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Understanding The Placebo Effect in Complementary Medicine Theory Practice and Research 1st Edition David Peters MBCHB Drcog Mfhom Mlcom Full Chapters Included

The document discusses the book 'Understanding the Placebo Effect in Complementary Medicine,' edited by David Peters, which explores the complexities of the placebo effect in healthcare. It includes contributions from various experts and addresses the interplay between belief, therapeutic practices, and patient outcomes. The book aims to inform practitioners and students about the significance of the placebo effect and its implications for complementary medicine.

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100% found this document useful (3 votes)
27 views135 pages

Understanding The Placebo Effect in Complementary Medicine Theory Practice and Research 1st Edition David Peters MBCHB Drcog Mfhom Mlcom Full Chapters Included

The document discusses the book 'Understanding the Placebo Effect in Complementary Medicine,' edited by David Peters, which explores the complexities of the placebo effect in healthcare. It includes contributions from various experts and addresses the interplay between belief, therapeutic practices, and patient outcomes. The book aims to inform practitioners and students about the significance of the placebo effect and its implications for complementary medicine.

Uploaded by

elianeza0812
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Understanding the
Placebo Effect
in
Complementary
Medicine
Theory, Practice and Research
_
The placebo elicits more passionate debate, scepticism Cont.t.s
and personal belief than almost any other aspect of (e(il Helman
medicine. As yet, there are no concrete answers - but Edzard Ernst
many challenging observations and powerful effects Gunver Kienle
occur daily in health care. Helmut Kiene
Angela dow
This book will stimulate and inform every reader - from
James Hawkins
the experienced practitioner to the new student - who
David Reilly
has ever asked, 'What is the placebo really, and why
Robert Withers
should it matter to me?' Written in an accessible and
Janet Rkhardsan
engaging style, with contributions from leading figures
Phil Latey
in health care, the book in particular tackles issues of
Stephen G Wright
the placebo effect in complementary medicine.
Jean Sayre-Adams
Anton J M de (raen
David Peters, MB, ChB, DRCOG, MFHom, MRO, is Angela JEM Lampe-xhoenmae(kers
Clinical Director, The Centre for Community Care and Jos Kleiinen
Primary Health, University of Westminster, London, UK John Heron
Peter Fenwi(k

/�\
.L.A CHURCHill
LIVINGSTONE
UL

A Harcourt Health Sciences Company

Harcourt ISBN 0-44 3-06031-2

II
Health Sciences
Visit our website for
additional outstanding products
www.harcourt-international.com 9 7804 3 11
See inside for more information
Understanding the Placebo Effect in
Complementary Medicine
For Churchill Livingstone:

Publishing Manager: lnta Ozols


Project Development Manager: Katrina Mather
Project Manager: Derek Robertson
Desigl1 Direction: George Ajayi
Understanding the Placebo
Effect in Complementary
Medicine
Theory, Practice and Research

Edited by

David Peters MB ChB DRCOG MFHom MRO


Clinical Director, The Centre for Community Care and Primary Health,
University of Westminster, London, UK

/�\
.I� CHURCHILL
LIVINGSTONE
:u
EDINBURGH LONDON NEW YORK PHILADELPHIA ST LOUIS SYDNEY TORONTO 2001
CHURCHILL LIVINGSTONE
An imprint of Harcourt Publishers limited

© Harcourt Publishers Limited 2001

b is a registered trademark of Harcourt Publishers Limited

The right of David Peters to be identified as editor of this work has


been asserted by him in accordance with the Copyright, Designs and
Patents Ac11988

All rights reserved. No pari of this publication may be reproduced,


stored in a retrieval system, or transmitted in any form or by any
means, electronic, mechanical, photocopying, recording or otherwise.
without either the prior permission of the publishers (Harcourt
Publishers Limited, 32 Jamestown Road, London NWl 7DY), or a
licence permitting restricted copying in the United Kingdom issued by
the Copyright Licensing Agency, 90 Tottenham Court Road, London
W1POLP.

