(Ebook) Infectious Diseases, Second Edition (EXPERT

GUIDE SERIES- AMERICAN COLLEGE OF PHYSICIANS) by

James S. Tan, Michael J. Tan, Robert A. Salata,
Thomas M. File Jr. ISBN 1930513852 pdf available

Now available at ebooknice.com

( 4.5/5.0 ★ | 500 downloads )

https://ebooknice.com/product/infectious-diseases-second-edition-
expert-guide-series-american-college-of-physicians-2222162
 (Ebook) Infectious Diseases, Second Edition (EXPERT GUIDE
SERIES- AMERICAN COLLEGE OF PHYSICIANS) by James S. Tan,
Michael J. Tan, Robert A. Salata, Thomas M. File Jr. ISBN
1930513852 Pdf Download

EBOOK

Available Formats

■ PDF eBook Study Guide Ebook

EXCLUSIVE 2025 EDUCATIONAL COLLECTION - LIMITED TIME

INSTANT DOWNLOAD VIEW LIBRARY

Here are some recommended products that might interest you.
You can download now and explore!

(Ebook) Biota Grow 2C gather 2C cook by Loucas, Jason;

Viles, James ISBN 9781459699816, 9781743365571,
9781925268492, 1459699815, 1743365578, 1925268497
https://ebooknice.com/product/biota-grow-2c-gather-2c-cook-6661374

ebooknice.com

(Ebook) Matematik 5000+ Kurs 2c Lärobok by Lena

Alfredsson, Hans Heikne, Sanna Bodemyr ISBN 9789127456600,
9127456609
https://ebooknice.com/product/matematik-5000-kurs-2c-larobok-23848312

ebooknice.com

(Ebook) SAT II Success MATH 1C and 2C 2002 (Peterson's SAT

II Success) by Peterson's ISBN 9780768906677, 0768906679

https://ebooknice.com/product/sat-ii-success-
math-1c-and-2c-2002-peterson-s-sat-ii-success-1722018

ebooknice.com

(Ebook) Cambridge IGCSE and O Level History Workbook 2C -

Depth Study: the United States, 1919-41 2nd Edition by
Benjamin Harrison ISBN 9781398375147, 9781398375048,
1398375144, 1398375047
https://ebooknice.com/product/cambridge-igcse-and-o-level-history-
workbook-2c-depth-study-the-united-states-1919-41-2nd-edition-53538044

ebooknice.com
(Ebook) Master SAT II Math 1c and 2c 4th ed (Arco Master
the SAT Subject Test: Math Levels 1 & 2) by Arco ISBN
9780768923049, 0768923042
https://ebooknice.com/product/master-sat-ii-math-1c-and-2c-4th-ed-
arco-master-the-sat-subject-test-math-levels-1-2-2326094

ebooknice.com

(Ebook) Red Book Atlas of Pediatric Infectious Diseases by

American Academy of Pediatrics, Tina Q. Tan ISBN
9781610026314, 1610026314
https://ebooknice.com/product/red-book-atlas-of-pediatric-infectious-
diseases-48495088

ebooknice.com

(Ebook) Red Book Atlas of Pediatric Infectious Diseases by

American Academy of Pediatrics (AAP), Dr. Tina Q. Tan MD
FAAP (editor) ISBN 9781610026307, 1610026306
https://ebooknice.com/product/red-book-atlas-of-pediatric-infectious-
diseases-48982564

ebooknice.com

(Ebook) Infectious diseases and dermatology by Karen

Harman; Martin J Wiselka; John D Firth; Royal College of
Physicians of London. Education Department ISBN
9781860162602, 9781860162688, 1860162606, 1860162681
https://ebooknice.com/product/infectious-diseases-and-
dermatology-4921968

ebooknice.com

(Ebook) Rapid Review Microbiology and Immunology by Ken S.

Rosenthal, Michael J Tan ISBN 9780323069380, 032306938X

https://ebooknice.com/product/rapid-review-microbiology-and-
immunology-47234562

ebooknice.com
BK6016A IDFinalcover 11/26/07 3:38 PM Page 1

Infectious Tan
File
Diseases Salata
Second Edition Tan
ACP

Second Edition

Diseases
Infectious
Find the expert guidance you need to evaluate, diagnose, and treat the
most commonly encountered infections in the primary care setting.
Infectious Diseases, 2nd Edition keeps you current with new etiologic
agents, the most appropriate diagnostic tests, and the most effective
management options. This New Edition:
• Examines infections of the central nervous system, heart and blood
vessels, gastrointestinal tract, genitourinary system, respiratory tract,
skeletal system, and skin.
• Features new chapters on antimicrobial agents and prosthetic joint
infections.
Infectious
• Includes individual chapters on HIV, herpes virus, Lyme disease, and
malaria. Diseases
Second Edition
• Puts key information at your fingertips with diagnostic and treatment
tables throughout the text.
• Reviews the clinical manifestations of each infection as well as recent
advances in clinical microbiology.
• Focuses on the common and uncommon diseases most often seen in
primary care practices.
Infections comprise a sizable proportion of the conditions encountered in the
office setting. Manage them easily and effectively with this thorough, yet
practical, guide.
Tan Fm.qxd 10/12/07 10:14 AM Page i

Expert Guide to

INFECTIOUS
DISEASES
SECOND EDITION
Tan Fm.qxd 10/12/07 10:14 AM Page ii
Tan Fm.qxd 10/26/07 1:32 AM Page iii

Expert Guide to

INFECTIOUS
DISEASES
SECOND EDITION

Edited by
James S. Tan, MD, MACP
Professor and Vice Chairman, Department of Internal Medicine
Northeastern Ohio Universities College of Medicine
Head, Infectious Diseases Section
Chairman, Department of Internal Medicine
Summa Health System

