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 Editor

John D. Bonagura, DVM, MS, DACVIM

(Cardiology, Internal Medicine)
Professor
Department of Veterinary Clinical Sciences
College of Veterinary Medicine
The Ohio State University
Columbus, Ohio

Associate Editor

David C. Twedt, DVM, DACVIM

(Internal Medicine)
Professor
Department of Clinical Sciences
College of Veterinary Medicine and Biomedical Sciences
Colorado State University
Fort Collins, Colorado

with more than 325 illustrations

11830 Westline Industrial Drive
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KIRK’S CURRENT VETERINARY THERAPY XIV ISBN 978-0-7216-9497-9

Copyright © 2009, 2000, 1995, 1992, 1989, 1986, 1983, 1980, 1977, 1974, 1971, 1968, 1966,
1964 by Saunders, an imprint of Elsevier Inc.

All rights reserved. No part of this publication may be reproduced or transmitted in any
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Notice
Knowledge and best practice in this field are constantly changing. As new research and expe-
rience broaden our knowledge, changes in practice, treatment and drug therapy may become
necessary or appropriate. Readers are advised to check the most current information provided
(i) on procedures featured or (ii) by the manufacturer of each product to be administered, to
verify the recommended dose or formula, the method and duration of administration, and
contraindications. It is the responsibility of practitioners, relying on their own experience
and knowledge of the patient, to make diagnoses, to determine dosages and the best treat-
ment for each individual patient, and to take all appropriate safety precautions. To the fullest
extent of the law, neither the Publisher nor the Editors assumes any liability for any injury
and/or damage to persons or property arising out of or related to any use of the material
­contained in this book.
The Publisher

ISBN 978-0-7216-9497-9

Vice President and Publisher: Linda Duncan

Publisher: Penny Rudolph
Managing Editor: Jolynn Gower
Publishing Services Manager: Pat Joiner-Myers
Senior Project Manager: Karen M. Rehwinkel
Designers: Julia Dummitt, Charles J. Seibel

Printed in the United States of America

Last digit is the print number: 9 8 7 6 5 4 3 2 1

 Consulting Editors

SECTION I Critical Care SECTION VIII Cardiovascular Diseases

Nishi Dhupa, BVM, DACVIM (Internal John D. Bonagura, DVM, MS, DACVIM
Medicine), DACVECC (Cardiology, Internal Medicine)

SECTION II TOXICOLOGIC DISEASES SECTION IX Urinary Diseases

Michael J. Murphy, DVM, PhD, DACT India F. Lane, DVM, MS, DACVIM

SECTION III Endocrine and Metabolic SECTION X Reproductive Diseases

DisEASES
Margaret V. Root Kustritz, DVM,
Mark E. Peterson, DVM, DACVIM PhD, DACT

SECTION IV ONCOLOGY AND HEMATOLOGY SECTION XI Neurologic and

Musculoskeletal Diseases
Douglas H. Thamm, VMD, DACVIM
(Oncology) Rodney S. Bagley, DVM, DACVIM
(Neurology, Internal Medicine)
SECTION V Dermatologic Diseases
SECTION XII OphthalmIC Diseases
Craig E. Griffin, DVM, DACVD
Wayne S. Rosenkrantz, DVM, DACVD David J. Maggs, BVSc, DACVO

SECTION VI Gastrointestinal Diseases SECTION XIII Infectious Diseases

David C. Twedt, DVM, DACVIM Rance K. Sellon, DVM, PhD, DACVIM

(Internal Medicine)
Appendix I Table of Common Drugs:
SECTION VII Respiratory Diseases Approximate Dosages

Eleanor C. Hawkins, DVM, DACVIM Mark G. Papich, DVM, MS, DACVCP


This page intentionally left blank
 Contributors

Jonathan A. Abbott, DVM Verena K. Affolter, DVM, PhD

Associate Professor of Cardiology Associate Professor for Clinical Dermatopathology
Department of Small Animal Clinical Sciences Department of Pathology, Microbiology, and Immunology
Virginia-Maryland Regional College of Veterinary Medicine School of Veterinary Medicine
Virginia Polytechnic Institute and State University University of California
Blacksburg, Virginia Davis, California
Subaortic Stenosis Histiocytic Disease Complex
Nonneoplastic Nodular Histiocytic Diseases of the Skin
Mark J. Acierno, DVM, DACVIM
Assistant Professor P. Jane Armstrong, DVM, MS, MBA,
School of Veterinary Medicine DACVIM (SAIM)
The Louisiana State University Professor, Internal Medicine/Clinical Nutrition
Baton Rouge, Louisiana Department of Veterinary Clinical Sciences
Systemic Hypertension in Renal Disease College of Veterinary Medicine
University of Minnesota
Larry G. Adams, DVM, PhD, DACVIM (SAIM) St. Paul, Minnesota
Associate Professor, Small Animal Internal Medicine Feline Inflammatory Liver Disease
Department of Veterinary Clinical Sciences
Purdue University Clarke E. Atkins, DVM, DACVIM (Internal
West Lafayette, Indiana Medicine, Cardiology)
Laser Lithotripsy for Uroliths Professor of Medicine and Cardiology
Veterinary Teaching Hospital
Diane D. Addie, PhD, BVMS, MRCVS College of Veterinary Medicine
Feline Institute Pyrenees North Carolina State University
Etchebar, France; Raleigh, North Carolina
Honorary Senior Research Fellow Feline Heartworm Disease
Institute of Comparative Medicine
University of Glasgow Veterinary School Anne Avery, VMD, PhD
Glasgow, Scotland Assistant Professor
United Kingdom Director Clinical Immunopathology Service
Control of Viral Diseases in Catteries Department of Microbiology, Immunology, and
Feline Infectious Peritonitis: Therapy and Prevention Pathology
College of Veterinary Medicine and Biomedical Sciences
Christopher A. Adin, DVM, DACVS Colorado State University
Courtesy Faculty Appointment Fort Collins, Colorado
Small Animal Clinical Sciences Canine Lymphoma
College of Veterinary Medicine
University of Florida Sandra M. Axiak, DVM
Gainesville, Florida; Veterinary Specialists of North Texas and Animal
Small Animal Surgeon Care Center
Veterinary Specialists of Rochester Dallas, Texas
Rochester, New York Pulmonary Neoplasia
Renal Transplantation
Todd W. Axlund, DVM, MS, DACVIM (Neurology)
Darcy B. Adin, DVM, DACVIM (Cardiology) Director
Veterinary Specialists of Rochester Metropolitan Veterinary Hospital
Rochester, New York Akron, Ohio
Tricuspid Valve Dysplasia Treatment of Intracranial Tumors

