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Women’s Health in Mid-Life
A Primary Care Guide

This book highlights the needs and healthcare concerns of women in their mid
life. Women in middle age are often overlooked by medical practitioners. From
the end of childbearing to old age, approximately ages 40–65 years, their health
needs are complex and changing. This is a time of challenge and opportunity,
when the physician and woman working collaboratively can change her health
and future. Mid-life healthcare is far more than hormones. Healthy behaviors
such as good nutrition and exercise can be promoted, which will result in lower
risk and sometimes improved care of heart disease, hypertension, and diabetes.
Adequate screening and treatment can prevent diseases and complications.
This book performs a critical evaluation of the burgeoning literature on
allopathic and complementary medicine and compares it with that of
established medical care. Written by 20 primary-care physicians, this book will
help family practitioners provide the best possible healthcare for these women.

Dr Jo Ann Rosenfeld is Assistant Professor of General Internal Medicine at


Johns Hopkins School of Medicine, and former Professor of Family Medicine
at East State Tennessee University. Her editorial responsibilities include being
Associate Editor of BMJ USA, Associate Editor of AAFP FP Comprehensive
Monograph Course, and Associate Editor of the Johns Hopkins Advanced
Studies in Internal Medicine journal. She is the author of 50 articles on
women’s health, and three other books on the subject, including Handbook of
Women’s Health (Cambridge University Press, 2001) and Women’s Health in
Primary Care (Lippincott Williams & Wilkins, 1997).
Women’s Health
in Mid-Life
A Primary Care Guide

Edited by

Jo Ann Rosenfeld
cambridge university press
Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, São Paulo

Cambridge University Press


The Edinburgh Building, Cambridge cb2 2ru, UK
Published in the United States of America by Cambridge University Press, New York
www.cambridge.org
Information on this title: www.cambridge.org/9780521823401

© Cambridge University Press 2004

This publication is in copyright. Subject to statutory exception and to the provision of


relevant collective licensing agreements, no reproduction of any part may take place
without the written permission of Cambridge University Press.

First published in print format 2004

isbn-13 978-0-511-18472-7 eBook (NetLibrary)


isbn-10 0-511-18472-7 eBook (NetLibrary)

isbn-13 978-0-521-82340-1 paperback


isbn-10 0-521-82340-4 paperback

Cambridge University Press has no responsibility for the persistence or accuracy of urls
for external or third-party internet websites referred to in this publication, and does not
guarantee that any content on such websites is, or will remain, accurate or appropriate.
To my mother, Judy Rosenfeld,
who taught me how to write.
Contents

List of contributors page x

1 Introduction 1
Jo Ann Rosenfeld

Part I Health promotion


2 Physical activity and exercise 7
Tanya A. Miszko

3 Nutrition 23
Victoria S. Kaprielian, Gwendolyn Murphy and
Cathrine Hoyo

4 Psychosocial health promotion of mid-life women 45


Cathy Morrow

5 Sexual health 61
Margaret R. H. Nusbaum

6 Alcoholism, nicotine dependence, and drug abuse 81


Mary-Anne Enoch

7 Depression and anxiety 97


Anne Walling

Part II Hormonal changes


8 Physical changes in menopause and perimenopause 125
Margaret Gradison

vii
viii Contents

9 Spiritual and psychological aspects of menopause 137


Melissa H. Hunter and Dana E. King

10 Hormone therapy 151


Kathy Andolsek

11 Contraception and fertility 191


Tracey D. Conti

Part III Disease prevention


12 Prevention of coronary heart disease in women 209
Valerie K. Ulstad

13 Hypertension and stroke 225


Jo Ann Rosenfeld

14 Diagnosis and treatment of osteoporosis 235


Jeannette E. South-Paul

15 Diabetes in mid-life women 253


Phillippa Miranda and Diana McNeill

Part IV Cancer prevention


16 Breast cancer: screening and prevention 275
Jo Ann Rosenfeld

17 Cervical cancer: prevention, screening, and early


detection 287
Jo Ann Rosenfeld

18 Endometrial cancer: prevention, screening, and


early detection 293
Ellen Sakornbut

19 Ovarian cancer: prevention, screening, and early


detection 311
Jo Ann Rosenfeld
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Contents ix

20 Colon, lung, and skin cancer: screening and prevention 327


Jo Ann Rosenfeld

21 Common gastrointestinal and urinary problems 335


Jo Ann Rosenfeld

Index 357
Contributors

Kathy Andolsek, M. D. Victoria S. Kaprielian, M. D.