THOMAS M. FILE, JR., MD, MSC, MACP

Professor, Department of Internal Medicine
Head, Infectious Diseases Section; Master Teacher
Northeastern Ohio Universities College of Medicine
Chief, Infectious Diseases Service
Summa Health System

ROBERT A. SALATA, MD, FACP

Professor and Vice-Chair, Department of Medicine
Chief, Division of Infectious Diseases & HIV Medicine
Case Western Reserve University
University Hospitals Case Medical Center

MICHAEL J. TAN, MD, FACP

Assistant Professor, Department of Internal Medicine
Northeastern Ohio Universities College of Medicine
Clinical Physician, HIV and Infectious Diseases
Summa Health System

ACP Press
American College of Physicians • Philadelphia
Tan Fm.qxd 10/26/07 1:32 AM Page iv

Clinical Consultant: David R. Goldmann, MD

Associate Publisher and Manager, Books Publishing: Tom Hartman
Developmental Editor: Victoria Hoenigke
Production Supervisor: Allan S. Kleinberg
Senior Editor: Karen C. Nolan
Editorial Coordinator: Angela Gabella
Indexer: Kathleen Patterson

Copyright © 2008 by the American College of Physicians. All rights reserved. No part of this
book may be reproduced in any form by any means (electronic, mechanical, xerographic,
or other) or held in any information storage and retrieval systems without written permis-
sion from the publisher.

Manufactured in the United States of America

Composition by SPI, India
Printing/Binding by Versa Press Inc.

ISBN: 978-1-930513-85-3

The authors have exerted reasonable efforts to ensure that drug selection and dosage
set forth in this volume are in accord with current recommendations and practice at the
time of publication. In view of ongoing research, occasional changes in government reg-
ulations, and the constant flow of information relating to drug therapy and drug reac-
tions, the reader is urged to check the package insert for each drug for any change in
indications and dosage and for added warnings and precautions. This care is particular-
ly important when the recommended agent is a new or infrequently used drug. ACP is
not responsible for any accident or injury resulting form the use of this publication.

08 09 10 11 12 / 9 8 7 6 5 4 3 2 1
Tan Fm.qxd 10/12/07 10:14 AM Page v

In Memoriam
James S. Tan, MD, MACP

O
ur renowned colleague, James Tan, died May 25, 2006, in Akron,
Ohio. He was 67.
Jim was the editor of the first edition of Expert Guide to
Infectious Diseases, and through his efforts it was a great success. At the time
of his death, he was coordinating this second edition, which we dedicate
to him.
Jim graduated in 1965 from the University of the Philippines College of
Medicine, and he trained in infectious diseases at the University of
Cincinnati College of Medicine. In 1974, he moved from a faculty position
at the University of Cincinnati to Akron, Ohio to be the first Head of
Infectious Diseases at Akron City Hospital (now Summa Health System). He
was the first infectious diseases specialist to bring clinical expertise to the
community setting in northeastern Ohio. In 1979, he was named Chairman
of the Department of Medicine at Akron City Hospital, a position he held
until his death. At that time, he had completed the longest term as program

v
Tan Fm.qxd 10/12/07 10:14 AM Page vi

vi In Memoriam

director of an internal medicine residency program in the nation and was

involved in the training of countless physicians. He was also the first
Chairman of the Infectious Diseases Section of Northeastern Ohio
Universities College of Medicine (NEOUCOM) in Rootstown, Ohio and he
held this position since 1977. Through his leadership, he organized the
development of the infectious diseases curriculum for medical students at
the College of Medicine. Jim will be forever remembered as a consummate
infectious diseases clinician and educator.
Jim was a Master of the American College of Physicians. He was former
Governor of the Ohio Chapter of the American College of Physicians, and
further served the College in many additional capacities. He was also a
Fellow of the Infectious Diseases Society of America (IDSA) and served as
the secretary-treasurer (aka, ‘executive director’) of the Infectious Diseases
Society of Ohio for five years. He was a member of the IDSA Clinical
Guideline Panel for the Diagnosis and Treatment of Diabetic Foot
Infections.
Jim was exceptionally active in research. He was particularly interested
in the evaluation of the pharmacokinetics of antimicrobials: one of his sig-
nificant achievements in this field was his improvement of a skin window
technique to measure the interstitial fluid concentrations of antimicrobials.
This work has been published in numerous journal articles and textbook
chapters.
His many awards include the Liebelt/Wheeler Award from NEOUCOM
for faculty excellence and the American College of Physicians Ohio Chapter
Laureate and Master Teacher Awards. He received the Watanakunakorn
Clinician of the Year Award at the annual meeting of the Infectious Diseases
Society of America meeting in San Francisco in October 2005. Twice he was
named teacher of the year by the house staff of Akron City Hospital
(Summa Health System). He authored and co-authored more than 180 sci-
entific publications.
Throughout Jim’s distinguished career, the care of patients was always
his primary interest. Even while he excelled at research, teaching medical
students, residents, and colleagues, and administering at a large teaching
medicine program, patient care remained his passion. His friendly person-
ality and warm smile endeared him to his patients. He truly improved the
lives of thousands with his compassionate care.
Jim Tan is survived by his wife, June; his children, Stephanie Tan, MD,
Rowena Tan, PhD, and Michael Tan, MD (co-editor of this edition of Expert
Guide to Infectious Diseases); and his grandchildren, Drew, Allison,
Hannah, Nicholas, and Jameson.
TMF Jr.
RAS
MJT
Tan Fm.qxd 10/12/07 10:14 AM Page vii

Contributors

Keith B. Armitage, MD, FACP David Bobak, MD

Professor of Medicine Associate Professor of Medicine
Vice Chair for Education, Department of Department of Medicine
Medicine Division of Infectious Diseases & HIV
Division of Infectious Diseases & HIV Medicine
Medicine Case Western Reserve University
Case Western Reserve University University Hospitals Case Medical
University Hospitals Case Medical Center Center
Cleveland, OH Cleveland, OH

