Pluryal Mesoline

SHINE
 Pluryal Mesoline
SHINE
It is a highly effective formula
consisting of skin lightening
components to improve
homogenization of the skin
colour

2
 Pluryal Mesoline SHINE

INGREDIENTS
▸ Ascorbic acid
▸ Phytic acid
▸ Pyruvic acid
▸ Kojic acid
▸ Mulberry leaf extract
3
 ASCORBIC ACID

▸ Ascorbic acid or vitamin C is a potent antioxidant to treat and

prevent changes associated with photoageing.

▸ It can also be used for the treatment of hyperpigmentation and to

lighten the skin

Telang P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146. https://doi.org/10.4103/2229-5178.110593
4
 Mechanism of Action

▸ Antioxidant effect
▹ The most plentiful antioxidant in human skin
▹ Protect the skin from Reactive Oxygen Species (ROS)
▹ Water soluble  Functions in the aqueous compartments of
the cell
▹ When the skin is exposed to UV light  ROS; superoxide
ion, peroxide, and singlet oxygen are generated  Vit. C
protects the skin by donating electrons to neutralize free
radicals

Telang P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146. https://doi.org/10.4103/2229-5178.110593
5
 Mechanism of Action

▸ Photoprotection
▹ UV light generates ROS  Damage the cells  Alterations
of DNA, cell membrane, and cellular proteins; collagen
▹ Oxidative stress
■ Increases Matrix Metalloproteinase (MMP)  Collagen
breakdown
■ Induces Nuclear Transcription Factor kappa B (NFkB)
 Inflammation and skin ageing

Telang P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146. https://doi.org/10.4103/2229-5178.110593
Farris PK. Cosmetical Vitamins: Vitamin C. In: Draelos ZD, Dover JS, Alam M, editors. Cosmeceuticals. Procedures in Cosmetic Dermatology. 2nd ed. New York:
6 Saunders Elsevier; 2009. pp. 51–6.
 Mechanism of Action

▸ Photoprotection
▹ Vit. C is equally effective against UVA and UVB
▹ Repeated small doses of UVA penetrate 30-40 times deeper into the
dermis as against UVB  Affects epidermis
▹ UVA mutates  Destroys collagen, elastin, proteoglycans, and other
dermal cellular structure
▹ UVA  Skin ageing  Possibly melanoma formation
▹ UVB  Sunburn, ROS, epidermal mutations, skin cancer

Telang P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146. https://doi.org/10.4103/2229-5178.110593
Farris PK. Cosmetical Vitamins: Vitamin C. In: Draelos ZD, Dover JS, Alam M, editors. Cosmeceuticals. Procedures in Cosmetic Dermatology. 2nd ed. New York:
7 Saunders Elsevier; 2009. pp. 51–6.
 Mechanism of Action

▸ Photoprotection
▹ Sunscreens  Prevent UV-induced erythema and thymine
dimer mutations; which contributes to carcinogenesis
▹ Sunscreens only block 55% of the free radicals by UV
▹ To optimize UV protection  Combination of sunscreens and
antioxidant
▹ Vit. C doesn’t absorb UV light but ecerts a UV-protective
effect by neutralizing free radicals

Telang P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146. https://doi.org/10.4103/2229-5178.110593
Farris PK. Cosmetical Vitamins: Vitamin C. In: Draelos ZD, Dover JS, Alam M, editors. Cosmeceuticals. Procedures in Cosmetic Dermatology. 2nd ed. New York:
8 Saunders Elsevier; 2009. pp. 51–6.
 Mechanism of Action

▸ Depigmenting agent
▹ Vit. C interacts with copper ions at the tyrosinase-active site 
Inhibits action of enzyme tyrosinase  Decreases melanin formation
▸ Anti inflammatory
▹ Vit. C inhibits NFkB  Inhibits the activation of pro-inflammatory
cytokines; TNF-alfa, IL1, IL6, IL8  Vit. C has an anti-inflammatory
effect  Promote wound healing, acne, and prevent post-
inflammatory hyperpigmentation

Telang P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146. https://doi.org/10.4103/2229-5178.110593
Draelos ZD. Dermatol Ther. 2007 Sep-Oct; 20(5):308-13. Traikovich SS. Arch Otolaryngol Head Neck Surg. 1999 Oct; 125(10):1091-8.
9
 Mechanism of Action

