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Introduction To Biopharmaceutics & Pharmacokinetics: Vi Semester

The document provides an introduction to biopharmaceutics and pharmacokinetics. It defines key terms like absorption, distribution, metabolism, elimination and pharmacokinetics. It also discusses concepts like ADME, cytochrome P450, dose regimen and bioavailability.

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Himanshu Jangir
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42 views13 pages

Introduction To Biopharmaceutics & Pharmacokinetics: Vi Semester

The document provides an introduction to biopharmaceutics and pharmacokinetics. It defines key terms like absorption, distribution, metabolism, elimination and pharmacokinetics. It also discusses concepts like ADME, cytochrome P450, dose regimen and bioavailability.

Uploaded by

Himanshu Jangir
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
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INTRODUCTION TO

BIOPHARMACEUTICS &
PHARMACOKINETICS
VI SEMESTER
BIOPHARMACEUTICS

• It is defined as the study of factors influencing rate and amount of drug that reaches the
systemic circulation and use of this information to optimize the therapeutic efficacy of
drug product.
• It is the study of physiochemical properties of a drugs, their dosage form in which
they are administered & route of administration as related to onset, duration and
intensity of drug action.
ADME

• A- Absorption
• D- Distribution
• M- Metabolism/Biotransformation
• E- Exertion/Elimination
ABSORPTION

• Movement of drug from its site of administration to systemic-circulation is called as


Absorption.
• Movement of drug in bloodstream.
• Unchanged form to systemic circulation.
DISTRIBUTION

• It is the movement of drug from one compartment to other ( generally blood and other
extravascular tissues) is referred to as distribution.
METABOLISM/BIOTRANSFORMTION

• It is the on version of drug from one form to another via various enzymatic actions.
• It is also known as metabolism i.e. inactivation of drug to finally ending up in
elimination.

Cytochrome P450
ELIMINATION

• It is defined as the process that tends to remove the drug from the body and terminates its
action.
Elimination= Biotransformation+Excretion
PHARMACOKINETICS

• It is defined as the study of time course of drug ADME & their relationship with its
therapeutic and toxic effect of the drug.

“WHAT THE BODY DOES TO THE DRUG”


PHARMACODYNAMICS

Showing clinical response.

“WHAT DRUG DOES TO THE BODY”


DOSE REGIMEN & BIOAVAILABILITY

• The manner in which dose should be taken.


• Dose size.
• Time interval.

• Bioavailability- It is the rate and extent of drug that reaches systemic circulation after
first pass metabolism

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