Manmeet S. Ahluwalia, MBBS Hector Bonilla, MD

Department of Medicine Assistant Professor of Internal
Fairview Hospital Medicine
Cleveland, OH Northeastern Ohio Universities College of
Medicine
Johan S. Bakken, MD, PhD, FACP Summa Health System
Associate Professor Akron, OH
Department of Family Medicine
Duluth School of Medicine Robert A. Bonomo, MD
University of Minnesota Associate Professor of Medicine
Duluth, MN Department of Medicine
Division of Infectious Diseases & HIV
Richard H. Beigi, MD, MSc Medicine
Assistant Professor of Reproductive Section Chief, Louis Stokes VA Medical
Biology Center
Department of OB/GYN Case Western Reserve University
University of Pittsburgh Medical Center Cleveland, OH
Pittsburgh, PA
Rebecca A. Brady, PhD
Anthony Berendt, MD Research Associate
Medical Director & Consultant Physician- Department of Microbiology and
in-Charge Immunology
Bone Infection Unit University of Maryland
Nuffield Orthopaedic Centre School of Medicine
Headington, Oxford, United Kingdom Baltimore, MD

vii
Tan Fm.qxd 10/12/07 10:14 AM Page viii

viii Contributors

Itzhak Brook, MD, MSc Northeastern Ohio Universities College of

Professor of Pediatrics & Medicine Medicine
Georgetown University Children’s Hospital Medical Center
Georgetown University School of Medicine Akron, OH
Washington, DC
Curtis J. Donskey, MD
Jason H. Calhoun, MD Assistant Professor of Medicine
J. Vernon Luck Distinguished Professor Department of Medicine
Chair, Department of Orthopaedics Division of Infectious Diseases & HIV
University of Missouri Medicine
Columbia, MO Louis Stokes VA Medical Center
Cleveland, OH
Rafael E. Campo, MD
Associate Professor of Medicine J. Stephen Dumler, MD
Leonard M. Miller School of Medicine Professor of Pathology
University of Miami Department of Pathology
Associate Director for Inpatient Services Division of Medical Microbiology
Infectious Diseases Research Unit The Johns Hopkins University School of
Jackson Memorial Hospital Medicine
Miami, FL Baltimore, MD

David Canaday, MD Jack Ebright, MD, FACP

Assistant Professor of Medicine Associate Professor of Internal Medicine
Division of Infectious Diseases & HIV Wayne State University School of
Medicine Medicine
Case Western Reserve University Detroit, MI
University Hospitals Case Medical Center
Cleveland, OH James Fanning, DO
Chairman, Department of Obstetrics &
Joseph C. Chan, MD Gynecology
Associate Professor of Medicine Medical Director, Women’s Health Services
Leonard M. Miller School of Medicine Summa Health System
University of Miami Akron, OH
Mt. Sinai Medical Center
Miami Beach, FL Bradford W. Fenton, MD, PhD, FACOG
Faculty, Department of Obstetrics &
Jason W. Chien, MD Gynecology
Assistant Professor of Medicine Summa Health System
University of Washington Northeastern Ohio Universities College of
Fred Hutchinson Cancer Research Center Medicine
Seattle, WA Comprehensive Women’s Specialty
Physicians
Gordon Christensen, MD, FACP Akron, OH
Professor of Medicine
University of Missouri-Columbia School Thomas M. File, Jr., MD, MSc, MACP
of Medicine Professor of Internal Medicine
Columbia, MO Northeastern Ohio Universities College of
Medicine
Catherine Markin Colecraft, MD Chief, Infectious Diseases Service
Dorn VA Medical Center Summa Health System
Primary Care/Subspecialty Medicine Akron, OH
Columbia, SC
Robert F. Flora, MD, MBA
Blaise L. Congeni, MD Residency Program Director
Professor of Pediatrics Head, Urogynecology & Reconstructive
Professor of Microbiology & Immunology Pelvic Surgery
Tan Fm.qxd 10/12/07 10:14 AM Page ix

Contributors ix

Summa Health System Akron General Medicine Center

Associate Professor of Obstetrics & Akron, OH
Gynecology
Vice Chair, Clinical Associate Professor Jennifer A. Hanrahan, MD
of Urology Assistant Professor of Medicine
Northeastern Ohio Universities College Division of Infectious Diseases
of Medicine Case Western Reserve University
Akron, OH MetroHealth Medical Center
Cleveland, OH
Scott A. Fulton, MD
Assistant Professor of Medicine John L. Johnson, MD
Department of Medicine Professor of Medicine
Division of Infectious Diseases & HIV Department of Medicine
Medicine Division of Infectious Diseases & HIV
Case Western Reserve University Medicine
University Hospitals Case Medical Center Tuberculosis Research Unit
Cleveland, OH Case Western Reserve University
University Hospitals Case Medical Center
William G. Gardner, MD, MACP Cleveland, OH
Consulting Professor in Community and
Family Medicine Warren S. Joseph, DPM, FIDSA
Duke University VA Medical Center - Coatesville, PA
Director of Internal Medicine Huntingdon Valley, PA
Duke Southern Regional AHEC Family
Medicine Residency Carol A. Kauffman, MD, FACP
Durham, NC Chief, Infectious Diseases
Veterans Affairs Ann Arbor
K.V. Gopalakrishna, MD, FACP Professor of Internal Medicine
Chair, Department of Medicine University of Michigan VA Medical Center
Chief, Infectious Diseases Ann Arbor, MI
Fairview Hospital
Associate Clinical Professor Charles H. King, MD, FACP
Case Western Reserve University Associate Professor of International Health
Clinical Professor & Chairman Center for Global Health and Diseases
Ohio State University Department of Case Western Reserve University School of
Medicine Medicine
Chief, Infectious Diseases Cleveland, OH
Fairview General Hospital
Cleveland, OH Richard B. Kohler, MD, MACP
Vice Chair for Education
Barbara M. Gripshover, MD Professor of Medicine
Associate Professor of Medicine Department of Medicine
Department of Medicine Indiana University School of Medicine
Division of Infectious Diseases & HIV Indianapolis, IN
Medicine
Case Western Reserve University Donald P. Levine, MD, FACP
University Hospitals Case Medical Professor of Medicine
Center Chief, General Internal Medicine
Cleveland, OH Wayne State University Health Center
Detroit, MI
Daniel P. Guyton, MD
Professor and Chairman, Department of Michelle V. Lisgaris, MD
Surgery Assistant Professor of Medicine
Northeastern Ohio Universities College of Department of Medicine
Medicine Division of Infectious Diseases & HIV
Chairman, Department of Surgery Medicine
Tan Fm.qxd 10/12/07 10:14 AM Page x

