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Diagnostic Radiology
Paediatric Imaging
PIONEERS OF AIIMS-MAMC-PGI IMAGING COURSE SERIES
Manorama Berry Sudha Suri Veena Chowdhury
PAST EDITORS
Sima Mukhopadhyay Sushma Vashisht
AIIMS-MAMC-PGI IMAGING SERIES
Diagnostic Radiology
Paediatric Imaging
THIRD EDITION
Editors
Arun Kumar Gupta MD MAMS Veena Chowdhury MD Niranjan Khandelwal MD DNB FICR
Professor and Head Director Professor and Head Professor and Head
Department of Radiodiagnosis Department of Radiodiagnosis Department of Radiodiagnosis
All India Institute of Medical Sciences Maulana Azad Medical College PGIMER, Chandigarh, India
Ansari Nagar, New Delhi, India New Delhi, India
Associate Editors
Ashu Seith Bhalla MD Sanjay Thulkar MD
Associate Professor Associate Professor
Department of Radiodiagnosis Department of Radiodiagnosis (IRCH)
All India Institute of Medical Sciences All India Institute of Medical Sciences
Ansari Nagar, New Delhi, India Ansari Nagar, New Delhi, India
JAYPEE BROTHERS MEDICAL PUBLISHERS (P) LTD
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Diagnostic Radiology: Paediatric Imaging
© 2011, Jaypee Brothers Medical Publishers
All rights reserved. No part of this publication should be reproduced, stored in a retrieval system, or transmitted in any form or by any
means: electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the editors and the
publisher.
This book has been published in good faith that the material provided by contributors is original. Every effort is made to ensure
accuracy of material, but the publisher, printer and editors will not be held responsible for any inadvertent error(s). In case of any
dispute, all legal matters are to be settled under Delhi jurisdiction only.
First Edition: 1997
Second Edition: 2004
Third Edition: 2011
ISBN 978-93-5025-205-5
Typeset at JPBMP typesetting unit
Printed at
CONTRIBUTORS
Ajay Garg MD Ashu Seith Bhalla MD Department of Radiodiagnosis
Assistant Professor Associate Professor PGIMER, Chandigarh, India
Department of Neuroradiology Department of Radiodiagnosis
All India Institute of Medical Sciences All India Institute of Medical Sciences Manisha Jana MD DNB FRCR
Ansari Nagar Ansari Nagar Senior Resident
New Delhi, India New Delhi, India Department of Radiodiagnosis
All India Institute of Medical Sciences
Akshay Kumar Saxena MD Atin Kumar MD MNAMS DNB Ansari Nagar, New Delhi, India
Associate Professor Assistant Professor
Department of Radiodiagnosis Department of Radiodiagnosis Naveen Kalra MD
PGIMER, Chandigarh, India Trauma Centre Associate Professor
All India Institute of Medical Sciences Department of Radiodiagnosis
Alpana Manchanda MD Ansari Nagar, New Delhi, India PGIMER, Chandigarh, India
Professor
Department of Radiodiagnosis Deep N Srivastava Niranjan Khandelwal MD DNB FICR
Maulana Azad Medical College MD MNAMS MBA Professor and Head
New Delhi, India Professor Department of Radiodiagnosis
Department of Radiodiagnosis PGIMER, Chandigarh, India
Amar Mukund MD All India Institute of Medical Sciences
Pool Officer Ansari Nagar, New Delhi, India P Singh
Department of Radiodiagnosis Additional Professor
All India Institute of Medical Sciences Gaurav S Pradhan DMRD DNB Department of Radiodiagnosis
Ansari Nagar, New Delhi, India Professor PGIMER, Chandigarh, India
Department of Radiodiagnosis
Anjali Prakash DMRD DNB MNAMS Maulana Azad Medical College Raju Sharma MD MNAMS
Professor New Delhi, India Additional Professor
Department of Radiodiagnosis Department of Radiodiagnosis
Maulana Azad Medical College Gurpreet Singh Gulati MD All India Institute of Medical Sciences
New Delhi, India Assistant Professor Ansari Nagar, New Delhi, India
Department of Cardiac Radiology
Anju Garg MD Cardio-Thoracic Centre Rashmi Dixit MD
Director Professor All India Institute of Medical Sciences Professor
Department of Radiodiagnosis Ansari Nagar, New Delhi, India Department of Radiodiagnosis
Maulana Azad Medical College Maulana Azad Medical College