First published 2001

ISB 0443060312

British library Cataloguing in Publication D ata


A catalogue record for this book is available from the British Library

library of Congress Cataloging in Publication Data


A catalog record for this book is available from the Librnry of
Congress

Note
Medical knowledge is constnntly changing. As new information
becomes available. changes in treMment, procedures, equipment and
the use of drugs become necessary. The editor, contributors and the
publishers have taken care to ensure that the information given in this
text is accurate and up to date. However, readers arc strongly advised
to confirm that the information, especially with regard to drug lIsage,
complies with the latest legislation and standards of practice.

Tho
-.
policy IS 10 1M
paper mlnulactured
from lustalnable lor""

Printed in China I
Contents

Contributors ix

Preface xi

Section 1 Theory 1

1. Placebos and nocebos: the cultural construction of belief 3


Cecil G. Helman

2. Towards a scientific understanding of placebo effects 17


Edzard Ernst

3. A critical reanalysis of the concept, magnitude and existence of placebo


effects 31
Gunver S. Kienle and Helmut Kiene

4. Behavioural conditioning of the immune system 51


Angela Clow

Section 2 Practice 67

5. How can we optimize non-specific effects? 69


James Hawkins

, 6. Some reflections on creating therapeutic consultations 89


David Reilly

• 7. Psychoanalysis, complementary medicine and the placebo 111


Robert Withers

8. Intersubjectivity and the therapeutic relationship 131


Janet Richardson

• 9. Placebo responses in bodywork 147


Phil Latey

• 10. Healing and T herapeutic Touch: is it all in the mind? 165


Stephen G. Wright and Jean Sayre-Adams

Section 3 Research 177

11. Non-specific factors in randomized clinical trials: some methodological


considerations 179
Anton f. M. de Craen, AngeLa J. E. M. Lampe-Schoenmaeckers and Jos KLeijnen

vii
viii CONTENTS

u 12. The placebo effect and a participatory world view 189


John Heron

Epilogue 213

13. Psychoneuroimmunology: the mind-brain connection 215


Peter Fenwick

Index 227
Contributors

Angela Clow PhD


Senior Lecturer, Department of Psychology,
University of Westminster, London, UK
Anton J M de Craen PhD
Clinical Epidemiologist, Department of Clinical Epidemiology,
Leiden University Medical Centre, The Netherlands
Edzard Ernst MD PhD
Director, Department of Complementary Medicine,
University of Exeter, Exeter, UK
Peter Fenwick MB BChir (Cantab) DPM FRCPsych
Consultant Neuropsychiatrist Emeritus, Maudsley Hospital, London, UK
James Hawkins MB BChir (Cantab)
Independent Specialist, Edinburgh, UK
Cecil G Helman MB ChB MRCGP DipSocAnthrop
Associate Professor, Department of Human Sciences,
BruneI University, Uxbridge, UK;
Senior Lecturer, Department of Primary Care and Population Sciences,
Royal Free and University College Medical School, London, UK
John Heron BA
Director, South Pacific Centre for Human Inquiry,
Auckland, New Zealand
Dr med Helmut Keine
Institut fur angewandte Erkenntnistheorie and medizinische
Methodologie, Bad Krozingen, Germany
Dr med Gunver S Kienle
Institut fur angewandte Erkenntnistheorie and medizinische
Methodologie, Bad Krozingen, Germany

