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Cardiac Catheterization and Percutaneous
Interventions
Cardiac Catheterization and
Percutaneous Interventions
Edited by

I Patrick Kay MBChB PhD

Interventional Cardiologist
Cardiology Department
Dunedin Hospital
Dunedin ,New Zealand

Manel Sabaté MD PhD FESC

Servicio de Cardiologia Intervencionista


Hospital Clinico Universitario San Carlos
Madrid , Spain

Marco A Costa MD PhD FSCAI

Assistant Professor of Medicine


Director of Research & Cardiovascular Imaging Core Laboratories
Division of Cardiology, University of Florida, Shands Jacksonville
Jacksonville, FL, USA

Foreword by Patrick W Serruys MD PhD FACC FESC

LONDON AND NEWYORK


A MARTIN DUNITZ BOOK
© 2004 Taylor & Francis, an imprint of the Taylor & Francis Group
First published in the United Kingdom in 2004 by Taylor & Francis, an imprint of the Taylor &
Francis Group, 11 New Fetter Lane, London EC4P 4EE Tel.: +44 (0) 20 7583 9855 Fax.: +44 (0)
20 7842 2298 E-mail: [email protected] Website: http://www.dunitz.co.uk/
This edition published in the Taylor & Francis e-Library, 2005.
“To purchase your own copy of this or any of Taylor & Francis or Routledge’s collection of
thousands of eBooks please go to http://www.ebookstore.tandf.co.uk/.”
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or
transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or
otherwise, without the prior permission of the publisher or in accordance with the provisions of the
Copyright, Designs and Patents Act 1988 or under the terms of any licence permitting limited
copying issued by the Copyright Licensing Agency, 90 Tottenham Court Road, London W1P 0LP.
Although every effort has been made to ensure that all owners of copyright material have been
acknowledged in this publication, we would be glad to acknowledge in subsequent reprints or
editions any omissions brought to our attention.
The Authors have asserted his right under the Copyright, Designs and Patents Act 1988 to be
identified as the Author of this Work.
Although every effort has been made to ensure that drug doses and other information are presented
accurately in this publication, the ultimate responsibility rests with the prescribing physician.
Neither the publishers nor the authors can be held responsible for errors or for any consequences
arising from the use of information contained herein. For detailed prescribing information or
instructions on the use of any product or procedure discussed herein, please consult the prescribing
information or instructional material issued by the manufacturer.
A CIP record for this book is available from the British Library.
Library of Congress Cataloging-in-Publication Data
Data available on application

ISBN 0-203-49483-0 Master e-book ISBN

ISBN 0-203-59572-6 (Adobe e-Reader Format)


ISBN 1-84184-230-3 (Print Edition)
Distributed in North and South America by Taylor & Francis 2000 NW Corporate Blvd Boca
Raton, FL 33431, USA
Within Continental USA Tel.: 800 272 7737; Fax.: 800 374 3401 Outside Continental USA Tel.:
561 994 0555; Fax.: 561 361 6018 E-mail: [email protected]
Distributed in the rest of the world by Thomson Publishing Services Cheriton House North Way
Andover, Hampshire SP10 5BE, UK Tel.: +44 (0)1264 332424 E-mail:
[email protected]
Composition by EXPO Holdings, Malaysia
Contents

List of Contributors viii


Foreword xiv
Preface xvi

1. Who should not go to the cathlab? 1


I Patrick Kay and Robert J Walker
2. Radiation safety in the catheterization laboratory 13
Ad den Boer
3. Current use of antiplatelet agents 43
Brett M Sasseen, Deepak L Bhatt
4. Complications and how to deal with them 97
Rosanna Hernandez Antolín
5. Vascular access 126
I Patrick Kay
6. Basic coronary angiography: techniques, tools and troubleshooting 141
John Ormiston, Mark Webster, Barbara O’Shaughnessy
7. Right heart catheterization and hemodynamic profiles 161
Arthur W Crossman, Brett M Sasseen
8. Balloon angioplasty 215
Ken Kozuma
9. Coronary stenting 232
Marco A Costa
10. Ablative techniques in coronary intervention 246
Paul S Gilmore
11. Treatment of complex angioplasty subsets 264
Carlo Di Mario
12. Primary angioplasty for acute myocardial infarction 275
Giuseppe De Luca, Harry Suryapranata
13. The role of distal protection devices 295
Arun Kuchela, Campbell Rogers
14. Pathophysiology of restenosis 312
Stefan Verheye, Glenn Van Langenhove, Guiseppe M Sangiorgi
15. Pharmacological treatment of restenosis 332
Manel Sabaté
16. Mechanical treatment of in-stent restenosis .355
Fernando Alfonso, María-José Pérez-Vizcayno
17. Restenosis and brachytherapy 386
Patrick Kay, Manel Sabaté
18. Drug-eluting stents 409
Marco A Costa
19. Intravascular ultrasound 437
Dominick J Angiolillo, Fernando Alfonso
20. Physiological assessment of coronary circulation using pressure and 477
Doppler guidewires
Javier Escaned
21. Invasive imaging of vulnerable plaque 510
Glenn Van Langenhove, Johannes Schaar, Stefan Verheye
22. Noninvasive coronary imaging with multislice spiral computed tomography 527
Pedro A Lemos, Koen Neiman
23. Myogenesis: an update in muscle regeneration 539
Chi Hang Lee, Pieter C Smits
24. Circulatory assist devices 561
Dominick J Angiolillo
25. Groin closure devices 583
Manel Sabaté
26. Stent retrieval 606
Goran Stankovic, Antonio Colombo
27. Percutaneous atrial septal defect, patent foramen ovale closure and patent 620
ductus arteriosus closure
David McGaw, Richard Harper
28. Carotid and peripheral angiography and intervention 661
Gishel New, Sriram S Iyer, Jiri J Vitek, Gary S Roubin
29. The importance of echocardiography to the interventionalist 693
Michael JA Williams
30. Percutaneous mitral valvuloplasty 710
Gerard T Wilkins

