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Regenerative Medicine
Technology
On-a-Chip Applications for
Disease Modeling, Drug Discovery
and Personalized Medicine
 GENE AND CELL THERAPY SERIES
Series Editors
Anthony Atala & Graça Almeida-Porada

PUBLISHED TITLES
Regenerative Medicine Technology: On-a-Chip Applications for Disease Modeling,
Drug Discovery and Personalized Medicine
Sean V. Murphy and Anthony Atala
Therapeutic Applications of Adenoviruses
Philip Ng and Nicola Brunetti-Pierri
Cellular Therapy for Neurological Injury
Charles S. Cox, Jr
Placenta: The Tree of Life
Ornella Parolini
 GENE AND CELL THERAPY

Regenerative Medicine
Technology
On-a-Chip Applications for
Disease Modeling, Drug Discovery
and Personalized Medicine

Edited by
Sean V. Murphy
Anthony Atala
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742

© 2017 by Taylor & Francis Group, LLC

CRC Press is an imprint of Taylor & Francis Group, an Informa business

No claim to original U.S. Government works

Printed on acid-free paper

Version Date: 20161010

International Standard Book Number-13: 978-1-4987-1191-3 (Hardback)

This book contains information obtained from authentic and highly regarded sources. Reasonable efforts
have been made to publish reliable data and information, but the author and publisher cannot assume
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have attempted to trace the copyright holders of all material reproduced in this publication and apologize to
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Library of Congress Cataloging‑in‑Publication Data

Names: Murphy, Sean V., editor. | Atala, Anthony, 1958- editor.

Title: Regenerative medicine technology : on-a-chip applications for disease
modeling, drug discovery and personalized medicine / [edited by] Sean V.
Murphy and Anthony Atala.
Other titles: Gene and cell therapy series.
Description: Boca Raton : Taylor & Francis, 2017. | Series: Gene and cell
therapy series | Includes bibliographical references and index.
Identifiers: LCCN 2016027009| ISBN 9781498711913 (hardback : alk. paper) |
ISBN 9781498711920 (e-book)
Subjects: | MESH: Lab-On-A-Chip Devices | Artificial Organs | Personalized
Medicine | Printing, Three-Dimensional | Bioprinting | Regenerative
Medicine--methods
Classification: LCC R856 | NLM QT 26 | DDC 610.28/4--dc23
LC record available at https://lccn.loc.gov/2016027009

Visit the Taylor & Francis Web site at

http://www.taylorandfrancis.com

and the CRC Press Web site at

http://www.crcpress.com
 Dedication

To my wife, Jess

Sean V. Murphy

To my family—Katherine, Christopher and Zachary

Anthony Atala
Contents
List of Figures ...........................................................................................................xi
Series Preface .........................................................................................................xvii
Preface.....................................................................................................................xix
Editors ....................................................................................................................xxv
Contributors .........................................................................................................xxvii

Section i technologies

Chapter 1 Microfabrication and 3D Bioprinting of Organ-on-a-Chip.................. 3

Prafulla Chandra, Carlos Kengla and Sang Jin Lee

Chapter 2 Three-Dimensional Cell Culture........................................................ 29

Ivy L. Mead and Colin E. Bishop

Chapter 3 Electrochemical Sensors for Organs-on-a-Chip ................................ 45

Joyce Han-Ching Chiu, Ge-Ah Kim, Rodney Daniels
and Shuichi Takayama

Chapter 4 Microfluidics ...................................................................................... 65

Panupong Jaipan and Roger Narayan

Chapter 5 From Big Data to Predictive Analysis from In Vitro Systems .......... 85
Andre Kleensang, Alexandra Maertens and Thomas Hartung

Chapter 6 Lab-on-a-Chip Systems for Biomedical Applications ..................... 103

David Wartmann, Mario Rothbauer and Peter Ertl

Section ii organs-on-chips

Chapter 7 From 2D Culture to 3D Microchip Models: Trachea, Bronchi/

Bronchiole and Lung Biomimetic Models for Disease Modeling,
Drug Discovery, and Personalized Medicine ................................... 141
Joan E. Nichols, Stephanie P. Vega, Lissenya B. Argueta,
Jean A. Niles, Adrienne Eastaway, Michael Smith,
David Brown and Joaquin Cortiella
vii
viii Contents

Chapter 8 Liver and Liver Cancer-on-a-Chip ................................................... 175

Aleksander Skardal

Chapter 9 Heart-on-a-Chip ............................................................................... 187

Megan L. McCain

Chapter 10 Skin-on-a-Chip .................................................................................209

Claire G. Jeong

Chapter 11 Tissue-Engineered Kidney Model.................................................... 235

Erica P. Kimmerling and David L. Kaplan

Chapter 12 Body-on-a-Chip ................................................................................ 253

Mahesh Devarasetty, Steven D. Forsythe, Thomas D. Shupe,
Aleksander Skardal and Shay Soker

Section iii Applications

Chapter 13 Integrated Multi-Organoid Dynamics .............................................. 271

Aleksander Skardal, Mahesh Devarasetty, Sean Murphy,
and Anthony Atala

Chapter 14 Cancer Metastasis-on-a-Chip ........................................................... 287

Ran Li, Michelle B. Chen, and Roger D. Kamm

Chapter 15 Breast Cancer-on-a-Chip .................................................................. 315

Pierre-Alexandre Vidi and Sophie A. Lelièvre

Chapter 16 Disease Modeling ............................................................................. 345

Uta Grieshammer and Kelly A. Shepard
Contents ix

Chapter 17 In Vivo, In Vitro, and Stem Cell Technologies to Predict Human

Pharmacology and Toxicology ......................................................... 363
Harry Salem, Russell Dorsey, Daniel Carmany
and Thomas Hartung

Chapter 18 Personalized Medicine ..................................................................... 377

Elisa Cimetta, Michael Lamprecht, Sarindr Bhumiratana,
Nafissa Yakubova, and Nina Tandon

Index ...................................................................................................................... 421

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