: Role of Inorganic Chemistry in Bioinorganic Research Thermodynamic
Aspect (09 L)
HSAB concept, chelate effect and Irving-William series, pKa values of coordinated ligands,
Tuning of redox potential, Biopolymer effects. Kinetic aspects- Electron transfer reaction,
Electronic substitution reaction. Reactions of coordinated ligands and Template effect,
concept of spontaneous self-assembly model compounds. Ref-1 Page No. 21-41.
Chapter-3: Functions and Transport of Alkali and Alkaline Earth Metal Ions (07 L)
Importance of alkali and alkaline earth metals, Distribution of cationic and anionic
electrolytes in blood plasma and intracellular fluid, Ionophores: Natural and Synthetic,
Application of ionophores, Different mechanism involved in exchange of ions across cell-
wall,Na+/K+- ATPase ion pump for active transport of Na+ and K+; Ref-1: Page No. 152-
171.
Chapter-4: Choice, Uptake and Assembly of Metal-Containing Units in Biology (05 L)
Bioavailability of metal ions, Enrichment strategies and intracellular chemistry of low
abundance metal, Spontaneous self-assembly of metal cluster (FeS cluster) Ref-1: Page No.
103-125.
Chapter 5: Miscellaneous Topics of Bio-Inorganic Chemistry (05 L)
(a) Ca in Blood coagulation. Ref-4 (b) Magnesium in Photosystem I Ref-2 Page No. 67-75
and Ref-3 311-321 (c) Manganese in Photosystem II Ref-2 Page No. 67-75 and Ref-3 311-
321 (d) Iron in Ferritin, Transferrin, Porphyrin based system. Ref-3 Page No. 247-277 (e)
Zinc Finger protein, Calmodulin, Mercury detoxification; Ref-1 and 3
References:
1. Principles of Bioinorganic Chemistry by S.J. Lippard and J. M. Berg

39 | P a g e
2. Bioinorganic Chemistry: Inorganic Elements in Chemistry of Life by W.Kaim and B.
Schwederski. 2nd Edition
3. Biological Inorganic Chemistry by Robert R. Crichton, 2nd Edition
4. Mikaelsson, M. E. (1991). The Role of Calcium in Coagulation and Anticoagulation.
Coagulation and Blood Transfusion, 29– 37. doi:10.1007/978- 1-4615-3900-1_3
Course Outcomes: At the end of course student should able to –
CO-1: Define metalloproteins, metallo-eznymes, photosynthesis, HSAB concept, nucleic
acids, metalloregulation, Biopolymer effects and acetylcholine receptor.
CO-2 : Explain chelate effect and Irving-William series, pKa values of coordinated
ligands,Tuning of redox potential, and Reactions of coordinated ligands.
CO-3: Describe Fe-S clusters, model compounds and spontaneous self-assembly, metals
inmedicine, blue copper proteins, and cytochromes, and Na/K pumps.
CO-4: Express nitrogen fixation, detoxification of mercury, structure of RNA, cis-platin,
amino acids, siderophore,and calmoduline zinc finger proteins.
CO-5: Distinguish between hemoglobin and myoglobin, transferrin and ferritin,
photosystem-I and photosystem-II.
CO-6: Decide role of metals in biological system, medicine, blood coagulation, oxygen
storage and transport, photosynthesis and uptake and transport of iron