▸ Collagen synthesis
▹ Vit. C influences quantitative collagen synthesis and stimulating
qualitative changes in collagen molecule
▹ Vit. C  Co-factor for the enzymes prolysyl and lysyl hydroxylase
(enzymes for stabilizing and cross-linking the collagen molecules)
▹ Vit. C also stimulates lipid peroxidation  Produces
malondialdehyde  Stimulates collagen gene expression
▹ Vit. C activates transcription of collagen synthesis  Stabilizes
procollagen mRNA  Regulates collagen synthesis

Telang P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146. https://doi.org/10.4103/2229-5178.110593
Draelos ZD. Dermatol Ther. 2007 Sep-Oct; 20(5):308-13. Traikovich SS. Arch Otolaryngol Head Neck Surg. 1999 Oct; 125(10):1091-8.
10
 PHYTIC ACID

▸ Phytic acid is an ester of acid hexaphosphoric inositol

▸ It is a chelating agent that inhibits entrance iron and copper in to the cells
and therefore inhibits melanin production

▸ According to a study by Yokomizo et al, phytic acid is very safe and

effective agent for the treatment of melasma in darker skins

A double-blind controlled study of a nonhydroquinone bleaching cream in the treatment of melasma.Levy JL, Pons F, Agopian L, Besson R J Cosmet Dermatol.
2005 Dec; 4(4):272-6
Faghihi, G., Taheri, A., Shahmoradi, Z., & Nilforoushzadeh, M. A. (2017). Solution of Azelaic Acid (20%), Resorcinol (10%) and Phytic Acid (6%) Versus
Glycolic Acid (50%) Peeling Agent in the Treatment of Female Patients with Facial Melasma. Advanced biomedical research, 6, 9. https://doi.org/10.4103/2277-
9175.200784
Yokomizo VMF, et al. Chemical peels: review and practical applications. Surg Cosmet Dermatol. 2013;5(1):58–68.
11
 PYRUVIC ACID

▸ Pyruvic acid (CH3-CO-COOH) is α-kato acid with properties such as

keratolytic, antimicrobial, the ability to stimulate collagen building, and
formation of elastic fibers.

▸ Pyruvic acid efficacy is known for the treatment of many skin diseases
such as acne, superficial scars, photo-damage, and pigment disorders

Clinical and instrumental evaluation of skin improvement after treatment with a new 50% pyruvic acid peel.Berardesca E, Cameli N, Primavera G, Carrera M.
Dermatol Surg. 2006 Apr; 32(4):526-31
Jaffary, F., Faghihi, G., Saraeian, S., & Hosseini, S. M. (2016). Comparison the effectiveness of pyruvic acid 50% and salicylic acid 30% in the treatment of
acne. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 21, 31. https://doi.org/10.4103/1735-1995.181991

12
 KOJIC ACID

▸ Kojic acid is a natural metabolite produced by fungi that has the ability to
inhibit tyrosinase activity in synthesis of melanin

▸ It has the ability to act as a UV protector, suppressor of hyperpigmentation

in human and restrainer of melanin formation, due to its tyrosinase
inhibitory activity

Saeedi M, Eslamifar M, Khezri K. Kojic acid applications in cosmetic and pharmaceutical preparations. Biomed Pharmacother. 2019;110:582–93.
13
 Mechanism of Action

Saeedi M, Eslamifar M, Khezri K. Kojic acid applications in cosmetic and pharmaceutical preparations. Biomed Pharmacother. 2019;110:582–93.
14
 MULBERRY LEAF EXTRACT

▸ An extract of mulberry is rich in natural antioxidant

▸ It has high phenolic compounds which have high levels of total
Anthocyanin - They are considered as very good antioxidant agents
▸ The presence of tyrosinase inhibitors activities and its free radical
scavenging role are important in skin whitening
▸ It has been reported to show tyrosinase inhibition and inhibitory effects on
tyrosinase activity and melanin formation in B-16 melanoma cells

