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Big Data in eHealthcare
Challenges and Perspectives
Big Data in eHealthcare
Challenges and Perspectives
Nandini Mukherjee
Sarmistha Neogy
Samiran Chattopadhyay
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
This book contains information obtained from authentic and highly regarded sources. Reasonable
efforts have been made to publish reliable data and information, but the author and publisher cannot
assume responsibility for the validity of all materials or the consequences of their use. The authors and
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Preface xv
Acknowledgements xvii
Authors xix
1 Introduction 1
References 12
2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
2.2 Electronic Health Records . . . . . . . . . . . . . . . . . . . 14
2.3 EHR Standards . . . . . . . . . . . . . . . . . . . . . . . . . 16
2.3.1 ISO 13606 . . . . . . . . . . . . . . . . . . . . . . . . . 17
2.3.2 HL7 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18
2.3.3 OpenEHR . . . . . . . . . . . . . . . . . . . . . . . . . 23
2.4 Adoption of EHR Standards . . . . . . . . . . . . . . . . . . 30
2.5 Ontology-based Approaches . . . . . . . . . . . . . . . . . . . 32
2.5.1 Developing an Ontology . . . . . . . . . . . . . . . . . 33
2.5.2 Ontologies for EHR . . . . . . . . . . . . . . . . . . . 33
2.5.3 Ontologies in Healthcare . . . . . . . . . . . . . . . . . 34
2.6 Chapter Notes . . . . . . . . . . . . . . . . . . . . . . . . . . 35
vii
viii Contents
References 40
3.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
3.2 What Is Big Data? . . . . . . . . . . . . . . . . . . . . . . . 44
3.3 Big Data Properties . . . . . . . . . . . . . . . . . . . . . . . 45
3.4 Why Is Big Data Important? . . . . . . . . . . . . . . . . . . 47
3.5 Big Data in the World . . . . . . . . . . . . . . . . . . . . . . 49
3.6 Big Data in Healthcare . . . . . . . . . . . . . . . . . . . . . 50
3.6.1 Is Health Data Big Data? . . . . . . . . . . . . . . . . 51
3.6.2 Big Data: Healthcare Providers . . . . . . . . . . . . . 52
3.7 Other Big Data Applications . . . . . . . . . . . . . . . . . . 54
3.7.1 Banking and Securities . . . . . . . . . . . . . . . . . . 55
3.7.2 Communications, Media, and Entertainment . . . . . 55
3.7.3 Manufacturing and Natural Resources . . . . . . . . . 56
3.7.4 Government . . . . . . . . . . . . . . . . . . . . . . . . 56
3.7.5 Transportation . . . . . . . . . . . . . . . . . . . . . . 56
3.7.6 Education . . . . . . . . . . . . . . . . . . . . . . . . . 56
3.8 Securing Big Data . . . . . . . . . . . . . . . . . . . . . . . . 57
3.8.1 Security Considerations . . . . . . . . . . . . . . . . . 57
3.8.2 Security Requirements . . . . . . . . . . . . . . . . . . 58
3.8.3 Some Observations . . . . . . . . . . . . . . . . . . . . 59
3.9 Big Data Security Framework . . . . . . . . . . . . . . . . . 59
3.10 Chapter Notes . . . . . . . . . . . . . . . . . . . . . . . . . . 61
References 62
4.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
4.2 Wireless Body Area Network . . . . . . . . . . . . . . . . . . 66
4.2.1 BAN Design Aspects . . . . . . . . . . . . . . . . . . . 68
4.2.2 WBAN Sensors . . . . . . . . . . . . . . . . . . . . . . 70
4.2.3 Technologies for WBAN . . . . . . . . . . . . . . . . . 70
4.2.3.1 Bluetooth and Bluetooth LE . . . . . . . . . 70
4.2.3.2 ZigBee and WLAN . . . . . . . . . . . . . . 71
4.2.3.3 WBAN standard . . . . . . . . . . . . . . . . 71
4.2.4 Network Layer . . . . . . . . . . . . . . . . . . . . . . 73
4.2.5 Inter-WBAN Interference . . . . . . . . . . . . . . . . 74
