MALE CIRCUMCISION AND PENILE CANCER:
A SYSTEMATIC REVIEW AND META-ANALYSIS
PENILE CANCER
• Relatively rare : 1 case per 100,000 person-years in Western
countries
• Typically occurs in later life
• Types of Penile cancer :
1. Penile Intra-epithelial Neoplasia (PIN) Several studies:
2. Penile Cancer in situ Circumcision have a
good effect for this
3. Invasive penile cancer stage
• Still need the systematical review and epidemiological evidence
about association between male circumcision and penile cancer
• To discuss the possible mechanisms and biological pathways for this
association
PHIMOSIS
• A condition occurring most commonly in young
boys where the foreskin cannot be fully retracted
over the glans and is a risk factor for penile
cancer
The Association Of Phimosis, Circumcision And Penile Cancer
• To examine the association of circumcision with
penile cancer beyond the effect mediated
through phimosis
• Two papers stratified analyses by history of
phimosis found an association of circumcision
with invasive penile cancer among all subjects,
but no evidence of an association among those
with no history of phimosis
MATERIALS AND METHODS
• Pubmed and Embase databases were searched
on 22 April 2009 and updated on 15 September
2010
• No language restrictions were imposed.
• We did not include circumcision in the search
terms to avoid detection bias
• All abstracts were reviewed independently by
two authors (NL and HW).
QUALITY OF STUDY
THE OVERALL RISK OF BIAS ACROSS STUDIES
WAS HIGH
• Only one study classified with no quality
domains at high risk of bias
• Only two studies were confined to incident
cases due to the rarity of penile cancer and in
the studies which included at least some
prevalent cases
• Risk of length (survival) bias was considered to
be high.
• One study had five quality domains classified as
low risk and two domains classified as unclear
risk; all other studies had a high risk of bias in
one or more of the quality domains
• The potential for length bias was considered to
be high for three case–control studies
METHODOLOGICAL QUALITY OF INCLUDED STUDIES
• Seven quality domains were identified for case–
control studies and six for cross-sectional studies
• Studies were considered to be at high risk of
length bias (survival bias)
DATA ANALYSIS
• The effect of circumcision on penile cancer was
estimated using odds ratios (OR)
• Where ORs were not presented→crude ORs and
95% CI were calculated from the data when
possible
• Estimate was calculated as the adjusted estimate
where present and the crude estimate otherwise
• This best available estimate was included in a
random effects metaanalysis, using Stata 11
DATA ANALYSIS
• The meta-analysis included
(1) analyses of circumcised men compared to men
never circumcised
(2) analyses in which the temporality between
circumcision procedure and cancer diagnosis
were defined (assuming that circumcision before
the age of 18 years preceded penile cancer)
AGE AT CIRCUMCISION
Categorized into three groups:
• childhood/adolescence (all
participants\18 years)
• mostly adults (median age C 18 years;
minimum 10 years old)
• age inadequately reported
Eight papers :
Evaluating the effect of circumcision on
penile cancer (one cross-sectional study
and seven case–control studies)
Populations :
Europe (n = 4), USA (n = 3), and
China (n = 1).
Four studies:
One study:
-the age at circumcision was not
-the exact age at circumcision was not
reported or incompletely
reported
reported
-the authors report that none of the
-the temporality of any
boys were circumcised at birth and all
observed association between
participants were circumcised more
circumcision and penile cancer
than 5 years prior to the study
could not be assessed
RESULT
• A total of 3,366 papers were identified from the
database searches and the full text was obtained for 306
• Total of 269 papers were excluded based on the full
text, including two studies that compared the
prevalence of circumcision among cases of invasive
penile carcinoma with cases of in situ penile cancer.
• An additional six papers were identified from
references and review papers
• Eight eligible papers were identified which included
information on penile cancer
One study : zero case of penile
cancer in men whom circumcised
in childhood/adolescence (95%
ASSOCIATION OF CI)
CIRCUMCISION WHEN
CHILDHOOD/ADOLESCENCE
ON PIN AND IN SITU PENILE Two studies have bias in research
CANCER
(SEVEN STUDIES)
Three studies did not analyze the
age when circumcision
LOW EVIDENCE between association of circumcision
when childhood/adolescence on PIN and in situ penile
cancer
Nine analyses from six papers
evaluated the effect
Three analyses showed strong
evidence of a protective effect
(summary OR = 0.33; 95% CI
THE EFFECT OF 0.13–0.83)
CIRCUMCISION ON
INVASIVE PENILE Two studies shown weak evidence
CANCER effect (Odd Radio=0,5; 95%CI
0,29-0,86)
Two studies in USA : assuming
childhood/adolescent
circumcision related to invasive
penile cancer (27% and 50% )
EFFECT OF CIRCUMCISION ON
IN SITU PENILE CANCER
VS
INVASIVE PENILE CANCER
Circumcision had Circumcision didn’t
a protective have a protective
association with evidence of an
invasive penile effect on PIN/in
cancer situ
In situ vs Five analyses about the effect of
invasive penile cancer: childhood/adolescent circumcision :
- Daling et al =
OR 0,53 vs 0,91 -Weak evidence that the effect
differed for in situ and invasive penile
- Tseng et al = cancer (p = 0.20)
OR 0,41 vs 1,0 -Power for this analysis was low
Case control study in UK :
estimate for
Age at childhood/adolescent
Circumcision circumcisions gave similar results
(summary OR = 0.36; 95% CI
and invasive 0.17–0.75; n = 4) to the overall
penile cancer summary at these ages (OR =
0.33; 95% CI 0.13–0.83; n = 3)
Phimosis is one of the strongest
risk factors for penile cancer
CIRCUMCISION AND
PHIMOSIS
There was no evidence of an
association of circumcision with
invasive disease when analyses
were restricted to individuals
with no history of phimosis
HPV infection is not a necessary cause
of penile cancer
HPV prevalence : 15- 71% among penile
cancer cases
Circumcision
And Penile
HPV Infection There was some suggestion of a
greater protective association of
childhood/adolescent circumcision
with HPV (-) tumours than HPV (+)
tumours
(the CIs estimates were wide and
overlapping)
DISCUSSION
• Circumcision in childhood/adolescence was protective
against invasive penile cancer, with a summary odds ratio
of 0.33 (95% CI 0.13–0.83).
• Although there was some evidence of heterogeneity (p =
0.11, I 2 = 55%)
• All three studies demonstrated a protective effect (ORs
0.07, 0.41 and 0.53,
• There was some evidence that the risk of invasive
penile cancer was elevated among men circumcised
mostly as adults
• There was little evidence of an association of
circumcision at any age with PIN or in situ penile
cancer
CONCLUSIONS
• These data suggest that childhood/adolescent circumcision is
protective against invasive penile cancer
• This effect could be mediated partly through an effect on
phimosis
• Circumcision services among adults are currently being
expanded as an HIV prevention strategy and neonatal/ infant
circumcision is emerging as a cost-effective longterm HIV
prevention strategy
• Some countries in sub Saharan Africa experience considerably
higher incidence of penile cancer compared to Western
countries and expansion of circumcision services in this region
provides an opportunity to reduce penile cancer as well as HIV
in men