vii
viii Contributors

Rodney S. Bagley, DVM, DACVIM (Neurology, Adrienne Bentley, DVM

Internal Medicine) Resident in Surgery
Professor, Neurology and Neurosurgery School of Veterinary Medicine
Department of Veterinary Clinical Sciences University of Pennsylvania
Washington State University Philadelphia, Pennsylvania
Pullman, Washington Drainage Techniques for the Septic Abdomen
Treatment of Canine Cervical Spondylomyelopathy:
A Critical Review Ellison Bentley, DVM, DACVO
Treatment of Degenerative Lumbosacral Stenosis Clinical Associate Professor
Vestibular Disease of Dogs and Cats Comparative Ophthalmology
Department of Surgical Sciences
Claudia J. Baldwin, DVM, MS, DACVIM School of Veterinary Medicine
(Internal Medicine) University of Wisconsin
Associate Professor, Veterinary Clinical Sciences Madison, Wisconsin
College of Veterinary Medicine Nonhealing Corneal Erosions in Dogs
Iowa State University
Ames, Iowa Allyson C. Berent, DVM, DACVIM
Pregnancy Loss in the Queen Staff Veterinarian in Small Animal Internal Medicine
and Interventional Radiology
Tania A. Banks, BVSc, FACVSc Waltham Lecturer: Minimally Invasive Diagnostics/
Brisbane Veterinary Specialist Centre Therapeutics
Albany Creek, Queensland Matthew J. Ryan Veterinary Teaching Hospital
Australia School of Veterinary Medicine
Canine Soft-Tissue Sarcomas University of Pennsylvania
Philadelphia, Pennsylvania
Jeanne A. Barsanti, DVM, MS, DACVIM (SAIM) Interventional Radiology in Urinary Diseases
Josiah Meigs Distinguished Teaching Professor
Department of Small Animal Medicine and Surgery Philip J. Bergman, DVM, MS, PhD, DACVIM
College of Veterinary Medicine (Oncology)
The University of Georgia Chief Medical Officer
Athens, Georgia Bright Heart Veterinary Centers
Multidrug-Resistant Urinary Tract Infection Armonk, New York
Malignant Melanoma
Joseph W. Bartges, DVM, PhD, DACVIM, DACVN
Professor of Medicine and Nutrition Adam J. Birkenheuer, DVM, DACVIM (Internal
The Acree Endowed Chair of Small Animal Research Medicine)
Department of Small Animal Clinical Sciences Assistant Professor of Internal Medicine
College of Veterinary Medicine Department of Clinical Sciences
The University of Tennessee College of Veterinary Medicine
Knoxville, Tennessee North Carolina State University
Interpreting and Managing Crystalluria Raleigh, North Carolina
Babesiosis
Shane W. Bateman, DVM, DVSC, DACVECC Thrombocytopenia
Associate Professor, Clinical
Department of Veterinary Clinical Sciences Karyn Bischoff, DVM, MS, DABVT
College of Veterinary Medicine Diagnostic Toxicologist
The Ohio State University Animal Health Diagnostic Center
Columbus, Ohio Assistant Professor
Fluid Therapy College of Veterinary Medicine
Ventilator Therapy Cornell University
Ithaca, New York
Karin M. Beale, DVM, DACVD Aflatoxicosis in Dogs
Staff Dermatologist Automotive Toxins
Gulf Coast Veterinary Dermatology & Allergy
Houston, Texas Dana R. Bleifer, DVM
Feline Demodicosis Warner Center Pet Clinic
Woodland Hills, California
Ellen N. Behrend, DVM, DACVIM False Pregnancy in the Bitch
Associate Professor
Department of Clinical Sciences
College of Veterinary Medicine
Auburn University
Auburn, Alabama
Interpretation of Endocrine Diagnostic Test Results for
Adrenal and Thyroid Disease
 Contributors ix

