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Advances in Experimental Medicine and Biology 1089
Cell Biology and Translational Medicine

Kursad Turksen Editor

Cell Biology and

Translational
Medicine, Volume 2
Approaches for Diverse Diseases
and Conditions
Advances in Experimental Medicine
and Biology
Cell Biology and Translational Medicine

Volume 1089

Subseries Editor
Kursad Turksen
More information about this subseries at http://www.springer.com/series/15838
Kursad Turksen
Editor

Cell Biology and

Translational Medicine,
Volume 2
Approaches for Diverse Diseases and
Conditions
Editor
Kursad Turksen (Retired)
Ottawa Hospital Research Institute
Ottawa, ON, Canada

ISSN 0065-2598 ISSN 2214-8019 (electronic)

Advances in Experimental Medicine and Biology
ISSN 2522-090X ISSN 2522-0918 (electronic)
Cell Biology and Translational Medicine
ISBN 978-3-030-04169-4 ISBN 978-3-030-04170-0 (eBook)
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Preface

While there is a great interest in understanding fundamental aspects of the cell

and molecular biology of stem cells, a key goal is to be able to harness this
understanding in tissue repair, regeneration, and restoration of function in
disease states. Realizing the potential of stem cells for therapeutic benefits in
specific diseases and conditions will require detailed disease-specific
approaches and trials, but lessons can be learned by comparisons of results
and advances being made across diverse tissues, organs, and disease states.
With the latter goals in mind, I am very pleased to introduce the second
volume in the new series titled Cell Biology and Translational Medicine
(CBTMED), part of Springer Nature’s long-standing and very successful
Advances in Experimental Medicine and Biology book series. Each volume
of the CBTMED series will cover emerging areas of regenerative medicine
and translational aspects of stem cells. For this second volume, I have
recruited outstanding researchers to highlight developments in both the
basic research and clinical arenas for a variety of diseases and conditions.
I remain very grateful to Peter Butler, Editorial Director, and Meran Lloyd-
Owen, Senior Editor, for their ongoing support of this series that we have
embarked upon.
I would also like to acknowledge and thank Sara Germans-Huisman,
Assistant Editor, for her outstanding efforts in getting the volume to the
production stages.
Finally, I thank the contributors not only for their support of the series but
also for their efforts to capture both the advances and remaining obstacles in
their areas of research. I am grateful for their efforts and trust readers will find
their contributions interesting and helpful.

Ottawa, ON, Canada Kursad Turksen

v
Contents

Stem Cell and Obesity: Current State and Future

Perspective . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Moloud Payab, Parisa Goodarzi, Najmeh Foroughi Heravani,
Mahdieh Hadavandkhani, Zeinab Zarei, Khadijeh Falahzadeh,
Bagher Larijani, Fakher Rahim, and Babak Arjmand
A Comprehensive Review of Stem Cells for Cartilage
Regeneration in Osteoarthritis . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
Gauthaman Kalamegam, Adnan Memic, Emma Budd,
Mohammed Abbas, and Ali Mobasheri
Exploring Stem Cells and Inflammation in Tendon
Repair and Regeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
A. Vinhas, M. T. Rodrigues, and M. E. Gomes
Therapeutic Potential of Mesenchymal Stem Cell-Derived
Exosomes in the Treatment of Eye Diseases . . . . . . . . . . . . . . . . . . 47
C. Randall Harrell, Bojana Simovic Markovic, Crissy Fellabaum,
Aleksandar Arsenijevic, Valentin Djonov, Nebojsa Arsenijevic,
and Vladislav Volarevic
Transplantation and Alternatives to Treat Autoimmune
Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
Pravin Shende, Bernice Rodrigues, and R. S. Gaud
Therapeutic Applications of Mesenchymal Stem Cells
for Systemic Lupus Erythematosus . . . . . . . . . . . . . . . . . . . . . . . . 73
Jianyong Xu
Potential Use of Stem Cells in Mood Disorders . . . . . . . . . . . . . . . 87
Gabriela D. Colpo, Laura Stertz, Breno S. Diniz,
and Antonio L. Teixeira
Cancer Stem Cells in Metastasis Therapy . . . . . . . . . . . . . . . . . . . 97
Esra Aydemir Çoban and Fikrettin Şahin
Regenerative Medicine Applications of Mesenchymal
Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115
Samaneh Hosseini, Leila Taghiyar, Fatemeh Safari,
and Mohamadreza Baghaban Eslaminejad

vii
viii Contents

Stem Cells Application in Thoracic Surgery: Current

Perspective and Future Directions . . . . . . . . . . . . . . . . . . . . . . . . . 143
Francesco Petrella and Lorenzo Spaggiari

Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149
Adv Exp Med Biol – Cell Biology and Translational Medicine (2018) 2: 1–22
https://doi.org/10.1007/5584_2018_227
# Springer International Publishing AG, part of Springer Nature 2018
Published online: 7 June 2018

Stem Cell and Obesity: Current State

and Future Perspective

Moloud Payab, Parisa Goodarzi, Najmeh Foroughi Heravani,

Mahdieh Hadavandkhani, Zeinab Zarei, Khadijeh Falahzadeh,
Bagher Larijani, Fakher Rahim, and Babak Arjmand