Duke University Medical Center, Department of Community and
Durham, NC, USA Family Medicine, Duke University
Medical Center, Durham, NC, USA
Tracey D. Conti, M. D.
Dana E. King, M. D.
University of Pittsburgh, Pittsburgh,
Department of Family Medicine,
PA, USA
University Family Medicine,
Charleston, SC, USA
Mary-Anne Enoch, M. D.,
M. R. C. G. P Diana McNeill, M. D., F. A. C. P
Laboratory of Neurogenetics, Department of Medicine, Division of
National Institute of Alcohol Abuse Endocrinology and Metabolism,
and Alcoholism, National Institutes Duke University Medical Center,
of Health, Bethesda, MD, USA Durham, NC, USA

Phillippa Miranda, M. D.
Margaret Gradison, M. D. Department of Medicine, Division of
Department of Community and Endocrinology and Metabolism,
Family Medicine, Duke University Duke University Medical Center,
Medical Center, Durham, NC, Durham, NC, USA
USA
Tanya A. Miszko, Ed. D., C. S. C. S
Cathrine Hoyo, M. P. H., Ph. D. VA Medical Center (Atlanta),
Department of community and Decatur, GA, USA
Family Medicine, Duke University
Cathy Morrow, M. D.
Medical Center, Durham, NC,
Marine Dartmouth Family Practice
USA
Residency

Melissa H. Hunter, M. D. Gwendolyn Murphy, Ph. D., R. D.


Department of Family Medicine, Department of Community and
University Family Medicine, Family Medicine, Duke University
Charleston, SC, USA Medical Center, Durham, NC, USA

x
List of contributors xi

Margaret R. H. Nusbaum, D. O., Jeannette E. South-Paul, M. D.


M. P. H. Department of Family Medicine,
Department of Family Medicine, University of Pittsburgh, Pittsburgh,
University of North Carolina, Chapel PA, USA
Hill, NC, USA
Valerie K. Ulstad, M. D., M. P. H.,
Jo Ann Rosenfeld, M. D. M. P. A., F. A. C. C.
Johns Hopkins School of Medicine, West Hennepin County Medical
Baltimore, MD Center, Minneapolis, MN, USA

Ellen Sakornbut, M. D. Anne Walling, M. D.


University of Iowa University of Kansas, Wichita
1

Introduction
Jo Ann Rosenfeld

The middle ages of women are an often forgotten time and the women are often
overlooked in healthcare. No longer in their childbearing and birth control
years, and not yet geriatric, the women are frequently ignored or their needs
and wishes combined into one homogeneous group. Regularly, healthcare
providers address only the women’s hormonal needs and minimize discussion
of their health and wellbeing. These women, who are from the ages of 40 to
65, are in a variety of situations and circumstances, both medical and social.
These ages are a time of change, stress, and opportunity.
Despite the fact that there are more women than men at every age, this
time of change is poorly studied and understood for women (Figure 1.1).
Many large population studies have not included women, have included only
a few women, or have not reported data by gender. Few studies have examined
this age group. The change to adolescence, adulthood, and elder has been
well examined and researched. Each of these ages has their own specialists
(obstetrician/gynecologist or geriatrician). However, the middle ages are often
neglected. Menopause is not a disease, a definite time, or a curse. Its needs,
challenges, and effects on women’s health are not understood well. Familial
and social stresses may be challenging or overpowering, as the woman has to
redefine herself within society, employment, and her family.
The opportunities for improvement for future health are immense. Women
can make lifestyle changes that will profoundly affect their future health, com-
fort, and length of life. Quitting smoking, improving exercise regimens, and
achieving ideal body weight can improve the rest of a woman’s life. Treatment
of hypertension and diabetes is believed to improve mortality and morbidity.
Screening for cancer may improve mortality. Health promotion and disease
prevention are possible if each woman is considered an individual and her
health needs addressed personally.
The social variations and changes in this age group are immense. The
woman can be a new mother, a mother of small children or adolescents, child-
less, a grandmother living with her husband or family, a widow alone, or a

1
2 Jo Ann Rosenfeld

12 000 000
10 000 000
Number of people

8 000 000
Women
6 000 000
Men
4 000 000

2 000 000
0

45--49 50--54 55--59 60--64


Age (years)

Figure 1.1 Population by age and gender, from US Census 2000.

Grandmother only 27

Family headed by Grandparents only 31

Grandmother with parents 13

0 10 20 30 40

Percentage increase

Figure 1.2 Percentage increase in families headed by grandmothers/grandparents


1990–1997. (From Casper, L. M. and Bryson, K. R. Co-resident grandparents and
their grandchildren: grandparent maintained families. Population Division, US Bu-
reau of the Census, Washington, DC, March 1998. http://www.census.gov/population/
www/documentation/twps0026/twps0026.html. Accessed April 13, 2003.)

grandmother raising small grandchildren. Twenty five million women aged


15–44 in the USA are childless.1 Approximately 19% of women age 40–44
were childless in 1994 in the USA, almost double the number in 1970.2
They can be single, married, divorced, or widowed. The traditional depic-
tion of the aging mother or grandmother with “empty nest” concerns may
not be valid. The number of never-married women aged 39 almost tripled
from 1970 to 1994, from 5 to 13%.1 The woman may have husband, mother,
grown children, or their children living with her. Women are more likely
to be living alone than men. Approximately 14% of women live alone, and
this number has doubled from 1970 to 1994.1 In the past decade, the num-
ber of grandmother-headed families has increased tremendously, and those
grandparent- or grandmother-headed families are more likely to be in poverty
or receiving public assistance (Figures 1.2 and 1.3).3
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