Naveed, Akhtar & Hisham, Jehad & Khan, Haji M. shoaib & Khan, Barkat & Saeed, Tariq. (2012). Whitening and Antierythemic effect of a cream containing
15 Morus alba extract. Hygeia J. Drugs Med.. 4.
Pluryal Mesoline
CLEAR
 Pluryal Mesoline
CLEAR
It is a formula consisting of
ingredients which regulates oil
secretion in the skin, maintains
skin moisture level and skin
health

17
 Pluryal Mesoline CLEAR

INGREDIENTS
▸ Retinyl palmitate
▸ Ginkgo biloba
▸ Salicylic acid
▸ Vitamin B complex (B3/B5/B6)
▸ Hyaluronic acid

18
 RETINYL PALMITATE

Retinyl palmitate is a form of Retinol -

It an ester of retinol and is the major
form of vitamin A found in the
epidermis. This compound has been
widely used in pharmaceutical and
cosmetic

Zasada, M., & Budzisz, E. (2019). Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments. Postepy
19 dermatologii i alergologii, 36(4), 392–397. https://doi.org/10.5114/ada.2019.87443
 Mechanism of Action

▸ It stimulates the process of epidermal cell proliferation, accelerates

the elimination of sebum remaining in ducts, therefore reducing
inflammation in sebaceous glands; loosens connections among
cells in stratum corneum and inhibits keratosis

Zasada, M., & Budzisz, E. (2019). Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments. Postepy
20 dermatologii i alergologii, 36(4), 392–397. https://doi.org/10.5114/ada.2019.87443
 GINKGO BILOBA

▸ Ginkgo biloba is a medicinal plant which contains potent

antioxidants such as flavonoids, biflavones, and terpenoids

▸ These antioxidants have antiinflammatory, anti ageing and

antibacterial properties which are beneficial to the skin

Poláková, K., Fauger, A., Sayag, M., & Jourdan, E. (2015). A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of
adapalene in patients with acne vulgaris: result from a controlled randomized trial. Clinical, cosmetic and investigational dermatology, 8, 187–191.
https://doi.org/10.2147/CCID.S81691
Feng X, Zhang L, Zhu H. Comparative anticancer and antioxidant activities of different ingredients of Ginkgo biloba extract (EGb 761). Planta Med.
21 2009;75(8):792-796. doi:10.1055/s-0029-1185451
 GINKGO BILOBA

▸ It has been shown that Ginkgo biloba extract could significantly moisturize
the skin
▸ It acts on fibroblast proliferation, production of collagen, and extracellular
fibronectin  Improvement of skin texture / microrelief
▸ It enhanced viable epidermis thickness and the number of cell layers 
moisturizing effect in skin deeper layer, and increased cell renewal
▸ It also acts on the skin elasticity and skin barrier function

Campos, M. M, Patricia. Gianeti, M. Journal of drugs in dermatology [Internet]. 2014;13(9) [cited 2020 Sep 9]. Available from:
22 https://jddonline.com/articles/dermatology/S1545961614P1092X
 SALICYLIC ACID

▸ Salicylic acid Salicylic acid (SA) is a member of a group of

compounds known as hydroxy acids, which are widely used for a
number of cosmetic indications because of their many important
properties

▸ SA is used in many acne preparations. It is also known to enhance

the penetration of other topical agents

Arif T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, cosmetic and investigational dermatology, 8, 455–461.
23 https://doi.org/10.2147/CCID.S84765
 VITAMIN B COMPLEX – B3, B5, B6

▸ Vitamin B Complex in this formula includes Vitamin B3, B5, B6

▸ Deficiency in Vit. B3 (Niacin)  Skin problem

▸ Vit. B5 (Pantothenic Acid)  Improves wound healing

▸ Vit. B6 (Pyridoxine)  Hormone modulation

Rembe J-D, Fromm-Dornieden C, Stuermer EK. Effects of vitamin B complex and vitamin C on human skin cells: Is the perceived effect measurable? Adv Skin
Wound Care. 2018;31(5):225.
Vitamin B Complex - an overview | ScienceDirect Topics [Internet]. Sciencedirect.com. [cited 2020 Sep 10]. Available from:
https://www.sciencedirect.com/topics/medicine-and-dentistry/vitamin-b-complex
24
 VITAMIN B COMPLEX – B3, B5, B6