John D. Bonagura, DVM, MS, DACVIM Amanda Burrows, BSc, BVMS, FACVSc
(Cardiology, Internal Medicine) (Veterinary Dermatology)
Professor Veterinary Hospital
Department of Veterinary Clinical Sciences Murdoch University
College of Veterinary Medicine Murdoch
The Ohio State University Western Australia
Columbus, Ohio Avermectins in Dermatology
Management of Heart Failure in Dogs
Ventricular Septal Defect Julie K. Byron, DVM, MS, DACVIM
Assistant Professor, Small Animal Medicine
Dino M. Bradley, DVM, MS Department of Clinical Medicine
Research Associate University of Illinois at Urbana-Champaign
Scott-Ritchey Research Center Urbana, Illinois
College of Veterinary Medicine Urinary Incontinence: Treatment With Injectable Bulking Agents
Auburn University
Auburn, Alabama Clay A. Calvert, DVM, DACVIM (Internal
Acral Lick Dermatitis Medicine)
Professor
Edward B. Breitschwerdt, DVM, DACVIM Department of Small Animal Medicine
Professor of Medicine and Infectious Diseases College of Veterinary Medicine
Director, NCSU-CVM Biosafety Laboratory University of Georgia
Adjunct Associate Professor of Medicine Athens, Georgia
Duke University Medical Center Cardiomyopathy in Doberman Pinschers
Department of Clinical Sciences Syncope
College of Veterinary Medicine
North Carolina State University Anthony P. Carr, DrMedVet, DACIM
Raleigh, North Carolina Associate Professor
Bartonellosis Western College of Veterinary Medicine
University of Saskatchewan
Janice M. Bright, BSN, MS, DVM, DACVIM Saskatoon, Saskatchewan
(Internal Medicine, Cardiology) Canada
Professor of Cardiology von Willebrand’s Disease and Other Hereditary Coagulopathies
Department of Clinical Sciences
College of Veterinary Medicine and Biomedical Sciences Elizabeth W. Carsten, DVM, DACVIM
Colorado State University Internal Medicine Consultant
Fort Collins, Colorado IDEXX Laboratories, Inc.
Cardioversion Oro Valley, Arizona
Esophagitis
Marjory B. Brooks, DVM, DACVIM
Associate Director, Comparative Coagulation Laboratory James L. Catalfamo, MS, PhD
Department of Population Medicine and Diagnostic Director, Comparative Coagulation Laboratory
Sciences Department of Population Medicine and Diagnostic
College of Veterinary Medicine Sciences
Cornell University College of Veterinary Medicine
Ithaca, New York Cornell University
Antiplatelet and Anticoagulant Therapy Ithaca, New York
Platelet Dysfunction Platelet Dysfunction

Cathy A. Brown, VMD, PhD, DACVP Daniel L. Chan, DVM, MRCVS, DACVECC, DACVN
Professor, Pathology Lecturer in Emergency and Critical Care
Athens Diagnostic Laboratory Department of Veterinary Clinical Sciences
College of Veterinary Medicine The Royal Veterinary College
University of Georgia University of London
Athens, Georgia London, England
Glomerular Disease United Kingdom
Nutrition in Critical Care
Barret J. Bulmer, DVM, MS, DACVIM
(Cardiology) Annie V. Chen, DVM
Assistant Professor Department of Veterinary Clinical Sciences
Veterinary Clinical Sciences College of Veterinary Medicine
College of Veterinary Medicine Washington State University
Oregon State University Pullman, Washington
Corvallis, Oregon Treatment of Canine Cervical Spondylomyelopathy:
Mitral Valve Dysplasia A Critical Review
 Contributors

