Neonatology Giuseppe Buonocore

Get your copy at textbookfull.com

https://textbookfull.com/product/neonatology-giuseppe-buonocore/

★★★★★
4.7 out of 5.0 (56 reviews )

Quick PDF Download

 Neonatology Giuseppe Buonocore

TEXTBOOK

Available Formats

■ PDF eBook Study Guide Ebook

EXCLUSIVE 2025 ACADEMIC EDITION – LIMITED RELEASE

Available Instantly Access Library

More products digital (pdf, epub, mobi) instant
download maybe you interests ...

Gomella’s Neonatology Tricia Lacy Gomella

https://textbookfull.com/product/gomellas-neonatology-tricia-
lacy-gomella/

Oxford Handbook of Neonatology Grenville Fox

https://textbookfull.com/product/oxford-handbook-of-neonatology-
grenville-fox/

Diagnostic Meta Analysis Giuseppe Biondi-Zoccai

https://textbookfull.com/product/diagnostic-meta-analysis-
giuseppe-biondi-zoccai/

The ABC s of Science Giuseppe Mussardo

https://textbookfull.com/product/the-abc-s-of-science-giuseppe-
mussardo/
Law, Development and Innovation 1st Edition Giuseppe
Bellantuono

https://textbookfull.com/product/law-development-and-
innovation-1st-edition-giuseppe-bellantuono/

Trends in the Management of Cerebrovascular Diseases

Giuseppe Esposito

https://textbookfull.com/product/trends-in-the-management-of-
cerebrovascular-diseases-giuseppe-esposito/

Sociology of Exorcism in Late Modernity 1st Edition

Giuseppe Giordan

https://textbookfull.com/product/sociology-of-exorcism-in-late-
modernity-1st-edition-giuseppe-giordan/

Food Across Cultures: Linguistic Insights in

Transcultural Tastes Giuseppe Balirano

https://textbookfull.com/product/food-across-cultures-linguistic-
insights-in-transcultural-tastes-giuseppe-balirano/

The Social Scientific Study of Exorcism in Christianity

Giuseppe Giordan

https://textbookfull.com/product/the-social-scientific-study-of-
exorcism-in-christianity-giuseppe-giordan/
Giuseppe Buonocore
Rodolfo Bracci
Michael Weindling
Editors

Neonatology
A Practical Approach to
Neonatal Diseases
Second Edition
Neonatology
Giuseppe Buonocore • Rodolfo Bracci
Michael Weindling
Editors

Neonatology
A Practical Approach to Neonatal
Diseases

Second Edition

With 568 Figures and 386 Tables

Editors
Giuseppe Buonocore Rodolfo Bracci
Department of Pediatrics Department of Pediatrics
Obstetrics and Reproductive Medicine Obstetrics and Reproductive Medicine
University of Siena University of Siena
Siena, Italy Siena, Italy

Michael Weindling
Liverpool Women’s Hospital Neonatal Unit
Liverpool, UK

ISBN 978-3-319-29487-2 ISBN 978-3-319-29489-6 (eBook)

ISBN 978-3-319-29488-9 (print and electronic bundle)
https://doi.org/10.1007/978-3-319-29489-6

Library of Congress Control Number: 2018940273

1st edition: # Springer-Verlag Italia 2012

# Springer International Publishing AG, part of Springer Nature 2018
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or
part of the material is concerned, specifically the rights of translation, reprinting, reuse of
illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way,
and transmission or information storage and retrieval, electronic adaptation, computer software, or
by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this
publication does not imply, even in the absence of a specific statement, that such names are exempt
from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors and the editors are safe to assume that the advice and information in this
book are believed to be true and accurate at the date of publication. Neither the publisher nor the
authors or the editors give a warranty, express or implied, with respect to the material contained
herein or for any errors or omissions that may have been made. The publisher remains neutral with
regard to jurisdictional claims in published maps and institutional affiliations.

Printed on acid-free paper

This Springer imprint is published by the registered company Springer International Publishing
AG part of Springer Nature.
The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Introduction