▸ A clinical study by Rembe et al, demonstrated that Vitamin B

Complex may promote skin health

▸ It has been shown that Vitamin B Complex promote proliferation

and migration of human skin fibroblasts and keratinocytes which
may benefit would healing

Rembe J-D, Fromm-Dornieden C, Stuermer EK. Effects of vitamin B complex and vitamin C on human skin cells: Is the perceived effect measurable? Adv Skin
Wound Care. 2018;31(5):225.
Vitamin B Complex - an overview | ScienceDirect Topics [Internet]. Sciencedirect.com. [cited 2020 Sep 10]. Available from:
https://www.sciencedirect.com/topics/medicine-and-dentistry/vitamin-b-complex
25
 HYALURONIC ACID

▸ The key molecule involved in skin moisture is hyaluronic acid (HA) that
has unique capacity in retaining water molecules

▸ Skin aging is also associated with loss of skin moisture

▸ The predominant component of the skin extracellular matrix is HA

▸ The administration of HA will promote skin hydration

Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253–258.
26 https://doi.org/10.4161/derm.21923
Pluryal BOOSTER
 Pluryal BOOSTER
It is a highly concentrated
formula to improve skin
elasticity and maintain skin
hydration

28
 Pluryal BOOSTER

INGREDIENTS
▸ Hyaluronic acid
▸ Glycerol – stabilizing agent
▸ Phosphate citrate buffer

29
 HYALURONIC ACID

▸ The key molecule involved in skin moisture is hyaluronic acid (HA) that
has unique capacity in retaining water molecules

▸ Skin aging is also associated with loss of skin moisture

▸ The predominant component of the skin extracellular matrix is HA

▸ The administration of HA will promote skin hydration

Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253–258.
30 https://doi.org/10.4161/derm.21923
 BIOSYNTHESIS OF HA

▸ The synthesis of HA increases during tissue injury and wound healing

▸ HA regulates several aspects of tissue repair, including activation of

inflammatory cells to enhance immune response and the response to injury
of fibroblasts and epithelial cells

Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253–258.
31 https://doi.org/10.4161/derm.21923
 HYALURONIC ACID IN SKIN

▸ The hydration of the skin critically depends on the HA-bound water in the
dermis and in the vital area of the epidermis, while maintenance of
hydration essentially depends on the stratum granulosum

▸ The HA content of the dermis is significantly higher than that of the

epidermis, while papillary dermis has much greater levels of HA than
reticular dermis

Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253–258.
32 https://doi.org/10.4161/derm.21923
 HYALURONIC ACID IN SKIN

▸ HA in the dermis regulates water balance, osmotic pressure and ion flow
and functions as a sieve, excluding certain molecules, enhancing the
extracellular domain of cell surfaces and stabilizes skin structures by
electrostatic interactions

▸ Dermal fibroblasts provide the synthetic machinery for dermal HA and

should be the target for pharmacologic attempts to enhance skin hydration

Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253–258.
33 https://doi.org/10.4161/derm.21923
 HA AND SKIN AGEING

▸ The most significant histochemical change observed in ageing skin is the

marked disappearance of epidermal HA, while HA is still present in the
dermis

▸ Progressive reduction of the size of the HA polymers in skin as a result of

aging has also been reported. Therefore, the epidermis loses the principle
molecule responsible for binding and retaining water molecules, resulting
in loss of skin moisture

Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253–258.
34 https://doi.org/10.4161/derm.21923
 GLYCEROL – Stabilizing agent

▸ Glycerol is a trihydroxy alcohol that has been included for many

years in topical dermatological preparations

▸ Endogenous Glycerol plays a role in skin hydration, cutaneous

elasticity and epidermal barrier repair

▸ An antimicrobial effect has also been demonstrated

Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008;159(1):23-34. doi:10.1111/j.1365-
35 2133.2008.08643.x
 PHOSPHATE CITRATE BUFFER

▸ The pH plays an important physiological role in humans; pH influences

skin barrier function, lipid synthesis and aggregation, epidermal
differentiation and desquamation

▸ Buffers adjusted to a specific pH may contain citrate, phosphate or

glycolate, or a combination. These compounds have several effects on skin
integrity, for example, enhancing SC hydration by glycolate

Proksch E. pH in nature, humans and skin. J Dermatol. 2018;45(9):1044–52.