40 | P a g e
 Semester-II
CHEPIA-553, Organic Chemistry-I I (2 credits, 30 L)
(Molecular Rearrangements and Organic Spectroscopy)
Chapter-1: Molecular Rearrangements (12 L)
Mechanism to nucleophilic, electrophilic, and free radical molecular rearrangements,
migratory aptitude
Carbon-carbon rearrangements: Pinacol-Pinacolone, Favorskii, Wolff and Benzil-Benzilic
acid rearrangements.
Carbon-nitrogen rearrangements: Hoffmann, Curtius, Lossen, Schmidt and Beckmann
rearrangements.
Carbon-oxygen rearrangements: Bayer-Villiger rearrangement, Dakin oxidation
Oxygen-Carbon rearrangement: Fries rearrangement
Problem solving
Chapter-2: Organic Spectroscopy (18 L)
UV and IR Spectroscopy: Calculation of λmax of aromatic system, Solvent effects, Factors
affecting stretching frequencies and functional group interpretation from IR spectra, problems
based on IR
1
H-NMR: Principle, chemical and magnetic non-equivalence, chemical shifts and factors
influencing chemical shift, chemical shifts of acidic protons, D2O exchange, spin-spin
splitting, multiplicity patterns and coupling constant, Pascal’s triangle, temperature dependent
NMR.
13 13 13
C NMR: Basic of C-NMR: Chemical shift and factors affecting chemical shifts in C
13
NMR, off resonance and proton decoupled spectra. Simple problems on C-NMR.
Combined problems: Combined problems based on UV, IR and 1H-NMR should be solved.
References
Essential books
1. Mechanism and Structure in Organic Chemistry by E.S. Gould, 1st Edition, Holt, Rinehart
and Winston of Canada Ltd.
2. Organic Chemistry, Jonathan Clayden, Nick Geeves, Stuart Warren, 1st Edition, Oxford
University Press
3. Strategic Applications of Named Reactions in Organic Synthesis by Laszlo Kurti, Barbara
Czako, 1st Edition, Academic Press

41 | P a g e
4. Reactions, Rearrangements and Reagents by S.N. Sanyal, 4th edition Bharati Bhawan
Publishers.
5. Introduction to Spectroscopy by Donald L. Pavia Gary M. Lampman George S. Kriz
James R. Vyvyan, 3rd Edition.
6. Spectrometric identification of organic compounds by R. M. Silverstein, F. X. Webster,
6th Edition, John Wiley and Sons.
Further reading
1. Conservation of orbital symmetry by R. B. Woodward and R. Hoffmann, Verlag chemie,
weinheim (1970).
2. Orbital Symmetry: A problem solving approach by R. E. Lehr and A. P. Marchand;
Academic (1972).
3. Organic reactions and orbital symmetry by T. L. Gilchrist and R. C. Storr; Cambridge, 2nd
Edition, University Press.
4. Spectroscopic methods in organic chemistry by D. H. Williams and I. Fleming, McGraw-
Hill
5. Spectroscopy of Organic Compounds by P.S. Kalsi, 7th Edition, New Age International
Private Limited.
6. Organic Spectroscopy: Principles and Applications by Jag Mohan, Narosa

Course Outcome: Student will able to -

CO1: Understand the concepts of molecular rearrangements
CO2: Basic knowledge of Organic Spectroscopy such as UV, IR and NMR.
CO3: Solve the problems based on molecular rearrangement reactions.
CO4: Deduce the structure from the spectral data and justify the findings.
CO5: Apply the concepts of oxidations and reduction to solve the advance problems.
CO6: Develop problem solving ability.