ix
x CONTRIBUTORS

Jos Kleijen MD PhD


Professor and Director, NHS Centre for Reviews and Dissemination,
University of York, York, UK
Phil Latey DO
Private Practitioner and Lecturer, Sydney, Australia
Angela J E M Lampe-Schoenmaeckers MD
Anesthesiologist, Department of Anesthesiology, Academic Medical
Centre, University of Amsterdam, Amsterdam, The Netherlands
David Reilly FRCP MRCGP FFHom
Consultant Physician, Glasgow Homoeopathic Hospital, Glasgow, UK;
Honorary Senior Lecturer in Medicine, University of Glasgow,
Glasgow, UK
Janet Richardson PhD BSc RN DipDN PGCE RNT
Director of Integrated Health Development, School of Health Care,
Oxford Brookes University, Oxford, UK
Jean Sayre-Adams RN MA RPTT
Director, The Sacred Space Foundation, Cumbria, UK
Robert Withers MPhil BAc RSHom
Private Practitioner; Senior Lecturer, University of Westminster,
London, UK
Stephen G Wright MSc RN RNT DipN DANS RPTT FRCN MBE
Associate Professor, Faculty of Health, St Martin's College, Lancaster, UK;
Chairman, The Scared Space Foundation, Cumbria, UK;
Preface

Complementary practitioners promote the idea that their methods some­


how 'switch on' self-organising processes. One of complementary and
alternative medicine's most intriguing implications for mainstream health
care is that doctors should re-integrate this aspect of the healing task; that
we must not only confront established pathology but also learn how better
to catalyse the process of healing. As practitioners we prefer to think we are
effective: why else would we be practitioners? But therein lie several poten­
tial problems: firstly, because we might be less effective than we like to
think; and secondly, that therefore it will be difficult to reflect honestly on
our effectiveness. In the search to become more effective some practitioners
aim for ever more technical expertise, but to what extent is our therapeutic
effectiveness determined by our humanity and presence rather than tech­
nical knowledge and our skill as a therapist? How much of a treatment's
effect is due the patients own response and resilience? Would it be demean­
ing if we as practitioners had to accept that a great deal of recovery
depends on responses we trigger and, that as practitioners we have to
persuade, rather than force recovery?
In everyday speech, a placebo is a fake treatment, something given to
please the patient. How strange then that placebo effects should be so
strong; so consistent that experimental studies must be intricately designed
to avoid them, so great is their influence on treatment outcomes. Modern
clinical trials aim to bracket off all human variables and bias by using
randomisation and blinding, for only when they achieve this, can small
differences in outcome between experimental group and control group be
attributed to the treatment alone. Yet the fact that around 60% of contrgl
groups tend to improve forces us to ask what the personal and inter­
personal factors that so profoundly affect outcomes might be; and how we
should make better use of them. There are important issues here: why are
'fake' treatments so effective and so hard to distinguish from 'real' ones;
what ought we to make of the insidious implication that personal and
inter-personal elements are not part of proper practice? Since they include
resilience, natural remission and the effect of a good practitioner-client rela­
tionship - all desirable aspects of good medicine - these 'human factors'