Abstract is remained unsolved. Therefore, finding a

Obesity as a worldwide growing challenge is new approach that can overcome previous
determined by abnormal fat deposition, which limitations is very attractive for both
may damage general health. Weight loss and researchers and clinicians. Cell-based therapy
control of related risk factors like type2 diabe- using adipose-derived stromal cells seems to
tes, dyslipidemia, hypertension, cardiovascu- be a promising strategy to control obesity and
lar diseases, and metabolic syndrome is an related syndromes. To attain this aim, under-
important concern in obesity management. standing of different type of adipose tissues,
Different therapeutic approaches such as life- main signaling pathways, and different factors
style change, medications, and surgery are involved in development of adipocyte is essen-
introduced for obesity treatment. Despite of tial. Recently, several cell-based methods like
gaining partially desirable results, the problem stem cell administration, brown adipose tissue

M. Payab
Obesity and Eating Habits Research Center, Endocrinology
and Metabolism Molecular-Cellular Sciences Institute,
B. Larijani
Tehran University of Medical Sciences, Tehran, Iran
Endocrinology and Metabolism Research Center,
P. Goodarzi Endocrinology and Metabolism Clinical Sciences
Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran,
Institute, Tehran University of Medical Sciences, Tehran, Iran Iran
N. Foroughi Heravani and M. Hadavandkhani F. Rahim
Cell Therapy and Regenerative Medicine Research Center, Health Research Institute, Thalassemia and
Endocrinology and Metabolism Molecular-Cellular Hemoglobinopathy Research Center, Ahvaz Jundishapur
Sciences Institute, Tehran University of Medical Sciences, University of Medical Sciences, Ahvaz, Iran
Tehran, Iran
B. Arjmand (*)
Z. Zarei Cell Therapy and Regenerative Medicine Research Center,
Department of Tissue Engineering and Applied Cell Endocrinology and Metabolism Molecular-Cellular
Science, School of Advanced Technologies in Medicine, Sciences Institute, Tehran University of Medical Sciences,
Tehran University of Medical Sciences, Tehran, Iran Tehran, Iran
K. Falahzadeh Metabolomics and Genomics Research Center,
Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular
Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences,
Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Tehran, Iran e-mail: [email protected]

1
2 M. Payab et al.

transplantation, cell lysates and exosomes ENG Endoglin (protein)

have been examined on obese mouse models ERK Extra cellular receptor kinase
to manage obesity and related disorders. Suc- ES Embryonic stem cell
cessful outcome of such preclinical studies can EVs Extracellular vesicles
encourage the cell-based clinical trials in the FDA Food and drug administration
near future. FGF10 Fibroblast growth factor 10
FPG Fasting plasma glucose
Keywords FTO Fat mass and obesity associated
Adipocyte · Adipose tissue · Animal models · (gene)
Cell therapy · Mesenchymal stem/stromal H3K9 Histone H3 lysine 9
cells · Obesity HDL High-density lipoprotein
HFD High-fat diet
Hh Hedgehog
HOXC8 HomeoboxC8
Abbreviations IDF International diabetes federation
ADAMTS5 A disintegrin and IGF1 Insulin-like growth factor1
metalloproteinase with IL6 Interlukine 6
thrombospondin motif 5 LOX lysyl oxidase
ADSC Adipose derived mesenchymal M-BA MSC-derived BAT
stem cells Mef2 Myocyte enhancer factor 2
AKR1B10 Aldo-keto reductase family miR-196a MicroRNA 196a
1 member B10 miRNAs MicroRNAs
aP2 Adipocyte protein 2 MSC Mesenchymal stem cells
ASCs Adipose derived-stem cells Myf5 Myogenic factor 5
BAT Brown adipose tissue NICD Notch intracellular domain
BMI Body mass index NRs Number of nuclear receptors
BM-MSCs Bone marrow mesenchymal stem Pax7 Paired box 7
cells PDGF Platelet-derived growth factor
BMP4 Bone morphogenic protein 4 PDGPR α / Platelet derived growth factor
C/EBP α CCAAT/enhancer-binding protein b receptor α/β
(A)/β/δ α/β/δ PGCα Peroxisome proliferator-activated
CB-MSC Umbilical cord blood- receptor-gamma coactivator α
mesenchymal stem cell PLIN Perilipin
CB-plasma Cord blood plasma PPAR-γ/G Peroxisome proliferator-activated
CD24 Cluster of differentiation 24 receptor-γ
Cidea Cell death-inducing DFFA-like PPRE PPAR response element
effector a PRb/Rb Retinoblastoma protein/
CIT Cold induced thermogenesis retinoblastoma
Cox2 Cyclooxygenase 2 PRDM16 PR domain containing 16
CRE cAMP response element PREF1 Preadipocyte factor 1
CXCL3 Chemokine(C-X-C motif) ligand3 RARE Retinoic acid response element
DIO Diet-induced obese RIP Receptor interacting protein
DIT Diet-induced thermogenesis SAT Subcutaneus white adipose tissue
Dlk1 Delta like non-canonical notch SMA Spinal muscular atrophy
ligand 1 STAT3 Signal transducers and activators
EBF2 Early B cell factor 2 of transcription 3
EHMT1 Euchromatic histone lysine TC1 Immune response regulator
methyltransferase 1
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