New Delhi, India Jyoti Kumar MD New Delhi, India
Associate Professor
Ankur Gadodia MD DNB FRCR Department of Radiodiagnosis Sanjay Sharma MD FRCR DNB
Senior Resident Maulana Azad Medical College Associate Professor
Department of Radiodiagnosis New Delhi, India Department of Radiodiagnosis
All India Institute of Medical Sciences All India Institute of Medical Sciences
Ansari Nagar, New Delhi, India Kushaljit Singh Sodhi Ansari Nagar, New Delhi, India
Assistant Professor
Arun Kumar Gupta MD MNAMS Department of Radiodiagnosis Sanjay Thulkar MD
Professor and Head PGIMER, Chandigarh, India Associate Professor
Department of Radiodiagnosis Department of Radiodiagnosis (IRCH)
All India Institute of Medical Sciences Mahesh Prakash All India Institute of Medical Sciences
Ansari Nagar, New Delhi, India Assistant Professor Ansari Nagar, New Delhi, India
vi Diagnostic Radiology: Paediatric Imaging
Sanjiv Sharma MD All India Institute of Medical Sciences Sumedha Pawa MD
Professor and Head Ansari Nagar Director Professor
Department of Cardiac Radiology New Delhi, India Department of Radiodiagnosis
Cardio-Thoracic Centre Maulana Azad Medical College
All India Institute of Medical Sciences Shivanand Gamanagatti MD MNAMS New Delhi, India
Ansari Nagar, New Delhi, India Assistant Professor
Department of Radiodiagnosis Veena Chowdhury MD
Sapna Singh MD DNB MNAS Trauma Centre Director Professor and Head
Associate Professor All India Institute of Medical Sciences Department of Radiodiagnosis
Department of Radiodiagnosis Ansari Nagar, New Delhi, India Maulana Azad Medical College
Maulana Azad Medical College New Delhi, India
New Delhi, India Smriti Hari MD
Assistant Professor Vivek Gupta MD
Shailesh B Gaikwad MD Department of Radiodiagnosis Assistant Professor
Additional Professor All India Institute of Medical Sciences Department of Radiodiagnosis
Department of Neuroradiology Ansari Nagar, New Delhi, India PGIMER, Chandigarh, India
PREFACE TO THE THIRD EDITION
The first edition of diagnostic radiology on Paediatric Imaging was published in 1997, while the second edition followed
in 2004. The ever-evolving field of radiology and our commitment to our readers has motivated us to publish the third
edition now.
Rapid advances are taking place in the field of imaging. This results in the need for re-evaluating and redefining the
role of a modality in different clinical scenarios. Coupled to this, particularly in paediatric radiology is the need for
ensuring patient safety. The industry has made significant attempts to minimize radiation exposures in imaging and this
is pre-requisite that cannot be over-emphasized in children. Paediatric radiology is already a well-established subspecialty
in the West, but in the developing world due to the paucity of trained radiologists in proportion to our population, every
practicing radiologist needs to be aware of the special needs and disease entities in children.
The third edition of the book has been designed to include current recommendations, guidelines and existing
knowledge on the subject. The content of all chapters has been updated, while some have been significantly restructured.
New chapters have also been added. It is our earnest hope that our readers will find this text informative and that it will
aid in their learning process and daily practice.
We wish to thank all the contributors from the institutions, i.e. All India Institute of Medical Sciences, New Delhi;
Maulana Azad Medical College, New Delhi and Postgraduate Institute of Medical Education and Research, Chandigarh
for their efforts in updating this edition. We would also like to express our sincere appreciation to Shri Jitendar P Vij,
Chairman and Managing Director, Mr Tarun Duneja (Director-Publishing), Mr Subrato Adhikary (Author Co-ordinator),
Mrs Samina Khan (PA to Director-Publishing) and other staff of M/s Jaypee Brothers Medical Publishers (P) Ltd, for
their professionalism and dedication towards publication of this edition.