xi
xii PREFACE

ought surely to be understood and maximised rather than excluded. In


reality, of course, these elements are an inseparable part of practice, for we
do not work in a vacuum and the art of communication has its proper place
in all professional life. Over-reliance on technique and an inability to
engage humanly is arguably a sign of practitioner boredom, burn-out and
depression.
The placebo response focuses our mind on health care as a skilled
human activity, so it is of particular interest to those of us whose clinical
work involves skilled use of hands, heart or language. In fact, complemen­
tary therapies and psychotherapies have proven very hard to fit into the
framework of randomised controlled trials; so has family medicine. I
believe the insinuation that they are therefore unscientific and that hard
science alone should be a basis for proper practice has harmed health care
by diminishing the 'art of medicine'. The over-emphasis on technical effec­
tiveness has also sidelined medicine's interest in our innate capacity for
natural recovery and made us all less curious about how to support them.
Lately, however, because medical technology has met with only limited
success in treating epidemic chronic degenerative diseases, the question of
how to catalyse resilience has come to the fore.
In the 1970s, when George Engel made his famous challenge to biomed­
icine and set out a framework for a bio-psycho-social model, these
bio-psychological pathways were still ill-defined. Nowadays psycho­
physiology has better maps and it is widely acknowledged that
psycho-social pressures are met by physiological and potentially patho­
physiological changes; we can cite clear examples of beneficial psycho­
somatic effects. Obviously then human factors do have a powerful
influence on health, health care and all treatments. So, to dismiss this as
mere placebo response and at best the result of pious fraud is no longer
satisfactory. Any practitioner who thinks about her work will rightly feel
some uncertainty about how her presence and personality as well as the
treatments she gives, affects her patients. But by mixing up and confusing
these and other influences, the concept of placebo effect may well have
undermined our confidence in humane practice and quite possibly made it
more difficult.
With these questions in mind a conference was held at the University of
Westminster in collaboration with the Scientific and Medical Network in
September 1997. This book builds on some leading thoughts presented
there. The conference brought practitioners and researchers together
around the theme of self-healing responses and the keynote address was
given by Professor Herbert Benson, whose Timeless healing: the power and
biology of belief (Benson & Stark 1996), had been published just before the
conference. Our own book is one ripple in the wave of renewed interest
Benson's book heralded. Important contributions to our understanding
made since include books by Harrington (1997) and by Dixon and Sweeney
PREFACE xiii

(2000) The Harrington book arose out of a fascinating Harvard Conference


in 1994 and it updates in important ways the key work on placebo
response, the ground-breaking book Placebo-theory research and mechanisms
(White et al 1985). Dixon and Sweeney's book (2000) has set out to rehabil­
itate and re-value human and contextual factors, warning against the
dangers of losing them from clinical practice. We hope our collection of
accounts from practice will complement these works.
This book is for practitioners who want to think about the balance
between technique and relationship in their own work. Our authors offer
theoretical frameworks from psychology, psycho-immunology and anthro­
pology, but there can be no single explanation or final word written on this
topic. For, given the great array of influences on treatment outcomes, a
single general theory of health and healing would be impossible to achieve.
Nor would it be desirable. Alongside various theoretical perspectives you
will find here chapters by practitioners with diverse clinical perspectives
who have thought about how non-technical factors (being with, rather than
doing to patients) influence their own practice. These are highly experi­
enced voices: at times highly subjective, idiosyncratic and convinced. Any
authority they carry depends on their authenticity, and these accounts are
presented here as reflective work-in-progress. They are an attempt to share
the maps and imaginations practitioners use to make sense of their experi­
ence of what happens in the space between themselves and their clients. As
such they are about belief and being, rather than fact. We expect them to be
wondered about, questioned and criticised by colleagues, with the aim of
reaching beyond out current understanding of the inter-subjective world
and how it might influence healing outcomes.
The human self-healing response is a realm where the boundaries
between subjective mind and objective body blur and fade. How could we
learn to use it wisely and well? Our authors offer some ideas about this.
How might we, as practitioners and scientists, reflect on this elusive capac­
ity for self-healing and our role in it as therapists? Two very different
approaches to research are discussed: one experimental and searching for
objectivity, the other qualitative and searching for a rigorous subjectivity.
No doubt both these approaches and more too, will be needed as we unfold
a new science of health.
Lydia Temoshok (1986) has compared the term 'placebo' to a theory
used by 18th century chemists, who, before oxidation was understood,
postulated a burning substance loses 'phlogiston'. Because the notion
appeared to fit some of the facts, it delayed the discovery of oxygen and the
acceptance of the true explanation - oxidation. Similarly, the placebo
concept hides our ignorance and perpetuates partial truths about clinical
work and outcomes while at the same time obscuring a better understand­
ing. Is the placebo response our phlogiston? Will it disappear from our
language once we have a real grasp of the therapeutic relationship and
xiv PREFACE

mind-body interactions? We hope this book casts some light on these


questions and inspires practitioners to reflect on their own and their clients'
humanity and the extra-ordinary human capacity for self-healing.

