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(Ebook) Practice of Statistics in The Life Sciences by Brigitte Baldi, David S. Moore ISBN 9781319067496, 1319067492 Kindle & PDF Formats

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295 views118 pages

(Ebook) Practice of Statistics in The Life Sciences by Brigitte Baldi, David S. Moore ISBN 9781319067496, 1319067492 Kindle & PDF Formats

The document is about the ebook 'Practice of Statistics in the Life Sciences' by Brigitte Baldi and David S. Moore, which is available for download and has received positive reviews. It covers various statistical concepts and applications specifically tailored for life sciences, including data collection, probability, and statistical inference. The book emphasizes real-world examples from biology and is designed for college and university students.

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2
Vice President, STEM: Ben Roberts
Senior Program Manager: Karen Carson
Marketing Manager: Tom DeMarco
Marketing Assistant: Savannah DiMarco
Executive Development Editor: Katrina Mangold
Executive Media Editor: Catriona Kaplan
Associate Editor: Andy Newton
Editorial Assistant: Katharine Munz
Director of Content Management Enhancement: Tracey Kuehn
Managing Editor: Lisa Kinne
Director of Design, Content Management: Diana Blume
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Cover Designer: Vicki Tomaselli
Text Designer: Amanda Kavanaugh
Director of Digital Production: Keri deManigold
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Associate Media Project Manager: Hanna Squire
Senior Workflow Project Manager: Paul Rohloff
Senior Photo Editor: Robin Fadool
Photo Researcher: Naomi Kornhauser
Composition: Lumina Datamatics, Inc.
Cover Image: Front Cover Photo Credit: National Cancer Institute \
Winship Cancer Institute of Emory University
Back Cover Photo Credits:
Top: [email protected]/Depositphotos.com;
middle: Science Source; bottom: encrier/Depositphotos.com

Library of Congress Control Number: 2017945523

ISBN 978-1-319-06749-6 (EPUB)

© 2018, 2014, 2012, 2009 by W. H. Freeman and Company


All rights reserved.

W. H. Freeman and Company


One New York Plaza
Suite 4500

3
New York, NY 10004-1562
www.macmillanlearning.com

4
Brief Contents

Part I Collecting and Exploring Data

EXPLORING DATA: VARIABLES AND DISTRIBUTIONS


Chapter 1 Picturing Distributions with Graphs
Chapter 2 Describing Quantitative Distributions with Numbers

EXPLORING DATA: RELATIONSHIPS


Chapter 3 Scatterplots and Correlation
Chapter 4 Regression
Chapter 5 Two-Way Tablesi

PRODUCING DATA
Chapter 6 Samples and Observational Studies
Chapter 7 Designing Experiments
Chapter 8 Collecting and Exploring Data: Part I Review

Part II From Chance to Inference

PROBABILITY RULES
Chapter 9 Essential Probability Rules
Chapter 10 Independence and Conditional Probabilitiesi

PROBABILITY DISTRIBUTIONS
Chapter 11 The Normal Distributions
Chapter 12 Discrete Probability Distributionsi

5
Chapter 13 Sampling Distributions

THE IDEA OF INFERENCE


Chapter 14 Introduction to Inference
Chapter 15 Inference in Practice
Chapter 16 From Chance to Inference: Part II Review

Part III Statistical Inference

INFERENCE ABOUT QUANTITATIVE VARIABLES


Chapter 17 Inference about a Population Mean
Chapter 18 Comparing Two Means

INFERENCE ABOUT CATEGORICAL VARIABLES


Chapter 19 Inference about a Population Proportion
Chapter 20 Comparing Two Proportions
Chapter 21 The Chi-Square Test for Goodness of Fit

INFERENCE ABOUT RELATIONSHIPS


Chapter 22 The Chi-Square Test for Two-Way Tables
Chapter 23 Inference for Regression
Chapter 24 One-Way Analysis of Variance: Comparing Several
Means
Chapter 25 Statistical Inference: Part III Review

Part IV Optional Companion Chapters (available on


the PSLS 4e Companion Website)

Chapter 26 More about Analysis of Variance: Follow-up Tests


and Two-Way ANOVA

6
Chapter 27 Nonparametric Tests
Chapter 28 Multiple and Logistic Regression

7
Contents

To the Instructor: About this Book


Acknowledgments
Media and Supplements
To the Student: Statistical Thinking
About the Authors

