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The MRCP PACES Handbook
Second Edition
The MRCP PACES Handbook
Second Edition

Saira Ghafur
CCT in Respiratory and General Internal Medicine and Harkness
Fellow in Health Care Policy and Practice
New York City, New York, USA

Parminder K Judge
ST6 in Nephrology
Oxford, England, UK

Richard Kitchen
Consultant in Palliative Medicine
Glasgow, Scotland, UK

and

Samuel Blows
Consultant Geriatrician and Acute Physician
Ipswich, England, UK

Foreword by
Dr Fiona Moss
Dean of the Royal Society of Medicine
London, England, UK
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742

© 2017 by Taylor & Francis Group, LLC


CRC Press is an imprint of Taylor & Francis Group, an Informa business

No claim to original U.S. Government works

Printed on acid-free paper

International Standard Book Number-13: 978-1-4987-8632-4 (paperback)

This book contains information obtained from authentic and highly regarded sources. Reasonable efforts
have been made to publish reliable data and information, but the author and publisher cannot assume
responsibility for the validity of all materials or the consequences of their use. The authors and publishers
have attempted to trace the copyright holders of all material reproduced in this publication and apologize to
copyright holders if permission to publish in this form has not been obtained. If any copyright material has
not been acknowledged please write and let us know so we may rectify in any future reprint.

Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmit-
ted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented,
including photocopying, microfilming, and recording, or in any information storage or retrieval system,
without written permission from the publishers.

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Contents

Forewordix
Prefacexi
Authorsxiii
Acknowledgementsxv
List of Abbreviations xvii
The PACES Examination xxiii
Top Tips for PACES Success: An Examiner Speaks xxv

1 Station 1: Respiratory 1
Hints for the Respiratory Station 2
Bronchiectasis2
Chronic Obstructive Pulmonary Disease 4
Consolidation7
Cystic Fibrosis 9
Fibrotic Lung Disease 12
Lung Cancer 14
Old Tuberculosis 16
Pleural Effusion 18
Patient with Previous Lung Surgery 20
Respiratory Station Summary 22

2 Station 1: Abdominal 23
Hints for the Abdominal Station 24
Abdominal Case with a Normal Abdomen 24
Chronic Liver Disease 26
Generalised Lymphadenopathy 29
Hepatosplenomegaly31
Multiple Abdominal Scars 33
Palpable Kidneys 36
Renal Replacement Therapy 39
Splenomegaly42
Abdominal Station Summary 45

v
Contents

3 Station 2: History Taking 47


Hints for the History-Taking Station 48
Patient with an Abnormal Blood Result 48
Patient with Back Pain 51
Patient Who Has Collapsed 53
Patient with a Cough 56
Patient with Diarrhoea 58
Patient with Jaundice 60
Patient with Joint Pains 63
Patient with Left Arm Weakness 65
Patient with Visual Disturbance 67
Patient with Weight Loss 70
History-Taking Station Summary 73

4 Station 3: Neurology 75
Hints for the Neurology Station 76
Cerebellar Syndrome 77
Hemiparesis78
Myotonic Dystrophy 81
Ocular Palsies 83
Parkinson’ s Disease 85
Peripheral Neuropathy 88
Mononeuropathies90
Motor Neurone Disease 92
Multiple Sclerosis 95
Spastic Paraparesis 97
Visual Field Defects 99
Neurology Station Summary 100

5 Station 3: Cardiology 101


Hints for the Cardiology Station 102
Aortic Stenosis 102
Aortic Regurgitation 105
Eisenmenger’ s Syndrome 107
Hypertrophic Cardiomyopathy 110
Mitral Stenosis 112
Mitral Regurgitation 114
Mitral Valve Prolapse 117
Mixed Aortic Valve Disease 119
Mixed Mitral Valve Disease 120
Prosthetic Heart Valves 122

vi
Contents

Tricuspid Regurgitation 124


Ventricular Septal Defect 127
Cardiology Station Summary 130

6 Station 4: Ethics and Communication Skills 131


Hints for the Ethics and Communication Skills Station 132
Breaking Bad News 133
Care in the Deteriorating Patient 135
Driving Regulations 137
Initiating a New Therapy 140
Long-Term Condition 142
Medical Error 145
Mental Capacity 147
New Diagnosis 149
Organ Transplantation 152
Ethics and Communication Skills Station Summary 155