Dennis J. Chew, DVM, DACVIM (Internal Patrick Concannon, MS, PhD, DACT (Honorary)
Medicine) Visiting Fellow, Department of Clinical Sciences
Professor Director
College of Veterinary Medicine Laboratory for Comparative Reproduction Studies
The Ohio State University Department of Biomedical Sciences
Columbus, Ohio College of Veterinary Medicine
Idiopathic Feline Hypercalcemia Cornell University
Treatment of Hypoparathyroidism Ithaca, New York
Urinary Incontinence: Treatment With Injectable Estrus Suppression in the Bitch
Bulking Agents
Gheorge M. Constantinescu, DVM, PhD, Drhc
Ruthanne Chun, DVM, DACVIM (Oncology) Professor of Veterinary Anatomy
Clinical Associate Professor College of Veterinary Medicine
Member, University of Wisconsin Comprehensive University of Missouri
Cancer Center Columbia, Missouri
School of Veterinary Medicine Brachycephalic Upper Airway Syndrome in Dogs
University of Wisconsin
Madison, Wisconsin Johanna C. Cooper, BSc, DVM, DACVIM
Anal Sac Tumors Cape Cod Veterinary Specialists
Buzzards Bay, Massachusetts
Julie Churchill, DVM, PhD Diagnostic Approach to Hepatobiliary Disease
Assistant Clinical Professor
Veterinary Clinical Sciences Brendan M. Corcoran, MVB, DipPharm, PhD,
College of Veterinary Medicine MRCVS
University of Minnesota Senior Lecturer
St. Paul, Minnesota Hospital for Small Animals
Food Toxicoses in Small Animals Division of Veterinary Clinical Studies
The University of Edinburgh
Craig A. Clifford, DVM, MS, DACVIM Easterbush Veterinary Centre
(Oncology) Edinburgh, Scotland
Staff Oncologist United Kingdom
Red Bank Veterinary Hospital Interstitial Lung Diseases
Tinton Falls, New Jersey
Canine Hemangiosarcoma Etienne Côté, DVM, DACVIM (Cardiology, SAIM)
Assistant Professor
Joan R. Coates, DVM, MS, DACVIM (Neurology) Department of Companion Animals
Associate Professor Atlantic Veterinary College
Veterinary Medicine and Surgery University of Prince Edward Island
Neurology/Neurosurgery Service Leader Charlottetown, Prince Edward Island
Veterinary Medical Teaching Hospital Canada
Department of Veterinary Medicine and Surgery Feline Cardiac Arrhythmias
College of Veterinary Medicine
University of Missouri Nancy B. Cottrill, DVM, MS, DACVO
Columbia, Missouri Staff Ophthalmologist
Treatment of Animals With Spinal and Musculoskeletal Pain Angell Animal Medical Center, Western New England
Woburn, Massachusetts
Leah A. Cohn, DVM, PhD, DACVIM (SAIM) Differential Diagnosis of Anisocoria
Associate Professor of Veterinary Internal Medicine
Department of Veterinary Medicine and Surgery Dennis T. Crowe, Jr., DVM, NREMT-I, PI, CFF,
College of Veterinary Medicine DACVS, DACVECC
University of Missouri President
Columbia, Missouri Veterinary Surgery, Emergency and Critical Care Services
Canine Anaplasma Infection and Consulting
Bogart, Georgia
Lynette K. Cole, DVM, MS, DACVD Oxygen Therapy
Assistant Professor
Department of Veterinary Clinical Sciences Autumn P. Davidson, DVM, MS, DACVIM
College of Veterinary Medicine (Internal Medicine)
The Ohio State University Clinical Professor
Columbus, Ohio School of Veterinary Medicine
Systemic Therapy for Otitis Externa and Media University of California
Davis, California
Canine Brucellosis
Dystocia Management
 Contributors xi

Thomas K. Day, DVM, MS, DACVECC, DACVA Stephen P. DiBartola, DVM, DACVIM (SAIM)
Owner Professor
Louisville Veterinary Specialty & Emergency Services Department of Veterinary Clinical Sciences
Louisville, Kentucky College of Veterinary Medicine
Intravenous Anesthetic and Analgesic Techniques The Ohio State University
Columbus, Ohio
Douglas J. DeBoer, DVM, DACVD Acid-Base Disorders
Professor Fluid Therapy
Department of Medical Sciences
School of Veterinary Medicine Patricia M. Dowling, DVM, MSc, DACVIM,
University of Wisconsin DACVCP
Madison, Wisconsin Professor, Veterinary Clinical Pharmacology
Treatment of Dermatophytosis Western College of Veterinary Medicine
University of Saskatchewan
Linda J. DeBowes, DVM, MS, DACVIM, DAVDC Veterinary Biomedical Sciences
Shoreline Veterinary Dental Clinic Saskatoon, Saskatchewan
Seattle, Washington Canada
Feline Caudal Stomatitis Rational Empiric Antimicrobial Therapy

Louis-Philippe de Lorimier, DVM, DACVIM Kenneth J. Drobatz, DVM, MS, DACVIM,

(Oncology) DACVECC
Staff Medical Oncologist Director of the Emergency Service
Hôpital Vétérinaire Rive-Sud Chief of Critical Care Section
Brossard, Québec Matthew J. Ryan Veterinary Hospital
Canada School of Veterinary Medicine
Canine Hemangiosarcoma University of Pennsylvania
Philadelphia, Pennsylvania
Helio Autran de Morais, DVM, PhD, DACVIM Noncardiogenic Pulmonary Edema
(SAIM, Cardiology) Urethral Obstruction in Cats
Clinical Associate Professor
Department of Medical Sciences †Robert B. Duncan, DVM, PhD, DACVP
University of Wisconsin Associate Professor, Pathology
Madison, Wisconsin Department of Pathobiology and Biomedical Sciences
Acid-Base Disorders Virginia-Maryland Regional College of Veterinary Medicine
Virginia Polytechnic Institute and State University
Robert C. DeNovo, DVM, MS, DACVIM Blacksburg, Virginia
Professor and Head Gastric Helicobacter spp. and Chronic Vomiting in Dogs
Department of Small Animal Clinical Sciences
College of Veterinary Medicine Marilyn Dunn, DMV, MVSc, DACVIM (SAIM)
University of Tennessee Assistant Professor
Knoxville, Tennessee Clinical Sciences
Canine Megaesophagus University of Montreal
Small Animal Clinic
Curtis W. Dewey, DVM, MS, DACVIM Faculty of Veterinary Medicine
(Neurology), DACVS University of Montreal
Associate Professor, Neurology/Neurosurgery Saint-Hyacinthe, Quebec
Neurology/Neurosurgery Service Chief Canada
Cornell University Hospital for Animals Antiplatelet and Anticoagulant Therapy
Cornell University
Ithaca, New York
New Maintenance Anticonvulsant Therapies for Dogs and Cats
Traumatic Brain Injury
Treatment of Canine Chiari-Like Malformation and
Syringomyelia

Anna R. Deykin, BSc, BVMS, FACVSc

(Ophthalmology)
Veterinary Ophthalmologist
Brisbane Veterinary Specialist Centre
Brisbane, Queensland
Australia
Episcleritis and Scleritis in Dogs
†Deceased.
xii Contributors