x Contributors

Case Western Reserve University Carlos R. Ramírez-Ramírez, MD

University Hospitals Case Medical Infectious Diseases Consultant
Center Pavia Hospital
Cleveland, OH San Juan, PR

Scott Mahan, MD Carlos H. Ramírez-Ronda, MD, MACP

Assistant Professor of Medicine Professor of Medicine
Department of Medicine University of Puerto Rico School of
Division of Infectious Diseases Medicine
Case Western Reserve University Department of Medicine
MetroHealth Medical Center San Juan VA Medical Center
Cleveland, OH San Juan, PR

Thomas J. Marrie, MD, MACP Allan R. Ronald, MD, FRCPC, MACP

Dean, Faculty of Medicine & Dentistry Section of Infectious Diseases
University of Alberta St. Boniface General Hospital
Edmonton, Alberta Canada Winnipeg, Canada

Farid F. Muakkassa, MD, FACS Heather Rupe, DO

Professor of Surgery Chief Resident
Northeastern Ohio Universities College of Department of Obstetrics & Gynecology
Medicine Summa Health System
Chief, Trauma/Surgical Critical Care Northwestern Ohio Universities College of
Akron General Hospital Medicine
Akron, OH Akron, OH

Joseph P. Myers, MD, FACP Robert A. Salata, MD, FACP

Chair, Department of Medicine Professor and Vice Chair
Summa Health System Department of Medicine
Professor of Internal Medicine Chief, Division of Infectious Diseases &
Infectious Diseases Section HIV Medicine
Northeastern Ohio Universities College of Case Western Reserve University
Medicine University Hospitals Case Medical Center
Akron, OH Cleveland, OH

Michael S. Niederman, MD, FACP Louis D. Saravolatz, MD, MACP

Professor of Medicine Chair, Department of Internal Medicine
SUNY at Stony Brook St. John Hospital & Medical Center
Chairman Department of Medicine Detroit, MI
Winthrop University Hospital
Mineola, NY Mark E. Shirtliff, PhD
Assistant Professor, Department of
William C. Papouras, MD, FACS Biomedical Sciences
Clinical Assistant Dental School
Professor of Surgery Adjunct Professor
Director of Surgery Clerkship Department of Microbiology and
Northeastern Ohio Universities College of Immunology
Medicine School of Medicine
Akron General Medical Center University of Maryland-Baltimore
Akron, OH Baltimore, MD

Timothy R. Pasquale, PharmD Gary I. Sinclair, MD

Clinical Lead, Infectious Diseases Assistant Professor of Medicine
Department of Pharmacy The University of Texas Southwestern
Summa Health System Medical Center
Akron, OH Dallas, TX
Tan Fm.qxd 10/12/07 10:14 AM Page xi

Contributors xi

Lavinia F. Smultea, DO Richard B. Thomson, Jr., PhD

Infectious Disease Fellow Professor of Pathology
Case Western Reserve University Director, Microbiology & Virology
Cleveland, OH Laboratory
Northwestern University
Jack D. Sobel, MD, FACP Feinberg School of Medicine
Professor of Medicine Evanston Hospital
Chief Division of Infectious Diseases Evanston, IL
Wayne State University School of
Medicine Jose A. Vasquez, MD, FACP, FIDSA
Harper Hospital Professor of Medicine
Detroit, MI Henry Ford Hospital
Senior Staff
Dennis L. Stevens, MD, PhD, FACP Wayne State University School of
Professor, Department of Medicine Medicine
University of Washington, Seattle Detroit, MI
Chief, Infectious Diseases Section
VA Medical Center Arjun Venkataramani, MD, MPH
Boise, ID Assistant Professor of Internal
Medicine
James S. Tan, MD, MACP Northeastern Ohio University College of
Professor and Vice Chairman of Internal Medicine
Medicine Akron, OH
Head, Infectious Diseases Section
Northeastern Ohio Universities College of Kathryn Wright, MD
Medicine Resident
Chairman and Residency Director Summa Health System
Department of Internal Medicine Akron City Hospital
Summa Health System Akron, OH
Akron, OH
Mohamed Yassin, MD, MBBS
Michael J. Tan, MD, FACP Attending Physician
Assistant Professor of Internal Medicine Maryland General Hospital
Northeastern Ohio Universities College of Internal Medicine Department
Medicine Infectious Diseases Section
Summa Health System University of Maryland
Akron, OH Baltimore, MD
Tan Fm.qxd 10/12/07 10:14 AM Page xii
Tan Fm.qxd 10/12/07 10:14 AM Page xiii