36
Pluryal Mesoline
HAIR
 Pluryal Mesoline
HAIR
It is a highly concentrated
formula to stimulate hair
growth and treat hair loss
which affects both men and
women

38
 Pluryal Mesoline HAIR

INGREDIENTS
▸ Copper peptide
▸ Plant stem cells
▸ Vitamin B complex, amino acids, hyaluronic acid
▸ Caffeine
▸ Coenzyme Q10

39
 COPPER PEPTIDE

▸ The human copper-binding peptide GHK-Cu (glycyl-l-histidyl-l-lysine) is a small,

naturally occurring tri-peptide present in human plasma
▸ Copper Peptide established itself as a powerful protective and regenerative
ingredient, which is currently widely used in skin and hair products
▸ Copper Peptide has anti-inflammatory effects, skin repair actions, and the ability to
increase the size of hair follicles
▸ 5-alpha-reductase enzyme contributes to hair loss and Copper Peptide may inhibit the
activity of the enzyme

Pickart, L., & Margolina, A. (2018). Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International journal of
molecular sciences, 19(7), 1987. https://doi.org/10.3390/ijms19071987

Pickart, L. Improving Hair Growth with Skin Remodeling Copper Peptides. Dermatology Journal. 2004. Available from:
40 http://www.skinbiology.com/Articles/2004RussianHairRemodelingArticle.pdf
 COPPER PEPTIDE

▸ It has been shown that copper peptide is able to:

▹ Increase hair growth and thickness, enlarge hair follicle size
▹ Reduce inflammation and free radical damage
▹ Repair protective skin barrier proteins
▹ Tighten loose skin and reverse thinning of aged skin
▹ Improve skin firmness, elasticity, and clarity

Pickart, L., & Margolina, A. (2018). Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International journal of
41 molecular sciences, 19(7), 1987. https://doi.org/10.3390/ijms19071987
 PLANT STEM CELLS

▸ Plant regeneration at the cellular and tissue level is a unique process.

Similar to animals, the stem cells in plants have properties that help
stimulate and regenerate plants after injury

▸ The unique properties of plant stem cells have been beneficial to cosmetic
dermatology field

Gentile, P., & Garcovich, S. (2019). Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and
Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development. Cells, 8(5), 466. https://doi.org/10.3390/cells8050466
Trehan, S., Michniak-Kohn, B., & Beri, K. (2017). Plant stem cells in cosmetics: current trends and future directions. Future science OA, 3(4), FSO226.
https://doi.org/10.4155/fsoa-2017-0026
42
 PLANT STEM CELLS

▸ Aging of skin is a complex process involving all layers of the epidermis

and dermis, comprising denaturing proteins and reduced functioning of
regenerative stem cells

▸ Humans uphold a stem cell pool as mother cells with the capability of
continuous differentiation into any type of more specialized cells for
various tissues in the body, such as skin tissues

Gentile, P., & Garcovich, S. (2019). Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and
Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development. Cells, 8(5), 466. https://doi.org/10.3390/cells8050466
Trehan, S., Michniak-Kohn, B., & Beri, K. (2017). Plant stem cells in cosmetics: current trends and future directions. Future science OA, 3(4), FSO226.
https://doi.org/10.4155/fsoa-2017-0026
43
 PLANT STEM CELLS

▸ A study by Trehan et al suggested that plant stem cells could reverse the aging
process of skin fibroblasts by upregulating the expression of several genes vital for
cellular proliferation and growth as well as stimulate the expression of the valid
antioxidant enzyme hemeoxygenase-1

▸ It also demonstrated effectiveness in increasing the lifespan of isolated human hair

follicles

Gentile, P., & Garcovich, S. (2019). Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and
Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development. Cells, 8(5), 466. https://doi.org/10.3390/cells8050466
Trehan, S., Michniak-Kohn, B., & Beri, K. (2017). Plant stem cells in cosmetics: current trends and future directions. Future science OA, 3(4), FSO226.
https://doi.org/10.4155/fsoa-2017-0026
44
 VITAMIN B COMPLEX, AMINO ACIDS, AND
HYALURONIC ACID

