Schizophrenia and other
paranoid disorders
Dr. AMJAD HAKRO
MBBS, FCPS (Psych)
Consultant Psychiatrist, Senior Registrar
ATMCH, Karachi
Definition
• A long-term mental disorder of a type involving a breakdown in the
relation between thought, emotion, and behavior, leading to faulty
perception, inappropriate actions and feelings, withdrawal from
reality and personal relationships into fantasy and delusion, and a
sense of mental fragmentation.
Prevalence of schizophrenia
• Approx. 21 million people worldwide are affected.
• 1.5% of the population is suffering from this ailment in Pakistan
• Schizophrenia affects men and women with equal frequency.
• Mean age of 21years were found to have schizophrenia
Prevalence of schizophrenia
affected patients
50% 50%
male female
Types of schizophrenia
Schizophrenia
Paranoid Negative
Catatonic Hebephrenic unspecified
schizophrenia symptom
Positive Waxy
Early age disorganized
symptoms flexibility
Good
Bad prognosis
prognosis
Common symptoms
• Auditory hallucinations
• Ideas of reference
• Suspiciousness
• Voices speaking to the patient
• Delusions of persecution
• Thoughts spoken aloud
• Lack of insight
• Social withdrawal
• Underactivity
Etiology
• Genetic: 5-10% risk among 1st degree relative
• Obstetric complications: Antepartum hemorrhage, PPH, LBW,
asphyxia, RH incompatibility
• Maternal malnutrition, maternal influenza, Rubella infection,
Toxoplasmosis, Herpes simplex
• Paternal age
Structural brain changes
• Dec brain vol.
• Enlarged lateral ventricles
• Enlarged 3rd ventricle
• Dec. cortical grey matter
• Dec. brain weight
• Decreased synaptic markers
Differentials
• Depressive disorder
• Obsessive compulsive disorder
• Brief psychotic disorder
• Temporal Lobe epilepsy
• Substance abuse (cannabis etc.)
Treatment
• First generation anti-psychotics
• Second generation anti psychotics
• Family education
• CBT
• Social Skills training
• Illness management skills
• Supported employment
Paranoid/Delusional Disorders
• A fixed, false, firm belief that is held on inadequate grounds, not
affected by rational argument or evidence to the contrary
Types of delusional disorders
• Erotomania/ De Clermbault’s syndrome
• Morbid jealousy/ Othello syndrome
• Persecutory delusions
• Hypochondriacal delusions
Morbid Jealousy/ Othello Syndrome
• Commonest delusional Dx
• Greatest risk of dangerousness
• More common in men
• The main feature is; abnormal belief in partner’s infidelity
Differentials
• Schizophrenia
• Mood disorder
• Organic brain disorder
• Substance use (esp. Alcohol)
• Paranoid personality disorder
Treatment
• Antipsychotic
• Psychotherapy
• Inpatient treatment
• Separation advisable in extreme cases
Thank you