7 Station 5: Brief Clinical Encounters 157


Hints for the Brief Clinical Encounters Station 158
Ankylosing Spondylitis 158
Anticoagulation161
Diabetic Retinopathy 163
Facial Nerve Palsy 165
Falls167
Headache (Idiopathic Intracranial Hypertension) 170
Hyperthyroidism172
Neck Lump 174
Osteoporosis175
Proximal Myopathy 177
Psoriasis179
Rheumatoid Arthritis with Carpal Tunnel Syndrome 182
Systemic Sclerosis 184
Third Nerve Palsy or Patient Presenting with Diplopia 186
Brief Clinical Encounters Station Summary 188

Afterword: Hawks and Doves 189


Index191

vii
Foreword

Postgraduate medical exams are significant both as career-defining milestones for the
candidate and as one of the ways of ensuring that doctors who progress have all that it takes
to provide excellent patient care. Exams focus the minds of candidates for whom exam con-
tent and exam approach define what examiners consider important and so perhaps mould
approaches to practise. The Practical Assessment of Clinical Examination Skills (PACES), the
final part of the Membership of the Royal Colleges of Physicians (MRCP) examination, is a
pivotal step for all aspiring physicians, and this book will be an enormous support for them.
But, the MRCP PACES Handbook is so much more than a book for passing exams. A compre-
hensive book, it succinctly covers much of the necessary content, and for that it will be useful
to candidates. Responses and analyses to the questions posed are logical and practical and
cleverly proceed from the likely and frequent to the rarefied. It is also very well organised,
demonstrating not just how to pass an exam, but also the importance of an ordered approach
to clinical reasoning. Lists of key points at the ends of chapters keep the reader on track, and
the well-chosen lists of references really do encourage further reading. The real strength of
this handbook is that it gets to the heart of the purpose of the PACES examination.
The PACES exam reflects the work done through MRCP UK to develop assessments of all
the skills necessary for excellent clinical practice. Of course, this includes physical exami-
nation, recognition of clinical signs and differential diagnosis, the stuff of medical exami-
nations for many years. Now, assessments have become more patient centred and more
holistic and are designed to demonstrate explicitly the expectation of modern physicians
and good medical practice. Clinical judgement, communication, managing patient con-
cerns and maintaining patient welfare are four of the seven skills assessed through the
PACES exam, and these skills are very well covered in this handbook.
Not only are technical points covered, but by including, for example, outlines of themes
explored, suggestions for candidates and expectations for both candidates and patients,
this handbook provides a succinct but in-depth outline of some of the difficult but crucial
aspects of medical practice.
The simplicity of approach and the clear language throughout make it clear that this is not
a book for the ‘ superficial learner’ wanting a ‘ quick fix’ for an impending exam, but one
that encourages understanding and a mature approach to developing all the skills neces-
sary for becoming a good physician.
PACES, the final part of the MRCP exam, is what is says: practical. And reflecting the
essence of the PACES exam, this handbook is a supremely practical ‘ vade mecum’ . It is
a handbook that not only will be essential for those approaching their PACES exam or
those considering becoming a physician, but also will be a useful and continuing guide to
‘ practise after PACES’ for those entering higher training after PACES, and it will be useful
for anyone who teaches postgraduate or undergraduate medicine.
This is a book that will be bought and used to help aspiring physicians through their
PACES, will encourage development of a patient-centred approach to care and then, for
many years after, will stay in easy reach.

Dr Fiona Moss, CBE, MD, FRC


Dean of the Royal Society of Medicine

ix
Preface

Observe, record, tabulate, and communicate. Use your five senses. Learn to see, learn to hear,
learn to feel, learn to smell, and know that by practice alone you can become an expert.

