AF-2294
Faculty of Pharmacy
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B.Pharm. Semester–VII (New) Examination
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BP704T
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NOVEL DRUG DELIVERY SYSTEM
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Time : Three Hours] [Maximum Marks : 75
INSTRUCTIONS TO CANDIDATES
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(1) All question carry marks as indicated.
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(2) Answer All questions.
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(3) Assume suitable data wherever necessary.
(4) Illustrate your answer wherever necessary with the help of neat sketches.
(5) Use pen of Blue/Black ink/refill only for writing the answer book.
1. Multiple Choice Questions : 20
(1) An advantage of novel drug delivery system is :
(A) It causes fluctuation of blood levels (B) It cannot be target specific
(C) It increases toxicity of the drug
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(D) It reduces side effects of the drug
(2) Monolithic devices :
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(A) Have drugs with large therapeutic indices
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(B) Have rapid drug permeation
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(C) Only hydrophilic polymers are used
(D) Release is through polymer membrane
(3) Microspheres are prepared by coacervation using :
(A) Non solvent (B) Trituration
(C) pH (D) Pressure
(4) An ocular device that has shape of flag :
(A) Ocusert (B) Lacrisert
(C) NODS (D) SODI
(5) Which of the following characteristics is suitable for transdermal drug ?
(A) Large drug dose
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(B) Large molecular size
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(C) Drugs with narrow therapeutic indices
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(D) Drugs which are metabolized in the skin
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(6)
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___________ is an example of synthetic biodegradable polymer.
(A) Acrolein
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(B) Polyethylene glycol
(C) LDPE (D) Polystryene
LV–19355 1 (Contd.)
(7) Example of hydrophobic polymer used in nanoparticles is :
(A) Gelatin (B) Alginate
(C) Acrylate (D) Lectin
(8)
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Which are the characteristics of matrix diffusion controlled release system ?
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(A) Release the drug along the entire length of GIT
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(B) Drug disperse in an insoluble matrix of rigid hydrophobic material
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(C) Employ waxes to control the rate dissolution
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(D) Release only at specific site
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(9) Modified balance method is used to evaluate :
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(A) Particle size (B) Adhesive strength
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(C) Drug release (D) Swelling
(10) What is the characteristic of dissolution controlled release systems ?
(A) Release the drug along the entire length of GIT
(B) Prolong their residence in the GIT and release
(C) Release only at specific drug
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(D) Very slow dissolution rate
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(11) What are the characteristics of hydrodynamic pressure controlled drug delivery system ?
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(A) Buffering agents that adjust pH to the desired value
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(B) Drug dispersion in an insoluble hydrophobic polymeric matrix
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(C) Swelling of hydrophilic gum
(D) Complexation of drug and cation exchange resins
(12) Which of the following characteristic is suitable for IUD ?
(A) Small Dose of Drug (B) Large molecular size of drug
(C) Drug with narrow therapeutic indices (D) Drug metabolizing in the skin
(13) Controlled drug delivery doses form demonstrates which type of drug release order ?
(A) Zero order (B) First order
(C) Second order (D) Mixed order
(14) Sonophoresis is a use of __________ to increase the bio-absorption of topically applied
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drugs.
(A) Ultrasound
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(C) IR radiation (D) None of these
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(15) Chitosan __________ .
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(A) Increases stability of drug
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(B) Decreases stability of drug
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(C) Does not affect stability A
(D) None of the above
LV–19355 2 (Contd.)
(16) __________ Model describes the drug release characteristics as diffusion process based on
Fick's law relates with square root of time dependent.
(A) Korsmayer's and Peppa's model (B) Hixson-Crowell model
(C) Higuchi model
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(17) The effect of longer residence time of mucoadhesive product results in __________.
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(A) Increase in bioavailability (B) Decrease in bioavailability
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(C) Does not affect bioavailability (D) Uncertain bioavailability
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(18) The process of melting, mixing and forcing an polymer through an orifice/die is called
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__________.
(A) Solvent casting (B) Injection Moulding
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(C) Hot melt extrusion (D) Compression
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(19) Use of monoclonal antibodies for drug delivery to tumors is :
(A) Active targeting (B) Passive targeting
(C) Triggered drug targeting (D) Vector targeting
(20) Process variables that influence the efficiency and effectiveness of micro encapsulation using
spray drying technique are except :
(A) Coating material concentration
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(C) Inlet and outlet temperature
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2. Long answer questions (Any Two ) :
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Explain various methods for preparation of microcapsules.
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Define Transdermal Drug Delivery System (TDDS) ? Give its advantages and disadvantages.
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Describe various basic components of TDDS.
(3) What are liposomes. Classify them. Write the various structural components of liposomes.
Explain various applications of Liposomes.
3. Short answer questions (Any Seven) : 35
(1) Describe osmotically regulated Implants as new drug delivery system.
(2) Write note on Biodegradable and non biodegradable microspheres.
(3) Describe in detail about metered dose inhalers.
(4) Write short note on ocular drug delivery system.
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(5) Write in short about applications of naoparticles.
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Explain the biological factors affecting controlled release drug delivery systems.
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(7)
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Write short note on buccal mucoadhesive drug delivery system.
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(8)
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Write in detail about factors affecting permeation of transdermal drug delivery system.
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(9)
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Write a note on Low density and High density type of GRDDS.
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LV–19355 3 25
