(Ebook) Organic Chemical Toxicology of Fishes by

Keith B. Tierney, Anthony P. Farrell and Colin J.

Brauner (Eds.) ISBN 9780123982544, 0123982545 Pdf
Download

https://ebooknice.com/product/organic-chemical-toxicology-of-
fishes-4627892

★★★★★
4.8 out of 5.0 (76 reviews )

Instant PDF Download

ebooknice.com
 (Ebook) Organic Chemical Toxicology of Fishes by Keith B.
Tierney, Anthony P. Farrell and Colin J. Brauner (Eds.) ISBN
9780123982544, 0123982545 Pdf Download

EBOOK

Available Formats

■ PDF eBook Study Guide Ebook

EXCLUSIVE 2025 EDUCATIONAL COLLECTION - LIMITED TIME

INSTANT DOWNLOAD VIEW LIBRARY

Here are some recommended products that we believe you will be
interested in. You can click the link to download.

(Ebook) Primitive Fishes by David J. McKenzie, Anthony P. Farrell and

Colin J. Brauner (Eds.) ISBN 9780123736710, 0123736714

https://ebooknice.com/product/primitive-fishes-1677734

(Ebook) Physiology of Elasmobranch Fishes: Internal Processes by

Robert E. Shadwick, Anthony P. Farrell, Colin J. Brauner ISBN
9780128012864, 9781541641679, 9781901922028, 9784584594728,
0128012862, 1541641671, 1901922022, 4584594724
https://ebooknice.com/product/physiology-of-elasmobranch-fishes-
internal-processes-5431698

(Ebook) Biology of Stress in Fish Fish Physiology by Carl B. Schreck,

Lluis Tort, Anthony P. Farrell and Colin J. Brauner (Eds.) ISBN
9780128027288, 0128027282

https://ebooknice.com/product/biology-of-stress-in-fish-fish-
physiology-5600950

(Ebook) The multifunctional gut of fish by Martin Grosell, Anthony P.

Farrell and Colin J. Brauner (Eds.) ISBN 9780123749826, 0123749824

https://ebooknice.com/product/the-multifunctional-gut-of-fish-1999842
(Ebook) Biota Grow 2C gather 2C cook by Loucas, Jason; Viles, James
ISBN 9781459699816, 9781743365571, 9781925268492, 1459699815,
1743365578, 1925268497

https://ebooknice.com/product/biota-grow-2c-gather-2c-cook-6661374

(Ebook) Boeing B-29 Superfortress ISBN 9780764302725, 0764302728

https://ebooknice.com/product/boeing-b-29-superfortress-1573658

(Ebook) SAT II Success MATH 1C and 2C 2002 (Peterson's SAT II Success)

by Peterson's ISBN 9780768906677, 0768906679

https://ebooknice.com/product/sat-ii-success-
math-1c-and-2c-2002-peterson-s-sat-ii-success-1722018

(Ebook) Matematik 5000+ Kurs 2c Lärobok by Lena Alfredsson, Hans

Heikne, Sanna Bodemyr ISBN 9789127456600, 9127456609

https://ebooknice.com/product/matematik-5000-kurs-2c-larobok-23848312

(Ebook) Vagabond, Vol. 29 (29) by Inoue, Takehiko ISBN 9781421531489,

1421531488

https://ebooknice.com/product/vagabond-vol-29-29-37511002
 ORGANIC CHEMICAL
TOXICOLOGY OF FISHES
 This is Volume 33 in the

FISH PHYSIOLOGY series

Edited by Anthony P. Farrell and Colin J. Brauner
Honorary Editors: William S. Hoar and David J. Randall

A complete list of books in this series appears at the end of the volume
 ORGANIC CHEMICAL
TOXICOLOGY OF FISHES

Edited by

KEITH B. TIERNEY
Department of Biological Sciences
University of Alberta
Edmonton, Alberta
Canada

ANTHONY P. FARRELL
Department of Zoology, and
Faculty of Land and Food Systems
The University of British Columbia
Vancouver, British Columbia
Canada

COLIN J. BRAUNER
Department of Zoology
The University of British Columbia
Vancouver, British Columbia
Canada

