Bronchiolitis
Common disease of LRT of infants, results from
inflammatory obstruction of small airways
It occurs in the first 2 years of life
Peak incidence at approximately 6 month of age
Highest during winter and early spring
Occurs sporadically and epidemically
Etiology
Predominantly viral illness
RSV > 50%
Parinfluenza virus
Mycoplasma
Same adenovirus
Most common in male infants between 3- 6 month
who have not breast fed
Phathophysiology
characterized by bronchiolar obstruction due to
edema and accumulation of mucoid cellular debris
and by invasion of the small bronchial radicals by virus
Resistance in the small air passage is increased during
the inspiratory and expiratory phase
Small radius of air way lead to air trapping and over
inflation
conti
Atelectasis may occur when an obstruction became
complete and trapped air is absorbed
Impairs normal exchange of gases in the lungs
ventilation - perfusion mismatch results in hypoxemia
Hypercapnia occurs when respiratory rate exceeds 60
breaths /min
Clinical manifestation
Sx history of exposure to adults minor respiratory
disease with in a weak.
Mild RTI with nasal discharge and sneezing
Fever (38.5-39c) and loss of appetite
Gradual development of respiratory distress
characteristic by paroxysmal wheezing, cough,
dyspnea, and irritability
conti
Sn tachypinc with hyper-expanded chest and often in
extreme distress.
RR 60-80 breaths /min, severe air hunger and cyanosis
IC and SC retraction
Palpable liver and spleen as result of over inflation of
lung
conti
Crackles may be heard at the end of inspiration and
expiration
Expiratory phase is prolonged leading to audible
wheeze.
Investigation
Roentgnographic exam
hyperinflation increased AP diameter
scattered area of consolidation in 30%
Virus demonstration in nasopharyngeal secretion by
antigen detection
DDX
Asthma- family hx, repeated episodes, sudden
onset without proceeding infection,
eosnophillia, favorable to treat.
Cystic fibroses
Heart failure
Foreign body in the trachea
Pertusis
Organophosphate poising, B, pneumonia
Course and prognosis
Critical phase is the first 48-72 hrs
Case fatality rate is 1%
Death occurs from, paroxysmal apneic spell, severe
uncompensated respiratory acidosis or profound
dehydration
Prevention
RSV immuno globline IV or IM administration prior or
during RSV season.
Hospitalization
Supportive Rx- place an atmosphere cold, humidified
oxygen to relive hypoxemia and reduce insensible
water lose.
Comfortable sitting at 30-40 degree angle with head
and chest slightly elevated.
Ribovirine administered by aerasol may be considered
for infant with CHD or broncopulmonry dysplasia