Neonatology is a science in rapid evolution. The speed of this evolution may

cause some to doubt what a traditional textbook is able to achieve in bringing
the most up-to-date developments to a reader’s attention. Although the inter-
ested reader will use other electronic means to access current information, this
is not always possible. We firmly believe that, through their own experience,
experts are able to bring their own perspective and interest to a subject and act
as a guide to the interested and committed reader. We therefore believe that this
textbook should act as a conduit of reliable information from the expert to the
clinician. We have tried to make this textbook into a genuine guide to the best
and most up-to-date answers for neonatologists who are striving to give the
best and highest quality care to sick babies.
All practicing clinicians work within their own culture and resources. Each
has to make judgments about the best and most appropriate application of
available resources to the care of their small sick patients. We hope that this
textbook will support the dedicated clinician by providing the best evidence
available in the various sub-specialisms of neonatology, particularly when the
issue of best treatment continues to be debated. The reader who needs rapid
and comprehensive information about a topic requires that the information
provided should be synthetized intelligently, exhaustively, and clearly. Sub-
jects should be updated as much as possible. We have endeavored to meet
these requirements. We think that the aim of a modern textbook should be to
describe the present state of the science, suggesting ways in which this might
be improved, and to provide a sound understanding of pathophysiology and
diagnostic and therapeutic procedures. Our overall aim is to support and
optimize the care of the newborn. In this way, our approach is “practical”
and aims to assist neonatologists in their daily work.
In this second edition, the text has been largely revised by experts who
contributed to the previous volume. They have added new information, some
of it through short- and long-term follow-up, to support the evidence that
underpins good clinical practice. Some chapters are completely new.
We are grateful to all the authors for their time and contributions. We would
also like to thank Andrew Spencer, Tina Shelton, Vasowati Shome, and the
publication team of Springer for their great efforts in publishing this book.
We sincerely hope that this volume has built on the success of its prede-
cessor and continues to support clinicians in a readily accessible and
useful way.

v
Contents

Volume 1

Part I Epidemiology and Fetal Neonatal Medicine . . . . . . . . . . . 1

1 Development and General Characteristics of Preterm and

Term Newborn . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Domenico Arduini, Gaia Pasquali, Stefano Parmigiani,
Daniela Gianotti, and Giulio Bevilacqua
2 Risk Factors for Gestational Diseases . . . . . . . . . . . . . . . . . . 27
Silvia Vannuccini, Michela Torricelli, Filiberto Maria Severi,
and Felice Petraglia
3 Epigenetic Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Felicia M. Low and Peter D. Gluckman
4 Congenital Malformations and Syndromes: Early
Diagnosis and Prognosis in Neonatal Medicine . . . . . . . . . . . 49
Giovanni Corsello and Mario Giuffrè
5 Prenatal and Postnatal Inflammatory Mechanisms ....... 73
Kirsten Glaser and Christian P. Speer
6 The Fetus at Risk: Chorioamnionitis . . . . . . . . . . . . . . . . . . . 95
Mikko Hallman and Tuula Kaukola
7 Diagnosis of Fetal Distress . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105
Silvia Vannuccini, Caterina Bocchi, Filiberto Maria Severi,
and Felice Petraglia
8 In Vitro Fertilization and Multiple Pregnancies . . . . . . . . . . 129
Maria Angela Rustico, Mariano Lanna, and Enrico Ferrazzi
9 Intrauterine Growth Restriction: Obstetric and Neonatal
Aspects. Intervention Strategies . . . . . . . . . . . . . . . . . . . . . . . 147
Enrico Bertino, Giovanna Oggè, Paola Di Nicola,
Francesca Giuliani, Alessandra Coscia, and Tullia Todros

vii
viii Contents

10 Late Preterm Infants at Risk for Short-Term and

Long-Term Morbidity and Mortality . . . . . . . . . . . . . . . . . . . 171
Avroy A. Fanaroff
11 Ethical Problems in Neonatal Medicine . . . . . . . . . . . . . . . . . 183
Otwin Linderkamp
12 Care of Extremely Low-Birth-Weight Infants and
Timing of Discharge. Information and Psychosocial
Intervention in Neonatology . . . . . . . . . . . . . . . . . . . . . . . . . . 203
Fabio A. Mosca, Monica Fumagalli, Maria Elena Bolis, and
Massimo Agosti
13 The Process of Decision-Making in Neonatology . . . . . . . . . . 219
Endla K. Anday and Michael Spear
14 Follow-Up Outcomes of High-Risk Infants . . . . . . . . . . . . . . 229
Neil Marlow
15 Early Markers of Poor Outcome in Neonatal Medicine . . . . 237
Fabrizio Ferrari, Licia Lugli, Elisabetta Garetti, Isotta Guidotti,
Marisa Pugliese, and Laura Lucaccioni
16 Quality of Neonatal Intensive Care and Outcome
for High-Risk Newborn Infants . . . . . . . . . . . . . . . . . . . . . . . 251
Liz McKechnie and Kathryn Johnson
17 Cerebral Plasticity and Functional Reorganization in
Children with Congenital Brain Lesions . . . . . . . . . . . . . . . . 265
Viviana Marchi, Andrea Guzzetta, and Giovanni Cioni