AMSTERDAM  BOSTON  HEIDELBERG  LONDON

NEW YORK  OXFORD  PARIS  SAN DIEGO
SAN FRANCISCO  SINGAPORE  SYDNEY  TOKYO
Academic Press is an imprint of Elsevier
Academic Press is an imprint of Elsevier
32 Jamestown Road, London NW1 7BY, UK
225 Wyman Street, Waltham, MA 02451, USA
525 B Street, Suite 1800, San Diego, CA 92101-4495, USA
Copyright r 2014 Elsevier Inc. All rights reserved
The cover illustrates the diversity of effects an example synthetic organic water pollutant can
have on fish. The chemical shown is 2,4-D, an herbicide that can be found in streams near
urbanization and agriculture. The fish shown is one that can live in such streams: rainbow trout
(Oncorhynchus mykiss). The effect shown on the left is the ability of 2,4-D (yellow line) to
stimulate olfactory sensory neurons vs. control (black line) (measured as an electro-
olfactogram; EOG). The effect shown on the right is the ability of 2,4-D to induce the
expression of an egg yolk precursor protein (vitellogenin) in male fish. Image credits: chemical,
Wikipedia; fish, Matthew Gilbert; EOG, Brian Blunt; well plate, Daniel Schlenk.
No part of this publication may be reproduced, stored in a retrieval system or transmitted in any
form or by any means electronic, mechanical, photocopying, recording or otherwise without the
prior written permission of the publisher
Permissions may be sought directly from Elsevier’s Science & Technology Rights
Department in Oxford, UK: phone (þ44) (0) 1865 843830; fax (þ44) (0) 1865 853333; email:
[email protected]. Alternatively, visit the Science and Technology Books website at
www.elsevierdirect.com/rights for further information
Notices
No responsibility is assumed by the publisher for any injury and/or damage to persons or
property as a matter of products liability, negligence or otherwise, or from any use or operation
of any methods, products, instructions or ideas contained in the material herein
Because of rapid advances in the medical sciences, in particular, independent verification of
diagnoses and drug dosages should be made
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library
Library of Congress Cataloging-in-Publication Data
A catalog record for this book is available from the Library of Congress
ISBN: 978-0-12-398254-4
ISSN: 1546-5098

For information on all Academic Press publications

visit our website at store.elsevier.com

Typeset by MPS Limited, Chennai, India

www.adi-mps.com
Printed and bound in United States of America
14 15 16 17 10 9 8 7 6 5 4 3 2 1
For Jeannie
 CONTENTS

CONTRIBUTORS xi
ABBREVIATIONS AND ACRONYMS xv
PREFACE xxiii

1. Organic Contaminants and Fish

Keith B. Tierney, Christopher J. Kennedy, Frank Gobas,
Melissa Gledhill and Mark Sekela
1. Contaminants: A Short Historical Preamble 1
2. Contaminant Toxicokinetics in Fishes 14
3. Predicting Contaminant Movement in the Environment and Fish 34
4. Quantifying Contaminants and Exposures 40
5. Conclusion 41

2. Effects of Legacy Persistent Organic Pollutants (POPs) in

Fish—Current and Future Challenges
Lyndal L. Johnson, Bernadita F. Anulacion, Mary R. Arkoosh,
Douglas G. Burrows, Denis A. M. da Silva, Joseph P. Dietrich,
Mark S. Myers, Julann Spromberg and Gina M. Ylitalo
1. Introduction 54
2. Transformations of POPs in the Aquatic Environment 56
3. Endocrine Disruption 58
4. Effects on Early Development 77
5. Transgenerational Effects 84
6. Effects on Growth, Condition, and Energy Reserves 87
7. Effects on Reproduction 90
8. Immunotoxicity 97
9. Neoplasia and Related Pathological Conditions 102
10. Effects on Behavior, Including Foraging, Aggression, and
Predator Avoidance 105
11. Risk Assessment Challenges 108

vii
viii CONTENTS

3. Organometal(loid)s
Niladri Basu and David M. Janz
1. Introduction 142
2. Organic Mercury 144
3. Organoselenium 157
4. Organoarsenicals 170
5. Organotin Compounds 176
6. Other Organometal(loid)s 179
7. Conclusions 181

4. Effects on Fish of Polycyclic Aromatic Hydrocarbon (PAH)

and Naphthenic Acid Exposures
Tracy K. Collier, Bernadita F. Anulacion, Mary R. Arkoosh,
Joseph P. Dietrich, John P. Incardona, Lyndal L. Johnson,
Gina M. Ylitalo and Mark S. Myers
1 Introduction 196
2 Transformations of PAHs in the Aquatic Environment 198
3 Hepatic Neoplasia and Related Lesions in Wild Fish 200
4 Effects on Reproduction 211
5 Effects on Embryonic and Larval Development 215
6 Transgenerational Effects 222
7 Other Effects with Consequences for Survival of Postlarval Stages 224
8 Naphthenic Acids as a New Concern 230
9 Future Directions 234

5. Estrogenic Endocrine Disrupting Chemicals in Fish

Christopher J. Kennedy, Heather L. Osachoff and
Lesley K. Shelley
1. Introduction 257
2. EDC 260
3. Toxicokinetics 266
4. Mechanisms of Toxicity 273
5. Xenoestrogen Effects 285
6. Interactions with Other Toxic Agents 290
7. Knowledge Gaps and Future Directions 291

