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Bio Reactor Process Control

The document outlines the teaching-learning activities and assessment for a course on bioreactor process control, including lectures, group assignments, presentations and exams. It describes monitoring various process parameters like temperature, pH, foam, dissolved oxygen and carbon dioxide levels. Assessment is based on answering questions, reports, presentations and exam scores.

Uploaded by

Ferlita Mutiara
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© Attribution Non-Commercial (BY-NC)
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
75 views

Bio Reactor Process Control

The document outlines the teaching-learning activities and assessment for a course on bioreactor process control, including lectures, group assignments, presentations and exams. It describes monitoring various process parameters like temperature, pH, foam, dissolved oxygen and carbon dioxide levels. Assessment is based on answering questions, reports, presentations and exam scores.

Uploaded by

Ferlita Mutiara
Copyright
© Attribution Non-Commercial (BY-NC)
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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Bioreactor Process

Control
Tunjung Mahatmanto
Teaching – Learning Activities &
Assessment

Materials/Tools Activities Duration Assessment


Essential questions Answering questions 10 minutes Answer of questions [20%]
Basic concept Lecture 30 minutes -
Group Assignment Working in group 30 minutes Report [30%]
Brainstorming

Discussing

Report Brief presentation


Sketching 20 minutes Content delivery [20%]
Topic evaluation Answering feedback 10 minutes -
*Total score of each questionnaire
topic = 70%
Examination Answering questions 90 minutes Answer of questions [30%]
Activities – Entrepreneurial Soft
Skills Matrix

Entrepreneurial Soft Skills


Activitie
Answering
Critical Problem Decision Risk Taking Leadership Teamwork Communication
Lecture
sRole Play
Questions v
Thinking
v
Solving
v
Making

v v v
Brainstorming
v v
Discussion
v v v
Summarizing
v v
Brief Presentation
v
Giving Feedback
v v
Learning Objectives
Sub Topics Objectives
Process Parameter & Recognize fermentation process parameters

Control that should be monitored & controlled in a


bioreactor
Recognize instruments for monitoring &

controlling the parameters in a fermentation


process
Essential Questions
Type Learning Practice Questions
Which one Collecting information
 Which process parameter relates
Making informed decision stoichiometrically to the amount of substrate
Which is best Fresh thinking comparison Which is best: process parameter measurement via
utilization?
sampling or on-line?
How Understanding problems How do you measure temperature on-line?
Weighing options

What do you Using knowledge


Proposing solutionto look What do you suppose would happen if you measure
suppose will ahead & consider what is your sample pH at a different temperature?
Should
happen Making
likely to decisions
happen based on Should you periodically calibrate on-line probes?
evidence
Why Looking at cause & effect Process parameter monitoring is vital in a fermentation
relationships process. Why?
Temperature
Temperature
probe Jacketed bioreactor

Non - jacketed bioreactor Internal heat


exchanger

Heat which will have to be removed by a


cooling
Q exch = system
Q met +: Q ag + Q gas - Q acc -
Q sen - Q evap
pH

Cause Effect Monitoring Control


Microbial Reduce yield pH electrode Buffers

activity Acid/base

addition

Combination pH electrode Double junction reference electrode


Foam
Foam

Timer Detector

Antifoam Antifoam inlet


Mechanical defoamer reservoir Pump
Probe

A foam sensing and control unit


Viable Cells, Dissolved
O2 & CO2
 Viable Cells
 A viable cell will hold up an electrical
charge in direct relation to the number
of viable cells present in a vessel
 Dissolved Oxygen
 Oxygen is not soluble in culture media
(only 7 ppm at 37 °C ) but can be
consumed in large amounts by rapidly
growing microbial cultures
 Dissolved Carbon Dioxide
 The measurement of CO2 helps
determine the course of the
fermentation as well as the carbon
Group Assignment
Problem :
As a supplier, your team was asked to provide a list of manufacturers of on-line
bioreactor probes for temperature, pH, foam, dissolved oxygen, dissolved carbon
dioxide, and viable cells measurement

Task :
Provide the contact details of the manufacturer of each probe

Role Play :
1 team leader and 5-6 members

Report :

Probe Manufacturer Contact Details

Web address
Address
Telephone number
Email

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