42 | P a g e
 CHE- 554, Physical Chemistry Practical II [2 Credits, 60 L]
Part-I: Conductometry: (Any three)
1. Hydrolysis of NH4Cl or CH3COONa or aniline hydrochloride.
2.Determination of λ0 or λ∞ and dissociation constant of acetic acid.
3.Hydrolysis of ethyl acetate by NaOH.
4.Determination of ΔG, ΔH, and ΔS of silver benzoate by conductometry.
5.Determination of critical micellar concentration (CMC) and ΔG of micellization of Sodium
Lauryl Sulphate / Detergent
Part-II: Polarography (Any one)
6.Determination of half wave potential E1/2 and unknown concentration of Cu or Pb or Zn
ion.
7.Amperometric titration of Pb(NO3)2 with K2Cr2O7.
Part-III: Potentiomerty: (Any three)
8.Stability Constant of a complex ion.
9.Solubility of a sparingly soluble salt.
10.To determine the ionic product of H2O
11.Estimation of halide in mixture.
12.Determination of composition of Zinc ferrocyanide complex by potentiometry
Part-IV: pH metry (Any two)
13.Determination of the acid and base dissociation constant of an amino acid and hence the
isoelectric point of the acid.
14.Determination of dissociation constants of tribasic acid (phospheric acid)
15. Construct pH curve for titration of strong base – strong acid, strong base –weak acid and
predict the best indicator in these titrations (methyl orange, methyl orange, brocresol
green, phenolphthalein, etc.)
Part-V: Table Work (Any two)
16.Analysis of powder XRD of SrTiO3 and Ag metal or any two compounds (Calculation- d,
lattice constant, crystal volume and density, and assigning planes to peaks using JCPDS
data)
17.Cyclic voltamogram of K3Fe(CN)6 in KCl/H2O / Ferrocene in TEAP//MeCN
18.Detailed interpretation of Raman spectra of diatomic molecules.
N B.:
1. Use molar concentrations for volumetric /estimations/synthesis experiments.
43 | P a g e
2. Use optimum concentrations and volumes
3. Two burette method should be used for volumetric analysis (Homogeneous mixtures)
4. Use of microscale technique is recommended wherever possible

References
1. Practical physical chemistry, A. Findlay, T.A. Kitchner (Longmans, Green and Co.)
2. Experiments in Physical Chemistry, J.M. Wilson, K.J. Newcombe, A.r. Denko. R.M.W.
Richett(Pergamon Press)
3. Senior Practical Physical Chemistry, B.D. Khosla and V.S. Garg (R. Chand and Co.,
Delhi.).
4. Experimental Physical Chemistry by D. P. Shoemaker, Mc. Growhill, 7th Edition, 2003.
5. Physical chemistry by Wien (2001)
6. Advanced Physical Chemistry Experiment, Gurtu and Gurtu, Pragati Publication (Meerut)
Course outcomes:
1) Students will grasp the fundamental principles of Conductometry, Polarography,
Potentiometry and pH metry.
2) Students will familiar with the operation of Conductometer, Polarimeter, Potentiometer
and pH meter.
3) Students will understand the concepts of conductance, resistance and learn how to
calculate and interpret these values.
4) Students will learn to interpret polarographic waves and understand their significance in
identifying electroactive species and determining their concentration.
5) Students will explore the applications of Potentiometry in various fields such as acid- base
titrations, determination of pH and analysis of ionic concentration

44 | P a g e
 CHE-555: Inorganic Chemistry Practical-II (2 Credits, 60 L)
Part-I: Synthesis of Coordination Complexes (Any three) (Ref. 2)
1. Synthesis and Purity Chloropentaamminecobalt(III) chloride.
2. Synthesis and Purity Nitro pentaamminecobalt(III) chloride.
3. Synthesis and Purity Bis[TrisCu(I)thiourea]
4. Synthesis of Cis and Trans [Cu(gly)2 H2O] (Ref. 8)
5. Synthesis and purity of K3[Mn(C2O4)3].3H2O (Ref-2)

Part-II: Inorganic Conductometry (Any two)

6. Structural determination of metal complexes by conductometric measurement –
conductometric measurement of [Co(NH3)6]Cl3, [Co(NH3)5]Cl2[Co(NH3)4]Cl and
prediction of number of ionisable chlorides. (Ref-3).
7. To study complex formation between Fe(III)with sulfosalicylic acid by conductometry
(Ref- 3).
8. To verify the Debye Huckel theory of ionic conductance for strong electrolytes KCl (1:1
type), BaCl2 (1:2 type), K2SO4 (2:1 type) and [K3Fe(CN)6] (3:1 type). (Ref-3)

Part-III: Inorganic Characterization Techniques (Any two)