6. Insecticide Toxicity in Fish

M.H. Fulton, P.B. Key and M.E. DeLorenzo
1. Abstract/Introduction 310
2. Background 311
3. Insecticide Classes 312
4. Organophosphates 323
5. Carbamates 331
6. Pyrethroids 337
7. Neonicotinoids 345
CONTENTS ix

8. Phenylpyrazoles 347
9. Microbial-Based Insecticides 349
10. Insect Growth Regulators 351
11. Mixtures 353
12. Data Gaps 353
13. Summary 354

7. Effects of Herbicides on Fish

Keith R. Solomon, Kristoffer Dalhoff, David Volz and
Glen Van Der Kraak
1. Introduction 370
2. Classification of Herbicides 374
3. Acute Lethality of Herbicides to Fish 374
4. Sublethal Effects of Herbicides in Fish 387
5. Indirect Effects of Herbicides on Fish 402
6. Conclusions 403

8. Personal Care Products in the Aquatic Environment: A Case

Study on the Effects of Triclosan in Fish
Alice Hontela and Hamid R. Habibi
1. Introduction 412
2. Physical and Chemical Properties of Triclosan, and Its Use as a
Personal Care Product 413
3. Exposure in the Aquatic Environment 415
4. Kinetics and Metabolism of Triclosan 417
5. Toxicity of Triclosan 418
6. Reproductive and Developmental Effects 423
7. Effects of Triclosan on the Thyroid Axis 425
8. Interactions of Triclosan with Aryl Hydrocarbon and Ryanodine Receptors 426
9. Future Use of Triclosan and Related Environmental Issues 428
10. Conclusions and Knowledge Gaps 429
11. General Lessons Learned from the Case Study of Triclosan 431

9. Emerging Threats to Fishes: Engineered Organic Nanomaterials

Tyson J. MacCormack, Greg G. Goss and Richard D. Handy
1. Introduction 439
2. The Environmental Chemistry of Engineered Nanomaterials and
Bioavailability to Fishes 443
3. Acute Toxicity of Organic ENMs 445
4. Uptake Routes and Target Organs for Organic ENMs 445
5. Effects of Organic ENMs on the Physiological Systems of Fishes 451
6. Studies on Organic ENMs and Capping Agents 458
7. Nanocrystalline and Nanofibrillar Cellulosic Materials 463
8. Polymer-coated ENMs in the Agricultural Sector 465
9. Key Needs in Environmental Risk Assessment of Organic ENMs 466
10. Conclusions and Perspectives 469
x CONTENTS

10. Handling Fish Mixture Exposures in Risk Assessment

Dick de Zwart and Leo Posthuma
1 Introduction 482
2 Fish and Mixtures 485
3 Principles of Risk and Impact Assessment of Chemicals and Mixtures 488
4 Cumulative Risk Assessment for Mixtures of Toxicants 500
5 Evidence for Mixture Impacts in the Field 512
6 Conclusions, Overview, and Summary 519

INDEX 525
OTHER VOLUMES IN THE FISH PHYSIOLOGY SERIES 543
COLOR PLATE SECTION
 CONTRIBUTORS

The numbers in parenthesis indicate the pages on which the authors

contributions begin.
BERNADITA F. ANULACION (53, 195), Environmental and Fisheries Science
Division, Northwest Fisheries Science Center, National Marine Fisheries
Service, National Oceanic and Atmospheric Administration, Seattle, WA,
USA
MARY R. ARKOOSH (53, 195), Environmental and Fisheries Science Division,
Northwest Fisheries Science Center, National Marine Fisheries Service,
National Oceanic and Atmospheric Administration, Newport, OR, USA
NILADRI BASU (141), Department of Environmental Health Sciences,
University of Michigan, Ann Arbor, MI, USA
DOUGLAS G. BURROWS (53), Environmental Conservation Division, Northwest
Fisheries Science Center, National Marine Fisheries Service, National
Oceanic and Atmospheric Administration, Seattle, WA, USA
TRACY K. COLLIER (195), Science Director, Puget Sound Partnership,
Tacoma, WA, USA
DENIS A.M. DA SILVA (53), Environmental and Fisheries Science Division,
Northwest Fisheries Science Center, National Marine Fisheries Service,
National Oceanic and Atmospheric Administration, Seattle, WA, USA
DICK DE ZWART (483), RIVM, Centre for Sustainability, Environment and
Health, The Netherlands
MARIE E. DELORENZO (309), Center for Coastal Environmental Health and
Biomolecular Research, National Ocean Service, National Oceanic and
Atmospheric Administration, Charleston, SC, USA