Index 740
Contributors
Fernando Alfonso MD PhD FESC
Consultant Cardiologist
Interventional Cardiology
Cardiovascular Institute
San Carlos University Hospital
Madrid
Spain

Dominick J Angiolillo MD
International Cardiology Unit
Cardiovascular Unit
San Carlos University Hospital
Madrid
Spain

Theodore Adam Bass MD


Professor
Chief, Division of Cardiology
Medical Director, The Cardiovascular Center at Shands Jacksonville
Director, Interventional Cardiology Fellowship Program
FL, USA

Deepak L Bhatt MD
Interventional Cardiology
Director, Interventional Cardiology Fellowship
Associate Director, Cardiovascular Fellowship
The Cleveland Clinic Foundation
Department of Cardiovascular Medicine
Cleveland, OH, USA

Ad den Boer BSC


Technical Research Coordinator & Project Leader
Thoraxcentre
University Hospital-Dijkzigt
Rotterdam
The Netherlands

Antonio Colombo MD
EMO Centro Cuore Columbus
Milan, Italy
Marco A Costa MD PhD FSCAI
Assistant Professor of Medicine
Director of Research & Cardiovascular
Imaging Core Laboratories
Division of Cardiology, University of Florida, Shands Jacksonville
Jacksonville, FL, USA

Arthur W Crossman MD
The Cardiovascular Center at Shands
Jacksonville, FL, USA

Giuseppe De Luca MD
Interventional Cardiologist
Department of Cardiology
Isaka Kliniken
De Weezenlanden Hospital
Zwolle, The Netherlands

Carlo Di Mario MD PhD


Consultant Cardiologist
Royal Brompton Hospital
London, UK

Javier Escaned MD PhD FESC


Department of Interventional Cardiology
Hospital Clinico San Carlos
Madrid, Spain

Paul S Gilmore MD
The Cardiovascular Center at Shands
Jacksonville, FL, USA

Richard Harper MBBS FRACP FACC


Professor
Department of Medicine
Monash University
Department of Cardiology and Cardiovascular Research
Monash Medical Center
Clayton, VIC, Australia

Rosana Hernandez Antolín MD


PhD FESC
Interventional Cardiology Unit
Instituto Cardiovascular
Hospital Universitario San Carlos
Madrid
Spain

Sriram S Iyer MD
Director of Endovascular Therapy
Lenox Hill Hospital
New York NY, USA

I Patrick Kay MBChB PhD


Interventional Cardiologist
Cardiology Department
Dunedin Hospital
Dunedin
New Zealand

Ken Kozuma MD
Division of Cardiology
Department of Internal Medicine,
Teikyo University School of Medicine
Tokyo, Japan

Arun Kuchela MD FRCPC


Fellow in Interventional Cardiology
University of British Columbia, Vancouver Health Sciences Center
Cardiac Catherization Laboratories
Vancouver, BC, Canada

Chi Hang Lee MBBS MRCP FAMS


Associate Consultant Cardiologist
Cardiac Department
National University Hospital
Singapore

Pedro A Lemos MD
Thoraxcenter
Department of Cardiology
Erasmus Medical Center
Rotterdam
The Netherlands

David McGaw MBBS (PhD)


Centre for Heart and Chest Research
Monash University and Monash Medical Centre
Clayton
Melbourne, VIC, Australia
Koen Neiman MD Thoraxcenter
Department of Cardiology
Erasmus Medical Center
Rotterdam
The Netherlands