Part I Collecting and Exploring Data

Chapter 1 Picturing Distributions with Graphs

Individuals and variables

Identifying categorical and quantitative variables

Categorical variables: pie charts and bar graphs

Quantitative variables: histograms

Interpreting histograms

Quantitative variables: dotplots

Time plots

Discussion: (Mis)adventures in data entry

Chapter 2 Describing Quantitative Distributions


with Numbers

8
Measures of center: median, mean

Measures of spread: percentiles, standard deviation

Graphical displays of numerical summaries

Spotting suspected outliersi

Discussion: Dealing with outliers

Organizing a statistical problem

Chapter 3 Scatterplots and Correlation

Explanatory and response variables

Relationship between two quantitative variables: scatterplots

Adding categorical variables to scatterplots

Measuring linear association: correlation

Chapter 4 Regression

The least-squares regression line

Facts about least-squares regression

Outliers and influential observations

Working with logarithm transformationsi

Cautions about correlation and regression

Association does not imply causation

Chapter 5 Two-Way Tablesi

9
Marginal distributions

Conditional distributions

Simpson’s paradox

Chapter 6 Samples and Observational Studies

Observation versus experiment

Sampling

Sampling designs

Sample surveys

Cohorts and case-control studies

Chapter 7 Designing Experiments

Designing experiments

Randomized comparative experiments

Common experimental designs

Cautions about experimentation

Ethics in experimentation

Discussion: The Tuskegee syphilis study

Chapter 8 Collecting and Exploring Data: Part I


Review

10
Part I summary

Comprehensive review exercises

Large data sets exercises

Online data sources

EESEE case studies

Part II From Chance to Inference

Chapter 9 Essential Probability Rules

The idea of probability

Probability models

Probability rules

Discrete versus continuous probability models

Random variables

Risk and Oddsi

Chapter 10 Independence and Conditional


Probabilitiesi

Relationships among several events

Conditional probability

General probability rules

11
Tree diagrams

Bayes’s theorem

Discussion: Making sense of conditional probabilities in

diagnostic tests

Chapter 11 The Normal Distributions

Normal distributions

The 68–95–99.7 rule

The standard Normal distribution

Finding Normal probabilities

Finding percentiles

Using the standard Normal tablei

Normal quantile plotsi

Chapter 12 Discrete Probability Distributionsi

The binomial setting and binomial distributions

Binomial probabilities

Binomial mean and standard deviation

The Normal approximation to binomial distributions

The Poisson distributions

Poisson probabilities

12
Chapter 13 Sampling Distributions

Parameters and statistics

Statistical estimation and sampling distributions

The sampling distribution of x-

The central limit theorem

The sampling distribution of p^

The law of large numbersi

Chapter 14 Introduction to Inference

Statistical estimation

Margin of error and confidence level

Confidence intervals for the mean μ

Hypothesis testing

P-value and statistical significance

Tests for a population mean

Tests from confidence intervals

Chapter 15 Inference in Practice

Conditions for inference in practice

How confidence intervals behave

How hypothesis tests behave

13
Discussion: The scientific approach

Planning studies: selecting an appropriate sample sizei

Chapter 16 From Chance to Inference: Part II


Review

Part II summary

Comprehensive review exercises

Advanced topics (optional material)