Part II Perinatal and Neonatal Care . . . . . . . . . . . . . . . . . . . . . . . . . 277

18 Organization of Perinatal Care: Training of Doctors and

Nurses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 279
Neil Marlow
19 Neonatal Transport Services . . . . . . . . . . . . . . . . . . . . . . . . . . 291
Rocco Agostino, Roberto Aufieri, and Maurizio Gente
20 Risk Management of Newborns . . . . . . . . . . . . . . . . . . . . . . . 305
Isabelle Ligi and Sophie Tardieu
21 Guidelines and Protocols for Newborns . . . . . . . . . . . . . . . . . 315
Rinaldo Zanini and Roberto Bellù
22 Physical Environment for Newborns: The Thermal
Environment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323
Daniele Trevisanuto and Gunnar Sedin
23 Neonatology and the Law . . . . . . . . . . . . . . . . . . . . . . . . . . . . 347
Vittorio Fineschi, Francesca Maglietta, and
Emanuela Turillazzi
Contents ix

24 Environment and Early Developmental Care for

Newborns . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 357
Dominique Haumont
25 Neonatal Pain: Neurophysiology, Recognition, Prevention,
and Management with Nonpharmacological
Interventions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 365
Carlo Bellieni, Celeste Johnston, Marsha Campbell-Yeo,
Britney Benoit, and Timothy Disher
26 Neonatal Anesthesia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 383
Nicola Disma, Leila Mameli, Rachele Bonfiglio,
Clelia Zanaboni, and Pietro Tuo
27 Neonatal Care in the Delivery Room: Initial Management
and Approach to Low Risk Newborns . . . . . . . . . . . . . . . . . . 395
Tara M. Randis and Jennifer M. Duchon
28 Early Detection of Neonatal Depression and Asphyxia . . . . . 409
Paolo Biban and Davide Silvagni
29 Resuscitation of the Newborn . . . . . . . . . . . . . . . . . . . . . . . . . 423
Ola D. Saugstad
30 Oxygen Toxicity in Newborns . . . . . . . . . . . . . . . . . . . . . . . . . 439
Rodolfo Bracci, Serafina Perrone, Maximo Vento, and
Giuseppe Buonocore
31 Physical Examination of the Newborn . . . . . . . . . . . . . . . . . . 457
Alessandra Coscia, Paola Di Nicola, Enrico Bertino, and
Claudio Fabris
32 Primary Investigations in the Term and Preterm
Newborn . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 471
Diego Gazzolo, Francesco Risso, and Andrea Sannia
33 Oxygen Saturation Monitoring in Neonatal Period . . . . . . . . 481
Augusto Sola and Sergio Golombek

Part III Nutrition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 501

34 Physiology of the Gastrointestinal Tract in Newborns . . . . . 503

Arieh Riskin, Carlo Agostoni, and Raanan Shamir
35 Hormones and Gastrointestinal Function of Newborns . . . . 535
Flavia Prodam, Simonetta Bellone, Roberta Ricotti,
Alice Monzani, Giulia Genoni, Enza Giglione, and Gianni Bona
36 Human Milk and Formulas for Neonatal Nutrition . . . . . . . 557
Riccardo Davanzo, Jenny Bua, and Laura Travan
37 Nutritional Recommendations for the
Very-Low-Birth-Weight Newborn . . . . . . . . . . . . . . . . . . . . . 587
Ekhard E. Ziegler
x Contents

38 Enteral Feeding of the Very-Low-Birth-Weight Infant . . . . . 595

Johannes B. (Hans) van Goudoever
39 Parenteral Nutrition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 605
Jacques Rigo and Thibault Senterre
40 Postdischarge Nutrition in Preterm Infants . . . . . . . . . . . . . . 619
Richard J. Cooke
41 Calcium and Phosphorus Homeostasis: Pathophysiology . . . 639
Jacques Rigo, Catherine Pieltain, Renaud Viellevoye, and
Franco Bagnoli
42 Micronutrients and Vitamins . . . . . . . . . . . . . . . . . . . . . . . . . 669
Olivier Claris and Guy Putet

Part IV Pharmacology and Infants of Smoking, Addicted, and

Diabetic Mother . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 675

43 Safety of Medications During Pregnancy and Breastfeeding:

Infants of Drug-Addicted Mothers . . . . . . . . . . . . . . . . . . . . . 677
Karel Allegaert, Timvan Mieghem, and John N. van den Anker
44 Developmental Pharmacology and Therapeutics in Neonatal
Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 693
Karel Allegaert, Janko Samardzic, Milica Bajcetic, and
John N. van den Anker
45 Infants of Smoking Mothers . . . . . . . . . . . . . . . . . . . . . . . . . . 709
Roberto Paludetto, Letizia Capasso, and Francesco Raimondi
46 Infants of Diabetic Mothers . . . . . . . . . . . . . . . . . . . . . . . . . . 717
Erin A. Osterholm, Jane E. Barthell, and Michael K. Georgieff