9. Determination of equilibrium constant of M – L systems Fe(III)– Sulphosalicylic acid or
Fe(III)–β–resorcilic acid by Mole ratio method or any other M-L system (Ref.-3, 5)
10. Solution state preparation of [Ni(en)3]S2O3, [Ni(H2O)6]Cl2, [Ni(NH3)6]Cl2. Record
absorption spectra in solution of all three complexes and calculate 10 Dq. Arrange three
ligands according to their increasing strength depending on your observations. (Ref. -5)
11. Determination of magnetic susceptibility (χg and χm) of mercury tetracyanato cobalt or
Fe(acac)3 or Ferrous ammonium sulfate by Faraday or Gouy method. (Ref. -3, 5)
Part-IV: Inorganic Kinetics Experiment (Any two)
12. Synthesis and photochemistry of K3[Fe(C2O4)3].3H2O. (Ref-4)
13. Kinetics of substitution reaction of [Fe(Phen)3]2+ (Ref. 3)
14. Kinetics of formation of Cr(III)-EDTA complex (Ref. 3)
Part-V: Ion – Exchange Chromatography (Any one) (Ref. -1 and 3)
15. Separation of mixture of Zn(II) and Mg(II) using Amberlite IRA 400 anion exchanger
andquantitative estimation of separated ions Zn(II) and Mg(II)
16. Determination of anion exchange capacity of anion exchange resin.

45 | P a g e
Part-VI: Solvent Extraction and Colorimetry (Any one) (Ref. -1 and 3)
17. Determination of Cu(II) by solvent extraction as Dithiocarbamate complex
18. Determination of iron by solvent extraction techniques in a mixture of Fe(III) +Al(III)
or Fe(III) + Ni(III) using 8–hydroxyquinoline reagent.
N B.:
1. Use molar concentrations for volumetric /estimations/synthesis experiments.
2. Use optimum concentrations and volumes
3. Two burette method should be used for volumetric analysis (Homogeneous mixtures)
4. Use of microscale technique is recommended wherever possible

References
1. Vogel’s Textbook of Inorganic quantitative analysis A.I. Vogel 4th Edn. (1964).
2. Experimental Inorganic Chemistry, MounirA. Malati, Horwood Seriein Chemical Science
(Horwood publishing,Chichester) 1999.
3. Experiments in Chemistry, D. V. Jahagirdar, Himalaya Publishing House
4. General Chemistry Experiments,Anil. J Elias, University Press (2002)
5. Practical Physical Chemistry, B. Vishwanathan and P. S. Raghwan, Viva Books (2005)
6. Practical Inorganic Chemistry; Preparations, reactions and instrumental methods by
Geoffrey Pass , Haydn Sutcliffe
7. Geoffrey Pass, Second Edition, 1974 Geoffrey Pass and Haydn Sutcliffe, Originally
published by Chapman and HalI in 1974.
8. Synthesis of Cis [Cu(gly)2 H2O], trans [Cu(gly)2], and Cis-Ni(gly)2(H2O)2 and their
characterization using thermal and spectroscopic techniques – A capstone inorganic
laboratory, Journal of Chemical Education,
https://doi.org/10.1021/acs.jchemed.9b00631
Course Outcome: Student will able to
CO1: Define coordination complex, cell constant, resistance, specific conductance,
equilibrium constant, absorbance, Beers law, solubility product, chromatography, etc.
CO2: Discuss photochemistry of potassium trioxalatoferrate complex, kinetics of formation
of Cr(III)-EDTA, Determination of Cu(II)and Fen(II) by solvent extraction technique.
CO3: Outline the flow-chart for synthesis of [Mn(acac)3], Chloropentaamminecobalt(III)
chloride, Nitro pentaamminecobalt(III) chloride, Bis[TrisCu(I)thiourea complexes.

46 | P a g e
CO4: Estimate purity of the [Mn(acac)3], Chloropentaamminecobalt(III) chloride, Nitro
pentaamminecobalt(III) chloride, Bis[TrisCu(I)thiourea complexes.
CO5: Determine equilibrium constant of M–L systems Fe(III)–Sulphosalicylic acid, magnetic
susceptibility (χg and χm) of mercury tetracyanato cobalt or Fe(acac) and magnetic
susceptibility (χg and χm) of mercury tetracyanato cobalt or Fe(acac).
CO6: Calculate the quantity from observation of the experiments and Interpret the result
obtained respective experiments.