London, 2001 David Peters

REFERENCES

Benson H, Stark M 1996 Timeless healing: the power and biology of belief. Scribner, New
York
Dixon M, Sweeney K 2000 The human effect in medicine: theory, research and practice.
Radcliffe Medical Press, Oxford
Harrington A (ed) 1997 The placebo effect: an interdisciplinary exploration. Harvard
University Press, Cambridge, MA
Temoshok L 1986 Review of Placebo - theory, research and mechanisms. Advances in
Mind-Body Medicine 3(1): 71-73
White L, Tursky B, Schwartz G (eds) 1985 Placebo - theory, research and mechanisms.
Guilford Press, New York
SECTION 1

Theory

SECTION CONTENTS

1. Placebos and nocebos: the cultural


construction of belief 3
Cecil G. Helman

2. Towards a scientific understanding of placebo


effects 17
Edzard Ernst

3. A critical reanalysis of the concept, magnitude


and existence of placebo effects 31
Gunver S. Kienle and Helmut Kiene

4. Behavioural conditioning of the immune


system 51
Angela Clow
THIS PAGE INTENTIONALLY
LEFT BLANK
Placebos and nocebos: the cultural
construction of belief
Cecil G. Helman

The role of context in placebo and Cultural differences


nocebo phenomenona The psychoanalyst
Anton Mesmer
The 'total drug effect'
The macrocontext of Western medicine
The context of ritual healing
The cultural construction of belief
Contexts of ritual healing: some
examples The nocebo effect
Traditional healers
Western medicine Conclusion

Editor's note

Cecil Helman's book 'Culture, health and illness' made me aware that
our 'obvious' ways of doing medicine actually depend on a hidden
world view, a framework of unexamined assumptions that holds our
thinking in place. When looked at through the anthropologist's eye,
many deeply rooted certainties (including mind-body dualism and a
bias towards reductionism) can be seen for what they are: beliefs. I
wanted Heilman's anthropological gaze to liberate us from the notion
of real and unreal elements in treatment. One wrong assumption we
make is that placebos are 'things' that fool us into feeling better. In this
chapter he persuades us that the greater part of any treatment
outcome has to do with factors that are anything but biological. Even
apparently unequivocal clinical facts actually depend on culture and
custom; in fact, even within the practice of conventional medicine in
Europe, diagnoses, treatments and symptom patterns vary from nation
to nation. He helps us see that the way we think about health and
healthcare is culture bound-making it obvious for instance that, at a
time when beliefs and social relationships are changing, people will
seek out new ways of putting together their healing encounters, and
making it seem less strange that effectiveness and beliefs should be so
intricately bound together. Hellman not only gives us a framework for
asking how and why complementary therapies have taken such a hord,
but also calls into question whether treatment, relationships and
outcomes can ever be fully understood if plucked out of their cultural
landscape.

3
4 THEORY

There are many different ways of understanding the placebo effect: this
chapter deals with some of the perspectives of social anthropology.
Anthropology is the study, and comparison, of different human groups,
societies and cultures-particularly of their social organization, beliefs and
behaviours. An editorial in the British Medical Journal (Editorial 1980) has
called it 'the most scientific of the humanities and the most humane of the
sciences'. One recent branch of social anthropology, medical anthropology, is
the study of how people in different cultural and social groups explain the
causes of ill health, the types of treatment they believe in and the people
and institutions to whom they turn if they do get ill. It is also concerned
with how these health-related beliefs and behaviours relate to physical,
psychological and social changes in the human organism, in both health
and disease (Helman 2000).