Arun Kumar Gupta
Veena Chowdhury
Niranjan Khandelwal
PREFACE TO THE FIRST EDITION
If we are to reach real peace in this world and we are to carry on real
war against war; we shall have to begin with children
MK Gandhi
Just as paediatrics is now justifiably recognized as a specialized area of medical practice, so has paediatric radiology, in
recent years gained recognition as a specialized branch of general radiology requiring specific knowledge of the diseases
of the young.
Children are not merely “little people” or “young adults”, nor are the disorders to which they are particularly
susceptible, merely variants of the diseases of adult life. The paediatric radiologist therefore must deal with many
disorders, some of which are encountered only in the young and others only in the newborn. This book although not a
complete text on paediatric radiology, is aimed at touching upon some aspects of basic and up-to-date paediatric radiology.
It covers both conventional radiology and advances in imaging. This incorporates a collaborative effort of many
distinguished teachers who have contributed in their own ways giving us a unique opportunity to share the art and science
of radiology.
However, reader must remember the words of Dr John Caffey, the father of Paediatric Radiology “A diagnosis is not
made from a single type of examination such as a radiograph, but rather from a cluster of findings derived from history,
physical examination and laboratory studies including a radiograph”. Reader must therefore always remember the basic
rule to interpret radiological features in the background knowledge of clinical and biochemical information. Our goal in
this book has been to be concise, relevant and reader-friendly. We hope the readers will find it useful.
We wish to take this opportunity to thank Prof K Subbarao, Dr Ashok Khurana and our faculty colleagues from
AIIMS, MAMC and PGIMER, for their active support, coordination and timely submission of the manuscripts. We also
express our sincere thanks to the publishers M/s Jaypee Brothers Medical Publishers (P) Ltd for timely publication of
this volume in the series of AIIMS-MAMC-PGI Imaging Courses in Diagnostic Radiology.
Manorama Berry
Sudha Suri
Veena Chowdhury
Arun Kumar Gupta
Sudha Katariya
CONTENTS
SECTION 1—GENERAL
1. Technical Considerations in Pediatric Imaging ................................................................................. 1
Ashu Seith Bhalla, Arun Kumar Gupta, Amar Mukund
Minimizing Heat Loss ........................................................................................................................................... 1
Immobilization ...................................................................................................................................................... 1
Sedation ................................................................................................................................................................. 1
Nil Per Orally (NPO) Status .................................................................................................................................. 2
Reduction of Radiation Dosage ............................................................................................................................. 2
Use of Contrast Media ........................................................................................................................................... 8
2. Recent Advances in Pediatric Radiology .......................................................................................... 11
Akshay Kumar Saxena, Kushaljit Singh Sodhi
Radiation Protection ............................................................................................................................................ 11
Neuroradiology .................................................................................................................................................... 11
Thoracic Imaging ................................................................................................................................................. 12
Gastrointestinal Imaging ..................................................................................................................................... 14
Uroradiology........................................................................................................................................................ 16
Musculoskeletal Imaging ..................................................................................................................................... 16
3. Interventions in Children ................................................................................................................... 19
Part A—Vascular Interventions ....................................................................................................................... 19
Gurpreet Singh Gulati, Sanjiv Sharma
Introduction ......................................................................................................................................................... 19
Techniques ........................................................................................................................................................... 20
Procedures ........................................................................................................................................................... 20
Embolization Materials and Substances .............................................................................................................. 21
Angioplasty.......................................................................................................................................................... 27
Thrombolysis ....................................................................................................................................................... 30
Foreign Body Removal ........................................................................................................................................ 30
Part B—Nonvascular Interventions ................................................................................................................ 32
Amar Mukund, Ashu Seith Bhalla, Shivanand Gamanagatti
Patient Evaluation ................................................................................................................................................ 32
Sedation and Anesthesia ...................................................................................................................................... 32
Basic Procedures ................................................................................................................................................. 32
Thoracic Interventions ......................................................................................................................................... 33
Gastrointestinal Interventions ............................................................................................................................. 33
Genitourinary Interventions ................................................................................................................................ 36
xii Diagnostic Radiology: Paediatric Imaging
4. Imaging of Pediatric Trauma............................................................................................................. 39
Shivanand Gamanagatti, Atin Kumar
Imaging Methods ................................................................................................................................................. 39
SECTION 2—CHEST
5. Neonatal Respiratory Distress ........................................................................................................... 57
Akshay Kumar Saxena, Kushaljit Singh Sodhi
Medical Causes of Neonatal Respiratory Distress .............................................................................................. 57
6. Childhood Pulmonary Infections ...................................................................................................... 68
Jyoti Kumar
Introduction ......................................................................................................................................................... 68
Pneumonia ........................................................................................................................................................... 68
Tuberculosis (TB) ................................................................................................................................................ 78
Fungal Infections ................................................................................................................................................. 81
Parasitic Infestations ........................................................................................................................................... 84