Sir William Osler, FRS, FRCP

The Practical Assessment of Clinical Examination Skills (PACES) should be seen as


the defining moment of your medical training when you have been accepted into the
fold – the final hurdle you need to jump over before gaining the elusive title of ‘ Medical
Registrar’ . The wise words from Sir William Osler sum up the skills needed to achieve this
goal.
This book is designed to be a comprehensive revision aid that will be invaluable to can-
didates studying for their PACES examination. The book is designed to be used at the
patient’ s bedside to guide clinical examination, as well as having enough detail to cover
pertinent points in the case in question.
Each of the chapters contains hints and tips on how to tackle each of the examinations
and a summary at the end to consolidate key learning points. The cases represent a col-
lection of those which are most frequently encountered in the PACES examination and
are set out in a standardised format. Each chapter has been reviewed by senior clinicians
within the specialty. The information within the handbook has been updated and is sup-
ported by evidence-based literature and supporting guidelines.
Passing PACES requires not only an in-depth knowledge of the subject of the case but also
the fine art of being able to present in a concise and coherent manner. Each case contains
a section on presentation which will aid the candidate in perfecting this skill.
Excellent communication skills are the cornerstone of every doctor’ s interaction with
patients and colleagues and are essential in passing the PACES examination. Uphold the
legacy of Dr Kate Granger, who initiated the #hellomynameis campaign, and treat every
patient with the utmost respect, kindness and compassion.
PACES is feared as the unachievable milestone; the key to passing the exam is hard work
and sheer dedication. The blood, sweat and tears will all be worth it in the end when you
have attained the highly sought after title of Membership of the Royal Colleges of Physi-
cians of the United Kingdom (MRCP UK).
If you follow in the footsteps of those who have gone before you, you are guaranteed to
succeed.

Good luck – go forth and conquer!

SG, PKJ, RK and SB

xi
Authors

Saira Ghafur graduated from the University of Dundee Medical School. She has a dual
CCT in respiratory and general internal medicine and has a particular interest in com-
munity respiratory medicine. She is currently a post-CCT Harkness Fellow in Health Care
and Policy at the Commonwealth Fund in New York City, New York.

Parminder K Judge graduated from the University of Birmingham Medical School. She
is a nephrology registrar on the Oxford rotation. She recently took time out of clinical
training to undertake research in clinical trials and epidemiology at the University of
Oxford, Oxford, United Kingdom.

Richard Kitchen graduated from the University of Leicester Medical School. He has a
CCT in palliative medicine (obtained on the West Midlands rotation) and has a particular
interest in medical education, having completed a master’ s degree in this area. He has
recently been appointed as a consultant in palliative medicine at Ardgowan Hospice and
Inverclyde Royal Hospital, Greenock, United Kingdom.

Samuel Blows graduated from the University of Leicester Medical School. He trained
in geriatrics and general internal medicine in London with a sabbatical at Bankstown
Hospital, Sydney, Australia. He has an interest in medical education and has recently
been appointed as a consultant in complex care/interface geriatrics at Ipswich Hospital,
Ipswich, United Kingdom.

The authors all worked together at the University Hospitals of Leicester as junior doctors,
during which time they all passed the PACES examination and developed their interest in
medical education and evidenced-based medicine.

xiii
Acknowledgements

We would like to thank the following people for all their support, knowledge and input
in the chapters and cases relating to their area of expertise and their guidance in making
this book possible:

Dr Mark Ardron
Consultant Geriatrician, University Hospitals of Leicester NHS Foundation Trust

Dr Parry Blaxill
Consultant in Respiratory Medicine, Lung Cancer Lead, Mid Yorkshire NHS Foundation
Trust

Dr Binith Cheeran
Honorary Consultant Neurologist, Oxford University Hospitals NHS Foundation Trust
Senior Clinical Fellow, University of Oxford

Dr Rachael Curley
Consultant in Respiratory Medicine (Cystic Fibrosis), Sheffield Teaching Hospitals NHS
Foundation Trust

Dr Marni Greig
Consultant in Diabetes and Endocrine, Sheffield Teaching Hospitals NHS Foundation
Trust

Dr Kar-Ping Kuet
Consultant Rheumatologist, Sheffield Teaching Hospitals NHS Foundation Trust

Dr Sapna Ladani
Consultant Haematologist, University Hospitals of Leicester NHS Foundation Trust
Honorary Senior Lecturer, University of Leicester