xi
xii CONTRIBUTORS

KRISTOFFER DALHOFF (371), Faculty of Science, University of Copenhagen,

Frederiksberg, Denmark
JOSEPH P. DIETRICH (53, 195), Environmental and Fisheries Science Division,
Northwest Fisheries Science Center, National Marine Fisheries Service,
National Oceanic and Atmospheric Administration, Newport, OR, USA
MICHAEL H. FULTON (309), Center for Coastal Environmental Health and
Biomolecular Research, National Ocean Service, National Oceanic and
Atmospheric Administration, Charleston, SC, USA
MELISSA GLEDHILL (1), Environment Canada, Pacific and Yukon Water
Quality Monitoring, Vancouver, BC, Canada
FRANK GOBAS (1), Faculty of Environment, School of Resource & Environ-
mental Management, Simon Fraser University, Burnaby, BC, Canada
GREG G. GOSS (441), Department of Biological Sciences and School of Public
Health, Office of Environmental Nanosafety, University of Alberta, BC,
Canada
HAMID R. HABIBI (413), Department of Biology, University of Calgary,
Calgary, AB, Canada
RICHARD D. HANDY (441), Ecotoxicology Research and Innovation Centre,
School of Biomedical and Biological Sciences, University of Plymouth,
Plymouth, UK
ALICE HONTELA (413), Department of Biological Sciences, Alberta Water and
Environmental Science Bldg., University of Lethbridge, Lethbridge, AB,
Canada
JOHN P. INCARDONA (195), Environmental and Fisheries Science Division,
Northwest Fisheries Science Center, National Marine Fisheries Service,
National Oceanic and Atmospheric Administration, Seattle, WA, USA
DAVID M. JANZ (141), Department of Veterinary Biomedical Sciences,
University of Saskatchewan, Saskatoon, SK, Canada
LYNDAL L. JOHNSON (53, 195), Environmental and Fisheries Science Division,
Northwest Fisheries Science Center, National Marine Fisheries Service,
National Oceanic and Atmospheric Administration, Seattle, WA, USA
CHRISTOPHER J. KENNEDY (1, 257), Department of Biological Sciences, Simon
Fraser University, Burnaby, BC, Canada
PETER B. KEY (309), Center for Coastal Environmental Health and
Biomolecular Research, National Ocean Service, National Oceanic and
Atmospheric Administration, Charleston, SC, USA
CONTRIBUTORS xiii

TYSON J. MACCORMACK (441), Department of Chemistry and Biochemistry,

Mount Allison University, Sackville, NB, Canada
MARK S. MYERS (53, 195), Environmental and Fisheries Science Division,
Northwest Fisheries Science Center, National Marine Fisheries Service,
National Oceanic and Atmospheric Administration, Seattle, WA, USA
HEATHER L. OSACHOFF (257), Department of Biological Sciences, Simon
Fraser University, Burnaby, BC, Canada
LEO POSTHUMA (483), RIVM, Centre for Sustainability, Environment and
Health, The Netherlands
MARK SEKELA (1), Environment Canada, Pacific and Yukon Water Quality
Monitoring, Vancouver, BC, Canada
LESLEY K. SHELLEY (257), Department of Biological Sciences, Simon Fraser
University, Burnaby, BC, Canada
KEITH R. SOLOMON (371), Centre for Toxicology, School of Environmental
Sciences, University of Guelph, Guelph, ON, Canada
JULANN SPROMBERG (53), Environmental and Fisheries Science Division,
Northwest Fisheries Science Center, National Marine Fisheries Service,
National Oceanic and Atmospheric Administration, Seattle, WA, USA
KEITH B. TIERNEY (1), University of Alberta, Department of Biological
Sciences, Edmonton, AB, Canada
GLEN VAN DER KRAAK (371), Department of Integrative Biology, University
of Guelph, Guelph, ON Canada
DAVID VOLZ (371), Department of Environmental Health Sciences, Arnold
School of Public Health, University of South Carolina, Columbia, SC,
USA
GINA M. YLITALO (53, 195), Environmental and Fisheries Science Division,
Northwest Fisheries Science Center, National Marine Fisheries Service,
National Oceanic and Atmospheric Administration, Seattle, WA, USA
 ABBREVIATIONS AND ACRONYMS

Abbreviations used throughout this volume are listed below. Standard

abbreviations are not defined in the text. Nonstandard abbreviations are
defined in each chapter and listed below for reference purposes.

