RADIESSE : A Cutting®️
Edge Collagen Stimulator of
the Future
Dr. Aji Bayu Chandra, M. Biomed (AAM)
MAHARVA clinic - Surabaya
Review of Radiesse®
Radiesse® is a sterile, latex-free, non-pyrogenic,
cohesive injectable dermal filler
Principle component of Radiesse® is:
30% of synthetic calcium
hydroxylapatite (CaHA)
(Ca10(PO4)6(OH)2) CaHA Particles
Uniform and spherical
Naturally-occurring mineral in body 25–45 microns
70% of aqueous sodium
carboxymethylcellulose (CMC) gel
matrix
Generally recognized as safe by US
FDA
Radiesse® Approved Indications
Radiesse® (+) Lidocaine injectable
implant is indicated for plastic and
reconstructive procedures, including
deep dermal and sub-dermal soft tissue
augmentation of the facial area, and is
also intended for restoration and
correction of fat or volume loss
(lipoatrophy) in the facial area and for
rejuvenation of the hands.
History of Radiesse® Technology:
A Success Story
Mode of Action: Immediate and Long-
Lasting Effect
Immediate 1:1 correction is achieved through the sodium carboxymethylcellulose gel matrix
followed by gradual and individual biodegradation
The remaining CaHA-microspheres form a “scaffold” that provides mechanical stimuli
triggering fibroblasts into producing collagen and elastin
Immediate 1:1 correction High density
Before treatment
after injection of collagen and elastin
Fibroblasts
Mechanism of Action
RADIESSE® treatment provides immediate correction
when injected
Overtime, the CMC gel is absorbed and the CaHA
microspheres support in-growth of the resident tissue
In the skin, cells deposit new collagen, creating new
dermal matrix
This new tissue formation combined with CaHA is
responsible for extended correction length
As the gel is absorbed, the CaHA
particles act as a scaffold around
which new collagen is deposited
Mode of Action: Long-Term Effect – New
Tissue Formation
New Tissue Formation:
The immediate lifting and volumising effect of Radiesse® is gradually followed by new
tissue formation through:
Neocollagenesis (production of collagen type III, gradually converted to type I)1,2
Elastin production (improves skin elasticity)1
Dermal cell proliferation (e.g., fibroblasts)1
Angiogenesis (formation of new blood vessels)1
The result is a long-lasting aesthetic effect characterized by a tight and elastic skin with
increased skin thickness.
1. Yutskovskaya Y, et al. A randomized, split-Face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a
hyaluronic acid-based dermal filler. J Drugs Dermatol. 2014;13(9):1047–1052.
2. Berlin AL, et al. Calcium Hydroxylapatite Filler for Facial Rejuvenation: A Histological and Immunohistochemical Analysis. Derm
Surg. 2008;34:64-67.
Radiesse® is Biocompatible
The Radiesse® microspheres are slowly metabolised through natural endogenous
mechanisms via phagocytosis.(11) The released calcium and phosphate ions are
identical to the mineral portion of the body.(11)
Intact, non-degraded
CaHA-microspheres*
Partially degraded
CaHA-microspheres*
* Scanning electron photomicrograph.
Biodegradable Nature of CaHA
Immediately after injection 25 months post-injection
Radiesse® injected on the cheek (1.6 mL on each side)
2.5 years after injection-revealed no presence of CaHA
The long-term correction provided by CaHA is due to collagen production,
and not due to the continued presence of the microspheres
Pavicic T. Complete biodegradale nature of calcium hydroxylapatite after injection for malar enhancement: an MRI study. Clin
Cosmet Investig Dermatol. 2015 0;8:19–25.
The Lifting Filler: Summary
Radiesse® has been approved in the EU since 2004* and FDA-approved since
2006
Radiesse® consists of 30% CaHA-microspheres suspended in a sodium CMC gel
carrier
Radiesse® immediately corrects lost volume and gradually promotes new tissue
formation for long-lasting results
Radiesse® is a lifting filler with a triple effect for Versatile Filling, Volume Lifting
and Contouring, and Skin Rejuvenation
Radiesse® has excellent rheological properties
* Radiesse® received European approval as a medical device as early as 2004. In 2006, Radiesse® was specifically CE-marked for
plastic and reconstructive surgery.
The Lifting Filler: Summary
Radiesse® is one of the most well-studied fillers
Radiesse® is one of the safest dermal fillers available
Clinical data on more than 4000 patients*
6 million syringes has been shipped worldwide**
Studies revealed:
i. Long-term effectiveness
ii.Excellent safety profile and tolerability
iii.High patient satisfaction
iv.Superiority of Radiesse® over leading HA fillers
v.No overt radiographic safety concerns
vi.Safe and effective
*As of 01/2015
** As of 05.2016
