NHL VS.
HL
COMPARE & CONTRAST
CATEGORY
NHL
HL
REED-STERNBERG
CELL
ABSENT
PRESENT
ORIGIN
B/T CELL
B CELL
PATHOGNOMONIC SIGN ENLARGED LN
ANY LN OR ORGAN
AGE
>60
15-24; >60
SX
PAINLESS SWELLING
PAINLESS SWELLING
AREA
THROUGHOUT BODY
NECK, UNDERARM, CHEST
PROGRESS
ADVANCED
SLOW
NON-HODGKINS
LYMPHOMA
TYPES
B-CELL LYMPHOMA
DIFFUSE LARGE BCL
PRIMARY MEDIASTINAL
INTRAVASCULAR
FOLLICULAR L
CLL/SLL
MANTLE CELL L
MARGINAL ZONE BCL
EXTRANODAL MZBCL
NODAL MZBCL
SPLENIC MZBCL
BURKITT L
LYMPHOPLASMACYTIC L
HAIRY CELL LEUKEMIA
PRIMARY CNS L
RISK FACTORS
AGE
GENDER
RACE, ETHNICITY,
GEOGRAPHY
EXPOSURE TO
CHEMICALS
RADIATION
IMMUNODEFICIENCY
AUTOIMMUNE DSS
INFXN
OBESITY
IMPLANTS
S/SX
ENLARGED LN
SWOLLEN ABDOMEN
FEELING OF FULLNESS
CHEST PAIN
FATIGUE
ANEMIA
SOB/COUGH
LEAKAGE
FEVER
WT. LOSS
NIGHT SWEATS
DX
PE
BIOPSY
LAB TEST
FLOW CYTOMETRY
IMMUNOHISTOCHEM
CYTOGENETICS
MOLECULAR GENETIC TESTS
BLOOD TEST
IMAGING
STAGING (ANN ARBOR SS)
S1 1 LN; 1 AREA OF SINGLE ORGAN OUTSIDE LS
S2 >2 LN SAME SIDE OF DIAPHRAGM; EXTEND FROM
SINGLE GROUP INTO NEARBY ORGAN/OTHER LN ON
SAME SIDE DIAPHRAGM
S3 LN BOTH AREA; SPREAD TO ORGAN NEXT TO LN,
SPLEEN OR BOTH
S4 - METASTASIS
STAGING
BULKY DSS
A vs. B
TX (CHEMO)
Alkylating agents
Cyclophosphamide
(Cytoxan)
Chlorambucil
Bendamustine (Treanda)
Ifosfamide (Ifex)
Corticosteroids
Prednisone
Dexamethasone
(Decadron)
Platinum drugs
Cisplatin
Carboplatin
Oxaliplatin
Purine analogs
Fludarabine (Fludara)
Pentostatin (Nipent)
Cladribine (2-CdA,
Leustatin)
Anti-metabolites
Cytarabine (ara-C)
Gemcitabine (Gemzar)
Methotrexate
Pralatrexate (Folotyn)
Others
Vincristine (Oncovin)
Doxorubicin (Adriamycin)
Mitoxantrone
Etoposide (VP-16)
Bleomycin
IMMUNOTHERAPY
Antibodies that
target CD20
Rituximab (Rituxan)
Obinutuzumab (Gazyva)
Ofatumumab (Arzerra)
Ibritumomab tiuxetan
(Zevalin)
Antibodies targeting
CD52
Alemtuzumab
(Campath)
Antibodies that
target CD30
Brentuximab vedotin
(Adcetris)
Interferon
Immunomodulating
agents
Thalidomide (Thalomid)
Lenalidomide (Revlimid)
TX
RADIATION
HIGH-DOSE CHEMO
STEM CELL
SURGERY