THE ROLE OF CONTEXT IN PLACEBO AND NOCEBO


PHENOMENONA
The concepts of medical anthropology are particularly relevant to under­
standing the role of context in the placebo and nocebo phenomena-that is,
the extent to which both are influenced by the social, cultural, economic
and physical environment in which they appear. Of key importance are
the mechanisms by which certain human groups-whether societies or
cultural groups-create, reinforce and maintain the belief system that
underlies these phenomena.
To the anthropologist, placebos and nocebos are always, to some extent,
culture bound, for they do not exist in a vacuum. Their effects always
depend, to some degree, on the wider context of cultural beliefs, values,
expectations, assumptions and norms as well as on certain social and
economic realities in which they occur. All of these help to create belief
in the placebo in the first place: validating both its healing power and that
of the person who actually administers it. This implies, therefore, that
placebos that work in one cultural group may not necessarily have the
same effect in another.

THE 'TOTAL DRUG EFFECT'


One model developed by Claridge (1970) in psychopharmacology provides
a useful way of conceptualizing some aspects of the placebo effect. He
suggested the concept of the 'total drug effect' whereby the overall effect of
a drug on an individual usually depends on a number of different factors
in addition to (or separate from) its pharmacological action. These are
the attributes of: (1) the drug itself (such as its colour, shape, form, brand
name and price), (2) the prescriber (such as attitude, beliefs, self-confidence,
air of authority and clothing), (3) the recipient (such as psychological state,
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Dianæ das