Pulmonary Infections in HIV-positive Children .................................................................................................. 84
7. Chest Masses ....................................................................................................................................... 87
Sanjay Thulkar, Arun Kumar Gupta
Lung Masses ........................................................................................................................................................ 87
Mediastinal Masses ............................................................................................................................................. 91
Chest Wall Masses ............................................................................................................................................... 96
8. Pediatric Airway ................................................................................................................................. 99
Ashu Seith Bhalla
Upper Airway Obstruction ................................................................................................................................ 100
Acute Obstruction .............................................................................................................................................. 101
Chronic Obstruction .......................................................................................................................................... 101
Lower Airway Obstruction ................................................................................................................................ 104
SECTION 3—GASTROINTESTINAL AND BILIARY TRACT, LIVER AND PANCREAS
9. Developmental Anomalies of Gastrointestinal Tract ..................................................................... 120
Alpana Manchanda, Sumedha Pawa
Imaging Modalities ............................................................................................................................................ 120
Esophagus .......................................................................................................................................................... 121
Stomach ............................................................................................................................................................. 125
Developmental Obstructive Defects .................................................................................................................. 125
Contents xiii
Duodenum ......................................................................................................................................................... 128
Small Bowel ...................................................................................................................................................... 130
Large Bowel ...................................................................................................................................................... 138
10. Imaging of Anorectal Anomalies ..................................................................................................... 144
Arun Kumar Gupta
ARA in Males .................................................................................................................................................... 147
ARA in Females ................................................................................................................................................ 149
11. Gastrointestinal Masses in Children ............................................................................................... 154
Arun Kumar Gupta
Plain Radiographs .............................................................................................................................................. 154
Contrast Studies ................................................................................................................................................. 154
Ultrasonography ................................................................................................................................................ 154
Computed Tomography ..................................................................................................................................... 154
Magnetic Resonance Imaging ........................................................................................................................... 154
Esophageal Masses in Children ......................................................................................................................... 154
Gastric Masses in Children ............................................................................................................................... 155
Neoplastic Masses ............................................................................................................................................. 157
Bezoars .............................................................................................................................................................. 159
Small Bowel Masses in Children ...................................................................................................................... 159
Neoplastic Masses ............................................................................................................................................. 160
Mesenteric Masses in Children ......................................................................................................................... 164
Colonic Masses in Children .............................................................................................................................. 165
12. Hepatic and Pancreatic Masses in Children .................................................................................. 171
Akshay Kumar Saxena, Kushaljit Singh Sodhi, Naveen Kalra
Imaging .............................................................................................................................................................. 171
Hepatic Masses .................................................................................................................................................. 172
Hepatoblastoma ................................................................................................................................................. 172
Hepatocellular Carcinoma (HCC) ..................................................................................................................... 173
Rhabdomyosarcoma .......................................................................................................................................... 174
Hepatic Metastases ............................................................................................................................................ 175
Infantile Hemangioendothelioma ...................................................................................................................... 175
Hemangioma ...................................................................................................................................................... 176
Mesenchymal Hamartoma ................................................................................................................................. 178
Focal Nondular Hyperplasia (FNH) and Hepatic Adenoma ............................................................................. 179
Peliosis Hepatis ................................................................................................................................................. 179
Inflammatory Lesions ........................................................................................................................................ 179
Simple Hepatic Cyst .......................................................................................................................................... 181
Polycystic Liver Disease ................................................................................................................................... 181
xiv Diagnostic Radiology: Paediatric Imaging
Caroli’s Disease ................................................................................................................................................. 182
Pancreatic Masses ............................................................................................................................................. 182
Islet Cell Tumors ............................................................................................................................................... 184
Solid and Papillary Epithelial Neoplasm (SPEN) (Frantz Tumor) ................................................................... 185
Mesenchymal Tumors ....................................................................................................................................... 185
Pancreatic Adenocarcinoma .............................................................................................................................. 186
