Chapter 1
Contrast Media
Azka Asghar(MSDU)
Fluoroscopy
• Fluoroscopy is a medical imaging
procedure that uses X-rays to
create real-time moving images
of internal organs and tissues.
Contrast Media
• Definition-They are a group of chemical agents
developed to aid in the characterization of
pathology by improving the contrast
resolution of an imaging modality.
• Specific contrast media have been developed
for every structural imaging modality, and
every conceivable route of administration.
Positive Contrast Agents
• They are substances that increase the x-ray
attenuation within the body, making the
tissues or structures containing these agents
appear whiter or brighter on the x-ray image.
• These agents are generally radiopaque,
meaning they absorb x-rays more readily than
surrounding tissues
Continue….
• Barium and iodine preparations are the
commonest positive contrast media. Barium is
presented as barium sulphate and iodine as
complex organic molecules.
• These agents are commonly used in various
diagnostic imaging procedures, such
as angiography, CT scans, and gastrointestinal
examinations.
Negative Contrast Agents
• In radiology, these agents are particularly
beneficial for visualizing vessels and soft
tissues.
• Air is a commonly used negative contrast
agent in radiology.
• It is readily available and has a low cost,
making it a convenient option for imaging
procedures.
• Examples of radiolucent, or negative, contrast
agents are air, oxygen, carbon dioxide, and
nitrous oxide.
• Most of the available gasses have been used
as negative contrast agents with varying
results; however, the four gases listed here are
the most commonly used negative
(radiolucent) contrast agents.
• CO2, or carbon dioxide, is commonly used as a
negative contrast agent for angiography and
CT colonography.
• In angiography, CO2 is used to visualize blood
vessels.
• In patients with renal dysfunction or iodinated
contrast allergy, the use of Iodinated Contrast
Agent poses the risk of considerable
morbidity.
• Similarly, use of Gadolinium is discouraged in
subject with severe renal dysfunction. Use of
carbon dioxide (CO2) as an intravascular
contrast, offers an alternative in such patients
for certain procedures, as it is not nephrotoxic
and it does not incite allergic reactions.
Route of Administration
• Intravenous
• Intra-arterial
• Oral
• Intra-rectal
Advantage
• Contrast materials help distinguish or
"contrast" selected areas of the body from
surrounding tissue.
• By improving the visibility of specific organs,
blood vessels or tissues, contrast materials
help physicians diagnose medical conditions