Mark Latimour
LLB (Hons), BA, GradDip (Legal Practice)

Dr Ajay M Verma
Consultant Gastroenterologist, Kettering General Hospital

Dr David Warriner
SpR in Cardiology, Yorkshire, and the Humber Deanery

xv
List of Abbreviations

A2 aortic component of heart sound 2


AA amyloid A
ABG arterial blood gas
ABPA allergic bronchopulmonary aspergillosis
ACE angiotensin-converting enzyme
ACF antecubital fossa
ACPA anticitrullinated protein antibodies
ACTH adrenocorticotrophic hormone
ADH antidiuretic hormone
ADLs activities of daily living
ADPKD autosomal dominant polycystic kidney disease
AF atrial fibrillation
AFB acid-fast bacilli
AFP alpha-fetoprotein
AKI acute kidney injury
AL amyloid L
ALD adrenoleukodystrophy
ALD alcoholic liver disease
ALP alkaline phosphatase
ALS amyotrophic lateral sclerosis
AMA antimitochondrial antibody
AMTS abbreviated mental test score
ANA antinuclear antibody
APKD adult polycystic kidney disease
AR aortic regurgitation
ARB angiotensin receptor blocker
ARDS acute respiratory distress syndrome
AS aortic stenosis
ASA aminosalicylic acid
ASD atrial septal defect
AV arteriovenous
AVA aortic valve area
AVR aortic valve replacement
AXR abdominal X-ray
AVSD atrioventricular septal defect
BCC basal cell carcinoma
BP blood pressure
BTS British Thoracic Society
CABG coronary artery bypass graft
CCF congestive cardiac failure
CDT Clostridium difficile toxin
CF cystic fibrosis

xvii
List of Abbreviations

CFTR cystic fibrosis transmembrane conductance regulator


Ch chromosome
CK creatine kinase
CKD chronic kidney disease
CLL chronic lymphocytic leukaemia
CML chronic myeloid leukaemia
CMV cytomegalovirus
CN cranial nerve
CO carbon monoxide
COMT catechol-o-methyltransferase
COPD chronic obstructive pulmonary disease
COX cyclo-oxygenase
CRF chronic renal failure
CRP C-reactive protein
CSF cerebrospinal fluid
CT computerised tomography
CVA cerebrovascular accident
CXR chest X-ray
DCCT Diabetes Control and Complications Trial
DEXA dual-energy X-ray absorptiometry
DMARD disease-modifying antirheumatoid drug
DNase deoxyribonuclease
DVLA Driver and Vehicle Licensing Agency
EBUS endobronchial ultrasound
EBV Epstein– Barr virus
ECG electrocardiogram
EDM end-diastolic murmur
EMA endomysial antibody
EMG electromyogram
ENT ear, nose and throat
ESR erythrocyte sedimentation rate
ESRD end-stage renal disease
FBC full blood count
FEV1 forced expiratory volume in first second
FiO2  fraction of inspired oxygen
FSH follicle-stimulating hormone
FVC forced vital capacity
GBM glomerular basement membrane
GBS Guillain– Barré syndrome
GGT gamma-glutamyl transpeptidase
GH growth hormone
GI gastrointestinal
GIM general internal medicine
GNRH gonadotrophin-releasing hormone
GP general practitioner
HCM hypertrophic cardiomyopathy
HIV human immunodeficiency virus
HLA human leucocyte antigen
HPOA hypertrophic pulmonary osteoarthropathy