Pseudocysts ....................................................................................................................................................... 186
Pancreatic Tuberculosis ..................................................................................................................................... 186
13. Childhood Biliopathies ..................................................................................................................... 189
Veena Chowdhury
Definition and Pathophysiology of Cholestasis ................................................................................................ 189
Physiological Neonatal Jaundice ....................................................................................................................... 189
Etiology of Jaundice in the Neonate and Infant ................................................................................................ 189
Diagnosis of Jaundice in Infancy and Childhood .............................................................................................. 190
Neonatal Hepatitis ............................................................................................................................................. 190
Biliary Atresia (BA) .......................................................................................................................................... 191
Hepatobiliary Cystic Malformations ................................................................................................................. 196
Caroli’s Disease ................................................................................................................................................. 199
Primary Sclerosing Cholangitis (PSC) .............................................................................................................. 205
Cystic Fibrosis ................................................................................................................................................... 206
Destructive Cholangitis Associated with Langerhans’ Cell Histiocytosis ........................................................ 206
Bile Duct Paucity ............................................................................................................................................... 207
Spontaneous Perforation of CBD ...................................................................................................................... 207
Inspissated Bile Syndrome (IBS) ...................................................................................................................... 209
Jaundice in Older Children ................................................................................................................................ 209
Hepatitis ............................................................................................................................................................. 209
Chronic Active Hepatitis ................................................................................................................................... 209
Metabolic ........................................................................................................................................................... 210
Cirrhosis ............................................................................................................................................................ 210
Biliary Tract Neoplasms .................................................................................................................................... 211
Diseases of the Gallbladder ............................................................................................................................... 212
SECTION 4—GENITOURINARY
14. Congenital Anomalies of the Urinary Tract ................................................................................... 216
Smriti Hari, Arun Kumar Gupta
Introduction ....................................................................................................................................................... 216
Abnormalities of Kidney ................................................................................................................................... 219
Anomalies of the Ureter .................................................................................................................................... 227
Anomalies of the Urinary Bladder .................................................................................................................... 230
Abnormalities of the Urethra ............................................................................................................................. 233
Contents xv
15. Urinary Tract Infections (Including VUR and Neurogenic Bladder) .......................................... 237
Kushaljit Singh Sodhi, Akshay Kumar Saxena
16. Renal and Retroperitoneal Masses ................................................................................................. 248
Anju Garg
Imaging .............................................................................................................................................................. 248
Renal Masses ..................................................................................................................................................... 249
Wilms’ Tumor (Nephroblastoma) ...................................................................................................................... 249
Nephroblastomatosis ......................................................................................................................................... 254
Mesoblastic Nephroma (Bolande’s Tumor) ...................................................................................................... 254
Clear Cell Sarcoma ............................................................................................................................................ 256
Rhabdoid Tumor ................................................................................................................................................ 256
Renal Cell Carcinoma ....................................................................................................................................... 256
Multilocular Cystic Renal Tumor ...................................................................................................................... 257
Angiomyolipoma ............................................................................................................................................... 257
Ossifying Renal Tumor of Infancy .................................................................................................................... 258
Metanephric Adenoma (Nephrogenic Adenofibroma, Embryonal Adenoma) .................................................. 259
Lymphoma ......................................................................................................................................................... 259
Leukemia ........................................................................................................................................................... 260
Primary Neurogenic Tumors of the Kidney ...................................................................................................... 260
Cystic Diseases of the Kidney ........................................................................................................................... 261
Adrenal Masses ................................................................................................................................................. 261
Neuroblastoma ................................................................................................................................................... 261
Ganglioneuroblastoma ....................................................................................................................................... 265
Ganglioneuroma ................................................................................................................................................ 265
Pheochromocytoma ........................................................................................................................................... 265
Adrenal Cortical Tumors ................................................................................................................................... 266
Adrenal Hemorrhage ......................................................................................................................................... 268
Adrenal Cysts .................................................................................................................................................... 268
Primary Retroperitoneal Tumors ....................................................................................................................... 268