Gishel New MBBS PhD FRACP FACC


Director of Cardiology
Box Hill Hospital
Monash University Department of Medicine
Melbourne, Australia

John Ormiston FRACR, FRACP


Cardiac Investigation Rooms
Green Lane and Mercy Hospitals
Epsom
Auckland
New Zealand

Barbara O’Shaughnessy DSR BHSc


Mercy Angiography
Newmarket
Auckland
New Zealand

María José Pérez-Vizcayno MD


Interventional Cardiology
Cardiovascular Institute
San Carlos University Hospital
Madrid, Spain

Campbell Rogers MD FACC


Director, Cardiac Catheterization Laboratory
Director, Experimental Cardiovascular Interventional Laboratory
Brigham and Women’s Hospital
Harvard Medical School
Boston, MA, USA

Gary S Roubin MBBS PhD FRACP


FACC FAHA
Director of Cardiology
Alfred Hospital
Monash University
Melbourne, Australia
Manel Sabaté MD PhD FESC
Interventional Cardiology Department
Cardiovascular Institute
San Carlos University Hospital
Madrid
Spain

Giuseppe M Sangiorgi MD
Interventional Cardiology
Emo Centro Cuore Columbus
Milan
Italy

Brett M Sasseen MD
Assistant Professor, Associate Director
Cardiovascular Disease Fellowship
Program and Associate Director,
Interventional Cardiology Fellowship Program

Johannes Schaar MD
Erasmus MC
Thoraxcenter
Rotterdam, The Netherlands

Pieter C Smits MD PhD


Clinical Director
Department of Interventional Cardiology
Erasmus Medical Center
Thoraxcenter
Rotterdam
The Netherlands

Goran Stankovic MD
Institute for Cardiovascular Diseases
Clinical Center of Serbia
Belgrade
Serbia and Montenegro

Harry Suryapranata, MD PhD


Interventional Cardiologist
Director of Clinical Research and Catheterization Laboratory
Isala Klinieken
Hospital De Weezelanden
Department of Cardiology
Zwolle, The Netherlands
Glenn Van Langenhove MD PhD
Interventional Cardiology
Middelheim Hospital Antwerp
Antwerp
Belgium

Stefan Verheye MD FESC


Cardiovascular Translational Research Institute
Antwerp
Belgium

Jiri J Vitek MD PhD


Lenox Hill Hospital
New York, NY, USA

Robert J Walker MBChBMD(Otago)


FRACP
Professor of Medicine
Consultant Nephrologist
Head of Department, Department of Medical & Surgical Sciences
Dunedin School of Medicine
University of Otago Dunedin
New Zealand

Mark Webster FRACP


Mercy Angiography
Newmarket
Auckland
New Zealand

Michael JA Williams MD FRACP


FACC
Cardiologist
Dunedin Hospital
Dunedin, New Zealand

Gerard T Wilkins MB ChB FRACP


Clinical Leader
Cardiology, Cardiothoracic Surgery,
Respiratory, Nephrology and Endocrinology
Dunedin Hospital
Senior Lecturer in Medicine
University of Otago Medical School Dunedin
New Zealand
Foreword

“The results of coronary angioplasty in patients with single vessel disease are sufficiently
good to make the procedure acceptable for prospective randomised trials.” So wrote
Andreas Gruntzig in 1979, reporting the results of the first 50 patients treated with
angioplasty. This paper represented the birth of one the major medical techniques of the
20th century.
Andreas Gruntzig pioneered and championed the new science of interventional
cardiology. Since his time there has been a spiralling increase in technology and
information. The transformation into an invasive or interventional cardiologist must
account for these new technologies in a tactile and cognitive sense.
Drs Kay, Sabaté and Costa have created a book with both practical and scientific
application, that will greatly assist the cardiologist. Chapters have been written by leading
authors in their field and rising stars.
I congratulate the editors on their execution of their assignment. At last we have a text
that is truly useful to the growth of the interventionalist.
Patrick W Serruys,
February 2004
Preface

Few fields of medicine have advanced at a more rapid rate than that of percutaneous
intervention. Training and experience is the foundation on which an accomplished
interventionalist stands. No text can profess to supplant this foundation, but in Cardiac
Catheterization and Percutaneous Interventions we have created a practical text that will
allay the fears of these early encounters and create confidence in performing
percutaneous coronary and peripheral intervention.
We have created novel and exciting chapters addressing the basics (the things you
wouldn’t dare to ask), the pitfalls (the problems to avoid before you start), the proven
approaches (the facts you are expected to know) and the new innovations (the techniques
you will want to be first to perfect).
We would like to thank the contributors, all great practitioners and teachers who
responded so willingly to our quest to create a current, practical and challenging text.
Special thanks should go to Alan Burgess and Abigail Griffin from Martin Dunitz
Publishers whose expert guidance at critical moments allowed Cardiac Catheterization
and Percutaneous Interventions to come to fruition.
I Patrick Kay, Manel Sabaté, Marco A Costa
1
Who should not go to the cathlab?
I Patrick Kay, Robert J Walker

General

Theoretically, there are few absolute contraindications to coronary angiography.


