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Curcumin - A Multifunctional Compound From Natural Sources and Current State of Its Research

This document summarizes a presentation on curcumin given at the 9th International Congress on Nutrition & Health in Berlin, Germany on February 20-21, 2017. The presentation discussed the history of research on curcumin, its chemical and biochemical properties, mechanisms of action, and formulations being studied to improve its bioavailability. Key points included that curcumin has many potential health benefits but its absorption and bioavailability are limited due to poor solubility, rapid metabolism, and elimination from the body. Researchers are developing various nanoparticle and emulsion formulations to enhance curcumin's solubility, stability, antioxidant effects, and bioaccessibility in order to maximize its potential health benefits.

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62 views14 pages

Curcumin - A Multifunctional Compound From Natural Sources and Current State of Its Research

This document summarizes a presentation on curcumin given at the 9th International Congress on Nutrition & Health in Berlin, Germany on February 20-21, 2017. The presentation discussed the history of research on curcumin, its chemical and biochemical properties, mechanisms of action, and formulations being studied to improve its bioavailability. Key points included that curcumin has many potential health benefits but its absorption and bioavailability are limited due to poor solubility, rapid metabolism, and elimination from the body. Researchers are developing various nanoparticle and emulsion formulations to enhance curcumin's solubility, stability, antioxidant effects, and bioaccessibility in order to maximize its potential health benefits.

Uploaded by

Amsterdam84
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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9th International Congress on Nutrition & Health

Curcumin – a multifunctional compound


from natural sources and current state of its
research

Zorka D. Stanic

Faculty of Science
University of Kragujevac

February 20-21, 2017 Berlin, Germany


• When/how interest related to curcumin started :

Human
Scientific community
My research group
Evolution of the number of publications related to curcumin
a) 1871 – 2015
b) 2000 – 2015
(source: SciFinder Scholar)
Turmeric, Curcuma longa L.

O O

O O
CH2

HO OH

CURCUMIN
1,7-bis(4-hydroxy-3-methoxy-phenyl)hepta-
1,6-diene-3,5-dione
Basics of the chemical and biochemical properties of
curcumin

Curcumin
(75%)

Turmeric

DMCur BDMCur
(20%) (5%)
DMCur – demethoxycurcumin
BDMCur - bisdemethoxycurcumin Keto-enol tautomerism of curcumin
main degradation
product at pH 3-10

trans-6-(4-hydroxy-3-methoxyphenyl)-2,4-dioxo-5-hexenal

H3Cur → H2Cur- + H+, pKa1= 8.38  0.04


(acetylacetone group)
H2Cur- → HCur2- + H+, pKa2 = 9.88  0.02
(hydrogen from the phenol group)
HCur2- → Cur3- + H+, pKa3 = 10.51  0.01
(hydrogen from the phenol group)
O OH

O O

Curcumin
HO OH

O OH
O O

-OOC O OH
O
OH Curcumin glucuronide
HO
OH
O OH
O O

-O3SO
Curcumin sulphate
OH
Chemical structures of
O OH the major metabolites of
O O
curcumin inside the body
HO OH
Tetrahydrocurcumin

O OH
O O

HO OH
Hexahydrocurcumin

OH OH
O O

HO OH
Hexahydrocurcuminol
Electrochemical properties of curcumin and its
bioactivity

Mechanism of curcumin
electrooxidation Antioxidant mechanism of curcumin –carbon-
centered radical scavenging activity
The most recent curcumin investigations and their contributions

Multiple biological activities of curcumin


The most recent curcumin investigations and their contributions

solubility poor absorption


stability   rapid elimination from
rapid metabolism the body

Solutions?
Enhancing the nutraceutical bioavailability of curcumin

How?
Formulations Effects
Starch nanoparticle Increases water solubility
Increases stability
Retains antioxidant activity
Mixed surfactant aggregate Increases water solubility
P Increases stability
O Increases antioxidant activity
Chitosan-tripolyphosphate nanoparticle Increases stability
S Prolonged release
S Solid lipid nanoparticle Increases water solubility
Increases stability
I Multilayer nanoemulsion Increases stability
B Lipid nanoemilsion Increases stability
Chitosan hydrogel Prolonged release
L Chitosan-gumarabic nanoparticle Increases stability
E Increases antioxidant activity
Prolonged release
Polyacrylamide-grafted-xanthan gum nanoparticle High gastric resistance
S Increases pH-dependent solubility
O-carboxymethyl chitosan/fucoidan nanoparticle Increases cellular uptake
O Low density lipoprotein/pectin nanogels pH-depended controlled release
L Nanoencapsulation by milk fat/sodium caseinate Increases antioxidant activity
U Mixed colloidal, protein and lipid nanoparticle Increases stability
Increases bioaccessibility
T Zein colloidal particle Increases stability
Limits free radical induced
I oxidation
O Corn oil-in-water emulsion Increases oral bioavailability
N
S
• Additional activities of curcumin
Nutrition supplement
Photo-inactivation of fungal spores

• Curcumin helps in the analysis of different indispensable


substances
Conclusion
Useful suggestions for nutrition and health

• “Turmeric belongs to the group of the healthiest beneficial


spices on the planet.”

• Turmeric and its primary polyphenol – curcumin provide


more than 600 potential health benefits! (MEDLINE)

• HOW TO INCREASE TURMERIC’S BIOAVAILABILITY?


Always mix with black pepper
Add a healthy fat to turmeric
Heat increases turmeric’s bioavailability
Thank you for your attention

“let food be thy medicine and medicine be thy food”


Hippocrates

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