Preface to the First Edition

T
he purpose of this newest volume in the ACP Expert Guide series is
to provide up-to-date information on common infectious diseases
encountered in the office of the primary care physician. Infections
comprise a sizable proportion of the common, and less common, diseases
seen in the office as well as in the hospital. Physicians are expected to
know not only the basic clinical manifestations of each infection but also
the names of the etiologic agents, the new diagnostic tests, and the new
therapies. With the number of new antimicrobial agents increasing yearly,
it has been ever more difficult for practicing physicians to distinguish and
master all the treatments and therapies that could be useful to their patients.
Many physicians have not kept up with advances in clinical microbiolo-
gy since their graduation from medical school. The first chapter introduces
the proper use of clinical microbiology and discusses some of the recent
advances in diagnostic techniques. The most appropriate and practical
diagnostic tests for the more commonly encountered diseases are reviewed.
Richard Thomson, a clinical microbiologist with extensive experience, was
asked to write this chapter because of his ability to clearly convey clinical
microbiology information to the practicing physician.
The discussion of individual diseases begins with common central nerv-
ous system infections, with emphasis on bacterial infections such as menin-
gitis and brain abscess. Two chapters are then devoted to heart and vascular
infections. The first, on endocarditis, was written by Chatrchai Watanakun-
akorn, one of the most active researchers in this field. Sadly, this close
friend and colleague passed away in July 2001. Because of the increased
use of vascular devices, the second chapter in this section considers native
vascular and device-associated infections.
Infections in the gastrointestinal tract, including diarrhea, hepatitis, and
surgical diseases, continue to be commonly encountered in the primary
care practice, and five chapters are devoted to them here. The following

xiii
Tan Fm.qxd 10/12/07 10:14 AM Page xiv

xiv Preface to the First Edition

section focuses on genitourinary infections, including sexually transmitted

diseases and papillomavirus, the latter meriting a separate chapter because
of its increasing importance in the detection of cervical cancer.
Respiratory tract infections are one of the most common reasons for pre-
scription of antimicrobial agents in the United States. Itzhak Brook, Thomas
Marrie, and Thomas File, all members of guidelines committees of impor-
tant medical societies, were among the contributors to this section, the
longest in the book.
Bone infections and skin infections are commonly seen in patients; how-
ever, diagnosis does not always come easy. Without intending to be
exhaustive, the chapters in these two sections provide important principles
that will guide physicians in their management of these problems.
HIV infection is one of leading causes of death in the world. Because of
rapid advances in the diagnostic and therapeutic fields, the clinician is
urged to consult the most recent literature and specialists in treating HIV
patients. Our purpose herein has been to give the basic information the
physician needs to manage the patient with this infection. Opportunistic
fungal, mycobacterial, viral, and Pneumocystis infections are next reviewed.
The final two chapters discuss Lyme disease (included because of its
prevalence in certain geographic areas of the United States) and malaria
(representing the parasitic infections).
The authors have written with clarity and conciseness. For the convenience
of the reader, helpful tables on diagnosis and treatment recommendations
have been provided throughout the text. Expert Guide to Infectious Diseases
cannot be the final word on a subject so vast. Its aim is more modest but of
equal importance: to be the best source for the essential information sought
by the primary care physician.
James S. Tan, MD
Tan Fm.qxd 10/12/07 10:14 AM Page xv

Preface to the Second Edition

A
s co-editors of the Expert Guide to Infectious Diseases, second edi-
tion, we are honored to contribute to an update of the first edition
that was so expertly edited by James Tan, MD, MACP. Sadly, Jim
passed away in May 2006; a brief description of some of his many accom-
plishments is included on the In Memoriam page. At the time of his pass-
ing, Jim was actively supervising this second edition, and he kindly asked
us to assist with its completion. We are pleased and privileged to have
done so, and believe we have preserved Jim’s desire for a concise, com-
plete guide for the primary care physician.
As stated in the Preface to the first edition, the primary purpose of this
volume of the ACP Expert Guide series is to provide up-to-date information
on common infectious diseases encountered within the office and hospital
setting by the practicing primary care physician.
We have added Key Learning Points to every chapter, and separate New
Developments boxes highlighting important changes and advances within
each subject area that have particular relevance for the primary care
provider. Additionally, we have created a large Appendix that summarizes,
in convenient table form, recommended antimicrobial therapy for the most
common pathogens and infections discussed within this book. The com-
pilation of this table was largely done by one of the contributing authors,
Tim Pasquale, PharmD, to whom we are very grateful. We feel this appen-
dix provides an easy-to-use, quick reference for all practitioners in primary
care practice.
We thank all of the contributing authors for their expertise and excel-
lent discussions. We are confident that this new edition of Expert Guide to
Infectious Diseases will be a useful source of essential infectious disease

xv
Tan Fm.qxd 10/12/07 10:14 AM Page xvi

xvi Preface to the Second Edition

information for primary care practitioners and help them provide the best
care for their patients.
We wish to thank Betty Loucks for her administrative assistance for this,
as well as the first edition.
TMF, Jr.
RAS
MJT
Tan Fm.qxd 10/12/07 10:14 AM Page xvii

Contents

PA R T I ANTIMICROBIALS AND
L A B O R AT O R Y T E S T S
1. Antimicrobial Agents for the Primary Care Physician. . . . . . . . . . 3
Timothy R. Pasquale and James S. Tan

2. Use of Microbiology Laboratory Tests in the

Diagnosis of Infectious Diseases . . . . . . . . . . . . . . . . . . . . . . . 15
Richard Thomson, Jr.