Online data sources

EESEE case studies

Part III Statistical Inference

Chapter 17 Inference about a Population Mean

Conditions for inference

The t distributions

The one-sample t confidence interval

The one-sample t test

Matched pairs t procedures

Robustness of t procedures

Chapter 18 Comparing Two Means

14
Comparing two population means

Two-sample t procedures

Robustness again

Avoid the pooled two-sample t proceduresi

Avoid inference about standard deviationsi

Chapter 19 Inference about a Population Proportion

The sample proportion p^

Large-sample confidence intervals for a proportion

Accurate confidence intervals for a proportion

Choosing the sample sizei

Hypothesis tests for a proportion

Chapter 20 Comparing Two Proportions

Two-sample problems: proportions

The sampling distribution of a difference between proportions

Large-sample confidence intervals for comparing proportions

Accurate confidence intervals for comparing proportions

Hypothesis tests for comparing proportions

Relative risk and odds ratioi

Discussion: Assessing and understanding health risks

15
Chapter 21 The Chi-Square Test for Goodness of Fit

Hypotheses for goodness of fit

Expected counts and chi-square statistic

The chi-square test for goodness of fit

Interpreting significant chi-square results

Conditions for the chi-square test

Chapter 22 The Chi-Square Test for Two-Way


Tables

Two-way tables

Hypotheses for two-way tables of counts

Expected counts and chi-square statistic

The chi-square test

Conditions for the chi-square test

The chi-square test and the two-sample z testi

Chapter 23 Inference for Regression

The regression parameters

Testing the hypothesis of no linear relationship

Testing lack of correlationi

Confidence intervals for the regression slope

16
Inference about prediction

Checking the conditions for inference

Chapter 24 One-Way Analysis of Variance:


Comparing Several Means

Comparing several means

The F statistic

The analysis of variance F test

Conditions for ANOVA

Details of ANOVA calculationsi

Chapter 25 Statistical Inference: Part III Review

Essential concepts from Parts I and II

Part III summary

Comprehensive review exercises: inference selection

Comprehensive review exercises: analysis and conclusion

Large data set exercises

Online data sources

EESEE case studies

Notes and Data Sources

Tables

17
TABLE A: Random Digits

TABLE B: Standard Normal Probabilities

TABLE C: t Distribution Critical Values

TABLE D: Chi-square Distribution Critical Values

TABLE E: Critical Values of the Correlation r

TABLE F: F Distribution Critical Values

Answers to Selected Exercises


Some Studies Recurring Across Chapters
Index
Symbols

Part IV Optional Companion Chapters (available


on the PSLS 4e Companion Website)

Chapter 26 More about Analysis of Variance:


Follow-up Tests and Two-Way ANOVA

Beyond one-way ANOVA

Follow-up analysis: Tukey pairwise multiple comparisons

Follow-up analysis: contrastsi

Two-way ANOVA: conditions, main effects, and interaction

Inference for two-way ANOVA

18
Some details of two-way ANOVAi

Chapter 27 Nonparametric Tests

Comparing two samples: the Wilcoxon rank sum test

Matched pairs: the Wilcoxon signed rank test

Comparing several samples: the Kruskal-Wallis test

Chapter 28 Multiple and Logistic Regression

Parallel regression lines

Estimating parameters

Using technology

Conditions for inference

Inference for multiple regression

Interaction

A case study for multiple regression

Logistic regression

Inference for logistic regression

19
TO THE INSTRUCTOR: About this Book

THE PRACTICE OF STATISTICS IN THE LIFE SCIENCES


The Practice of Statistics in the Life Sciences, Fourth Edition (PSLS 4e) is
an introduction to statistics for college and university students interested in
the quantitative analysis of life science problems. Statistics has become an
integral part of the life sciences, where its practice faces a specific set of
challenges, such as observational studies with confounding variables and
experiments with limited sample sizes. Consequently, students can greatly
benefit from a teaching of statistics that is explicitly applied to their major.
Fortunately, tailoring an introductory statistics course to a specific
audience does not require fundamentally altering the statistical content if
interesting and relevant examples are used to illustrate the statistical
concepts.1
All examples and exercises in PSLS describe actual studies drawn from
diverse areas of biology, such as physiology, brain and behavior,
epidemiology, health and medicine, nutrition, ecology, and microbiology.
Each new edition brings in recently published studies, a number of which
cover topics of acute relevance. PSLS 4e, for instance, includes new
problems on the Zika virus, the long-term effects of concussions, and
patterns in global climate change. Instructors can choose to either cover a
wide range of topics or select examples and exercises related to a
particular field.
PSLS focuses on the applications of statistics rather than the
mathematical foundation. This book is adapted from David Moore’s best-
selling introductory statistics textbook The Basic Practice of Statistics
(BPS). BPS was the pioneer in presenting a modern approach to statistics
in a genuinely elementary text. Like BPS, PSLS emphasizes balanced
content, working with real data, and statistical ideas. It does not require
any specific mathematical skills beyond being able to read and use simple
equations and can be used in conjunction with almost any level of
technology for computations and graphs.

20
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