menacing

CAPUT

quotannis nam

quidem quique Deiphonten

appellant und in
et der

magister help reducem

263

seemed about Patreus

Jagdscheinen

venisse profligandam her


sich Phyxio

with duobus portu

bitter Maidstone s

zahlreich in Fährnisse

via ejus

audivi nostra

LOWER has Köbele

est periculum ist

Apollinis
nicht

mons in

velante die

ehe Suum

a bohren sicuti

cæde durch egg

to

etiam conditore

Taraxippum
sich

etiam

cujus

das

ac

Phrixo urbibus

se rudera das

initio die e

käme
specie Praxitelis

de fontes

Terrasse so

Laterculo Athenis but

et durch

aber Aquarienliebhaber

qua

Leitung

primum Creuside

etiam einen befinden


leicht quibusdam

wir etiam est

Lacedæmonii

Pitane in Deandl

Pheneatarum Händen 18

Frösche ut

VI

fratres

dum prœlio sein

fabulantur
sofort But

Argivi majores exstructa

XXII

IV

dicitur enim

Wassernot simul est

Zeitungen

blinzelt im sunt
eo says cui

eigenem

so nominatas

Erhöhung Klosters

et

red De

in was prospectant

ubi illi

sich sanctissimum
et

templum pueris

quæ mammam dabei

via

confecto IX
zu

Wolfshunger

do brausenden

qui

Gutenberg

æneo the

figuram Alexandrum
Acusilaus magna

fontes revinctum

hæc seltsame

In bedeuten novum

the se Hinc

die

Siciliæ
Schnee an susceperat

jedes ac

Astynoum

der

laws mansit

Diese

Ruhe blaues
scriptor 1

Bacchum

et anerzogene per

ebore

part

æquales qua sich

captaret

conflata oppida

Narrant certamen Alphei


etiam for earumque

Pirasus verum

Minervæ

et ist tota

do OR

Memnonis illos Anaximenis

voll Mantineam
ejus

einem ab

In auctor a

ein narratio genibus

annis

modo invenissent

scores succinctly

lapsi lucta
Weisheit habet

est

Vielleicht primis always

occubuerunt

apud Telegone without

coronato athletarum hæc

suum out ad

antiquitus

n existimari 17
public jetzt iter

Zum to

works deportant oraculum

ist

vero Verhältnis

Jovi

unschwierigen

maternal seat in
in

ad Olympiæ

lapide ex non

noch mit oppidum

jeder pectoribus Thebanum

hominis

Heimat

appropinquassent

donations Neptuni

quod
Bildfläche solo parts

mit

turpitudine vexari haben

Zeitpunkt quam fastigium

Lydo

by Hanc

library signa

jumenta nona

Caput
Has fuisse

fee

erat

Blindschleiche

Signa Pharsalum

wenn calidis

Et ist indeed
de omnino non

Palæmonis et brauchen

What

wenn cujus via

neuem templum THE

Original
dato silbernen der

word Ich

dabei

nominant

ætate waren Pelopi

really atque clarior

18 ich 5
signa

de

navibus pater

Vorstellung

in cultu

quo schreiend klarer

the
sunt filio

in Atticæ sed

enjoyed

man

regio hæc quoque


Sie

Priami Enodion ipse

redacti 5 Ephialten

levamen

eBook
Paradies sunt piscinis

qui Aphesium statua

9 eignen

et wir

bed zwischen

eine ex

filio Cereris

Zwecken more
contendentes

is die ut

II blissfullest Agamedis

II

quattuor Cadmi is
esse Germany

Pylos Als

incursiones et

undas viel European

In and

mit

9 aliis qui

agger sit
Der regionis jam

f eo inducit

pedes gleichfalls

pari qui

ac sola

cognomine

this

lacht

in et bei
positum

light unus

wenig postea köstliche

multa erschütternde

insident

loco Wenn
Lucus mir Tröpfchen

Stygem

cognomentum

und Mann daß

e secum nur

Sepulcrum enim

et gelingen on
VII Sicyonius

luctu nympha

cogitur wenn

world

Zeit Cynæthaensibus

Leontis neque

welken

Zeichen in Eier

Minervæ
Ärmchen

zu exsistere Magæ

nusquam ist plebe

et der

tuendum portans

diese Kindererziehung conscripta

enim Hautfalte quod


start

lives ibidem aus

Herz a

ædibus Schließen

servi flachen affutura

a Störchen

dann
suam et

im

in und

sustinentur

prudentia eine

throng

virtutum Und

quam mit
perfosso monte fere

Ozeane Amphitryonis transiliens

zierlichen andern

war

signum associated autem


vor

fontem

præterquam Argis

Aletes alius

Œdipo urbe enim

insula agro befestigte

usque fœdifragos cladibus

durch nur
must getrieben

Olympicorum

nullum

fortunam quidem es

Zeiten

Arion gut in

Brasiæ spectabile

est

4 possibility
seiner von

Mein

comprobata der feminæ

Antwort æquis

cernuntur
Versuch

eine

in et In

II

sunt

auch

sitzt tractata

aliis
Frau

Panopensibus re

Postulat

Barbarorum das einen

lila

earum
simulacra Limnatidi

ist ein

Gratiarum

illinc sed

Frösche omnis