David A. Dzanis, DVM, PhD, DACVN James P. Farese, DVM, DACVS

Owner Associate Professor, Surgical Oncology
Dzanis Consulting & Collaborations Small Animal Clinical Sciences
Santa Clarita, California College of Veterinary Medicine
Nutrition in the Bitch During Pregnancy and Lactation University of Florida
Appendix III: AAFCO Dog and Cat Food Nutrient Profiles Gainesville, Florida
Surgical Oncology Principles
Nicole P. Ehrhart, VMD, DACVS
Associate Professor Edward C. Feldman, DVM, DACVIM
Department of Clinical Sciences Professor
College of Veterinary Medicine and Biomedical Sciences Department of Medicine and Epidemiology
Colorado State University School of Veterinary Medicine
Fort Collins, Colorado University of California
Osteosarcoma Davis, California
Canine Hypercalcemia and Primary Hyperparathyroidism
Bruce E. Eilts, DVM, MS, DACT
Professor of Theriogenology Deborah M. Fine, DVM, MS, DACVIM
Department of Veterinary Clinical Sciences (Cardiology)
School of Veterinary Medicine Assistant Professor
Louisiana State University Department of Veterinary Medicine and Surgery
Baton Rouge, Louisiana University of Missouri
Canine Pregnancy Termination Columbia, Missouri
Arterial Thromboembolism in Cats
Denise A. Elliott, BVSc (Hons), PhD, DACVIM,
DACVN Bente Flatland, DVM, MS, DACVIM (Internal
Director of Scientific Affairs Medicine)
Royal Canin Resident, Clinical Pathology
St. Charles, Missouri Department of Pathobiology
Gastrostomy Tube Feeding in Kidney Disease College of Veterinary Medicine
University of Tennessee
Jonathan Elliott, MA, Vet MB, PhD, Cert SAC, Knoxville, Tennessee
DECVPT, MRCVS Hepatic Support Therapy
Department of Veterinary Basic Sciences
Royal Veterinary College Daniel J. Fletcher, DVM, PhD, DACVECC
University of London Lecturer, Emergency and Critical Care
London, England Cornell University Hospital for Animals
United Kingdom Cornell University
Chronic Kidney Disease: Staging and Management Ithaca, New York
Traumatic Brain Injury
Gary C.W. England, BVetMed, PhD, DVR,
DVRep, DECAR, DACT, ILTM, FRCVS Richard B. Ford, DVM, MS, DACVIM
Foundation Dean Professor of Medicine
School of Veterinary Medicine and Science College of Veterinary Medicine
University of Nottingham North Carolina State University
Nottingham, England Raleigh, North Carolina
United Kingdom Bacterial Pneumonia
Breeding Management of the Bitch Bordetella bronchiseptica: Beyond Kennel Cough
Canine Vaccination Guidelines
Amara Estrada, DVM, DACVIM (Cardiology) Feline Vaccination Guidelines
Assistant Professor
Small Animal Clinical Sciences Lisa J. Forrest, VMD, DACVR
College of Veterinary Medicine Associate Professor
University of Florida Surgical Sciences
Gainesville, Florida University of Wisconsin
Pulmonic Stenosis Madison, Wisconsin
Nasal Tumors
Timothy M. Fan, DVM, DACVIM
Assistant Professor, Medical Oncology
Veterinary Clinical Medicine
University of Illinois at Urbana-Champaign
Urbana, Illinois
Osteosarcoma
 Contributors xiii

Theresa W. Fossum, DVM, MS, PhD, DACVS Tam Garland, DVM

Tom and Joan Read Chair in Veterinary Surgery Program Manager for Agricultural Security
Associate Director Cardiothoracic Surgery and Director for the Joint Agro Defense Office
Biomedical Devices, Michael E. DeBakey Institute Science and Technology Directorate
Professor of Surgery Department of Homeland Security
College of Veterinary Medicine Washington, District of Columbia
Texas A&M University Aflatoxicosis in Dogs
College Station, Texas
Pleural Effusion Laurent S. Garosi, DVM, MRCVS, DECVN,
RCVS
Susan F. Foster, BVSc, MVetClinStud, FACVSc, European Specialist in Veterinary Neurology
(Feline Medicine) Neurology/Neurosurgery Service Head
Adjunct Senior Lecturer in Small Animal Medicine Davies Veterinary Specialists
Murdoch University Manor Farm Business Park
Murdoch, Australia Higham Gobion, England
Nasopharyngeal Disorders United Kingdom
Treatment of Cerebrovascular Disease
Philip R. Fox, DVM, MSc, DACVIM (Cardiology),
DACVECC Anthony T. Gary, DVM, DACVIM
Cardiologist Arkansas Veterinary Internal Medicine
Bobst Hospital of the Animal Medical Center North Little Rock, Arkansas
Director, Caspary Research Institute Evaluation of Elevated Serum Alkaline Phosphatase
The Animal Medical Center in the Dog
New York, New York
Right Ventricular Cardiomyopathy in Cats Anna R.M. Gelzer, Dr Med Vet, DACVIM
(Cardiology), DECVIM (Cardiology)
Boel A. Fransson, DVM, MSc, PhD, DACVS Assistant Professor of Veterinary Cardiology
Assistant Professor, Small Animal Surgery College of Veterinary Medicine
Department of Veterinary Clinical Sciences Cornell University
Washington State University Ithaca, New York
Pullman, Washington Pacing in the Critical Care Setting
Treatment of Supraspinatus Tendon Disorders in Dogs Ventricular Arrhythmias in Dogs