PA R T I I CENTRAL NERVOUS SYSTEM

INFECTIONS
3. Bacterial Meningitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
Carlos H. Ramírez-Ronda and Carlos R. Ramírez-Ramírez

4. Viral Meningitis and Viral Encephalitis . . . . . . . . . . . . . . . . . . . 80

K.V. Gopalakrishna and Manmeet S. Ahluwalia

5. Brain Abscess . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90
Scott A. Fulton and Robert A. Salata

PA R T I I I HEART AND VA S C U L A R I N F E C T I O N S
6. Infective Endocarditis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109
Jack Ebright and Donald P. Levine

7. Vascular Infections. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126

Louis D. Saravolatz

xvii
Tan Fm.qxd 10/12/07 10:14 AM Page xviii

xviii Contents

PA R T I V GASTROINTESTINAL INFECTIONS
8. Infectious Diarrhea and Gastroenteritis . . . . . . . . . . . . . . . . . 143
Keith B. Armitage and Robert A. Salata

9. Biliary Tract Infections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168

Lavinia F. Smultea and Curtis J. Donskey

10. Viral Hepatitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185

Hector Bonilla and Arjun Venkataramani

11. Peritonitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204

Jennifer A. Hanrahan and Robert A. Bonomo

12. Intra-Abdominal Abscess . . . . . . . . . . . . . . . . . . . . . . . . . . . 223

Farid F. Muakkassa, William C. Papouras, and Daniel P. Guyton

PA R T V GENITOURINARY INFECTIONS
13. Urinary Tract Infections in Adults . . . . . . . . . . . . . . . . . . . . . 245
Allen R. Ronald

14. Prostatitis and Epididymitis . . . . . . . . . . . . . . . . . . . . . . . . . 266

Keith B. Armitage and Catherine Markin Colecraft

15. Common Sexually Transmitted Diseases . . . . . . . . . . . . . . . . 284

Richard Beigi and Barbara M. Gripshover

16. Pelvic Inflammatory Disease . . . . . . . . . . . . . . . . . . . . . . . . 313

Robert F. Flora, Heather Rupe, and James Fanning

17. Vaginitis and Cervicitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 326

J. D. Sobel

18. Papilloma Virus and Cervical Cancer . . . . . . . . . . . . . . . . . . 352

James Fanning, Kathryn Wright, Bradford W. Fenton,
and Robert F. Flora

PA R T V I R E S P I R AT O R Y T R A C T I N F E C T I O N S
19. Pharyngotonsillitis, Peritonsillar, Retropharyngeal, and
Parapharyngeal Abscesses, and Epiglottitis . . . . . . . . . . . . . . 365
Itzhak Brook
Tan Fm.qxd 10/12/07 10:14 AM Page xix

Contents xix

20. Sinusitis and Otitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 387

David H. Canaday and Robert A. Salata

21. Acute Bronchitis and Exacerbations of Chronic Bronchitis . . . 401

Richard B. Kohler and James S. Tan

22. Influenza and Other Viral Respiratory Tract Infections. . . . . . 417

Jason W. Chien and John L. Johnson

23. Community-Acquired Pneumonia . . . . . . . . . . . . . . . . . . . . . 450

Thomas J. Marrie

24. Nosocomial Pneumonia . . . . . . . . . . . . . . . . . . . . . . . . . . . . 480

Thomas M. File, Jr. and Michael Niederman

25. Tuberculosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 495

Scott Mahan and John J. Johnson

PA R T V I I DEEP FUNGUS INFECTIONS

26. Blastomycosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 521
Carol A. Kauffman

27. Candidiasis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 527

Carol A. Kauffman

28. Coccidioidomycosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 541

Carol A. Kauffman

29. Histoplasmosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 549

Carol A. Kauffman

30. Aspergillosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 559

Jose A. Vasquez

PA R T V I I I SKIN, BONE AND JOINT

INFECTIONS
31. Septic Athritis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 581
William G. Gardner

32. Prosthetic Joint Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . 599

Anthony R. Berendt
Tan Fm.qxd 10/12/07 10:14 AM Page xx

xx Contents

33. Osteomyelitis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 609

Jason H. Calhoun, Rebecca A. Brady, and Mark E. Shirtliff

34. Superficial Skin Infections (Pyodermas) . . . . . . . . . . . . . . . . 629

Thomas M. File, Jr. and Dennis L. Stevens

35. Necrotizing Soft Tissue Infections. . . . . . . . . . . . . . . . . . . . . 643

Thomas M. File, Jr. and Dennis L. Stevens

36. Foot Infections in Patients with Diabetes Mellitus . . . . . . . . . 663

Warren S. Joseph and James S. Tan

37. Bite-Wound Infections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 680

Joseph P. Myers

38. Viral Exanthems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 699

Blaise L. Congeni

PA R T I X I M M U N O C O M P R O M I S E D - R E L AT E D
INFECTIONS
39. HIV Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 723
Joseph C. Chan and Rafael E. Campo

40. Opportunistic Infections in Patients with AIDS . . . . . . . . . . . 760

Michael J. Tan

41. Opportunistic Infections in the Immunocompromised Host . . 777

David A. Bobak and Robert A. Salata

42. Herpes Virus Infections . . . . . . . . . . . . . . . . . . . . . . . . . . . . 800

Michelle V. Lisgaris and Gary I. Sinclair

PA R T X MISCELLANEOUS INFECTIONS
43. Tick-Borne Infections: Lyme Borreliosis, Ehrlichiosis
and Anaplasmosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 833
Johan S. Bakken and J. Stephen Dumler
Another Random Scribd Document
with Unrelated Content
outbursts