47 | P a g e
 CHE-556, Organic Chemistry Practical II (2-Credits; 60 L)
(Single stage preparations with spectral analysis and Two stage preparations)
A. Single stage preparations and spectral analysis of the product (Any six)
1. Vanillin to Vanillyl alcohol
2. O-phenylenediamine to Benzotriazole
3. Ethyl acetoacetate to 1-phenyl-3- Methylpyrazol-5-one
4. Benzil to Quinoxaniline
5. Diels alder reaction of anthracene and maleic anhydride
6. Glycine to Hipuric acid
7. Synthesis of Cinnamic acid using Perkin’s reaction
8. Synthesis of 2,6-Dicyanoaniline
9. O-phenylenediamine to 2-Methyl benzimidazole
10. p-Nitro Benzyl cyanide to p-Nitro Phenyl acetic acid
B. Two stage preparations (Any four)
1. Acetophenone → Benzalacetophenone → Epoxide
2. Benzoin → Benzil → Benzilic acid
3. Resorcinol → 4-methyl-7-hydoxycoumarin → 4-methyl-7-acetoxycoumarin
4. Cyclohexanone → Phenyl hydrazone → 1, 2, 3, 4-Tetrahydro carbazole
5. Phthalic anhydride → Phthalimide → Anthranilic Acid
6. Benzyl cyanide → p-Nitrobenzyl cyanide → p-Nitro phenyl acetic acid
7. Phthalimide → N-Benzylphthalimide → Benzylamine
8. O-Nitroaniline → O-Phenylenediamine → Benzimidazole

N B.:
1. Use molar concentrations for volumetric /estimations/synthesis experiments.
2. Use optimum concentrations and volumes
3. Two burette method should be used for volumetric analysis (Homogeneous mixtures)
4. Use of microscale technique is recommended wherever possible

References
1. Comprehensive Practical Organic Chemistry by V.K. Ahluwalia and Renu Aggarwal
2. Monograph on Green Chemistry Laboratory Experiments by Green Chemistry Task
Force Committee, DST
48 | P a g e
 3. Practical Organic Chemistry by Mann and Saunders, 4th edition, Pearson Education.
4. Vogel's Textbook of Practical Organic Chemistry, 5th edition Pearson India.
5. The synthesis, identification of organic compounds –Ralph L. Shriner, Christine K.F.
Hermann, Terence C. Morrill and David Y. Curtin
6. Solvent-free Organic Synthesis by Koichi Tanaka.
Course Outcome: Student will able to -
CO1: Understand the theoretical concepts behind organic synthesis.
CO2: Acquire the experimental skills for separation, purification, identification and synthesis
of organic compounds.
CO3: Design experimental set up for performing the organic reactions.
CO4: Monitor the organic reactions and analyse the products using spectral results.
CO5: Describe the mechanistic aspects of organic reactions.
CO6: Develop problem solving ability.