▸ The vitamin B complex aids in cell metabolism

▸ The role of folate and vitamin B12 in nucleic acid production

suggest that they might play a role in the highly proliferative hair
follicle

▸ Deficiencies of Vitamin B Complex has been associated with hair

loss

Almohanna, H. M., Ahmed, A. A., Tsatalis, J. P., & Tosti, A. (2019). The Role of Vitamins and Minerals in Hair Loss: A Review. Dermatology and therapy, 9(1),
45 51–70. https://doi.org/10.1007/s13555-018-0278-6
 VITAMIN B COMPLEX, AMINO ACIDS, AND
HYALURONIC ACID

▸ Amino acids are the main building blocks of the hair

▸ Loss of amino acids in the hair will affect the structure of the hair
shaft which will lead to hair damage

▸ Amino acids preparations will help improve the strength of the

hair and nourish the hair

2005. Replenishing amino acids in damaged hair. Journal of the American Academy of Dermatology. 52(3) [cited on 11 September 2020] Available from:
46 https://doi.org/10.1016/j.jaad.2004.10.463
 VITAMIN B COMPLEX, AMINO ACIDS, AND
HYALURONIC ACID

▸ Hyaluronic acid (HA) has been known with its ability to retain
moisture

▸ A study suggested that HA showed a positive effect on hair

growth, hydration, and health

Anastasia, R. Hyaluronic acid and sodium succinate in programs of hair loss correction. 2018 [cited 2020 Sep 11]; Available from:
47 https://www.alliedacademies.org/proceedings/hyaluronic-acid-and-sodium-succinate-in-programs-of-hair-loss-correction-2677.html
 CAFFEINE

▸ Caffeine has several molecular actions, including an ability to act as a

phosphodiesterase inhibitor, ryanodine, and adenosine receptor agonist, in
addition to numerous cytoprotective properties through its antioxidant role

▸ Caffeine has been shown to improve microcirculation in the scalp

Visconti MJ, Haidari W, Feldman SR. Therapeutic use of caffeine in dermatology: A literature review. J Dermatol Dermatol Surg [serial online] 2020 [cited  2020
Sep 4];24:18-24. Available from: http://www.jddsjournal.org/text.asp?2020/24/1/18/281426
Herman A, Herman AP. Caffeine's mechanisms of action and its cosmetic use. Skin Pharmacol Physiol. 2013;26(1):8-14. doi:10.1159/000343174
48
 COENZYME Q10
▸ Coenzyme Q10, Q10, or Ubiquinone represents an endogenously
synthesized lipid‐soluble antioxidant
▸ Oxidative stress is thought to play a significant role in biological pathways
accelerating the aging process – therefore a potent antioxidant play an
important role against ageing
▸ A study by Giesen et al suggested that Coenzyme Q10 may have anti
ageing effects on human hair  Improve and prevent hair loss

Knott, A., Achterberg, V., Smuda, C., Mielke, H., Sperling, G., Dunckelmann, K., Vogelsang, A., Krüger, A., Schwengler, H., Behtash, M., Kristof, S., Diekmann,
H., Eisenberg, T., Berroth, A., Hildebrand, J., Siegner, R., Winnefeld, M., Teuber, F., Fey, S., Möbius, J., … Blatt, T. (2015). Topical treatment with coenzyme Q10-
containing formulas improves skin's Q10 level and provides antioxidative effects. BioFactors (Oxford, England), 41(6), 383–390. https://
doi.org/10.1002/biof.1239
Giesen, Melanie & Welss, Thomas & Schulze Zur Wiesche, Erik & Scheunemann, V. & Gruedl, S. & Oezkabakcioglu, Y. & Poppe, E. & Petersohn, Dirk. (2009).
Coenzyme Q10 has anti-aging effects on human hair. International Journal of Cosmetic Science. 31. 154-155. 10.1111/j.1468-2494.2008.00451_5.x.
49
Pluryal Mesoline
ANTIOX
 Pluryal Mesoline
ANTIOX
It is a formula consisting of
potent antioxidants to act
against free radicals in the
skin and to prevent skin
ageing

