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Anti Fibrinolytic Drug: Sakura, MD Department of Pharmacology Hasanuddin University

Anti-fibrinolytic drugs work by catalyzing the formation of plasmin from plasminogen to rapidly lyse thrombi. They include streptokinase, urokinase, tissue plasminogen activator, alteplase, and reteplase. Streptokinase is a protein made by streptococci that combines with plasminogen to activate plasminogen. Urokinase is a human enzyme synthesized by the kidneys. These drugs are used to treat multiple pulmonary embolisms, central deep venous thrombosis, acute myocardial infarction, and peripheral vascular disease, with streptokinase given at an initial dose of 250,000 units IV followed by 100,000 units for 24-

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45 views6 pages

Anti Fibrinolytic Drug: Sakura, MD Department of Pharmacology Hasanuddin University

Anti-fibrinolytic drugs work by catalyzing the formation of plasmin from plasminogen to rapidly lyse thrombi. They include streptokinase, urokinase, tissue plasminogen activator, alteplase, and reteplase. Streptokinase is a protein made by streptococci that combines with plasminogen to activate plasminogen. Urokinase is a human enzyme synthesized by the kidneys. These drugs are used to treat multiple pulmonary embolisms, central deep venous thrombosis, acute myocardial infarction, and peripheral vascular disease, with streptokinase given at an initial dose of 250,000 units IV followed by 100,000 units for 24-

Uploaded by

David Christian
Copyright
© © All Rights Reserved
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Anti Fibrinolytic Drug

Sakura, MD
Department of Pharmacology
Hasanuddin University
• Consist of :
- Streptokinase
- Urokinase
- Tissue plasminogen activator
- Alteplase
- Reteplase
• Rapidly lysis thrombi by catalysing the
formation of the serine protease plasmin
from its precursor zymogen, plasminogen
• Streptokinase
- protein synthesized by streptococci,
combines with proactivator plasminogen
- catalyzes the conversion of inactive
plasminogen to active plasmin
• Urokinase
- human enzyme syntesize by the
kidney
Indication

• Multiple pulmonary emboli


• Central deep venous thrombosis
• Acute myocardial infarction
• Peripheral vascular disease
Dosage

• Streptokinase
LD : 250.000 units (IV), followed by
100.000 units for 24-72 hours
• Urokinase
LD : 300.000 units (10 minutes),
MD : 300.000 units for 12 hours

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