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Essential Dental
Therapeutics
 Essential
Dental
Therapeutics
Edited by
David Wray
University of Glasgow
UK
This edition first published 2018
© 2018 John Wiley & Sons Ltd

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any
means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission
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The right of David Wray to be identified as the author of this work has been asserted in accordance with law.

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Library of Congress Cataloging-in-Publication Data

Names: Wray, David, author.

Title: Essential dental therapeutics / by David Wray.
Description: First edition. | Chichester, West Sussex ; Hoboken : Wiley,
2018. | Series: Essentials | Includes index. |
Identifiers: LCCN 2017014504 (print) | LCCN 2017015962 (ebook) | ISBN
9781119057413 (pdf ) | ISBN 9781119057420 (epub) | ISBN 9781119057390 (pbk.)
Subjects: | MESH: Dental Care | Drug Therapy
Classification: LCC RK51.5 (ebook) | LCC RK51.5 (print) | NLM WU 29 | DDC
617.6–dc23
LC record available at https://lccn.loc.gov/2017014504

Cover design: Wiley

Cover image: © Vstock LLC/ Gettyimages

Set in 10/12pt, AGaramondPro by SPi Global, Chennai, India.

10 9 8 7 6 5 4 3 2 1
Contents
List of contributors vii
Preface ix
About the companion website xi

1 Introduction to pharmacology and therapeutics – pharmacodynamics 1

Alan Nimmo
2 Introduction to pharmacology and therapeutics – pharmacokinetics 7
Alan Nimmo
3 Introduction to pharmacology and therapeutics – drug safety 15
Alan Nimmo
4 Antimicrobials – antiseptics and disinfectants 23
Martina Shepard
5 Antimicrobials – antibiotics 31
Esther Hullah
6 Antimicrobials – antifungals 41
John Steele and Jenny Taylor
7 Antimicrobials – antivirals 47
John Steele and Jenny Taylor
8 Therapeutics of pain management 53
Roddy McMillan
9 Corticosteroids 65
Jenny Taylor and John Steele
10 Fluoride and toothpaste 69
Sabine Jurge
11 Treatments for dry mouth 73
Roddy McMillan
12 Therapeutics for medical emergencies in dental practice 77
Roddy McMillan
13 Central nervous system 1 – mood disorders 85
Alan Nimmo
vi / Contents

14 Central nervous system 2 – neurodegenerative and acquired disorders 93

Alan Nimmo
15 Central nervous system 3 – genetic and developmental disorders 101
Alan Nimmo
16 Endocrine disorders 1 109
Alan Nimmo
17 Endocrine disorders 2 – diabetes mellitus 117
Alan Nimmo
18 Cardiovascular therapeutics 125
Roddy McMillan
19 The respiratory system 137
Martyn Ormond
20 Coagulation 145
Martina Shepard
21 Gastrointestinal pharmacology 153
Esther Hullah
22 Antineoplastic therapeutics 159
Jenny Taylor and John Steele
23 Vitamins and minerals 167
Sabine Jurge
24 Musculoskeletal therapeutics 175
Martyn Ormond

Index 181
List of contributors

Dr. Esther A. Hullah, BDS, MB ChB, MFDS RCS Eng, FDS (OM) RCS Eng, FHEA., Consultant and
Specialist in Oral Medicine, Department of Oral Medicine, Guy’s and St Thomas’ NHS Foundation Trust
& Honorary Lecturer in Oral Medicine, Kings College London Dental Institute, Guy’s Hospital, London,
United Kingdom
Dr Sabine Jurge, DDS, MSc, MBBS, MFDS RCS Eng, FDS (OM) RCPS, FHEA., Consultant and
Specialist in Oral Medicine, Charles Clifford Dental Hospital, Sheffield Teaching Hospitals NHS Foundation
Trust & Honorary Senior Clinical Lecturer in Oral Medicine, The School of Clinical Dentistry University
of Sheffield, London, United Kingdom
Dr. Roddy McMillan, BDS, MB ChB, MFDS RCS Eng, FDS (OM) RCPS, FHEA., Consultant & Specialist
in Oral Medicine, Eastman Dental Hospital, University College London Hospitals NHS Trust & Honorary
Clinical Teaching Fellow in Oral Medicine and Facial Pain, Eastman Dental Institute, University College
London, London, United Kingdom
Professor Alan J. Nimmo, PhD, BSc(Hons)., Professor of Medical Science, College of Medicine and
Dentistry, James Cook University, Smithfield Campus, Cairns, Australia
Dr. Martyn Ormond, BDS, MBBS, MFDS RCS Ed., Specialty Registrar in Oral Medicine, Department
of Oral Medicine, Guy’s and St Thomas’ NHS Foundation Trust & Honorary Lecturer in Oral Medicine,
Department of Oral Medicine, Kings College London Dental Institute, Guy’s Hospital, London, United
Kingdom
Dr. Martina K. Shephard, BDent(Hons), MBBS(Hons), FRACDS, FDS (OM) RCS Eng., Consultant &
Specialist in Oral Medicine, Eastman Dental Hospital, University College London Hospitals NHS Trust,
London, United Kingdom
Dr. John C. Steele, BDS, MB ChB, MFDS RCS Ed, FDS (OM) RCS Ed, Dip OM, PGCTLCP, FHEA.,
Consultant & Specialist in Oral Medicine, The Leeds Teaching Hospitals NHS Trust & Honorary Senior
Lecturer in Oral Medicine, Leeds Dental Institute, Faculty of Medicine & Health, University of Leeds,
London, United Kingdom
Dr Jennifer Taylor, BDS, MB ChB, MFDS RCS Ed, FDS (OM) RCPS., Consultant and Specialist in
Oral Medicine, Greater Glasgow and Clyde NHS Trust, &, Honorary Senior Lecturer in Oral Medicine,
University of Glasgow, Glasgow Dental Hospital and School, 378 Sauchiehall Street, Glasgow, United
Kingdom
Professor David Wray, MD(Hons), BDS, MB ChB, FDS RCPS, FDS RCS Ed, F Med Sci., Emeritus
Professor, University of Glasgow, University Avenue, Glasgow, United Kingdom
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