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 Pluryal Mesoline ANTIOX

INGREDIENTS
▸ Glutathione and Alpha Lipoic Acid
▸ Mannitol
▸ N-acetyl-cysteine
▸ Amino acids (Taurine, Proline, Cysteine, and Cystine)
▸ Minerals (Zinc and Copper)

52
 GLUTATHIONE

▸ Glutathione is an antioxidant commonly found in the human body

▸ It has been demonstrated that glutathione is related to melanogenesis. Its

antimelanogenic properties result from a variety of mechanisms including stimulation
of pheomelanin synthesis rather than darker eumelanin, its antioxidant effects and
interference with intracellular trafficking of melanogenic enzymes  Skin lightening

▸ Glutathione also possesses anti ageing properties

Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol.
53 2017;10:147–53.
 ALPHA LIPOIC ACID

▸ Alpha Lipoic Acid or the reduced form dihydrolipoate (DHLA) is

a potent scavenger with anti-inflammatory properties

▸ Alpha lipoic acid is synthesized in mitochondria and has been

shown to neutralize oxygen free radicals

▸ Clinical studies showed that Alpha Lipoic Acid has a beneficial

effect on skin ageing
Sheldon, P. Lin, J. 2004. Alpha lipoic acid is ineffective as a topical photoprotectant of skin. Journal of the American Academy of Dermatology. 50(3) [cited
2020 Sep 11]. Available from: https://www.jaad.org/article/S0190-9622(03)03879-9/fulltext
Beitner H. Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of
facial skin. Br J Dermatol. 2003;149(4):841-849. doi:10.1046/j.1365-2133.2003.05597.x
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 N-ACETYL-CYSTEINE

▸ N-acetylcysteine (NAC) is a potent antioxidant which has been shown to

be efficacious in several dermatologic conditions

▸ NAC acts as an effective scavenger of free radicals, minimizing reactive

oxygen that damage deoxyribonucleic acid (DNA), proteins, and lipids in
cells

▸ NAC is considered to be an antioxidant and free-radical scavenger that

increases Glutathione

Janeczek, M., Moy, L., Riopelle, A., Vetter, O., Reserva, J., Tung, R., & Swan, J. (2019). The Potential Uses of N-acetylcysteine in Dermatology: A Review. The
55 Journal of clinical and aesthetic dermatology, 12(5), 20–26.
 AMINO ACIDS

▸ Amino acids are generally known to regulate protein metabolism

▸ Skin collagen metabolism abnormalities induced by ultraviolet (UV)

radiation are the major causes of skin ageing

▸ Amino acids plays an important role in collagen synthesis and therefore

help improve skin ageing

Murakami, H., Shimbo, K., Inoue, Y., Takino, Y., & Kobayashi, H. (2012). Importance of amino acid composition to improve skin collagen protein synthesis rates
56 in UV-irradiated mice. Amino acids, 42(6), 2481–2489. https://doi.org/10.1007/s00726-011-1059-z
 MINERALS: ZINC

▸ Zinc is an essential micronutrient for humans that is needed for

regulation of lipid, protein and nucleic acid metabolism, and gene
transcription

▸ The benefit of zinc includes suppression of sebum production by

its antiandrogenic activity as well as skin lightening

Gupta, M., Mahajan, V. K., Mehta, K. S., & Chauhan, P. S. (2014). Zinc therapy in dermatology: a review. Dermatology research and practice, 2014, 709152.
57 https://doi.org/10.1155/2014/709152
 MINERALS: COPPER

▸ Copper is one of those nine minerals that are recognized as essential nutrients for
humans, as it plays a crucial role in different physiological normal processes in
basically all human tissues as well as in the skin
▸ Roles of Copper in the skin:
▹ Stimulates dermal fibroblasts proliferation
▹ Upregulates collagen and elastin fiber components
▹ Serves as a cofactor of superoxide dismutase, an antioxidant enzyme present in
the skin, important for protection against free radicals
▹ Inhibits cellular oxidative effects such as membrane damage and lipid
peroxidation
▹ Serves as a cofactor of tyrosinase, a melanin biosynthesis essential enzyme
responsible for skin pigmentation

Borkow G. (2014). Using Copper to Improve the Well-Being of the Skin. Current chemical biology, 8(2), 89–102.
58 https://doi.org/10.2174/2212796809666150227223857
 Thank You

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