Lisa M. Freeman, DVM, PhD, DACVN Alexander J. German, BVSc, PhD, DECVIM-CA
Associate Professor (Internal Medicine)
Department of Clinical Sciences Senior Lecturer, Department of Veterinary Clinical
Cummings School of Veterinary Medicine Sciences
Tufts University Small Animal Hospital
North Grafton, Massachusetts The University of Liverpool
Nutritional Management of Heart Disease Liverpool, England
United Kingdom
Joni L. Freshman, DVM, MS, DACVIM Inflammatory Bowel Disease
Owner
Canine Consultations Rudayna Ghubash, DVM, DACVD
Colorado Springs, Colorado Staff Dermatologist
Pregnancy Loss in the Bitch Animal Dermatology Clinic
Marina del Rey, California
Angela E. Frimberger, VMD, DACVIM Feline Viral Skin Disease
(Oncology)
Director, Veterinary Oncology Consultants Urs Giger, PD, Dr Med Vet, MS, FVH, DACVIM,
Wauchope, New South Wales DECVIM, DECVCP
Australia Charlotte Newton Sheppard Professor of Medicine
Anticancer Drugs and Protocols: Traditional Drugs Chief of Medical Genetics
Department of Clinical Studies
Virginia Luis Fuentes, MA VetMB, PhD, CertVR, School of Veterinary Medicine
DVC, MRCVS, DACVIM (Cardiology), University of Pennsylvania
DECVIM (Cardiology) Philadelphia, Pennsylvania
Senior Lecturer Blood-Typing and Crossmatching
Veterinary Clinical Sciences
Royal Veterinary College Sophie Gilbert, DVM, PhD, DACVD
Hatfield, Hertfordshire New York City Veterinary Specialists
United Kingdom New York, New York
Management of Feline Myocardial Disease Feline Pruritus Therapy
xiv Contributors

Rebecca E. Gompf, DVM, MS, DACVIM Clare R. Gregory, DVM, DACVS

(Cardiology) Professor
Associate Professor Department of Surgical and Radiological Sciences
Small Animal Clinical Sciences Director, Comparative Transplantation Laboratory
College of Veterinary Medicine School of Veterinary Medicine
University of Tennessee University of California
Knoxville, Tennessee Davis, California
Ventricular Septal Defect Immunosuppressive Agents

Jody L. Gookin, DVM, PhD, DACVIM Joel D. Griffies, DVM, DACVD

(Internal Medicine) Animal Dermatology Clinic
Assistant Professor, Molecular Biomedical Sciences Tustin, California
College of Veterinary Medicine Topical Immunomodulators
North Carolina State University
Raleigh, North Carolina Craig E. Griffin, DVM, DACVD
Tritrichicomonas Animal Dermatology Clinic and Animal Allergy
Specialists
Sonya G. Gordon, DVM, DVSc, DACVIM San Diego, California
(Cardiology) Allergen-Specific Immunotherapy
Assistant Professor Cyclosporine Use in Dermatology
Department of Small Animal Clinical Sciences
College of Veterinary Medicine and Biomedical Sciences Carol B. Grindem, DVM, DACVP (Clinical
Texas A&M University Pathology)
College Station, Texas Professor
Canine Heartworm Disease College of Veterinary Medicine
Patent Ductus Arteriosus North Carolina State University
Raleigh, North Carolina
Gregory F. Grauer, DVM, MS, DACVIM Thrombocytopenia
(Internal Medicine)
Professor Amy M. Grooters, DVM, DACVIM (SAIM)
Department of Clinical Sciences Associate Professor and Chief
Kansas State University Companion Animal Medicine
Manhattan, Kansas Veterinary Clinical Sciences
Proteinuria: Implications for Management Louisiana State University;
Chief of Staff
Deborah S. Greco, DVM, PhD, DACVIM Small Animal Clinic
Nestle Purina Petcare Veterinary Teaching Hospital
St. Louis, Missouri Baton Rouge, Louisiana
Complicated Diabetes Mellitus Pythiosis and Lagenidiosis

Eric M. Green, DVM, DACVR (Radiology, Sharon M. Gwaltney-Brant, DVM, PhD,

Radiation Oncology) DABVT, DABT
Associate Professor ASPCA Animal Poison Control Center
Veterinary Clinical Sciences Urbana, Illinois
College of Veterinary Medicine Lead Toxicosis in Small Animals
The Ohio State University Recently Recognized Animal Toxicants
Columbus, Ohio
Radiotherapy: Basic Principles and Indications Susan G. Hackner, BVSc, MRCVS, DACVIM,
DACVECC
Henry W. Green, III, DVM, DACVIM Department Chair
(Cardiology) Critical Care and Emergency Services
Assistant Professor, Cardiology The Animal Medical Center
Veterinary Clinical Sciences New York, New York
School of Veterinary Medicine Pulmonary Thromboembolism
Purdue University
West Lafayette, Indiana Kevin A. Hahn, DVM, PhD, DACVIM
Dilated Cardiomyopathy in Dogs (Oncology)
Gulf Coast Veterinary Specialists
Houston, Texas
Pulmonary Neoplasia
 Contributors xv