49 | P a g e
 Chemistry electives
(Any one option from the following four courses)
CHE-557(A), Organometallic Compounds and Inorganic Reaction
Mechanism (2 Credits, 30L)
Chapter-1: Synthesis, Structure, Bonding and Applications of Organometallic
Compounds (15 L)
Introduction to Organometallic Compounds, 18-Electron Rule and EAN rule, Metal carbonyl:
preparation and properties, Polynuclear carbonyl: Structures, Carbonylate ions/Anionic
carbonyl complexes: Isoelectronic and isostructural carbonyl and carbonylate ions, carbonyl
Hydrate ions, Metal alkyls, Carbenes, carbynes and carbides, alkyls complexes, Metallocene
containing four, five, six, seven, and eight membered ring, Synthesis, Bonding and structures
of cyclopentadienyl complexes. Spectral analysis and characterization of organometallic
complexes: IR and NMR, examples, Applications of organic metallic compounds:
Hydroformylation, Monsanto acetic acid process, Wacker Process, Hydrogenation by
Wilkinson’s catalyst, Olefin metathesis, heterogeneous catalysis: Ziegler Natta
Polymerization, Water gas reduction (Reference-1. Page No: 573-630, Reference-2 Page No:
475- 547).
Chapter-2: Inorganic Reaction Mechanism (15 L)
Introduction, background of Inorganic reaction mechanism Inert and labile compounds,
Substitution reaction in square planner complexes, Rate law for Nucleophilic substitution
reaction in square planner complexes, Trans effect and trans directing series, Stereochemistry
of reactions: substitution in trans complexes, substitution in cis complexes Mechanism for
Nucleophilic substitution reaction in square planner complexes, kinetics of octahedral
substitution, Ligand field effect and reaction rates, Mechanism of substitution reaction in
octahedral complexes, Reaction rates influenced by acids and bases, racemization and
isomerization, Mechanism of redox reaction: Outer sphere mechanism and Inner sphere
mechanism. Reaction of coordinated ligands: Hydrolysis of ester, Amides and peptides (Ref
1, Page no: 542-568)
References
1. Inorganic Chemistry: principles of structure and reactivity by James E. Huheey 4th
Edition.
2. Inorganic Chemistry by Gary L. Miessler, Paul J. Fischer and Donald A. Tarr 5th

50 | P a g e
 Edition.
Course Outcomes: At the end of course student should able to -
CO1: Define various terms in organometallic chemistry and inorganic reaction mechanism
etc.
CO2: Explain/Discuss various reaction mechanisms such as ligand insertion, inner and
outersphere mechanism, ligand substitution reaction.
CO3: Discuss 1. Structure and bonding in carbonyl and organometallic complexes, 2:
Trans effect, 3. Ligand field effects, catalytic cycles, 4. Inert and labile complexes, 5.
Synthesismethods of organometallic compounds, etc.
CO4: Apply 18 electron rule. Applications of organometallic compounds and mechanism
of these reactions.
CO5: Demonstrate IR spectra of carbonyl complexes, deduce structure of carbonyl
complexes
CO6: Justify structures of organometallic compounds from spectral data

51 | P a g e
 CHE-557(B), Material Characterization Techniques (2 credits, 30 L)
Chapter-1: X-Ray Diffraction Methods (08 L)
Miller and Weiss indices, X-Ray Radiation, Generation of X-Rays, X-Ray Absorption,
Theoretical Background of Diffraction, Diffraction Geometry, Bragg’s Law, Reciprocal
Lattice, Diffraction Intensity, Structure Extinction, X-Ray Diffractometry, Instrumentation,
System Aberrations, Samples and Data Acquisition, Sample Preparation, Acquisition and
Treatment of Diffraction Data, Distortions of Diffraction Spectra, Crystallite Size,
Applications, Crystal-Phase Identification, Quantitative Measurement , Wide-Angle X-Ray
Diffraction and Scattering, Wide-Angle Diffraction, Wide-Angle Scattering. Problem on
XRD (Calculation of d values, assigning planes, calculation of crystal parameters)
Chapter-2: Transmission Electron Microscopy (06 L)
Instrumentation, Electron Sources, Thermionic Emission Gun, Field Emission Gun,
Electromagnetic Lenses, Specimen Stage, Specimen Preparation, Prethinning, Final
Thinning, Electrolytic Thinning, Ultramicrotomy, Image Modes (Mass–Density Contrast,
Diffraction Contrast, Phase Contrast), Selected-Area Diffraction (SAD), Selected-Area
Diffraction Characteristics.
Chapter-3: Scanning Electron Microscopy (06 L)
Instrumentation, Optical Arrangement, Signal Detection, Detector, Probe Size and Current
Contrast Formation, Electron–Specimen Interactions, Topographic Contrast, Compositional
Contrast, Operational Variables, Working Distance and Aperture Size, Acceleration Voltage
and Probe Current, Astigmatism, Specimen Preparation, Preparation for Topographic
examination.
Chapter-4: X-Ray Spectroscopy for Elemental Analysis (10 L)
Features of Characteristic X-Rays, Types of characteristic X-Rays, Selection Rules,
Comparison of K, L, and M Series, X-Ray Fluorescence Spectrometry, Wavelength
Dispersive Spectroscopy, Analysing Crystal, Wavelength Dispersive Spectra, Energy
Dispersive Spectroscopy, Detector, Energy Dispersive Spectra, Advances in Energy,
Dispersive Spectroscopy, XRF Working Atmosphere and Sample Preparation, Energy
Dispersive Spectroscopy in Electron Microscopes, Special Features, Scanning Modes,
Qualitative and Quantitative Analysis, Qualitative Analysis, Quantitative Analysis,
Quantitative Analysis by X-Ray Fluorescence, Fundamental Parameter Method, Quantitative
Analysis in Electron Microscopy, Numerical.