4.3 Crowdsourcing . . . . . . . . . . . . . . . . . . . . . . . . . . 76
4.4 Social Network . . . . . . . . . . . . . . . . . . . . . . . . . . 79
4.5 Chapter Notes . . . . . . . . . . . . . . . . . . . . . . . . . . 83
References 84
Contents ix
5.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 88
5.2 Artificial Neural Networks . . . . . . . . . . . . . . . . . . . 90
5.2.1 Model of an ANN . . . . . . . . . . . . . . . . . . . . 90
5.2.2 Modes of ANN . . . . . . . . . . . . . . . . . . . . . . 92
5.2.3 Structure of ANNs . . . . . . . . . . . . . . . . . . . . 93
5.2.4 Training a Feedforward Neural Network . . . . . . . . 93
5.2.5 ANN in Medical Domain . . . . . . . . . . . . . . . . 96
5.2.6 Weakness of ANNs . . . . . . . . . . . . . . . . . . . . 97
5.3 Classification and Clustering . . . . . . . . . . . . . . . . . . 98
5.3.1 Clustering via K-Means . . . . . . . . . . . . . . . . . 99
5.3.2 Some Additional Remarks about K-Means . . . . . . . 100
5.4 Statistical Classifier: Bayesian and Naive Classification . . . 102
5.4.1 Experiments with Medical Data . . . . . . . . . . . . 104
5.4.2 Decision Trees . . . . . . . . . . . . . . . . . . . . . . 106
5.4.3 Clasical Indction of Decision Trees . . . . . . . . . . . 108
5.5 Association Rule Mining (ARM) . . . . . . . . . . . . . . . . 111
5.5.1 Simple Approach for Rule Discovery . . . . . . . . . . 112
5.5.2 Processing of Medical Data . . . . . . . . . . . . . . . 113
5.5.3 Association Rule Mining in Health Data . . . . . . . . 113
5.5.4 Issues with Association Rule Mining . . . . . . . . . . 114
5.6 Time Series Analysis . . . . . . . . . . . . . . . . . . . . . . 115
5.6.1 Time Series Regression Models . . . . . . . . . . . . . 116
5.6.2 Linear AR Time Series Models . . . . . . . . . . . . . 117
5.6.3 Application of Time Series . . . . . . . . . . . . . . . 120
5.7 Text Mining . . . . . . . . . . . . . . . . . . . . . . . . . . . 120
5.7.1 Term Frequency and Inverse Document Frequency . . 122
5.7.2 Topic Modeling . . . . . . . . . . . . . . . . . . . . . . 123
5.8 Chapter Notes . . . . . . . . . . . . . . . . . . . . . . . . . . 124
References 126
References 161
References 189
References 228
Index 233
List of Figures
xiii
xiv Big Data in eHealthcare: Challenges and Perspectives
6.1 (a) Linear speedup, (b) Super-linear speedup, and (c) Sub-
linear speedup . . . . . . . . . . . . . . . . . . . . . . . . . . 132
6.2 Execution of a parallel code - Amdahl’s law . . . . . . . . . 134
6.3 Shared memory multiprocessors . . . . . . . . . . . . . . . . 136
6.4 Distributed memory multicomputer . . . . . . . . . . . . . . 137
6.5 Distributed shared memory . . . . . . . . . . . . . . . . . . 138
6.6 A hierarchical hybrid architecture . . . . . . . . . . . . . . . 139
6.7 GPU architecture [Source: [10]] . . . . . . . . . . . . . . . . 141
6.8 Memory organization in a GPU architecture [Source: [10]] . 142
6.9 Shared Address Space programming model . . . . . . . . . . 144
6.10 Message Passing programming model . . . . . . . . . . . . . 145
6.11 A workflow of MapReduce program . . . . . . . . . . . . . . 146
6.12 MapReduce execution environment [Source: [6] [7]] . . . . . 148
6.13 Hadoop architecture overview . . . . . . . . . . . . . . . . . 149
6.14 YARN application execution . . . . . . . . . . . . . . . . . . 150
6.15 HDFS architecture . . . . . . . . . . . . . . . . . . . . . . . 151
6.16 Apache Flume data model. [Source: https://flume.apache.org] 157
6.17 Apache Spark Streaming . . . . . . . . . . . . . . . . . . . . 158
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