Kelly Hall, DVM Mattie J. Hendrick, VMD, DACVP

Assistant Clinical Professor Staff Pathologist and Adjunct Full Professor
Veterinary Clinical Sciences of Pathology
University of Minnesota School of Veterinary Medicine
St. Paul, Minnesota University of Pennsylvania
Toxicosis Treatments Philadelphia, Pennsylvania
Toxin Exposures and Treatments: Feline Vaccine-Associated Sarcomas
A Survey of Practicing Veterinarians
Diane V.H. Hendrix, DVM, DACVO
Holly L. Hamilton, DVM, MS, DACVO Associate Professor, Ophthalmology
Ophthalmologist Department of Small Animal Clinical Sciences
Animal Eye Center College of Veterinary Medicine
Loveland, Colorado University of Tennessee
Differential Diagnosis of Blindness Knoxville, Tennessee
Differential Diagnosis of the Red Eye
William R. Hare, DVM, MS, PhD, DABVT,
DABT Rosemary A. Henik, DVM, MS, DACVIM
Veterinary Medical Officer (Internal Medicine)
United States Department of Agriculture Clinical Associate Professor
Agricultural Research Service Department of Medical Sciences
Animal and Natural Resources Institute School of Veterinary Medicine
Beltsville Agricultural Research Center University of Wisconsin
Beltsville, Maryland Madison, Wisconsin
Urban Legends of Toxicology: Facts and Fiction Pulmonary Hypertension
Systemic Hypertension
Kenneth R. Harkin, DVM, DACVIM (SAIM)
Associate Professor Carolyn J. Henry, DVM, MS, DACVIM
Veterinary Clinical Sciences (Oncology)
College of Veterinary Medicine Associate Professor of Oncology
Kansas State University Department of Veterinary Medicine and Surgery
Manhattan, Kansas College of Veterinary Medicine
Leptospirosis Department of Internal Medicine
Division of Hematology/Oncology
Neil K. Harpster, VMD, DACVIM (Cardiology) School of Medicine
Department of Cardiology University of Missouri
Angell Memorial Animal Hospital Columbia, Missouri
Boston, Massachusetts Mammary Cancer
Feline Cardiac Arrhythmias
Michael E. Herrtage, MA, BVSc, DVSc, DVR,
Katrin Hartmann, Dr Med Vet, Dr Habil, DVD, DSAM, MRCVS, DECVIM, DECVDI
DECVIM-CA Reader in Small Animal Medicine
Professor of Internal Medicine Department of Veterinary Medicine
Head of Small Animal Internal Medicine Clinic University of Cambridge
University of Munich Cambridge, England
Munich, Germany United Kingdom
Feline Leukemia Virus and Feline Immunodeficiency Medical Management of Tracheal Collapse
Virus
A. Elizabeth Hershey, DVM, DACVIM (Oncology)
Elizabeth A. Hausner, DVM, DABT, DABVT Integrative Veterinary Oncology
Division of Cardio-Renal Drug Products Phoenix, Arizona
Center for Drug Evaluation and Research Feline Vaccine-Associated Sarcomas
U.S. Food and Drug Administration
Beltsville, Maryland Daniel G. Hicks, DVM
Herbal Hazards Resident, Neurology and Neurosurgery
Department of Veterinary Clinical Sciences
Eleanor C. Hawkins, DVM, DACVIM Washington State University
Professor, Internal Medicine Pullman, Washington
Department of Clinical Sciences Treatment of Degenerative Lumbosacral Stenosis
College of Veterinary Medicine
North Carolina State University
Raleigh, North Carolina
Pleural Effusion
xvi Contributors