Neurogenic Tumors ........................................................................................................................................... 268
Germ Cell Tumors ............................................................................................................................................. 269
Mesenchymal Tumors ....................................................................................................................................... 269
Retroperitoneal Lymphangioma ........................................................................................................................ 270
Lymph Node Masses ......................................................................................................................................... 270
Retroperitoneal Abscess and Hematoma ........................................................................................................... 270
17. Evaluation of Female Pelvis and Testicular Abnormalities .......................................................... 274
Kushaljit Singh Sodhi, Akshay Kumar Saxena
Anomalies of the Female Pelvis ........................................................................................................................ 276
Pelvic Masses in Children ................................................................................................................................. 277
Nongynecologic Pelvic Masses ......................................................................................................................... 281
xvi Diagnostic Radiology: Paediatric Imaging
Extratesticular Tumors ...................................................................................................................................... 290
Adrenal Rests .................................................................................................................................................... 291
18. Imaging of Intersex Disorders ......................................................................................................... 295
Sanjay Sharma, Arun Kumar Gupta
Introduction ....................................................................................................................................................... 295
Classification of Intersex ................................................................................................................................... 297
Clues to the Diagnosis ....................................................................................................................................... 305
SECTION 5—MUSCULOSKELETAL
19. Skeletal Dysplasias ............................................................................................................................ 307
Gaurav S Pradhan
Introduction ....................................................................................................................................................... 307
Terminology ...................................................................................................................................................... 307
Osteochondrodysplasias .................................................................................................................................... 308
Dysostoses ......................................................................................................................................................... 323
Idiopathic Multicentric Osteolysis .................................................................................................................... 324
Primary Disturbance of Growth ........................................................................................................................ 324
Constitutional Diseases of Bone with Known Pathogenesis ............................................................................. 324
20. Skeletal Maturity Assessment .......................................................................................................... 328
Arun Kumar Gupta
Measurement of Maturity .................................................................................................................................. 328
21. Spinal Dysraphism ............................................................................................................................ 333
Raju Sharma, Ankur Gadodia
Introduction ....................................................................................................................................................... 333
Classification ..................................................................................................................................................... 333
Embryology ....................................................................................................................................................... 333
Imaging Modalities ............................................................................................................................................ 334
Open Spinal Dysraphism (OSD) ....................................................................................................................... 337
Closed Spinal Dysraphism (CSD) ..................................................................................................................... 339
Split Cord Malformation (SCM) ....................................................................................................................... 346
Dorsal Dermal Sinus (DDS) .............................................................................................................................. 346
Caudal Agenesis (Caudal Regression Syndrome, CRS) .................................................................................... 348
Segmental Spinal Dysgenesis (SSD) ................................................................................................................. 348
22. Imaging of Pediatric Hip .................................................................................................................. 351
Anjali Prakash
Introduction ....................................................................................................................................................... 351
Methods of Investigation ................................................................................................................................... 351
Contents xvii
Pediatric Hip Disorders ..................................................................................................................................... 355
Developmental Dysplasia of the Hip ................................................................................................................. 356
Natural History and Pathology .......................................................................................................................... 356
Imaging in DDH ................................................................................................................................................ 356
Transient Synovitis of Hip ................................................................................................................................. 366
Legg-Calve-Perthes’ Disease ............................................................................................................................. 367
23. Benign Bone and Soft Tissue Tumors & Conditions ..................................................................... 381
Mahesh Prakash, Kushaljit Singh Sodhi
Cartilaginous Tumors ........................................................................................................................................ 381
Osseous Tumors ................................................................................................................................................ 383
Fibrous Tumors .................................................................................................................................................. 385
Histiocytosis X (Langerhans Cell Histiocytosis) .............................................................................................. 385
Giant Cell Tumor ............................................................................................................................................... 386
Tumor Like Lesions ........................................................................................................................................... 386
Soft Tissue Tumors ............................................................................................................................................ 387
Fibroblastic/Myofibroblastic Tumors ................................................................................................................ 390
24. Pediatric Malignant Bone and Soft Tissue Tumors ....................................................................... 395
