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Registration No :
Total Number of Pages : 01 M.Pharm
M.PH2A.2
2nd Semester Regular / Back Examination 2018-19
BIO-PHARMACEUTICS AND PHARMACOKINETICS
BRANCH : PHARMACEUTICS
Time : 3 Hours
Max Marks : 70
Q.CODE : F535
Answer Question No.1 which is compulsory and any FIVE from the rest.
The figures in the right hand margin indicate marks.
Q1 Answer the following questions : (2 x 10)
a) Define Bioavailability and Bioequivalence
b) State AUC.
c) Write the significant role of BBB
d) Define total clearance and clearance ratio.
e) Write at least two causes of non-linear pharmacokinetics.
f) Write about MDT
g) Describe the basic concept of physiological pharmacokinetic model.
h) Name four different sites of protein binding of HSA
i) What are the four phases of Plasma drug concentration time profile?
j) Define Cronotherapeutics.
Q2 a) Distinguish absolute and relative bioavailability (5)
b) Mention how bioequivalence data interpreted statistically. (5)
Q3 a) Mention the absorption process of Insulin (5)
b) Narrate how the drugs are classified on basis of solubility and permeability. (5)
Illustrate with proper example.
Q4 a) Define Michaelis-Menten equation (5)
b) Determination of Ka using urinary data is not suitable for rapidly absorbed (5)
drugs, why.
Q5 a) Narrate briefly about clinical significance of protein binding. (5)
b) Calculate the elimination half life of 1st order kinetics (5)
Q6 Discuss about non compartment pharmacokinetics. Mention how statistical (10)
moments analysis can be utilized in pharmacokinetics. Illustrate with proper
example.
Q7 Estimate the pharmacokinetic parameters of IV bolus administration follow (10)
one compartment open model.
Q8 Write short answer on any TWO : (5 x 2)
a) Method of Residual
b) Active transport
c) IVIVC
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