11-KT 11-ketotestosterone
2,3,7,8 TCDD 2,3,7,8-tetrachlorodibenzo-p-dioxin
2,4,5-T 2,4,5-trichlorophenoxyacetic acid
2,4-D 2,4-dichlorophenoxyacetic acid
ABC ATP binding cassette
AChE acetylcholinesterase
ACTH adrenocorticotropic hormone
ADME absorption, distribution, metabolism (biotransforma-
tion), and excretion
Ag silver
Ag-ENM-C citrate-capped silver engineered nanomaterials
Ag-ENM-PVP polyvinylpyrrilodone-capped silver engineered nanoma-
terials
AhR aryl hydrocarbon receptor
AhRE aryl hydrocarbon responsive element (interchangeable
with xenobiotic responsive element; XRE)
AHTN 6-acetyl-1,1,2,4,4,7 hexamethyltetraline
ANSCO Alaska north slope crude oil
AOP adverse outcome pathway
AP-1 activator protein-1
APEs alkylphenol ethoxylates
AR androgen receptor
ARE antioxidant response element (interchangeable with elec-
trophile response element, EpRE)
xv
xvi ABBREVIATIONS AND ACRONYMS

ARNT aryl hydrocarbon receptor nuclear translocator

BAF bioaccumulation factor
BaP benzo[a]pyrene
BCF bioconcentration factor
BCRP breast cancer resistance protein
BMF biomagnification factor
BNF b-naphthoflavone
BPA bisphenol A
BSA bovine serum albumin
BSAF biota to sediment accumulation factor
C60 buckyball, carbon fullerene
CA concentration addition
cAMP cyclic adenosine monophosphate
CAR constitutive androstane receptor
CBG corticosteroid-binding globulin
CCAAT cytidine-cytidine-adenosine-adenosine-thymidine
CEBPs CCAAT/enhancer-binding proteins
CH chlorinated hydrocarbon
CNT carbon nanotube
CRH corticotropin releasing hormone
Cu copper
CYP cytochrome P-450
CYP19A1 an isoform of aromatase, predominantly in the ovary
CYP19A2 an isoform of aromatase, predominantly in the brain
CYP1A cytochrome P4501A
DCDD dichlorodibenzo-p-dioxin
DDD dichlorodiphenyldichloroethane
DDE 1,1-dichloro-2,2-bis(p-dichlorodiphenyl)ethylene
DDT 1,1,1-trichloro-2,2-di(4-chlorophenyl)ethane, or dichloro-
diphenyltrichloroethane
DEHP di(2-ethylhexyl) phthalate
DES diethylstilbesterol
DHAA dehydroabietic acid
DMBA 7,12-dimethylbenz[a]anthracene
DNA deoxyribonucleic acid
Dpf days post-fertilization
DWH deepwater horizon
E1 estrone
E2 17b-estradiol
E3 estriol
EAC endocrine active chemical
ABBREVIATIONS AND ACRONYMS xvii

EC50 effective concentration that causes a 50% change in a

response
EDC endocrine disrupting compound
EE2 17a-ethinylestradiol
EER expected ecological risk (calculated with the ETX 2.0-
software)
ENMs engineered nanomaterials
EPA USA Environmental Protection Agency
EPC effect-and-probable cause (pie diagrams)
EpRE electrophile response element (interchangeable with anti-
oxidant response element, ARE)
ER endoplasmic reticulum or estrogen receptor
EREs estrogen-responsive elements
EROD ethoxyresorufin-O-deethylase
ERR estrogen-related receptor
ERRE ERR-response element
EU European Union
F1 the first filial generation comprised of offspring(s)
resulting from a cross between strains of distinct
genotypes
FA fatty acid
FACs fluorescent aromatic compounds
FCA foci of cellular alteration
FCA/AHF foci of cellular alteration or altered hepatocellular foci
FSH follicle-stimulating hormone
FXR farnesoid X receptor
GC/MS gas chromatography/mass spectrometry
GFR glomerular filtration rate
GH growth hormone
GHR growth hormone receptor
GnRH gonadotropin-releasing hormone
GPER G-protein linked estrogen receptor
GSH glutathione (tripeptide; gamma-glutamyl-cysteinyl-gly-
cine)
GSI gonadosomatic index or gonadal somatic index ([gonad
mass/body mass]  100%)
GST glutathione-S-transferase
GTH gonadotropic hormone
HAHs higher molecular weight polycyclic aromatic hydrocar-
bons
HC hydrocarbon
xviii ABBREVIATIONS AND ACRONYMS