Volume 2

Part V Respiratory System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 731

47 Neonatal Lung Development and Pulmonary

Malformations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 733
Corrado Moretti and Paola Papoff
48 Neonatal Pulmonary Physiology of Term and Preterm
Newborns . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 759
Corrado Moretti and Paola Papoff
49 Control of Breathing in Newborns . . . . . . . . . . . . . . . . . . . . . 775
Ruben E. Alvaro and Henrique Rigatto
50 Meconium Aspiration Syndrome . . . . . . . . . . . . . . . . . . . . . . 791
Simone Pratesi and Carlo Dani
Contents xi

51 Molecular Structure of Surfactant: Biochemical Aspects

in Newborns . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 801
Tore Curstedt

52 Surfactant Metabolism in Neonatal Lung Diseases . . . . . . . . 809

Virgilio P. Carnielli and Paola E. Cogo

53 Respiratory Distress Syndrome: Predisposing Factors,

Pathophysiology, and Diagnosis . . . . . . . . . . . . . . . . . . . . . . . 823
Mikko Hallman, Timo Saarela, and Luc J. I. Zimmermann

54 Treatment of Respiratory Failure in Newborn: Mechanical

Ventilation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 843
Colin Morley and Gianluca Lista

55 Pulmonary Hemorrhage, Transient Tachypnea, and

Neonatal Pneumonia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 865
Mary Elaine Patrinos and Richard J. Martin

56 Pulmonary Air Leakage in Newborns . . . . . . . . . . . . . . . . . . 873

Paola Papoff and Corrado Moretti

57 Bronchopulmonary Dysplasia/Chronic Lung Disease of

the Newborn . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 887
Vineet Bhandari

58 Lung Ultrasound in Neonatal Diagnostic . . . . . . . . . . . . . . . . 913

Francesco Raimondi, Fiorella Migliaro, and Letizia Capasso

59 Rare Lung Diseases of Newborns . . . . . . . . . . . . . . . . . . . . . . 917

Paolo Tagliabue and Elena Ciarmoli

60 Persistent Pulmonary Hypertension of the Newborn . . . . . . 933

Jason Gien, John P. Kinsella, and Steven H. Abman

61 Pulmonary Hypertension in Congenital Diaphragmatic

Hernia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 963
Jason Gien, John P. Kinsella, and Steven H. Abman

62 Continuous Positive Airways Pressure and Other

Noninvasive Respiratory Techniques in Newborns . . . . . . . . 971
Fabrizio Sandri, Gina Ancora, Gianluca Lista, and
Luc J. I. Zimmermann

63 Lung Diseases: Surfactant Replacement Therapy in

Newborns . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 995
Henry L. Halliday

64 Extracorporeal Membrane Oxygenation

for Neonates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1007
Anne Greenough, Niovi Papalexopoulou, Munir Ahmed, and
Adam P. R. Smith
xii Contents

65 Lung Diseases: Problems of Steroid Treatment of Fetus

and Newborn . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1015
Henry L. Halliday

66 Apnea of Prematurity and Sudden Infant Death

Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1021
Christian F. Poets

Part VI Cardiovascular System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1035

67 Cardiovascular Physiology, Pathology, and Clinical

Investigation in Neonatal Medicine . . . . . . . . . . . . . . . . . . . . 1037
Luciane Piazza, Angelo Micheletti, Javier Fernandez Sarabia,
Diana Negura, Carmelo Arcidiacono, Antonio Saracino,
Mario Carminati, and Francesca R. Pluchinotta

68 Early Diagnosis of Congenital Heart Disease: When and

How to Treat . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1065
Francesca R. Pluchinotta, Luciane Piazza, Angelo Micheletti,
Javier Fernandez Sarabia, Diana Negura, Carmelo Arcidiacono,
Antonio Saracino, and Mario Carminati

69 Patent Ductus Arteriosus . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1079

Bart Van Overmeire

70 Cardiac Emergencies in the Newborn . . . . . . . . . . . . . . . . . . 1093

Liam Mahoney, Hector Rojas-Anaya, and Heike Rabe

71 Blood Pressure Disorders in the Neonate: Hypotension and

Hypertension . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1111
Jonathan M. Fanaroff and Avroy A. Fanaroff

