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 BIOLOGICALLY ACTIVE
NATURAL PRODUCTS
Microbial Technologies and
Phyto-Pharmaceuticals in Drug Development
 BIOLOGICALLY ACTIVE
NATURAL PRODUCTS
Microbial Technologies and
Phyto-Pharmaceuticals in Drug Development

Edited by
Debarshi Kar Mahapatra, PhD
Swati Gokul Talele, PhD
Tatiana G. Volova, DSc
A. K. Haghi, PhD
First edition published 2021
Apple Academic Press Inc. CRC Press
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Library and Archives Canada Cataloguing in Publication
Title: Biologically active natural products : microbial technologies and phyto-pharmaceuticals in drug development /
edited by Debarshi Kar Mahapatra, PhD, Swati Gokul Talele, PhD, Tatiana G. Volova, DSc, A.K. Haghi, PhD.
Names: Mahapatra, Debarshi Kar, editor. | Talele, Swati Gokul, editor. | Volova, Tatiana G., editor. | Haghi, A. K., editor.
Description: Includes bibliographical references and index.
Identifiers: Canadiana (print) 20200327720 | Canadiana (ebook) 20200327887 | ISBN 9781771889049 (hardcover) |
ISBN 9781003057505 (hardcover)
Subjects: LCSH: Drug development. | LCSH: Natural products. | LCSH: Biological products. | LCSH: Microbial
biotechnology. | LCSH: Materia medica, Vegetable. | LCSH: Nanotechnology.
Classification: LCC RM301.25 .B56 2021 | DDC 615.1—dc23
Library of Congress Cataloging-in-Publication Data

CIP data on file with US Library of Congress

ISBN: 978-1-77188-904-9 (hbk)

ISBN: 978-1-00305-750-5 (ebk)
About the Editors

Debarshi Kar Mahapatra, PhD

Assistant Professor, Department of Pharmaceutical Chemistry, Dadasaheb
Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur
University, Nagpur, Maharashtra, India

Debarshi Kar Mahapatra, PhD, is currently an Assistant Professor in the

Department of Pharmaceutical Chemistry at Dadasaheb Balpande College of
Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maha-
rashtra, India. He was formerly Assistant Professor in the Department of
Pharmaceutical Chemistry, Kamla Nehru College of Pharmacy; RTM Nagpur
University, Nagpur, India. He has taught medicinal and computational chem-
istry at both the undergraduate and postgraduate levels and has mentored
students in their various research projects. His area of interest includes
computer-assisted rational designing and synthesis of low molecular weight
ligands against druggable targets, drug delivery systems, and optimization
of unconventional formulations. He has published research, book chapters,
reviews, and case studies in various reputed journals and has presented his
work at several international platforms, for which he has received several
awards by a number of bodies. He has also authored the book titled Drug
Design. Presently, he is serving as a reviewer and editorial board member
for several journals of international repute. He is a member of a number of
professional and scientific societies, such as the International Society for
Infectious Diseases (ISID), the International Science Congress Association
(ISCA), and ISEI.

Swati Gokul Talele, PhD

Assistant Professor, Department of Pharmaceutics, Sandip Institute of
Pharmaceutical Sciences, Savitribai Phule Pune University, Pune,
Maharashtra, India

Swati Gokul Talele, PhD, is currently serving as an Assistant Professor,

Department of Pharmaceutics at Sandip Institute of Pharmaceutical Sciences.
She has 18 years of experience in research along with teaching. She has
vi About the Editors

published more than 20 research papers in various reputed international

and national journals as well as more than 30 review papers. She has also
presented research work at several conferences and has received several
awards. She has authored the book titled Natural Excipients and has many
chapters and books that are in progress. She has supervised many MPharm
students and is currently associated with many research projects. She also
worked as a College Examination Officer (CEO) for more than three years
and is a member of the university examination committee. Dr. Talele has
delivered interactive talks at continuous education programs for registered
pharmacists and is a life member of the Association of Pharmacy Teachers of
India (APTI) and a member of the Indian Pharmaceutical Congress Associa-
tion (IPCA). Her interests are in the field of nanotechnology, natural poly-
mers, herbal formulations, and radiolabeling-based bio-distribution studies.