xviii
List of Abbreviations

IBD inflammatory bowel disease


IBS irritable bowel syndrome
ICD implantable cardioverter defibrillator
ICU intensive care unit
IE infective endocarditis
IGF-1 insulin-like growth factor 1
IIH idiopathic intracranial hypertension
IL interleukin
IMCA independent mental capacity advocate
INO internuclear ophthalmoplegia
INR international normalised ratio
ITP idiopathic thrombocytopenic purpura
IV intravenous
IVDU intravenous drug user
JAK2 Janus kinase 2
JVP jugular venous pressure
KCO carbon monoxide transfer coefficient
LA left atrium
LABA long-acting beta-agonist
LAMA long-acting muscarinic antagonist
LBBB left bundle branch block
LDH lactate dehydrogenase
LEMS Lambert– Eaton myaesthenic syndrome
LFT liver function test
LH luteinising hormone
LKM liver kidney microsomal
LMN lower motor neurone
LMWH low-molecular-weight heparin
LP lumbar puncture
LTOT long-term oxygen therapy
LUQ left upper quadrant
LV left ventricle
LVF left ventricular failure
LVH left ventricular hypertrophy
LVOTO left ventricular outflow tract obstruction
MAOB monoamine oxidase B
MCPJ metacarpophalangeal joint
MCV mean cell volume
MDT multidisciplinary team
MHC major histocompatibility complex
MMF mycophenolate mofetil
MND motor neurone disease
MR mitral regurgitation
MRC Medical Research Council
MRI magnetic resonance imaging
MS multiple sclerosis
MVP mitral valve prolapse
NCS nerve conduction study
NICE National Institute for Health and Care Excellence

xix
List of Abbreviations

NIH National Institutes of Health


NIPPV noninvasive positive-pressure ventilation
NOAC novel oral anticoagulant
NSAID nonsteroidal anti-inflammatory drug
NSCLC non-small-cell lung cancer
NSTEMI non-ST elevation myocardial infarction
NYHA New York Heart Association
OCP oral contraceptive pill
OD once daily
OGD oesophagogastroduodenoscopy
ON once nightly
OSA obstructive sleep apnoea
OT occupational therapist
P2 pulmonary component of heart sound 2
PACES Practical Assessment of Clinical Examination Skills
PBC primary biliary cirrhosis
PD peritoneal dialysis
PDA patent ductus arteriosus
PEG percutaneous endoscopic gastrostomy
PET positron emission tomography
PFT pulmonary function test
PLS primary lateral sclerosis
PMA progressive muscular atrophy
PPI proton pump inhibitor
PPM permanent pacemaker
PR pulmonary regurgitation
PRN as needed (pro re nata)
PRV polycythaemia rubra vera
PTH parathyroid hormone
PUVA psoralen and ultraviolet A
QOL quality of life
RA rheumatoid arthritis
RF rheumatoid factor
RIF right iliac fossa
RRT renal replacement therapy
S1 heart sound 1
S2 heart sound 2
S3 heart sound 3
S4 heart sound 4
SA-AG serum ascites-albumin gradient
SAA serum amyloid A
SABA short-acting beta-agonist
SAH subarachnoid haemorrhage
SALT speech and language therapist
SAP serum amyloid P
SBP spontaneous bacterial peritonitis
SCC squamous cell carcinoma
SCD sudden cardiac death
SCL-70 antitopoisomerase antibodies

xx
List of Abbreviations

SCLC small-cell lung cancer


SIADH syndrome of inappropriate antidiuretic hormone secretion
SIGN Scottish Intercollegiate Guidelines Network
SLE systemic lupus erythematosus
SOL space-occupying lesion
SSc systemic sclerosis
SVCO superior vena caval obstruction
SVD structural valve deterioration
TAVI transcutaneous aortic valve implantation
TB tuberculosis
TBLB transbronchial lung biopsy
TFT thyroid function test
TIA transient ischaemic attack
TLC total lung capacity
TLCO transfer factor of the lung for carbon monoxide
TNF tumour necrosis factor
TOE transoesophageal echocardiogram
TPO thyroid peroxidase
TR tricuspid regurgitation
TRH thyroid-releasing hormone
TSH thyroid-stimulating hormone
tTG tissue transglutaminase
U1-RNP U1 ribonucleoprotein
U&Es urea and electrolytes
UC ulcerative colitis
UDCA ursodeoxycholic acid
UIP usual interstitial pneumonia
UKPDS United Kingdom Prospective Diabetes Study
UMN upper motor neurone
US ultrasound
USS ultrasound scan
VATS video-assisted thoracoscopic surgery
VF ventricular fibrillation
VP ventriculoperitoneal
VSD ventricular septal defect
VT ventricular tachycardia
VTE venous thromboembolism
WHO World Health Organization

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