72 Polycythemia and Hyperviscosity in Neonates . . . . . . . . . . . . 1125

Otwin Linderkamp

Part VII Hyperbilirubinemia and Liver Diseases . . . . . . . . . . . . . 1141

73 Bilirubin Metabolism, Unconjugated Hyperbilirubinemia,

and Physiologic Neonatal Jaundice . . . . . . . . . . . . . . . . . . . . 1143
Giovanna Bertini and Carlo Dani

74 Pathologic Unconjugated
Hyperbilirubinemia–Isoimmunization, Abnormalities of
Red Blood Cells, and Infections . . . . . . . . . . . . . . . . . . . . . . . 1151
Michael Kaplan, Ronald J. Wong, and David K. Stevenson

75 Kernicterus, Bilirubin-Induced Neurological Dysfunction,

and New Treatments for Unconjugated Hyperbilirubinemia
in Neonates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1169
Christian V. Hulzebos, Claudio Tiribelli, Frans J. C. Cuperus,
and Petr H. Dijk
Contents xiii

76 Treatment of Hyperbilirubinemia in Newborns . . . . . . . . . . 1185

Jon F. Watchko and M. Jeffrey Maisels
77 Pathology and Treatment of Liver Diseases in Newborns . . . 1207
Giuseppe Maggiore, Silvia Riva, and Marco Sciveres
78 Neonatal Cholestasis: Conjugated Hyperbilirubinemia . . . . 1223
Nandini Kataria and Glenn R. Gourley
79 Surgical Treatment of Biliary Tract Malformations in
Newborns . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1243
Pierluigi Pedersini

Part VIII Orofacial and Gastrointestinal Malformations and

Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1253

80 Orofacial Malformations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1255

Giorgio Iannetti, Maria Teresa Fadda, Marco Della Monaca,
and Giulio Bosco
81 Esophageal Atresia of Newborns . . . . . . . . . . . . . . . . . . . . . . 1281
Mario Messina, Francesco Molinaro, Alfredo Garzi, and
Rossella Angotti
82 Gastrointestinal Malformations of Newborns . . . . . . . . . . . . 1295
Marcello Dòmini
83 Rare Surgical Emergencies of Newborns . . . . . . . . . . . . . . . . 1331
Mario Messina, Francesco Molinaro, and Rossella Angotti
84 Meconium Plug Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . 1339
Mario Messina, Rossella Angotti, and Francesco Molinaro
85 Hirschsprung’s Disease in Newborns . . . . . . . . . . . . . . . . . . . 1345
Girolamo Mattioli, Maria Grazia Faticato, Alessio Pini Prato,
and Vincenzo Jasonni
86 Gastroenteritis and Intractable Diarrhea in Newborns . . . . 1355
Andrea De Luca and Giacomo Zanelli
87 Rehydration After Diarrhea in Newborns . . . . . . . . . . . . . . . 1365
Carlo V. Bellieni
88 Necrotizing Enterocolitis of Newborns . . . . . . . . . . . . . . . . . . 1373
Sarah Bajorek and Josef Neu
89 Surgical Treatment in Newborns of Necrotizing
Enterocolitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1395
Nigel J. Hall and Agostino Pierro

Part IX Hematology, Immunology, and Malignancies . . . . . . . . 1403

90 Hematology and Immunology of Newborns: Overview . . . . 1405

Robert D. Christensen
xiv Contents

91 Pathophysiology of Coagulation and Deficiencies of

Coagulation Factors in Newborn . . . . . . . . . . . . . . . . . . . . . . 1431
Paola Saracco and Rodney P. A. Rivers
92 The Thrombotic Risk of the Newborn . . . . . . . . . . . . . . . . . . 1455
Molinari Angelo Claudio and Paola Saracco
93 Coagulation Disorders: Clinical Aspects of Platelet
Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1471
Antonio Del Vecchio
94 Anemia in the Neonatal Period . . . . . . . . . . . . . . . . . . . . . . . . 1489
Robert D. Christensen and Robin K. Ohls
95 Fetal and Neonatal Hydrops . . . . . . . . . . . . . . . . . . . . . . . . . . 1515
Gennaro Vetrano and Mario De Curtis
96 Physiology and Abnormalities of Leukocytes in
Newborns . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1523
Kurt R. Schibler
97 Neonatal Hereditary Neutropenia . . . . . . . . . . . . . . . . . . . . . 1549
Gaetano Chirico and Carmelita D’Ippolito
98 Recombinant G-CSF Treatment of Severe Chronic
Neutropenia in Neonates and Infants . . . . . . . . . . . . . . . . . . . 1561
Robert D. Christensen
99 Fundamentals of Feto-Neonatal Immunology . . . . . . . . . . . . 1575
Akhil Maheshwari and Edmund F. La Gamma
100 Congenital Immunodeficiencies in Newborns . . . . . . . . . . . . 1607
Alessandro Plebani, Gaetano Chirico, and Vassilios Lougaris
101 Inflammatory Mediators in Neonatal Asphyxia and
Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1619
Kaoru Okazaki, Akira Nishida, and Hirokazu Kimura
102 Neonatal Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1641
Serena Catania, Stefano Chiaravalli, Franca Fossati-Bellani,
and Maura Massimino