Tatiana G. Volova, PhD

Professor and Head, Department of Biotechnology, Siberian Federal
University, Krasnoyarsk, Russia

Tatiana G. Volova, DSc, is a Professor and Head, Department of Biotech-

nology at Siberian Federal University, Krasnoyarsk, Russia. She is the
creator and head of the Laboratory of Chemoautotrophic Biosynthesis at
the Institute of Biophysics, Siberian Branch of the Russian Academy of
Sciences. Professor Volova is conducting research in the field of physico-
chemical biology and biotechnology and is a well-known expert in the field
of microbial physiology and biotechnology. Dr. Volova has created and
developed a new and original branch in chemoautotrophic biosynthesis, in
which the two main directions of the XXI century technologies are conju-
gate, hydrogen energy, and biotechnology. The obtained fundamental results
provided significant outputs and were developed by the unique biotechnical
producing systems, based on hydrogen biosynthesis for single-cell protein,
amino acids, and enzymes. Under the guidance of Professor Volova, the pilot
production facility of single-cell protein (SCP), utilizing hydrogen, had been
created and put into operation. The possibility of involvement of man-made
sources of hydrogen into biotechnological processes as a substrate, including
synthesis gas from brown coals and vegetable wastes, was demonstrated in
her research. She had initiated and deployed in Russia the comprehensive
research on microbial degradable bioplastics; the results of this research
cover various aspects of biosynthesis, metabolism, physiological role,
About the Editors vii

structure, and properties of these biopolymers and polyhydroxyalkanoates

(PHAs), and have made a scientific basis for their biomedical applications
and allowed them to be used for biomedical research. Professor Volova is
the author of more than 300 scientific works, including 13 monographs, 16
inventions, and a series of textbooks for universities.

A. K. Haghi
Professor Emeritus of Engineering Sciences, Former Editor-in-Chief,
International Journal of Chemoinformatics and Chemical Engineering
and Polymers Research Journal; Member, Canadian Research and
Development Center of Sciences and Culture

A. K. Haghi, PhD, is the author and editor of 200 books, as well as 1000
published papers in various journals and conference proceedings. Dr. Haghi
has received several grants, consulted for a number of major corporations,
and is a frequent speaker to national and international audiences. Since
1983, he served as a professor at several universities. He is former Editor-
in-Chief of the International Journal of Chemoinformatics and Chemical
Engineering and Polymers Research Journal and is on the editorial boards of
many international journals. He is also a member of the Canadian Research
and Development Center of Sciences and Cultures (CRDCSC), Montreal,
Quebec, Canada.
Contents

Contributors ........................................................................................................... xi
Abbreviations........................................................................................................ xiii
Preface................................................................................................................. xvii

1. Azadirachta indica: Imperative Mini-Opinions on an

Ethnopharmacological Savior....................................................................... 1
Anshda Bhatnagar and Debarshi Kar Mahapatra

2. Arsenals of Pharmacotherapeutically Active Proteins and Peptides:

Old Wine in a New Bottle ............................................................................ 29
Kirti Dubli

3. Biotechnological Potential of Hydrogen-Oxidizing Bacteria ................. 135

Tatiana Grigorievna Volova, Evgeniy Gennadievich Kiselev, and Ekaterina Igorevna
Shishatskaya

4. Abutilon indicum, Prosopis juliflora, and Acacia arabica as

Antibacterial Agents Against Xanthomonas axonopodis pv. punicae..... 165
Aishwarya A. Andhare and Ravindra S. Shinde

5. Microbial Biotechnology: Synthesis, Production, Challenges,

and Opportunities ...................................................................................... 181
Akshada A. Bakliwal, Swapnali A. Patil, Meghawati R. Badwar, and Swati G. Talele

6. Pharmaceutical Natural and Synthetic Colorants, Pigments, Dyes,

and Lakes: Applications, Perspectives, and Regulatory Aspects........... 205
Debarshi Kar Mahapatra and Sanjay Kumar Bharti

7. Microbial Pigments: A Green Microbial Technology ............................. 225

Eknath Ahire, Swati G. Talele, and Gokul S. Talele

8. Ethnopharmacological Perspectives of the Traditional Herb

Tabermontana divaricate Linn. .................................................................. 245
Seema Wakodkar, Debarshi Kar Mahapatra, Shilpa Borkar, and Shailaja Latkar

9. A Closer View on Various Reported Therapeutically Active

Formulations Containing Aloe vera (Aloe barbadensis) ......................... 259
Vaibhav Shende and Debarshi Kar Mahapatra
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