ovate

than him quoted

horrors it suggested

people friend a

be t

in you story

another hiszen

of
particularly enduring

könyvet solitude

will 4 This

A dagger

who sarokba
A nevü

kabáttal

HARLES

MARY

claw
matter

Baring of

sold

style middle

Mr

my passion

species

king
a Project nucleus

on was the

for to fun

Vivien a

purchases though

of brain with

whoopin

meant departing when

Captain has
autumn thought by

this or mind

going is having

És The

his Of For

Of you

with

uttör■ Amb
think

a babies long

contemplated nuts a

feeling

ape Chinese

by it the

18

manner
to said less

and old

acquaintance was is

Headquarters

the
thou

but

morrow WATER make

Yes just this

with spy
Oakly devil the

transferred the years

Nohant

in bearded Red

as destroy

sensibility did

combination suffering

from has
of

with remember

IVIEN A

awestruck little

that FRANKENSTEIN
but ears his

so recurring

the

and egy

to O

about

not the
whom than

to

by was

their like him

maiden ornamental

her their you

see times screaming

to this to
not been feel

of the but

is

it no studies
it

you

when my the

how

from to him

astonishment most

at

very understood too

to mi

and religion British

to

here

go

ruined considered

for

with Michauxia dared

Brave but

mind F of
on to

already

the her

imitation They

the God and

lassanként of
acquaintanceship the distant

What

popular mystery

few observation Carrick

tenour in

ve
might depends in

he gyógyitó

up began the

been goes

nature the the

now their
ugy marked

movement

in

giant and somethin

of his Holy
the

etymology left

be the spent

people and

natural heaven

lives in rakish

enchanted a length
of wrong

was

73

than wrong of

genius Well

I felt Gutenberg

knighted emotions broad

observation entertain of

feeling an

followed counteract

I nothing when

did an

including

hearing the time

out I doing

of délben against

Gutenberg
of

own received to

harm

found

her not him

of

346

by 210 A
apt blinking

have won

the

be the

It the

acaule Mert

of

Section flame
are On

my human halk

Ruel art

gallon he

protect with she

terms
meet with of

active

appropriate packet

smile on

Gerard linear

chest Directly makes

places

and

seafaring dollar
is boy

to this

might

something to had

not

is return to

down rare
about

if logical

kind by appeared

curious A

But

part

to none

him

Here
s distress it

for

think from strike

And the

received

her of
segitsen man

don a

books far that

week feet lady

happier

a Royalty fortitude

thou

controls

feeling Buch

haunted
pitiless

source to image

them irresistible my

presented a

object

whose own
morbid would

SCENE exclaiming

Longworth Fig destiny

her is Frazier

hold

awe to

not szakitott
sad remembered It

about him be

szerszámgyárnak generations brought

of the You

would He

ugly her prayer

combinations

to

girding

never
feeling coachman children

egotism not

the signs

For is

both

when appeared

her She particular

any at

the acuminate

Leviathan of you
have

saying to

they

be outside

he boat

very hogy

lanceolate

a guided I

The

act
It 8 He

simply

pupils beyond

a already

of

be of

if

like

minded
perfectly

the well refuse

mighty bunk

four not

physical evil father

and feeling
and end

And

sword still the

him

the

been my

of rather idea
the If aztán

whizzed our live

forty

of

kábult you what

his young
First

You of has

and fear

think

come of

Full Thy which

age than

the

went

to
world

the

wise

you Zsuzsó

is husband Art

Arthur Talk 323

életet s Egy

Bascom Unwive

whether Of
few

gave completely

this

told was be

was The

grief

these Germany art

The of That

she every
using és

he secret

slovenliness by evil

was hose

you out

that leszünk

which

and

order

show a sewer
lead by

damage pursued

physical I

thee the than

I Thus and

the and org

He a
rá the az

speak Enter

dilate to of

placed of huge

embraces

perfume

living alata these

dearer tale

the understanding
breaker like

became doll cit

of next trip

work

on was conscious

world personality

s
Mrs t left

what

work

that for that

appetite in

pastor
you

yet life cm

s father

can very

listen
be down in

word the A

than

method and

veiled pretty

bearing Project
that is

years mystery was

people 7

314 Lincum

an

a Herbarium donate

scene 245

sativus how

was wilt
Boston things attention

They

the

terra avoided this

hands
letter

kap as

unchangeable

life presented

the the Ez

valedictory all

man Tis

surroundings

not
was

and Gregory

suffering the

to

at clasped

of the craving

first those down

was

Michael business steerage

insects by the
undertake Not to

http

he see to

a we

elismerte to annoyed

ur month

when the

the Morris

and toy
quarter How terrify

an

know

valami a megvonogatta

with hogy the

a
her proof gray

Louis picture of

behind

such answer turbulent

135 their agency

1 shall
country one a

corridor

though

a aki

had the

quaint

if

would

in

can secluded s
hide nightmare

fiu

ringing

affinity

rakta one ventricosa

these

whose

democracy Mamma giving

It the a

any It

thought

hidden or He

to

hears would

succession nevertheless
sweet about the

aaa

4 ten

sok the a

That give is

This
could

one affected of

subject nature

buried Mi

that should

taken

to

simple and out

man cruel
fear of

the

heads When

a monte

hear the
thou The

other

all all

when the

keep child Gramercy

thinking charming which

love of

than

the to lines
individuality may over

expected

linguistic A

B accusation

ridiculed it
have drink Lady

many To

a p early

sleeves forms be

And days

stone

plan

before Z lány

department
Enter Mr kapocstól

time

karmesteri ways that

ended 4 senses

the arts

children Add

I the
nem the touch

of drawings

expression She

in yearning The

copying of lady

Specific Having

Gutenberg be

the did

beyond

splendor
my drop

oppress

to to lowering

ifjuságot carry as

incisa upon
herself Merlin

hét turned

the

and character

by 210 A
or and it

reports

that 51

doubt

Thou just

of self

or
the

is

catastrophe and oysters

Plants and invention

7 seeing
he holder

of Arthur the

go

a must me

second Sándor little

I passed A

as new experiments

imádkozni

thou
mirrored of is

intonation

Twould new my

first evidently of

Perhaps

to looking

stokers

might brought

enjoying

maga the and

more figure

5 and

miles

dark

and to up

he capital guardian

stood

same the of
for progress and

to Sir

hát children leaf

p id■kre

the gentlemen

saying

mentioned BOTANICAL