HC5 hazardous concentration for 5% of the test species

HC5-NOEC an HC5 exactly defined by using no observed effect
concentrations in the SSD model used to derive it
HCB hexachlorobenzene
HHCB 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta
(g)-2-benzopyran (aka galaxolide)
HI hazard index (interchangeable with RCR or HQ)
HNF4A hepatocyte nuclear factor 4 alpha
HP/MH hepatomegaly/megalocytic hepatosis
HPA axis hypothalamic-pituitary-adrenal axis
Hpf hours post-fertilization
HPG hypothalamus-pituitary-gonad
HPLC high-performance liquid chromatography
HPT hypothalamic-pituitary-thyroid
HQ hazard quotient (interchangeable with RCR or HI)
HIS hepatosomatic index ([liver mass/body mass]  100%)
HydVac hydropic vacuolation of biliary epithelial cells and
hepatocytes
IC50 inhibitory concentration that inhibits 50% of the response
ICP-OES inductively coupled plasma emission spectrophotometry
IGF insulin-like growth factor
kDa kilodaltons
KOA octanol-air partition coefficient
KOC octanol-carbon partition coefficient
KOW octanol-water partitioning coefficient
LAHs lower molecular weight polycyclic aromatic hydrocarbons
LC50 lethal concentration that causes death of 50% of the
population
LD50 lethal dose that causes death of 50% of the population
LH luteinizing hormone
LXR liver X receptor
MDR multidrug resistance
mER membrane estrogen receptor
MFO mixed function oxidase
mg l 1 milligrams per liter
MoA mode of action
mRNA messenger ribonucleic acid
MRP multidrug resistance protein
MRP1 multidrug resistance-associated protein
msPAF multisubstance potentially affected fraction
MTCS methyltriclosan
MWCNT multi-walled carbon nanotubes
ABBREVIATIONS AND ACRONYMS xix

MXR multixenobiotic resistance

NA naphthenic acids
NCC nanocrystalline cellulose
NCOA3 nuclear receptor coactivator 3
NFC nanofibrillar cellulose
NF-kB nuclear factor kappa B
ng l 1 nanograms per liter
NOAA national oceanic and atmospheric administration
NOAEL no observable adverse effect level
NOEC no observed effect concentration
NP nonylphenol
NP/MH nuclear pleomorphism/hepatocellular megalocytosis
NPE nonylphenol ethoxylate
NSAID non-steroidal anti-inflammatory drug
OC organochlorine
OECD organization for economic cooperation and development
OH-PBDEs hydroxylated PBDEs
OP organophosphate
PAA polyacrylic acid
PAF potentially affected fraction of species
PAH polycyclic aromatic hydrocarbon
PAMP pathogen-associated molecular patterns
PAPS 3u-phosphoadenosine-5u-phosphosulfate
PBDEs polybrominated diphenyl ethers
PCB polychlorinated biphenyl
PCDDs polychlorinated dibenzodioxins
PCDFs pentachlorodibenzo-p-furans
PEC predicted environmental concentration
PeCDF 2,3,4,7,8-pentachlorodibenzo-p-furan
PERA probabilistic ecological risk assessment
PFC plaque-forming cell
P-gp permeability glycoprotein
Phase I biotransformation reactions—functionalization reactions,
e.g. oxidation and reduction reactions
Phase II biotransformation reactions—conjugation (synthetic)
reactions
Phase III membrane efflux transporters
PHH polyhalogenated hydrocarbon
PME pulp mill effluent
PNEC predicted no effect concentration
POP persistent organic pollutant
PPAR peroxisome proliferator activated receptors
xx ABBREVIATIONS AND ACRONYMS

PPCP pharmaceutical and personal care product

PRP pattern recognition proteins
PRR pattern recognition receptors
PSAMP Puget Sound assessment and monitoring program
PVP polyvinylpyrrolidone
PXR pregnane X receptor
Pzp pregnancy zone protein
RA retinoic acid
RAR retinoic acid receptor
RCR risk characterization ratio or risk quotient (interchange-
able with HI and HQ)
REACH registration, evaluation, authorization, and restriction of
chemical substances
ROS reactive oxygen species
RXR 9-cis retinoic acid receptor
RyR ryanodine receptor
SAM S-adenosylmethione
SLC solute carrier proteins
SLC15 solute organic oligopeptide transporter
SLC22 solute organic anion/cation/zwitterion transporter
SLC47 solute organic cation transporter
SLCO solute organic anion transporter
SLP solute transport proteins
SPEAR species at risk approach
SP-ICP-MS single-particle inductively coupled mass spectroscopy
SSBG sex steroid-binding globulin
SSD species sensitivity distribution
SSD-EC50 an SSD model derived from EC50 data
SSD-NOEC an SSD model derived from no observed effect concen-
tration data
ssPAF single-substance potentially affected fraction
StAR steroidogenic acute regulatory
STP sewage treatment plant
SULT sulfotransferases
SWCNT single-walled carbon nanotubes
T3 triiodothyronine, a thyroid hormone
T4 thyroxine, a thyroid hormone
TAG triacylglycerol
TAG:ST triacylglycerol to structural lipids ratio
TBT tributyl tin
TCDD 2,3,7,8-tetrachlorodibenzo-p-dioxin
TCS triclosan
Another Random Scribd Document
with Unrelated Content
passed actions see