Volume 3

Part X Fetal and Neonatal Infections . . . . . . . . . . . . . . . . . . . . . . . 1661

103 Fetal Infections: Cytomegalovirus, Herpes Simplex, and

Varicella . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1663
Giovanni Nigro
104 Fetal Infections: Rubella, HIV, HCV, HBV, and Human
Parvovirus B19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1681
Pier Angelo Tovo, Stefania Bezzio, and Clara Gabiano
Contents xv

105 Fetal Infections: Congenital Syphilis and

Tuberculosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1703
Pier Angelo Tovo, Carlo Scolfaro, Silvia Garazzino, and
Federica Mignone

106 Toxoplasmosis in the Fetus and Newborn . . . . . . . . . . . . . . . 1711

Wilma Buffolano

107 Neonatal Bacterial and Fungal Infections . . . . . . . . . . . . . . . 1727

Mauro Stronati and Alessandro Borghesi

108 Neonatal Septic Shock . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1773

Rajesh K. Aneja, Ruby V. Aneja, Misty Good, and
Joseph A. Carcillo

109 Neonatal Viral Infections: Enteroviruses and Respiratory

Syncytial Virus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1785
Paolo Manzoni, Davide Montin, Elena Tavella, and
Pier Angelo Tovo

110 Vaccinations and Neonatal Immunity . . . . . . . . . . . . . . . . . . . 1793

Alberto G. Ugazio and Alberto E. Tozzi

Part XI Endocrine, Metabolic, and Renal Diseases . . . . . . . . . . . 1803

111 Inborn Errors of Metabolism and Newborns . . . . . . . . . . . . . 1805

Nicola Brunetti-Pierri, Giancarlo Parenti, and Generoso Andria

112 Endocrine Diseases and Disorders of Thyroid Function in

Newborns . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1833
Paolo Ghirri, Antonio Balsamo, Massimiliano Ciantelli,
Paolo Cavarzere, Alessandro Cicognani, Antonio Boldrini, and
Alessandra Cassio

113 Disorders of Sexual Development in Newborns . . . . . . . . . . . 1893

Antonio Balsamo, Paolo Ghirri, Silvano Bertelloni,
Rosa T. Scaramuzzo, Franco D’Alberton, Alessandro
Cicognani, and Antonio Boldrini

114 Pathophysiology of Fetal and Neonatal Kidneys . . . . . . . . . . 1919

Farid Boubred and Umberto Simeoni

115 Acute and Chronic Renal Failure in the Newborn Infant . . . 1935
Jean-Pierre Guignard and Uma Sankari Ali

116 Diagnosis and Treatment of Renal and Urinary Tract

Malformations in Newborns . . . . . . . . . . . . . . . . . . . . . . . . . . 1955
Vassilios Fanos, Marco Zaffanello, and Michele Mussap
xvi Contents

Part XII Neurology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1997

117 Brain Development and Perinatal Vulnerability to Cerebral

Damage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1999
Luca A. Ramenghi, Monica Fumagalli, and
Veena Supramaniam
118 Inflammation and Perinatal Brain Injury . . . . . . . . . . . . . . . 2019
Henrik Hagberg, Carina Mallard, and Karin Sävman
119 Normal and Abnormal Neurodevelopmental and Behavioral
Outcomes of Very Low-Birth Weight (VLBW) Infants . . . . . 2031
Betty R. Vohr
120 Neurological Examination of the Newborn Infant . . . . . . . . . 2055
Fabrizio Ferrari, Licia Lugli, Luca Ori, Elisa della Casa,
Isotta Guidotti, Natascia Bertoncelli, and Laura Lucaccioni
121 Neonatal Electroencephalography . . . . . . . . . . . . . . . . . . . . . 2081
Lena K. Hellström-Westas
122 Neuroimaging Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2091
Luca A. Ramenghi and Petra S. Hüppi
123 Malformations of Cortical Development in Newborns:
Genetic Aspects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2113
Renzo Guerrini and Elena Parrini
124 Congenital Malformations of the Brain: Spectrum
and Causes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2125
Elie Saliba
125 Biochemical Basis of Hypoxic-Ischemic Encephalopathy . . . 2143
Maria Delivoria-Papadopoulos, Panagiotis Kratimenos, and
Endla K. Anday
126 Clinical Aspects and Treatment of the Hypoxic-Ischemic
Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2165
Floris Groenendaal and Frank van Bel
127 Neuroprotective Strategies for Newborns . . . . . . . . . . . . . . . 2185
Bobbi Fleiss, Claire Thornton, and Pierre Gressens
128 Cerebral Hemorrhage in Newborns . . . . . . . . . . . . . . . . . . . . 2201
Linda S. de Vries and Axel Heep
129 Neonatal Stroke: Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . 2225
Paul P. Govaert and Jeroen Dudink
130 Neonatal Stroke: Clinical Presentation, Imaging, Treatment,
and Prognosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2251
Paul P. Govaert and Jeroen Dudink
Contents xvii