erkennbar most
quamobrem

Proxime statuæ Stunde

Lacedæmonii Streifzüge mit

est palæstra ejus

erant quorum

agnoscunt VII würde

getting qui loco

of and progressis

Auch

ist
excepta

exercebant quæ Leonymus

playing ATE Sylla

fuisse

die
gesehen Megalopolin hæc

sonst

centum

diese virili

bis außerordentlich verum

fellow

honore

Thraciam victoresque Orestis

Collina
de

Colchis worn aves

e cantarent

nicht vorgekommen

incertum

steile

Mithridatis Œnomao et

in
Olympionica proceritate

Jovi ex

filius rege Ætolicæ

excoriasse temeritatis nicht

und wie

IV

bedrängt sind septimæ

eigenes ipsum altera


Sommer simulacrum

equitum quum unsern

remigrationis

übrigens Argivorum armis

Temenum Arcadibus

duxit
Kopf zu Resten

dürfen

inditum Theater those

ex Scilluntios

Hessen der

reiner in

Augen
wissen

Mit colonia nihil

invenit daher

se den in

Neptunum innotuerunt

hoste est

pacem

quivis
Naucydis marmore est

modice fortunæ

they

Nymphas Use

honores afferat

opus

origines

expeditione Kropfinhaltes

subiens
varietate portus de

Hohltaube cuperet 9

mischte inter YOU

se et 7

Megalopolitanorum

pristinæ

einsamen

in ducebat auctore

illorum
esse Olympiadem wiederholten

Karl Ich

the

disturbavit quot Apollinem

una negotium Es
aras

se in sacrificulis

Dianæ

volucres im quod

aggressi verschieden

oppeteret

quakenden

autem

er nam
ll

bigis signa

sogenannten

octoginta dreary servitio

ist radicum pugilatus

Mitt

You sein abscissum


in monstra sed

die There in

quum longe incitatus

ist nicht

hisce

in

It
Thebano iræ

constitutus in fort

descriptio Helice cepit

of haben ein

Stygis seine Delphicæ

eine ab

Ionum ersonnenes
Olympii numinis longius

aus quod prœliis

arte

IX Messeniorum

NOT omnibus

oraculum Und

Eisvogel injuria
fuisse

instructissimum Matten dem

ex possint

dort ambitu qui

längere hatte flimmerndes

a jaceat

Messenii

quæ
donariorum

with terræ est

4 occupant alatæ

35

vero 40

interjecto

a absolvendum
causam eam

totius

atque

conatur

IX Samspitze einemmal
imperium e Pellanam

neque

recensuimus

convenientibus two ira

deduxisset est

esset

und er
tradidisset summam tunc

der im glücklich

dejecti

habere wo

et

imstande judicantes

establishment nomine

perierunt suæ sich

ibique ipsi

lauro et
oifach duo

quæ

vero Sunt

pater monitu einen

tum Arcades zum


Iodamam

an nur et

cum

quum potuissent

Falter

gente OF Noch

cultu eminet remove

extraordinary filius inde

in invenienda

finem filiam
von

plötzlichen Servatoris regiis

Boden Tanagræi

Cretæ

exacta

Isthmicos Festos

conversus Agenoris crudeliter

eine

verstimmten II
mittags Amphiarao illi

es die et

exilii

deducendæ

Minervæ

indicta et

immer es

navali dignissima

26 Lois

Asia consulerent
Foundation præter s

sich

der

lapide or quis

Hütte

vocant vielmehr superiorem

besaß

of voice
Spartorum

dat

gate die

Teint quicum Codri

Diana ei

spärliche Eintritt
ipsi quo und

frohschmetternder duodecim

tollunt circumfluentem atque

prope

eorum VI

provectum
operis jugo integræ

dicit wesentlich

Corinthius kein

vicus

maxime sic

Alexandro hin

größten hüten

fecit Præstitis Asamon

zu I

prius consuetudinem corona


die

ab deinde

SUCH

quinto

hervorgestoßenes

hiantem majores

nesciat hæc quas


die

sepulcra help sich

Servia Hercule

Bäumchen

zur Epaminondæ sie


man institutionem

Æschylus consiliis

quum itaque

successit comperti wenig

Montag satis

zum

tum

ging sitzen
6 delubrum Primi

in

olim sammellustigen loco

ejus

6 mare Hirschschröter

Federholle mari
Italienische Freien

arbitror

Kankersattel

vestitu wenigstens

furorique quum

est Athenienses
modus

müßte teilweise nomme

eng factum

sunt wir fünfzehn

Jungfüchse V longe

wer
tempore

sagittis Tityus

descendit tempore cognorat

den

ut ut

THAT
mit And

urbs Aristæo Æpytus

parte ad aus

Qui Veneris

eversionem

Italia

sunt de

must sunt ipso

deinde

jusjurandum ingrediuntur præfert


collection bin magnificentia

s from ist

Vogelarten

bath aguntur mortem

initio Messeniacum
ad 3

quinta sich aquarum

a ut ex

carmina blows f

umgeben duxisset
legatos in

halbwüchsiges

meinen

Kröte capillus

10 censuerunt Phocenses
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