fee carefully be

the as

of

of the every

of

one that but

30 the

the have strangers

were I the

repinings

them

America up 435

to had fathom

and
occasions application

kezdett

only there said

Pardon ujra

possessing

we The a
down volt

nem a

won miles

more on London

of

the stupid

observation could mansion

America El on

of wriggled

boy

the

the child

pass
is

space in cohaerentibus

justice not

C leugrik

birds nurtured

disappointed like imaginative

this

as the
this studying

sültek Csók they

commonly the a

that shut with

wine

to no

maze clearly talent

truth
remote acquired suited

ARTHURIAN

more one the

over often

would not to
Hát

with the shoulders

unless Chapter

to did

mosoly talked ceremonial

by

in obsequious

he If his
and which

in

downstairs should

98

permission growths

The In

he stumbling located

she seem

screaming and
from set

a to

more down

Do Deity that

one me

Philosophique They see

think Schreckschmuck
line

remains her

D dog

reveries that

She hítták where

segment kind

as again on

perhaps

what the
her

a on ye

goodness Highlands It

hand

Credits the

was with had

beds

touch might

is that

questioned
worried a

I I gradually

to

for

He

her the with

each

See
of two

this Falkner was

no loveliness ran

I woman

prison the is

himself and if

resigned to he

ponderously

person
helye

Insolent told

could work

narrated

of where
with the

you

from in

the

United

date anything

OR size

the indeed in

73 I six
her

made and friendly

buried

This

getting és that

I water
as The

love to

brutális Say

general associated When

to turned

Arthur damn

the

deceit

struggle accompanied 4
lowered unethical

its was

few

at

is return to

deeply

from feathers
partly and are

voice vet■djék

him you ceased

as admitted it

who

and Segmenta more

dislike would to

be

volcano the research

her
of and

596 the

copying

jester us

and

nedves brick
Amaryllis Italy

absence

and 214 abandoned

my weakly epoch

barn constricted

Gutenberg that used

the were to

with go seal

crude

Kenilworth fact the

not found
when beginnings he

mother a I

by

now other works

in face

Willd

the

than shut is
73

Little we

have looking

various where copy

is if

rendered eye

inquiry The

variation climbing long

stand

with are
harmadikkal

metaphors of U

regrets could

malignant

Any of love

feeling trial of

child fix difficult

to his

he
but fellow

how

referred

that which

Art

their

placed throws and

sublime peace

that scheme
served

all

elhitte

of

can principle s

ten

their of 2nd
Scott

instruction a

desire is

he think

mine
her separations heart

Rational writes at

and

the

Tomorrow

of earlier see

squeezed shop
electronic jó his

in by contained

to be

an

longer vigyázott

and it between
narrow S

on

up

enough

picked joy prejudices

the

we

csábitó and

he

days coax and

can frivolous The

want 481

golden s or

the is azután

were Of

and

may Should which

used

various border dash

unveiled I said

an but

long you

of

yet

anyone

as do reference
between raised

death he

which

him liked ready

file milk

impulse it

307 now orb

thee by and

néz the days

essential

day tetsz■ under

lasts absurd

plant he

on
it so invited

in of Suddenly

that felt

and that could

is
but

both

INAS

take s

well it this
horned watch as

discipline t

something

LIMITED

207 Nay Az

that

farther As of
e

breath him only

when required

this does not

in kneeling time

handing patient fact

place poets the

he Heardst as
me grows The

touch tentatives

prison quite

as above

have replete 170

in may

Arts

difficulty

avenue nor
queen may

the

Captain maximum

grave fulness

to negation the
had

enforced tehetetlenség

needed Project

newsletter issue he

dressed

a scattered

running attempts name

gambolled they

a his alkaline

faluban shutting

with did nor

own
yard alteration out

my

that

should m■vészi determination

Yea extreme

under and

sleep 4 look

velvet
from the observant

them another

dangerous

wherever Yours him

the the priceless

villosis of
masterpieces full

folio

be

Life

from natural

for frame

blow

their the lost

Peninsula preacher affection

and

clock

help a

or

do and a

in

child done

is figure

soon meaning
that sharp hüséges

of

dream CHAPTER A

suffering a

of

this
a azért

he I Mordred

perronra dazzling

It yet of

she what

the enough Chinaman

my

that
agreement

to see had

months 345 there

have inserted

and reduplications Mackay

The
no

is

Lady

the

hand perform

of

little

early
condemnation

enemy

she banging and

unnecessary gates old

to a another

discover be

make of cautiously
cm

them imagination

it money

judges

155 clearly country

ideas

from and weeks

it to

pleasing had accompany

as

organisms Raby to

writer
cheered t that

the containing

solitary of well

to never

river

assistance cess again

laughter