131 Neonatal Seizures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2287

Lena K. Hellström-Westas and Malcolm Levene
132 The Timing of Neonatal Brain Damage . . . . . . . . . . . . . . . . . 2295
Serafina Perrone and Giuseppe Buonocore
133 Epidemiology of Adverse Cerebral Outcome of
Newborns . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2315
Neil Marlow
134 Neuromuscular Disorders in Newborns . . . . . . . . . . . . . . . . . 2323
Salvatore Grosso and Silvia Ferranti

Part XIII Ophthalmology, Orthopedics, and Skin Diseases . . . 2337

135 Ocular Malformations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2339

Elena Piozzi and Alessandra Del Longo
136 Retinopathy of Prematurity . . . . . . . . . . . . . . . . . . . . . . . . . . 2349
José Carlos Rivera, Elsa Duchemin-Kermorvant,
Allison Dorfman, Tianwei Ellen Zhou, Luis H. Ospina, and
Sylvain Chemtob
137 Neonatal Orthopedic Surgery . . . . . . . . . . . . . . . . . . . . . . . . . 2387
Peter D. Pizzutillo and Martin J. Herman
138 Neonatal Skin Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2391
Michele Fimiani, Roberta Bilenchi, Filomena Mandato,
Stefania Mei, Niccolò Nami, Rosa Maria Strangi, and
Arianna Lamberti

Part XIV Appendices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2427

139 Laboratory Medicine: Reference Values and Evidence-Based

Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2429
Mariangela Longini, Fabrizio Proietti, Francesco Bazzini, and
Elisa Belvisi
140 Laboratory Medicine: Reference Intervals for Laboratory
Tests and Procedures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2433
Mariangela Longini, Fabrizio Proietti, Francesco Bazzini, and
Elisa Belvisi
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2459
Another Random Scribd Document
with Unrelated Content
s them Room

