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THE THERAPEUTIC PROPERTIES
OF MEDICINAL PLANTS
Health-Rejuvenating Bioactive
Compounds of Native Flora
Innovations in Plant Science for Better Health: From Soil to Fork

THE THERAPEUTIC PROPERTIES

OF MEDICINAL PLANTS
Health-Rejuvenating Bioactive
Compounds of Native Flora

Edited by
Megh R. Goyal
Hafiz Ansar Rasul Suleria
Ademola Olabode Ayeleso
T. Jesse Joel
Sujogya Kumar Panda
Apple Academic Press Inc. Apple Academic Press Inc.
4164 Lakeshore Road 1265 Goldenrod Circle NE
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© 2020 by Apple Academic Press, Inc.
Exclusive worldwide distribution by CRC Press, a member of Taylor & Francis Group
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now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission
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Library and Archives Canada Cataloguing in Publication

Title: The therapeutic properties of medicinal plants : health-rejuvenating bioactive compounds of native flora/edited
   by Megh R. Goyal, Hafiz Ansar Rasul Suleria, Ademola Olabode Ayeleso, T. Jesse Joel, Sujogya Kumar Panda.
Names: Goyal, Megh Raj, editor. | Suleria, Hafiz, editor. | Ayeleso, Ademola Olabode, editor. | Joel, T. Jesse, editor. |
   Panda, Sujogya Kumar, editor.
Series: Innovations in plant science for better health.
Description: Series statement: Innovations in plant science for better health: from soil to fork | Includes bibliographical
   references and index.
Identifiers: Canadiana (print) 20190169990 | Canadiana (ebook) 20190170018 | ISBN 9781771888035 (hardcover) |
   ISBN 9780429265204 (ebook)
Subjects: LCSH: Materia medica, Vegetable. | LCSH: Medicinal plants—Research. | LCSH: Botanical chemistry—Research.
Classification: LCC RS164 .T54 2020 | DDC 615.3/21—dc23

Library of Congress Cataloging-in-Publication Data

Names: Goyal, Megh Raj, editor. | Suleria, Hafiz, editor. | Ayeleso, Ademola Olabode, editor. | Joel, T. Jesse, editor.
   | Panda, Sujogya Kumar, editor.
Title: The therapeutic properties of medicinal plants : health-rejuvenating bioactive compounds of native flora/edited
   by Megh R. Goyal, Hafiz Ansar Rasul Suleria, Ademola Olabode Ayeleso, T. Jesse Joel, Sujogya Kumar Panda.
Other titles: Innovations in plant science for better health
Description: Oakville, ON ; Palm Bay, Florida : Apple Academic Press, [2020] | Series: Innovations in plant science for better
   health: from soil to fork | Includes bibliographical references and index. | Summary: “This volume, The Therapeutic Properties
of Medicinal Plants, provides some informative research on the scientific evidence of the health benefits that can be derived
from medicinal plants and how their efficacies can be improved. The volume is divided into three sections covering the
phytochemistry of medicinal plants, disease management with medicinal plants, and novel research techniques in medicinal
plants. The pharmacological benefits of several specific plants, such as basil, fig, garlic, palm tree, etc., are discussed, addressing
health issues including metabolic and mental disorders, acute mountain sickness, polycystic ovarian syndrome, and specific
diseases such as Huntington’s. It also looks at the role of antioxidants in disease management. Additionally, the book covers
recent problems of drug resistance and how medicinal plants can serve as antibiotic, anthelmintic, and antiparasitic drugs that
will be helpful for human and animals. Furthermore, it also covers novel approaches for the screening of plant-based medicines,
extraction, toxicity and safety issues of essential oils, and nanoparticle-based delivery of plant metabolites. The findings reported
in this book will be useful in health policy decisions and will help to motivate the development of new health care products
from plants for health benefits. The book will further encourage the preservation of traditional medical knowledge of plants with
therapeutic qualities. It will be a valuable reference for researchers, scientists, students, growers, traders, processors, industry
professionals, dieticians, medical practitioners, and others”-- Provided by publisher.
Identifiers: LCCN 2019036017 (print) | LCCN 2019036018 (ebook) | ISBN 9781771888035 (hardcover) |
   ISBN 9780429265204 (ebook)
Subjects: LCSH: Materia medica, Vegetable. | Medicinal plants--Research. | Botanical chemistry--Research.
Classification: LCC RS164 .T522 2019 (print) | LCC RS164 (ebook) | DDC 615.3/21--dc23
LC record available at https://lccn.loc.gov/2019036017
LC ebook record available at https://lccn.loc.gov/2019036018
Apple Academic Press also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in
electronic format. For information about Apple Academic Press products, visit our website at www.appleacademicpress.com and the CRC Press
website at www.crcpress.com
OTHER BOOKS ON PLANT SCIENCE
FOR BETTER HEALTH
BY APPLE ACADEMIC PRESS, INC.