52 | P a g e
References
1. Elaine A. Moore, Lesley E. Smart - Solid State Chemistry - an Introduction. Fourth Ed.
CRC Press (2012)
2. YangLeng, Materials Characterization -Introduction to Microscopic and Spectroscopic
Methods, Second Ed. Wiley-VCH,
3. R. D. Braun, Introduction to Instrumental Analysis, Second Ed.

Course Outcome: Student will able to –

CO1: Students are able to understand different characterization techniques of solids
CO2: Discuss Principle of XRD, instrumentation of powder XRD, Brags law, applications of
XRD for crystal structure determination, numerical problems
CO3: Apply their knowledge to the interpretation of SEM and TEM images.
CO4: Differentiate between Scanning and Transmission of electron.
CO5: Explain the basics of X-rays, the Principle of XRF, types of XRF, instrumentation,
qualitative and quantitative analysis, and numerical analysis.
CO6: Applications of different characterization techniques

53 | P a g e
 CHE-557 (C) Green Chemistry [2 Credits, 30 L]
Chapter 1: Introduction to Green Chemistry (10 L)
What is Green Chemistry? Need for Green Chemistry. Goals of Green Chemistry. Problems
in the applications of the goals of Green Chemistry. The 12 Principles of Green chemistry:
application of principles, examples based on 12 principles. Environmentally benign solutions:
Organic solvents and volatile organic compounds, solvent free systems, super critical fluids-
supercritical carbon dioxide and supercritical water.
Chapter 2: Green Reactions: Case Studies (12 L)
1. Green Synthesis of the Compounds: Adipic Acid and Ibuprofen
2. Microwave assisted reactions: Oxidation of alcohols; Diels-Alder reaction in Organic
Solvent (Atom economy) and Water (Green Solvent and Atom economy).
3. Ultrasound assisted reactions: Simmon-Smith Reaction
4. Enzymatic Inter esterification for production of no Trans-Fats and Oils.
5. Vitamin C synthesis –enzyme routes
6. Polythene manufacture-metallocene catalysis
7. Surfactants for carbon dioxide.
Chapter 3: Future Trends in Green Chemistry (08 L)
Renewable raw materials, Reagents and catalysts; multifunctional reagents; Combinatorial
green chemistry; Click Chemistry, Solventless reactions; Solid Phase synthesis, Applications
of Green chemistry in Sustainable Development
References
1. Green Chemistry - Theory and Practical by P.T. Anastas and J.K. Warner, Oxford
University Press (1998).
2. Introduction to Green Chemistry by A.S. Matlack, Marcel Dekker (2001).
3. Real-World cases in Green Chemistry by M.C. Cann and M.E. Connely, American
Chemical Society, Washington (2000).
4. Introduction to Green Chemistry by M.A. Ryan and M. Tinnes, American Chemical
Society, Washington (2002).
5. Green Chemistry: An Introductory Text by M. Lancaster, RSC Publishing, 2nd Edition,
2010.
Course Outcomes: At the end of the course students will be able to-
CO1: Apply the principles of green chemistry to chemical processes.
CO2: Apply the principles of green chemistry to reduce the cost of chemical processes.
54 | P a g e
CO3: Develop economical synthetic route involving principles of green chemistry.
CO4: Analyze chemical data and choose safer and renewalbe raw materials for chemical
processes.
CO5: Develop processes in accordance with Sustainable Development Goals.