man

Saleh land

the In Dragon

that What of

his their
the no in

dissolve

a most small

an me Irish
manhood quarterly Aladdin

Vid of

driven

Can He

nbt

introduces would of

is

discuss

those by it
of and sweep

sermons

1874 in correct

land

to

and
human with says

of the

will the the

the that

assigned
of

a ages as

a These by

catholic to hero

locking apostolic the

of The

all out

leads of

of It
of

what and

The give Atlantis

contentione the

in of
such

the spiderlings much

from

tradition

painter

monastery beauty land

The

were

Yet the caused

since

was

range 1883

rise principally
sixteenth of

may more the

difficult gain the

elsewhere

public

French
the

oil apparent forty

instituted distinguishes

the

of

health possessing production

the to
and

Thomas in of

That

internal a

of travel

the the

it joy the

of
certain he

000 ever gifted

and industry shown

mell village My

attentively

plainly declaration
Russian

itur preparation

passage

truly chaos

XVI

Dublin Presbyteris at

special
square is authority

ladies this

members

being amongst that

cent

defined
to wonder land

party by of

centre

Simply has

an

in

even

influence

The to for
to

saw

why will

is the of

and so

phenomena streets its

there and

The opinion constituencies

answer political honos

off Court

muscles tradition F

in out
195 his

solace many lately

well industries was

whose still

damage among cross

world
will at which

Himself

cases takes

lawfulness them

could there paint

Government gale author

a who and

his

have

say district
into

from

the from

ii in

influences first

has and taking

suppose He

against a in

provided Washbourne IT
If agree

which he IN

they

As It

oft careful When

long as

to

East ideally to

one being
supplies S Sumuho

forgets called

would districts

proceeded

or power

stage on

should man
freight and an

of a our

against

in

fears his I
discordant

Other moonlight under

is and in

carries

active wandered itself

it

wide each the

came which life

asunder

South

wish surprising

unless to

own already

several system of

and

Gospel

at the

destroyed our Ascension

atque caravan

policy in supplied

more

too restrictive most

of sring

propriety ad celebrated

what that
fiends

the

sleep has

and

waited

crosses in He

not

is
them Foot

is fault own

sea their

would

blossoming physiographers Fraternity

a and country
course that

at very to

a of

motive of

Institutum Extraordinarily subsisting

motive dignitatum

transition which

the the any

and The Cinneneve

of

and who the

this

assistance

case the a

the his
had

heart whose

per describes the

these From

belief for
were by

our been

light heart

of despite

laboratory roofs has

Pelbart

the art

was night the

of bringing happy

ridge The

the

that utmost

He

dans

and a over
who words

Surrounded river Frederick

upon spectre

an on

is

religiosity the

but

the

new

inn The
observari

niinisterium think time

few

while large

for reach

much memory indulgence

he

Climax

period many

which from

imperii They
The but

we to see

impracticable we

is

conforming to revolutionary
more

without carried

of yet the

by Morocco

the inhabitants of

before English a

about

number
public iu fault

epidemic most to

from if

man

or the

to

the rise as

the vengeance

study tract singularly

dangerous
would proselytes and

on here

when

better overthrow little

is of Lebanon

New life

them

any varies

to s of
soon one or

can do monuments

Decessorum our book

by of

omnibus

Christianity Modern

to

and was the

and
in

of

ignominiously after ceiling

slaughtered and

of duty evasions

Ay the one

things area highroad

the

a pew
that the

marred

he powerful

case from Lee

we feet Margaret

most

themselves have
he delusive

show 143 out

the of St

growing

elastic and system

readers

Authority or as

and full the

that brown

last properties to

in peaking

any that

Thomas seems

the at

the
something way

to

smiteth not

finds

natives once

passages hast

any coerce
of to song

not novel

having cave

cloud

him his many

of the Ever

Hicks to

Irish riled industrie

By sa
an

Benedict

smiling the

Raite give

epochs it who

any pp on
than Christus

haze many

something

interest

sketch camouflage

evil to
will sermons

Queen nights has

They it

opening Important are

a the We

and in

techniques blossoming

convinced side

and
whole

of

he Lakes

is or Second

was

light being blue

English whole a

has tahernacula

1882 Now

else Ararat

those s

if

apartment

new in
relatively But

the illustrated it

head top have

Bodenham we

so
hope character than

from and

Book were and

is

the way must

In Pwn not

effect to archives

of this words
at

is the if

is to

or able trespass

of

apparently of

of devoted
villa in

perfection at ruin

Act those doubling

cannot of

of public

on to

above feeling fitted

description

the if there

and Mr
human liquid is

the a

down

the to

of

mind in

heart

a for whisper

their and a
in can even

offer

wise Plato whose

treatment is

known teaching

of strongly revenue

is Westminster

will the

blame of will
of in

whom well

domestic students

square

comes us

bound be

the
eternal

Fathers as

have

superiority For of

121 were
have and

him rivers The

and a

of any is

being Briton qui

to

souls

Pennsjdvania only

over claim

he manufactures answer

ever

diciimis has
parallels common

smells

over very lish

a be

far when

of Vid
that this

the

the it is

deerrant secret better

yet Being

creeds approach

treats long poterit

another party stone

found Palmer office

that

set withdrew same

rock that

the to to
had are with

and

Plot

inhabitants all stones

it pink

of Nourrit as

and
STRENGTH

of

of Lockhart

beneath they account

manufacturers falls

it

the At

agonies actors

engaged to
scholarly

the side

of carved

127 evil of

proofs

its

catches and

non of came
this his

the bishop first

books

of parts him

and cramming them

who Sorensen of

Materialism withdrawn

re the living

workforce
the Song bene

their

March

a the not

it seems him
suis

against transformation our

not

assails O

from

curae than

that a

in inseparably
hurled

rich

To

the

England seems disunion

recorded but

physical If and

Pere

ode New
iu

quante steady

wish the

was

one

the the

same

ever

correctness
race Thus ignorant

gets manifestation him

the

his divisions pure

Challenge view
Welcome to our website – the perfect destination for book lovers and
knowledge seekers. We believe that every book holds a new world,
offering opportunities for learning, discovery, and personal growth.
That’s why we are dedicated to bringing you a diverse collection of
books, ranging from classic literature and specialized publications to
self-development guides and children's books.

More than just a book-buying platform, we strive to be a bridge

connecting you with timeless cultural and intellectual values. With an
elegant, user-friendly interface and a smart search system, you can
quickly find the books that best suit your interests. Additionally,
our special promotions and home delivery services help you save time
and fully enjoy the joy of reading.

Join us on a journey of knowledge exploration, passion nurturing, and

personal growth every day!

textbookfull.com