Book Series: Innovations in Plant Science for Better Health: From Soil to Fork
Editor-in-Chief: Hafiz Ansar Rasul Suleria, PhD
Bioactive Compounds of Medicinal Plants: Properties and Potential
for Human Health
Editors: Megh R. Goyal, PhD, and Ademola O. Ayeleso
Bioactive Compounds from Plant Origins: Extraction, Applications,
and Potential Health Claims
Editors: Hafiz Ansar Rasul Suleria, PhD, and Colin Barrow, PhD
Human Health Benefits of Plant Bioactive Compounds: Potentials
and Prospects
Editors: Megh R. Goyal, PhD, and Hafiz Ansar Rasul Suleria, PhD
Plant- and Marine-Based Phytochemicals for Human Health:
Attributes, Potential, and Use
Editors: Megh R. Goyal, PhD, and Durgesh Nandini Chauhan, MPharm
Plant Secondary Metabolites for Human Health:
Extraction of Bioactive Compounds
Editors: Megh R. Goyal, PhD, P. P. Joy, PhD, and Hafiz Ansar Rasul Suleria, PhD
Phytochemicals from Medicinal Plants: Scope, Applications,
and Potential Health Claims
Editors: Hafiz Ansar Rasul Suleria, PhD, Megh R. Goyal, PhD, and
Masood Sadiq Butt, PhD
The Therapeutic Properties of Medicinal Plants: Health-Rejuvenating
Bioactive Compounds of Native Flora
Editors: Megh R. Goyal, PhD, PE, Hafiz Ansar Rasul Suleria, PhD,
Ademola Olabode Ayeleso, PhD, T. Jesse Joel, and Sujogya Kumar Panda
The Role of Phytoconstitutents in Health Care: Biocompounds in
Medicinal Plants
Editors: Megh R. Goyal, PhD, Hafiz Ansar Rasul Suleria, PhD, and
Ramasamy Harikrishnan, PhD
Assessment of Medicinal Plants for Human Health: Phytochemistry,
Disease Management, and Novel Applications
Editors: Megh R. Goyal, PhD, and Durgesh Nandini Chauhan, MPharm
ABOUT THE SENIOR EDITOR-IN-CHIEF

