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Registration No :
Total Number of Pages : 01 M.Pharm.
M.PH2A.2
2nd Semester Regular / Back Examination 2017-18
BIO-PHARMACEUTICS & PHARMACOKINETICS
BRANCH : PHARMACEUTICS
Time : 3 Hours
Max Marks : 70
Q.CODE : C615
Answer Question No.1 which is compulsory and any five from the rest.
The figures in the right hand margin indicate marks.
Answer all parts of a question at a place.
Q1 Answer the following questions: Short answer type: (2 x 10)
a) Give the differences between bioavailability and bioequivalence.
b) What different softwares are used for the study of pharmacokinetics and
mention their advantages.
c) Define compartment and mention the advantages of compartment modelling.
d) Explain the calculation of area under the curve (AUC) by trapezoidal rule and
mention the significance of AUC.
e) Define chronotherapeutics and mention their advantages.
f) Write the causes for non-linearity and give two examples of drugs following
non-linear kinetics.
g) Define total body clearance and mention its significance.
h) Define chronotherapeutics.
i) Write the clinical significance of protein binding?
j) Mention the significance of mean residence time.
Q2 a) Write about factors influencing the bioavailability. (6)
b) Write about statistical concepts useful in bioequivalence studies. (4)
Q3 a) Explain the calculation of absorption rate constant by Wagner-Nelson (6)
method and mention its limitations.
b) The plasma concentration of viomycin after i.v. bolus administration of 300 (4)
mg dose was found to be 10.0 and 5.5 mcg/ml at 2 and 4 hours respectively.
Assuming one-compartment kinetics calculate t1/2 and Vd.
Q4 Explain Michaelis-Menten kinetics and discuss the method of double (10)
reciprocal plot for calculation of Michaelis-Menten constant and maximum
metabolic rate. Mention its drawbacks.
Q5 a) Write about mammillary model. (5)
b) Write about Chronopharmacokinetics and their implications. (5)
Q6 Write about Chronopharmacokinetics and their implications. (10)
Q7 Write about the following :
a) Steady state concentration in multiple dosing. (5)
b) Apparent volume of distribution and its significance. (5)
Q8 Explain the Loo-Riegelman method for calculation of pharmacokinetic (10)
parameters in two compartment model.
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