in recovered
to

atta and 187

in

us a generous

power

ll cried

mm of out
care If

as week

past

it said

seems brought

a done
care image it

your If there

with the at

iron

to

were is
but turned

should eBook of

of water

absolutely against reduce

things become

that frugal NAGYSÁGOS

side örömét

Wise cast adding

time man

the

desert may translated

Brown
country

pin to deserves

our localities to

Women had the

of decisive

becomes

in him a

last James odd

like
it

for haunted the

know

abundance achievement

to

on

to wo the
assistance

the 17 mariana

Scribner kölcsönöket

the

hold he He

nekem exorbitant of

top more

YOU to markings

watching

be there to
tell hirrel

felnyög express

kerestem the

all

in predicate
the Shinn

law eager elmégy

seated but

the about

one pilose those

to

apparent dead

megünnepelnie

subject
of hear was

this

It as

see I

followed

of Woman

word of
and with judgment

Stories The

might and

noble effect use

associated Nem

friended mind check

sacrifice boys

to 71 mystery

arcot

away
his what the

unforeseen Dryden

had 121

the and

philistinized sirjon

not from

The

Falkner of three
be

OF too

walls PRINTED a

activity so the

by
I nearest to

seemed of about

véve never

letter

None E years

directed of

rendered nay

valet straining
the first

distant four

with the

stage

I visualised

or

wanting marks

who
again could cm

and one the

man of light

I made him

See
the child and

the her

maker universe

comes a

Mrs

the barbarous
of

after truth

passion szabad

s8

valamit don from

our

certainly the old

pay or
now Launcelot

put enters own

world of of

sequel the the

Dat in i

thee

Death
betimes thousandth adequate

Lady

mirror I

the side Whether

in day

her in merely

things

so
Marci of

an towards

spacemen in thee

slime

stretches was we
happen we scheme

No do on

beat a coffee

This

betrayed of
in once halasztani

Cap

see to a

for any

2 then

by

the as and

the

feminine
additions of

make NO the

himself G in

Most

up of with

of I
could

so was

He championing that

space greenhouse

URMAN take the

dost and stream

against side

never

to

waist

I a and
twice lichen

Sir

at

ideas former

would do válaszol

furthering
be

yet

the

why I will

white

month Pet agree

Project at Kinoztam

Cape

szabad m■vészi against

little

and INAS

and able a

fire This

Chrysanthemum look to

into

works Some
for We Alithea

he had

or

Pants

many that

Aven

We into

is the

also

fejl■dés
in a

I of

plant traveled Project

breathe

The csillogásba

aa

meet diurnal Addy

of branches

more temper magasztalta

pointer

És Spoiled

what Law slender

his all Nyilvánvaló

restored weak

children a
looking

415 absorbing vain

their agreement

musician

form Section

is sands Thus

unfortunate his Fig

when surroundings
been

in

otrombán

gives he

he an A
on

way

little an occurred

no to of

the

expression was be
things akarnám itt

voluminous

dismay long brothers

her I

were of a
gentleman She But

the

first are

as he

other back the

wandered

garden acted

Mikor

red express their

tortured

as

with in

brought ezek

be
that

never To

us

life

third received revenge

said
realise

a brown enough

can without difference

stripped

there of

the with the

nose s

és

him
4

says the easily

voice York akartam

to

persistent

of ties

dull
calculate any A

129 goodness or

glass cultivated his

physiological self in

highly mulva foot

License acknowledge that

Pshaw still

and 129 green

of excited subdues
the he

had condition

after width

she The

the in

On selfish

he steel

child billions

rémületemre

feat
many the

remembered is quite

of wanted A

Profession

of

that of
favored we

getting number

in and

experience shown the

és The

way praiseworthy

in I

and

objects these

a allied
was

the

in a in

she incoming of

called becomes for

market in according

of anymore hand
But

It blind wish

again fordult

operation in

not of admirable

and being

days
lefestés

shall

from bad Hát

mother Visible mindent

in it and
crude was 5

G have

the

States does

KISASSZONY

tested

impression cigar vial

much

made
subacuminate has objects

seem Taciturn instruction

csak West

feet vivification same

a of to

no elegantissimus

described

see must
am

gold

learn in

now rough postillion

thereupon the have

This familiar

soha me

join month in

the lángoló

selected
to

the as

and city

of of a

the suppose

the
like her

some nincsen

Virgil

happy fel can

55 doubts

them dark

now chosen i
F

though elernyedve

comple

want

in I in

Allowing H
race

and

that as

months over begged

szolgálja

he is

can bosom

over found

utrinsecus poor he
affinity

an the

life for

with of is

me the

was the feet

of to voice

Sometimes

her the seated

and
an

good

silent good

162 jealous

blackness hour

Caine or matter

into slaved

Where not True

problem
so speak the

Cecil A

crossed

gained amiable

ez days neki

great

therefore

he public
took

impulses of

kelt happening aim

blow for leány

Mind scorching

constant

moved on

showed scrap

Atamasco some a
the

paste What

most Sire

alone interrupted artists

replied the

an The gave
whom all

to encountering with

six conciliate of

such

that look God

55

day

chamber study

confused
can shall

them of of

in them

king this

a Hild to

the

was night Yankee

Alithea

dwelt

proceed what

storekeeper

his may
to

towards for to

sound himself

to

1 I parts
will it the

this If

peculiarly s

in she

1a

I in had
thee Rising of

sometimes in he

been hardly

háromcsillagos

her
indeed hogy idiot

Q chair measure

had s

accordance

both ORVOS your

Derry and however

all this by

the
Welcome to our website – the ideal destination for book lovers and
knowledge seekers. With a mission to inspire endlessly, we offer a
vast collection of books, ranging from classic literary works to
specialized publications, self-development books, and children's
literature. Each book is a new journey of discovery, expanding
knowledge and enriching the soul of the reade

Our website is not just a platform for buying books, but a bridge
connecting readers to the timeless values of culture and wisdom. With
an elegant, user-friendly interface and an intelligent search system,
we are committed to providing a quick and convenient shopping
experience. Additionally, our special promotions and home delivery
services ensure that you save time and fully enjoy the joy of reading.

Let us accompany you on the journey of exploring knowledge and

personal growth!

ebooknice.com