Megh R. Goyal, PhD

Retired Professor in Agricultural and
Biomedical Engineering, University of
Puerto Rico, Mayaguez Campus;
Senior Acquisitions Editor, Biomedical
Engineering and Agricultural Science,
Apple Academic Press, Inc.
Megh R. Goyal, PhD, PE, is a Retired Professor
in Agricultural and Biomedical Engineering
from the General Engineering Department in
the College of Engineering at the University of
Puerto Rico–Mayaguez Campus; and Senior Acquisitions Editor and Senior
Technical Editor-in-Chief in Agriculture and Biomedical Engineering for
Apple Academic Press, Inc. He has worked as a Soil Conservation Inspector
and as a Research Assistant at Haryana Agricultural University and Ohio State
University.
During his professional career of 50 years, Dr. Goyal has received many
prestigious awards and honors. He was the first agricultural engineer to
receive the professional license in Agricultural Engineering in 1986 from
the College of Engineers and Surveyors of Puerto Rico. In 2005, he was
proclaimed as “Father of Irrigation Engineering in Puerto Rico for the
Twentieth Century” by the American Society of Agricultural and Biological
Engineers (ASABE), Puerto Rico Section, for his pioneering work on
micro irrigation, evapotranspiration, agroclimatology, and soil and water
engineering. The Water Technology Centre of Tamil Nadu Agricultural
University in Coimbatore, India, recognized Dr. Goyal as one of the experts
“who rendered meritorious service for the development of micro irrigation
sector in India” by bestowing the Award of Outstanding Contribution
in Micro Irrigation. This award was presented to Dr. Goyal during the
inaugural session of the National Congress on “New Challenges and
Advances in Sustainable Micro Irrigation” held at Tamil Nadu Agricultural
University. Dr. Goyal received the Netafim Award for Advancements in
viii About the Senior Editor-in-Chief

Microirrigation: 2018 from the American Society of Agricultural Engineers

at the ASABE International Meeting in August 2018.
A prolific author and editor, he has written more than 200 journal articles
and textbooks and has edited over 70 books. He is the editor of three book
series published by Apple Academic Press: Innovations in Agricultural &
Biological Engineering, Innovations and Challenges in Micro Irrigation, and
Research Advances in Sustainable Micro Irrigation. He is also instrumental
in the development of the new book series Innovations in Plant Science for
Better Health: From Soil to Fork.
Dr. Goyal received his BSc degree in engineering from Punjab
Agricultural University, Ludhiana, India; his MSc and PhD degrees from
Ohio State University, Columbus; and his Master of Divinity degree from
Puerto Rico Evangelical Seminary, Hato Rey, Puerto Rico, USA.
ABOUT THE EDITORS

Hafiz Ansar Rasul Suleria, PhD

Alfred Deakin Research Fellow,
Deakin University, Melbourne, Australia;
Honorary Fellow, Diamantina Institute
Faculty of Medicine, The University of
Queensland, Australia
Hafiz Anasr Rasul Suleria, PhD, is currently
working as the Alfred Deakin Research Fellow
at Deakin University, Melbourne, Australia. He
is also an Honorary Fellow at the Diamantina
Institute, Faculty of Medicine, The University of Queensland, Australia.
Recently he worked as a postdoc research fellow in the Department of
Food, Nutrition, Dietetic and Health at Kansas State University, USA.
Previously, he has been awarded an International Postgraduate Research
Scholarship (IPRS) and an Australian Postgraduate Award (APA) for his PhD
research at the University of Queens School of Medicine, the Translational
Research Institute (TRI), in collaboration with the Commonwealth and
Scientific and Industrial Research Organization (CSIRO, Australia).
Before joining the University of Queens, he worked as a lecturer in the
Department of Food Sciences, Government College University Faisalabad,
Pakistan. He also worked as a research associate in the PAK-US Joint Project
funded by the Higher Education Commission, Pakistan, and the Department
of State, USA, with the collaboration of the University of Massachusetts,
USA, and National Institute of Food Science and Technology, University of
Agriculture Faisalabad, Pakistan.
He has a significant research focus on food nutrition, particularly in the
screening of bioactive molecules—isolation, purification, and characterization
using various cutting-edge techniques from different plant, marine, and animal
sources; and in vitro, in vivo bioactivities; cell culture; and animal modeling.
He has also done a reasonable amount of work on functional foods and
nutraceuticals, food and function, and alternative medicine.
Dr. Suleria has published more than 50 peer-reviewed scientific papers
in different reputed/impacted journals. He is also in collaboration with more
x About the Editors

than ten universities where he is working as a co-supervisor/special member

for PhD and postgraduate students and is also involved in joint publications,
projects, and grants. He is Editor-in-Chief for the book series Innovations in
Plant Science for Better Health: From Soil to Fork, published by AAP.
Readers may contact him at: [email protected].