55 | P a g e
 CHEPIA-557 (D), Pericyclic Reactions and Photochemistry
(2 credits, 30 L)
Chapter-1: Pericyclic reactions (15 L)
Electrocyclic, cycloaddition reactions, FMO approach, analysis by correlation diagrams,
sigmatropic reactions, ene reactions, 1,3-dipolar additions.
Problem solving
Chapter-2: Photochemistry (15 L)
Principles of photochemistry, Jablonski diagram, photosensitization, photo-enolization,
photochemistry of carbonyl and aromatic compounds, alkenes and dienes, photo
rearrangements, Paterno-Buchi Reaction, Barton reaction
Problem solving
References
Essential books
1. Pericyclic Reactions by Ian Fleming, 2nd edition, Oxford.
2. Photochemistry and Pericyclic Reactions by Jagdamba Singh and Jaya Singh, 4th Edition,
New Age International Publishers
3. Pericyclic Reactions: A Mechanistic and Problem-Solving Approach by Sunil Kumar
Vinod Kumar S.P. Singh, 1st edition, Academic Press.
4. Organic Chemistry, Jonathan Clayden, Nick Geeves, Stuart Warren, 1st Edition, Oxford
University Press
Further reading
1. Conservation of orbital symmetry by R. B. Woodward and R. Hoffmann, Verlag chemie,
weinheim (1970).
2. Orbital Symmetry: A problem solving approach by R. E. Lehr and A. P. Marchand;
Academic (1972).
3. Organic reactions and orbital symmetry by T. L. Gilchrist and R. C. Storr; Cambridge,
2nd Edition, University Press.
4. Organic Photochemistry by Robert O. Kan, McGraw-Hill
Course Outcome: Student will able to –
CO1: Understand the concepts of pericyclic and photochemical reactions.
CO2: Identify the type of pericyclic and photochemical reactions CO3: Understand and
identify the types of organic reactions.

56 | P a g e
CO3: Provide the solutions by analysing the reaction conditions.
CO4: Solve the problems based on pericyclic and photochemical reactions.
CO5: Design the appropriate synthetic routes
CO6: Develop problem solving ability of the students.

57 | P a g e
 CHE-558, On Job Training/Internship (4 credits, 120 hours)
Students in this course will be required to do On the Job Training (OJT)/Internship in
relevant industries/government sectors/institutes, etc. to gain practical training. As a
prerequisite for OJT, the department may conduct necessary lectures/workshops/seminars.
The course will be run as per the guidelines of the Institute /the University and Government
of Maharashtra. Most of our graduates are expected to seek employment in industries, pursue
teaching careers, or establish small enterprises after obtaining their M.Sc. degree. Therefore,
the following options would be provided to the students to develop skilled and competent
students.

a) Hands on Training on various analytical instruments- UV-Visible Spectrometer,

Fourier Transform Infrared Spectrometer, Nuclear Magnetic Resonance Spectrometer,
Mass Spectrometry, Gas Chromatography, HPLC, X-Ray Diffractometer, Powder X-ray
Diffractometer, Thermal Analyzer (TGA-DSC), Scanning electron microscope,
Transmission electron microscope, BET Surface Analyzer, Raman Spectrometer, CHN
Analyzer
Note: Analytical instruments (from above list) should be selected for OJT that should
complete 120 hours training.
OR
b) Teacher Training Course:
1) Development of MOOCS
2) Development of Learning Management System (LMS)
OR
c) Internship in Industry or National research laboratory.
OR
d) To develop Entrepreneurship, production of the following items, including
packaging
1) Dye
2) Acids, caustic soda
3) Fire Extinguisher
4) Fertilizers
5) Any other industry material

OR

e) Field projects that are aligned with the Chemistry Subject.

A detailed report should be submitted for the evaluation of On Job Training/Internship.

58 | P a g e