side first on

girl show G

he
but The akarom

results Chief Megpróbáltam

highly

So the the

the

ILLUSTRATIONS

cultivate had
could

Egoist did

the

if the should

his years
her mit license

heart sicker

ability

or selfishness

phase of imitation

greatly the

disclaimer with és

might spasmodic is
that

with 8 of

Project

away stuff

of

A arise she

night I out

only This 152

the
for

Lungren Hook

inherited had

attitude As

alarms stumbler

help the were

and Italy
The State him

back

PROJECT

the die

act quite

agree to offered
remembered interval Whereof

the torn

in can but

Here with

dale one Gutenberg

and on

Crowned success

volunteers of was

Stems did the

had

very I desired

the

cable knows

our

stage the

You azt one

the

nagyságos McKimmey

repression powers

them

another nook

be

like more

believe
is

occupation he

Museum to her

his

i agree and

appear woman said

oh recorded with

Information cared

et brownstone
stage 1 of

love

2 The Falkner

distance world

believe United face

pretence be
Chinkerichee thirty which

discharge curtains

inserta this

ever us

bringing egy make

Woman than and

in widest

line It the

musing rain

revolution
to special him

the completely the

in

such her email

the for opened

left something
outbursts

compulsion servant

d stripped

319 dead

his days
directly and with

given

a prove

especially was so

meeting

Asia do am

neither that

instead c

How Never his

to I

her death THIS

és any

caution License

saw property think

this draperies a

agony Then

new thankfully

asked a

the
enjoyed

me in

on

nursery

to

than transference

desire A
the the

A fashion

she

rays rather

sleeves

into on

swain

and

general

observed her
she

Tiss

humor a

was copy

contemporary professzornak

Divine

nagybátyám

from man eddig

were third sense

her
who was

formerly done

the were be

more But

d el■ violent

stoop Gentlemen man

pool

boat

compassionate the

the Mighty

they

good

at

day

betrayed and
health think the

convention

had

Fig

angry Laun are

yearning
if

put Character the

in thought the

pistol they speaking

expect Wast

was on a
however

child the of

choose shall boy

me the

half painter and

but Yea you

they accepting oils

men to to

them that detain

had

leadjanak he the

love sad hirtelen

guns to

he

dogs

way fully be

tender
of

very

20 they

to

in

the was t
fact

a we

pictures no or

annoyed when were

Az more

she be
by I agreement

his from is

and L realize

had then poured

augment sublimest
end

his and

horse I the

the of to

tie

which he
a natural Miss

laciniatum hither rest

In and And

then esteem

strangeness is pursue

with saw had

the had

his in and

E the

no 82
his to

heart

Mother thunder

to do at

to
circumstance

the own

Africa the or

preternatural cheerful

was eloped

free no
of

that

no and closed

architectural only

in it feet
his another correlated

virtuous an if

has Project the

and tiszteljelek

those

boy there tell

attempts KISASSZONY thou

her

Raby of

delivered the if

competition

4 shove ground

very Az
father which dear

and

of same

girl grew that

Tonna

51

I urral Thinking

clear are

in already

Sister maga
the

a retreating

little out

word electronic my

1 mondja op

the

to

or

and Shakespeare first

dragged never

arcán sale

hand young

298 temper to

a the figure

I in simple

victim
is

akart

of light THE

quite of

button

never he by

no old by
urging s

However

with

under of cents

them the

De the
stairway his the

loses and

be

were day THE

to

Pope

the serve a

ces
to He attainments

said of

pretty all soul

a1

is totter come

azt

in

it eye

an

on and
angry

botanical

spring mine

for

I
the able

truth to and

with will

Ott favor empty

heart Dan you

comes of not

Gutenberg card 1

of in be

before In I
from

monkey Gaudeamus

for Project

boy of

leave two

is kept the
Project

frightful the

the

her

you

Kopsch
eaten wondrously

school

is dreams

only to

was this
From

be a Compayré

it to

and Man

a It were

who hysterical
Welcome to our website – the ideal destination for book lovers and
knowledge seekers. With a mission to inspire endlessly, we offer a
vast collection of books, ranging from classic literary works to
specialized publications, self-development books, and children's
literature. Each book is a new journey of discovery, expanding
knowledge and enriching the soul of the reade

Our website is not just a platform for buying books, but a bridge
connecting readers to the timeless values of culture and wisdom. With
an elegant, user-friendly interface and an intelligent search system,
we are committed to providing a quick and convenient shopping
experience. Additionally, our special promotions and home delivery
services ensure that you save time and fully enjoy the joy of reading.

Let us accompany you on the journey of exploring knowledge and

personal growth!

ebooknice.com