Ademola Olabode Ayeleso, PhD

Senior Lecturer, Department of Biochemistry,
Adeleke University, Nigeria
Ademola O. Ayeleso, PhD, is a Senior Lecturer
in the Department of Biochemistry at Adeleke
University, Ede, Nigeria. Dr. Ayeleso is working
on the use of medicinal plants, plant products, and
synthesized compounds in the management of
diabetes mellitus that has become a major threat
to the lives of people in both urban and rural areas
throughout the world. He has presented research
papers at different international conferences. He has also worked as a Post-
doctoral Research Fellow at three different universities in South Africa. Dr.
Ayeleso is a prolific writer with over 20 publications to his credit.
Dr. Ayeleso obtained his BTech degree in Biochemistry at the Federal
University of Technology, Akure, Nigeria. He received his MSc degree in
Biochemistry at the University of Port Harcourt, Port Harcourt, Nigeria, and
his doctoral degree in Biomedical Technology at the Cape Peninsula Univer-
sity of Technology, Bellville, South Africa.

T. Jesse Joel, PhD

T. Jesse Joel, PhD, is at present an Assistant
Professor in Microbiology at the Biotechnology
and Biosciences Department in the School of
Agriculture and Biosciences at Karunya Univer-
sity, Coimbatore, India. He is an editorial board
member for the International Research Journal of
Biological Sciences and is also on the Scientific
and Technical Committee on Bioengineering
and Life Sciences. He teaches undergraduate
and postgraduate courses on microbiology, cell
biology, molecular biology, biochemistry, biomaterials and artificial organs,
taxonomy and phylogeny, etc.
About the Editors xi

During his professional career of 13 years, he has received two Awards

of Excellence for best paper and best lecture. Currently Dr. Joel is working
in the field of nanoscience using green synthesis of nanoparticles from
plant extracts, probiotics, and oral bioformulations as well as exploring the
ameliorative effects of oral microorganisms. He has published several book
chapters and has attended over 36 scientific events where he has chaired
sessions and delivered guest lectures and lead talks in conferences and tech-
nical symposiums, conducted nationally as well as abroad. He also works as
a consultant microbiologist on several projects.
He earned his BSc degree (Triple Major: in Microbiology, Chemistry, and
Botany) from Andhra Loyola College, Vijayawada, India; his MSc degree in
Applied Microbiology from K.S. Rangasamy College of Arts and Science,
Tiruchengode, India, and his PhD degree in Microbiology from the Faculty
of Engineering, Sam Higginbottom Institute of Agriculture, Technology and
Sciences, Allahabad, India. He also received DMin from the Theological
Extension Study Programme (TESPRO), Shillong, Meghalaya, India.

Sujogya Kumar Panda, PhD

Animal Physiology and Neurobiology,
KU Leuven, Belgium
Sujogya Kumar Panda, PhD, was formerly
a faculty member in the P.G. Department of
Microbiology at M.P.C (Auto) College and in
the Department of Biotechnology, North Orissa
University, Odisha, India. He has an eclectic
background that includes teaching, research,
writing, and publishing.
During the last 10 years he has worked in
the field of ethno-pharmacology, nanoparticles, infectious diseases, and
pharmaco-epidemiology. Dr. Panda is a reviewer and an editorial board
member for many professional journals. He has edited three books and
published more than 40 research articles in national and international peer-
reviewed journals. Dr. Panda has also received a Young Scientist Award from
the Science & Technology Department, Government of India; a Erasmus-
Mundus postdoc fellowship at KU Leuven, Belgium; and a CICOPS fellow-
ship at the University of Pavia, Italy, to his continue research. At present he
is continuing his postdoctorate in Animal Physiology and Neurobiology at
KU Leuven, Belgium, and is engrossed in purifying the active compounds
from Indian medicinal plants using bioassay guided purification.
xii About the Editors