Manisha Jana, Ashu Seith Bhalla, Deep N Srivastava
Introduction ....................................................................................................................................................... 395
Imaging Modalities ............................................................................................................................................ 395
Malignant Bone Tumors .................................................................................................................................... 397
Soft Tissue Tumors ............................................................................................................................................ 401
SECTION 6—CENTRAL NERVOUS SYSTEM
25. Congenital Brain Anomalies ............................................................................................................ 404
N Khandelwal
Introduction ....................................................................................................................................................... 404
Disorders of Organization ................................................................................................................................. 404
Disorders of Histogenesis .................................................................................................................................. 414
26. Hypoxic-Ischemic Encephalopathy ................................................................................................. 419
Atin Kumar, Arun Kumar Gupta
Neuroimaging in Infants with HIE .................................................................................................................... 419
Below 34 Weeks Group – The Premature Neonate ........................................................................................... 419
Above 34 Weeks Group – The Term Neonate ................................................................................................... 428
Hypoxic Ischemic Injury in Postnatal Age Group ............................................................................................. 431
Imaging Choice for Evaluation of Hypoxic-ischemic Injury ............................................................................ 432
Prediction of Clinical Outcome ......................................................................................................................... 432
xviii Diagnostic Radiology: Paediatric Imaging
27. Cranial Sonography ......................................................................................................................... 436
Rashmi Dixit, Veena Chowdhury
Destructive Brain Lesions ................................................................................................................................. 441
Hydrocephalus ................................................................................................................................................... 441
Intracranial Hemorrhage .................................................................................................................................... 444
Hypoxic or Ischemic Encephalopathy ............................................................................................................... 446
Neonatal and Acquired Infections ..................................................................................................................... 449
28. Inflammatory Diseases of the Brain................................................................................................ 454
V Gupta, N Khandelwal, P Singh
Introduction ....................................................................................................................................................... 454
Investigative Modalities .................................................................................................................................... 454
Bacterial Infections ............................................................................................................................................ 454
Cranial Tuberculosis .......................................................................................................................................... 457
Neurocysticercosis............................................................................................................................................. 461
Hydatid Disease ................................................................................................................................................. 464
Viral Encephalitis .............................................................................................................................................. 465
Congenital Infections ........................................................................................................................................ 468
Fungal Infections ............................................................................................................................................... 475
29. Pediatric Brain Tumors .................................................................................................................... 477
Shailesh B Gaikwad, Ajay Garg
Introduction ....................................................................................................................................................... 477
Classification of Childhood Tumors Based on Topography ............................................................................. 477
Posterior Fossa Tumors ..................................................................................................................................... 477
Supratentorial Tumors ....................................................................................................................................... 482
Sellar and Suprasellar Tumors........................................................................................................................... 485
Pineal Region Masses ........................................................................................................................................ 487
Extraparenchymal Tumors ................................................................................................................................ 488
Tumors of the Orbit and Neck ........................................................................................................................... 490
Ocular Tumors ................................................................................................................................................... 490
Retrobulbar Orbital Tumors .............................................................................................................................. 490
MR Spectroscopy (MRS) in Brain .................................................................................................................... 491
Nanotechnology ................................................................................................................................................. 492
30. Metabolic Disorders of the Brain .................................................................................................... 494
Sapna Singh, Veena Chowdhury
Introduction ....................................................................................................................................................... 494
Metabolic Disorders .......................................................................................................................................... 495
Lysosomal Storage Disorders ............................................................................................................................ 498
Peroxisomal Disorders ...................................................................................................................................... 505
Contents xix
Unclassified Leukodystrophies ......................................................................................................................... 509
Mitochondrial Disorders/Defects of the Respiratory Chain .............................................................................. 516
Disorders of Amino Acid Metabolism/Aminoacidopathies .............................................................................. 520
Organic Acidemias ............................................................................................................................................ 524
Metabolic Disorders Primarily Affecting Gray Matter ..................................................................................... 526
Disorders of Metal Metabolism......................................................................................................................... 527
Index ............................................................................................................................. 533
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