Fortunately most people who are suitable for angiography will also be suitable for
angioplasty. There are a few caveats that are relevant for patient selection, and we will
discuss them in the next few pages. Some of these issues will be resolved over the next
few years as non-invasive forms of coronary imaging become widely applicable. These
imaging modalities may still involve the use of contrast, depending on whether they are
based on computed tomography (CT) or magnetic resonance imaging (MRI). Despite
these innovations, angioplasty will persist as the therapeutic intervention of choice for the
majority of cases with coronary artery disease.
The first part of this chapter discusses areas that may cause concern, approaching the
problem from the standpoint of a ‘surgical sieve’. The second part discusses the very
important area of renal disease.

Non-renal areas of concern

Cardiac issues
The following would constitute relative contraindications to catheterization:
• Uncontrolled ventricular irritability. Patients with ventricular arrythmia commonly
require coronary angiography to rule out an ischemically mediated process. Indeed,
coronary angiography with percutaneous coronary intervention (PCI) may be the only
way to control a persistent malignant arrythmia under such circumstances.
• Severe electrolyte imbalance (potassium, sodium and calcium). These derangements
should be treated prior to presentation to the catheterization laboratory.
• Uncontrolled hypertension. Vigorous attempts should be made to control blood pressure
prior to presentation to the catheterization laboratory. Poor control may lead to groin
complications, increased coronary ischemia and stroke. The risk of stroke will also be
increased should aggressive antiplatelet therapy be required in this context.
• Uncontrolled left ventricular failure. Unless left ventricular failure has been induced by
an ischemically mediated event, in particular myocardial infarction with cardiogenic
shock, the case should be deferred. In cases with ischemically mediated cardiogenic
shock, intraaortic balloon pump insertion with angioplasty should be contemplated.
Cardiac catheterization and percutaneous interventions 2

• Drug toxicity (digitalis or overdose with other agents). This situation may lead to or
may be secondary to renal failure. Attempts should be made to decrease drug levels
and provide cardiac support prior to coronary angiography. Cardiac pacing may be
required.

Febrile illness
Cardiac catheterization is not absolutely contraindicated in patients with fever or
infections. It would be wise, however, to contemplate the source of the infection, as
substantial comorbidity could be associated even with a simple procedure such as
angiography. A typical example is renal tract infection (see later in this chapter). The
final decision will be placed in the hands of the physician, who will need to weigh up the
risk of cardiac disease against that of the infection and its source.

Hematopoietic
Not infrequently, the physician will be confronted with marked abnormalities in
hematological parameters. The most notable is likely to be thrombocytopenia. Most
operators would be ill advised to consider cardiac catheterization on individuals with
platelet counts less than 80 000. One would be even more reluctant to proceed if PCI
were contemplated, given that antiplatelet therapy is still likely to be prescribed. A
minimum platelet count of 100 000 is advised in those contemplating PCI. Similarly,
severe neutropenia in patients (neutrophil count < 0.5) would be considered an absolute
contraindication to either catheterization or PCI.
Severe anemia (Hb <80 g/l) may also be a contraindication to cardiac catheterization,
particularly if PCI is contemplated. Appropriate transfusion of blood and gastrointestinal
(GI) or bone marrow investigation should be contemplated. If urgent catheterization is
required, then this can be performed with increased risk. Polycythemia, thrombophilia,
and the leukemias are not absolute contraindications to cardiac catheterization. Instead,
the medication used in the control of these illnesses may interact with those used at the
time of catheterization/ PCI. Due consultation with a hematologist is advisable.
The final and of course most common cause of abnormal hematological finding is
iatrogenic in origin – abnormal coagulation profiles secondary to the therapeutic
ingestion of coumadin derivatives, or adverse reactions to other drugs. Generally
speaking, this does not pose a major problem, as patients can be deferred until the
international normalized ratio (INR) falls to lower levels (INR < 2.0). During this time,
subcutaneous or intravenous heparin can be substituted if necessary. Alternatively, the
femoral artery can be avoided and the radial approach used in preference if urgent
therapy is necessary.

Gastrointestinal
Active gastrointestinal bleeding is generally a contraindication to cardiac catheterization
and PCI. In individuals who develop GI bleeding prior to planned catheterization, the
procedure should be deferred until appropriate upper or lower GI investigation has been
completed. Urgent catheterization is only rarely required in those with active GI bleeding.
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