BP704T.
NOVEL DRUG DELIVERY SYSTEMS (NDDS) (Theory)
45 Hours
Course content:
Unit-I 10 Hours
Controlled drug delivery systems: Introduction, terminology/definitions and rationale,
advantages, disadvantages, selection of drug candidates. Approaches to design-controlled release
formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and
biological properties of drugs relevant to controlled release formulations.
Polymers: Introduction, classification, properties, advantages and application of polymers in
formulation of controlled release drug delivery systems.
Unit-II 10 Hours
Microencapsulation: Definition, advantages and disadvantages, microspheres
/microcapsules, microparticles, methods of microencapsulation, applications.
Mucosal Drug Delivery system: Introduction, Principles of bioadhesion/mucoadhesion,
concepts, advantages and disadvantages, transmucosal permeability and formulation
considerations of buccal delivery systems.
Implantable Drug Delivery Systems: Introduction, advantages and disadvantages, concept of
implants and osmotic pump.
Unit-III 10 Hours
Transdermal Drug Delivery Systems: Introduction, Permeation through skin, factors affecting
permeation, permeation enhancers, basic components of TDDS, formulation approaches.
Gastro-retentive drug delivery systems: Introduction, advantages, disadvantages, approaches
for GRDDS– Floating, high density systems, inflatable and gastro-adhesive systems and their
applications.
Naso-pulmonary drug delivery system: Introduction to Nasal and Pulmonary routes of drug
delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers.
Unit-IV 08 Hours
Targeted drug Delivery: Concepts and approaches advantages and disadvantages, introduction
to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications.
Unit-V 07 Hours
Ocular Drug Delivery Systems: Introduction, intra ocular barriers and methods to overcome–
Preliminary study, ocular formulations and ocuserts.
Intrauterine Drug Delivery Systems: Introduction, advantages and disadvantages,
development of intra uterine devices (IUDs) and applications.
Evaluation Scheme Bachelor of Pharmacy I, II, III & IV Year syllabus 2019-2020 Page 120
Recommended Books: (Latest Editions)
• Novel Drug Delivery Systems by Y W. Chien, 2nd edition, revised and expanded,
Marcel Dekker, Inc., New York, 1992.
• Controlled Drug Delivery Systems by Robinson, J. R., Lee V. H. L, Marcel Dekker,
Inc., New York, 1992.
• Encyclopaedia of Controlled Drug Delivery by Edith Mathiowitz, Wiley Interscience
Publication, John Wiley and Sons, Inc, New York. Chichester/Weinheim.
• Controlled and Novel Drug Delivery by N.K. Jain, CBS Publishers & Distributors, New
Delhi, First edition 1997 (reprint in 2001).
• Controlled Drug Delivery-Concepts and Advances by S.P. Vyas and R.K. Khar,
Vallabh Prakashan, New Delhi, First edition 2002.
• Modern Pharmaceutics by Gilbert S. Banker; Christopher T. Rhodes, 4th edition; (vol-
121), Marcel Dekker, Inc., NY.
• Handbook of Pharmaceutical Controlled Release Technology by Donald L. Wise,
Marcel & Dekker Inc., NY.
• Dermatological and Transdermal Formulations by Kenneth A. Walters, Mercell &
Dekker Inc., NY.
• Drug Delivery System by Vasant V. Ranaday, Manffred A. Hollinger, CRC Press, NY.
• Design of Controlled Release Drug Delivery System by Xialing Li, Bhaskara R. Jasti,
Mc-Graw Hill.
Journals
• Indian Journal of Pharmaceutical Sciences (IPA)
• Indian Drugs (IDMA)
• Journal of Controlled Release (Elsevier Sciences)
• Drug Development and Industrial Pharmacy (Marcel & Decker)
• International Journal of Pharmaceutics (Elsevier Sciences)
Evaluation Scheme Bachelor of Pharmacy I, II, III & IV Year syllabus 2019-2020 Page 121