Mark E. Hitt, DVM, MS, DACVIM (Internal Lynn R. Hovda, RPh, DVM, MS, DACVIM
Medicine) Director, Veterinary Services
Chief of Medicine Safety Call International
Atlantic Veterinary Internal Medicine, LLC Bloomington, Minnesota
Annapolis, Maryland Toxin Exposures in Small Animals
Drug-Associated Liver Disease
Lisa M. Howe, DVM, PhD, DACVS
Gaby Hoffmann, DVM, Dr Med Vet, DACVIM Associate Professor
Junior Lecturer, Clinical Genetics Department of Small Animal Medicine and Surgery
Clinical Sciences of Companion Animals College of Veterinary Medicine
Faculty of Veterinary Medicine Texas A&M University
Utrecht University College Station, Texas
Utrecht, The Netherlands Early-Age Neutering in the Dog and Cat
Copper-Associated Chronic Hepatitis
Geraldine B. Hunt, BVSc, MvetClinStud,
Daniel F. Hogan, DVM, DACVIM (Cardiology) PhD, FACVSc
Associate Professor Associate Professor
Chief of Comparative Cardiovascular Medicine University Veterinary Centre
Purdue University University of Sydney
West Lafayette, Indiana Sydney, New South Wales
Dilated Cardiomyopathy in Dogs Australia
Nasopharyngeal Disorders
Kathleen M. Holan, DVM, DACVIM
(Internal Medicine) Takuo Ishida, DVM
Assistant Professor Medical Director
Department of Small Animal Clinical Sciences Akasaka Animal Hospital
College of Veterinary Medicine Tokyo, Japan
Michigan State University Feline Infectious Peritonitis: Therapy and Prevention
East Lansing, Michigan
Feline Hepatic Lipidosis Toshiroh Iwasaki, DVM, PhD, DACVIM
Professor
Steven R. Hollingsworth, DVM, DACVO Department of Veterinary Internal Medicine
Assistant Professor of Clinical Ophthalmology Tokyo University of Agriculture & Technology
Department of Surgical and Radiological Sciences Tokyo, Japan
School of Veterinary Medicine Interferons
University of California
Davis, California Hilary A. Jackson, DVD, DACVD
Diseases of the Eyelids and Periocular Skin Dermatology Referral Services
Ocular Immunotherapy Glasgow, Scotland
United Kingdom
Bradford J. Holmberg, DVM, MS, PhD, DACVO Hypoallergenic Diets: Principles in Therapy
Staff Ophthalmologist
Veterinary Referral Centre Beth M. Johnson, DVM
Little Falls, New Jersey Resident, Internal Medicine
Ocular Neoplasia Department of Small Animal Clinical Sciences
College of Veterinary Medicine
David E. Holt, BVSc, DACVS University of Tennessee
Professor of Surgery Knoxville, Tennessee
School of Veterinary Medicine Canine Megaesophagus
University of Pennsylvania
Philadelphia, Pennsylvania Lynelle R. Johnson, DVM, PhD, DACVIM (SAIM)
Drainage Techniques for the Septic Abdomen Assistant Professor
Department of Medicine and Epidemiology
Heidi A. Hottinger, DVM, DACVS School of Veterinary Medicine
Department of Surgery University of California
Gulf Coast Veterinary Specialists Davis, California
Gulf Coast Veterinary Surgery Chronic Bronchitis in Dogs
Houston, Texas Rhinitis in the Cat
Canine Biliary Mucocele
 Contributors xvii

Boyd R. Jones, BVSc, FACVSc, DECVIM, MRCVS Rebecca Kirby, DVM, DACVIM (Internal
Faculty of Veterinary Medicine Medicine), DACVECC
University College Dublin Animal Emergency Center
Belfield, Dublin Glendale, Wisconsin
Ireland Colloid Fluid Therapy
Hypokalemic Myopathy in Cats Disseminated Intravascular Coagulation: Diagnosis
and Management
Bruce W. Keene, DVM, MSc, DACVIM
(Cardiology) Claudia A. Kirk, DVM, PhD, DACVN, DACVIM
Professor Associate Professor of Medicine and Nutrition
Department of Clinical Sciences Department of Small Animal Clinical Sciences
College of Veterinary Medicine College of Veterinary Medicine
North Carolina State University The University of Tennessee
Raleigh, North Carolina Knoxville, Tennessee
Management of Heart Failure in Dogs Interpreting and Managing Crystalluria
Obesity
Robert J. Kemppainen, DVM
Professor Deborah W. Knapp, DVM, MS, DACVIM (Oncology)
Department of Anatomy, Physiology, and Pharmacology Dolores L. McCall Professor of Veterinary Medicine
College of Veterinary Medicine (Comparative Oncology)
Auburn University Department of Veterinary Clinical Sciences
Auburn, Alabama Purdue University
Interpretation of Endocrine Diagnostic Test Results for West Lafayette, Indiana
Adrenal and Thyroid Disease Urinary Bladder Cancer

Michael S. Kent, MAS, DVM Stephanie J. Kottler, DVM

Assistant Professor Resident, Small Animal Internal Medicine
Surgical and Radiological Sciences Department of Veterinary Medicine and Surgery
College of Veterinary Medicine College of Veterinary Medicine
University of California University of Missouri
Davis, California Columbia, Missouri
Ocular Neoplasia Canine Anaplasma Infection

Marie E. Kerl, DVM, DACVIM (SAIM), Marc S. Kraus, DVM, DACVIM (Cardiology,
DACVECC Internal Medicine)
Clinical Associate Professor Faculty
Department of Veterinary Medicine and Surgery Department of Clinical Sciences
University of Missouri College of Veterinary Medicine
Small Animal Medicine Section Head Cornell University
Veterinary Medical Teaching Hospital Ithaca, New York
Columbia, Missouri Pacing in the Critical Care Setting
Treatment of Anemia in Renal Failure Syncope
Ventricular Arrhythmias in Dogs
Safdar A. Khan, DVM, MS, PhD, DABVT
Director of Toxicology Research John M. Kruger, DVM, PhD, DACVIM
ASPCA Animal Poison Control Center Associate Professor
Urbana, Illinois Department of Small Animal Clinical Sciences
Recently Recognized Animal Toxicants College of Veterinary Medicine
Michigan State University
Chand Khanna, DVM, PhD East Lansing, Michigan
Director, Comparative Oncology Program Management of Feline Nonobstructive Idiopathic Cystitis
Center for Cancer Research
National Cancer Institute Ned F. Kuehn, DVM, MS, DACVIM (SAIM)
National Institutes of Health Chief of Internal Medicine
Bethesda, Maryland Michigan Veterinary Specialists
Clinical Trials in Veterinary Oncology Southfield, Michigan
Rhinitis in the Dog
Peter P. Kintzer, DVM, DACVIM
Staff Internist
Department of Medicine
Boston Road Animal Hospital
Springfield, Massachusetts
Hypoadrenocorticism
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