Sujogya Kumar Panda holds a BSc in Botany (Honors) and MSc in

Applied and Industrial Microbiology with a specialization in Pharmaceutical
and Clinical Microbiology. He is trained in natural products and obtained a
PhD on working with medicinal plants.
CONTENTS

Contributors................................................................................................. xv
Abbreviations.............................................................................................. xix
Symbols.................................................................................................... xxvii
Preface by Megh R. Goyal........................................................................ xxix

PART I: Phytochemistry of Medicinal Plants...........................................1

1. Antioxidant Agents from Green Leafy Vegetables: A Review......................3
Abiola Fatimah Adenowo, Muhibah Folashade Ilori, and Mutiu Idowu Kazeem

2. Carpobrotus edulis L. (Sour Fig): Phytochemistry,

Pharmacology, and Toxicology.....................................................................23
Francis N. Nkede, Simeon A. Materechera, and Wilfred Otang-Mbeng

3. Phytochemistry, Pharmacology, and Safety Issues of Essential Oils:

Applications in Aromatherapy......................................................................... 35
Anindya Sundar Ray, Suman Kalyan Mandal and Chowdhury Habibur Rahaman

4. Extraction and Therapeutic Potential of Essential Oils: A Review.............. 73

Sujatha Govindaraj

PART II: Disease Management with Medicinal Plants........................103

5. Therapeutic Potential of Ocimum tenuiflorum L.:
Metabolic and Mental Disorders.................................................................... 105
Nishikant A. Raut, Dadasaheb M. Kokare, and Gail B. Mahady

6. Antimicrobial Compounds from Medicinal Plants:

Effects on Antibiotic Resistance to Human Pathogens.............................123
Olutoyin Omolara Bamigboye and Idowu Jesulayomi Adeosun

7. Plant-Based Natural Products Against Huntington’s Disease:

Preclinical and Clinical Studies..................................................................135
Banadipa Nanda, Samapika Nandy, Anuradha Mukherjee, and Abhijit Dey

8. Pathophysiology and Management of Acute Mountain

Sickness (AMS)............................................................................................167
Kushal Kumar, Kalpana Kumari Barwal, and Sunil Kumar Hota
xiv Contents

9. Antihelmintic Properties of Allium sativum L.: Effect on

Fecal Egg Count of West African Dwarf (WAD) Rams............................185
Azeez Olanrewaju Yusuf and Ganiyat Abiola Oladunmoye

10. Buriti (Mauritia flexuosa L.) Oil Supplementation:

Effects on Oxidative Stress and Hormonal Concentrations in
Male Wistar Rats..........................................................................................195
Boitumelo Rosemary Mosito, Nicole Lisa Brooks, and Yapo Guillaume Aboua

11. Herbal Management for Polycystic Ovarian Syndrome..........................223

Huma Bader-Ul Ain, Farhan Saeed, Muhammad Umair Arshad, and
Hafiz Ansar Rasul Suleria

12. Role of Herbal Medicines During Pregnancy and Labor.............................247

Fanuel Lampiao, Ibrahim Chikowe, Mayeso Gwedela, and Kondwani Katundu

PART III: Novel Research Techniques in Medicinal Plants................259

13. Omics Technology: Novel Approach for Screening of
Plant-Based Traditional Medicines............................................................261
Rojita Mishra, Satpal Singh Bisht, and Mahendra Rana

14. Automatic Recognition and Classification of Medicinal Plants:

A Review.......................................................................................................271
Olugbenga Kayode Ogidan and Abiodun Emmanuel Onile

15. Nanoparticle-Based Delivery of Plant Metabolites...................................285

Shesan John Owonubi, Emmanuel Mukwevho, and Neerish Revaprasadu

Index......................................................................................................................317
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