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International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
ISNS
CASE
STUDY
With Dr. Norbert Ketskes
on Parkinson’s Disease
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
Medical Disclaimer
The information provided is for educational purposes and is not
intended as medical advice, or a substitute for the medical advice
of a physician or other qualified health care professional. This is
for science and educational purposes only and cannot be used in
any aspect for sales or marketing. You should not use this
information for diagnosing a health or fitness problem or
disease. You should always consult with a doctor or other health
care professional for medical advice or information about
diagnosis and treatment. This is Confidential. Do not distribute
—for scientific educational purposes only.
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
DR. NORBERT KETSKÉS, MD
• Dr. Norbert Ketskés M.D. is one the most acknowledged
gastroenterologist in Hungary, specializing in natural and
organic nutritional solutions, leading the well-known Primus
Labor, a private clinic offering personalized nutritional
advices to its patients.
• Scientific Adviser of ISNS
• Medical Partner of the Hungarian Olympic Committee since
2015
• Member of the Medical board of Hungarian Karate
Association since 2015
• Leader of the Primus Labor Private Medical Clinic since
2013
• Working as a Family Doctor 1999 – 2012
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
CSISZTU ZSUZSA
• Television - Presenter, Anchor, Editor, Journalist and
Sports Lawyer, Sport-diplomat
• Spokesperson of the Giro d’Italia Grande Partenza,
(Road-Cycling World -Tour Championship)
• Spokesperson of the FINA (Swimming and Waters poets
World Championship)
• 2022 Vice-President of the Hungarian Sports Journalists’
Association
• Member of the Hungarian Olympic Committee
Member of the Advisory Board of the Hungarian Olympic
Academy
• Newly Elected Vice-President of the International Sports
Journalists Association, the first female ever in the field
from her homeland, and third globally since 1924 (AIPS)
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
What is Parkinson’s
Disease?
Parkinson’s Disease (PD) is a
chronic neurologic condition that
is named after Dr. James
Parkinson, who first described the
syndrome in 1817.
Parkinson’s disease is a brain
disorder that causes unintended
or uncontrollable movements,
such as shaking, stiffness, and
difficulty with balance or
coordination.
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
Parkinson’s Disease
PD is a slowly progressive disease,
which causes a gradual loss of nerve
cells in the brain that produce the
neurotransmitter dopamine. Because
dopamine carries signals to the part of
the brain that controls movement and
coordination, decreased dopamine
levels lead to the cardinal motor
symptoms of Parkinson’s disease:
• Resting tremor
• Generalized slowness (bradykinesia)
• Stiffness of the limbs (cogwheel
rigidity)
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
What Causes Parkinson’s disease?
The most prominent signs and symptoms of
Parkinson’s disease occur when nerve cells in
the basal ganglia, an area of the brain that
controls movement, become impaired and/or
die.
Normally, these nerve cells, or neurons, produce
an important brain chemical known as
dopamine. When neurons die or become
impaired, they produce less dopamine, which
causes movement problems associated with the
disease. Scientists still do not know what causes
the neurons to die.
People with Parkinson’s disease also lose the
nerve endings that produce norepinephrine, the
main chemical messenger of the sympathetic
nervous system, which controls many functions
such as heart rate and blood pressure.
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
What are the symptoms of
Parkinson’s Disease?
Parkinson’s has four main symptoms:
• A tremor in hands, arms, legs, jaw, or head
• Muscle stiffness, where muscle remains
contracted for a long time
• Slowness of movement
• Impaired balance and coordination,
sometimes leading to falls.
Other symptoms may include:
• Depression and other emotional changes
• Difficulty swallowing, chewing, and
speaking
• Urinary problems or constipation
• Skin problems
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
Risk Factors for Parkinson’s Disease
Scientists are working to better understand the broad range of environmental exposures linked to PD
Some risk factors that may increase the risk for no—Hodgkin’s lymphoma includes:
• Head Injury – traumatic brain injury- an injury that results in an alteration in the level of
consciousness – has been associated with an increased risk of developing PD years after injury.
• Area of Residence – there are differences in the geographic distribution of PD. These could be
due to differences in environmental factors and genetic risk factors.
• Occupation – certain occupational categories or job titles have been associated with a high
incidence of PD, but results have been inconsistent.
• Exposure to Metals - occupational exposures to various metals have been suggested to be related
to the development of PD.
• Solvents and Polychlorinated Biphenyls (PCBs)- Trichloroethylene (TCE) is a solvent used in
many industries and is the most common organic contaminant in groundwater. Exposure to TCE
was found to be associated with PD among workers whose factory jobs resulted in long-term
exposure.
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
CASE STUDY
Patient:Male
Age: 62
History: Family history is negative.
Parkinson’s syndrome was diagnosed 1/2 year ago.
Medical history:The diagnosis of Parkinson's disease is primarily clinical, based
on the patient's symptoms and a thorough neurological examination.
Symptoms:resting tremor in his right hand, stiffness, difficulty initiating
movement, slowness of movement, impaired coordination.
His wife also reports that he has been experiencing a reduced sense of smell, and
she has noticed a decrease in his facial expressions. His communication also
slowed down.
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
Conventional Treatment
Although there is no cure for Parkinson’s disease, medicines, surgical
treatment, and other therapies can often relieve some symptoms.
• Medications can help treat the symptoms of Parkinson’s by:
• Increasing level of dopamine in the brain.
• Having an effect on the other brain chemicals, such as neurotransmitters, which
transfer information between brain cells
• Helping control non-movement symptoms
The main therapy for Parkinson’s is levodopa. Nerve cells use
levodopa to make dopamine to replenish the brain’s dwindling supply.
The doctor may prescribe other medicine to treat Parkinson’s
symptoms, including:
- Dopamine agonist to stimulate the production of dopamine
in the brain
- Enzyme inhibitors (MAO-B inhibitors, COMT inhibitors)
to increase the amount of dopamine by slowing down the enzymes
that break down the dopamine in the brain
- Amantadine to help reduce involuntary movements
In his case:
Levodopa/Carbidopa/Entacapone 100 mg/25 mg/200 mg,
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
Method PROPRIETARY BLENDS LEGEND
Proprietary Blend I: Silica, Vitamin C, and Trace Minerals
• Proprietary blend I: 2x6 drops, morning and
evening, for 3 days, then every 3 days then Proprietary Blend II: N-acetyl L-tyrosine, Anhydrous Caffeine,
increased by 1-1 drops every 3 days to 2x12 L-theanine, Velvet Bean Seed, Pine Bark, Curcumin, and Vitamin
D
• Proprietary blend II :1 in the morning for 7
days, then 1 in the morning and 1 in the afternoon Proprietary Blend III: Black seed oil, Resveratrol, turmeric,
for 7 days, then 2 in the morning and 1 in the Raspberry Ketones, Apple Cider Vinegar, Aloe Vera, and D-
afternoon Ribose
• Proprietary blend III: Proprietary blend III:
Proprietary Blend IV: Vitamin C, zinc sulfate, and vitamin D3
1/2 sachet in the morning for 7 days then 1
sachet in the morning for 7 days then 1 sachet
in the morning and 1 sachet in the evening Proprietary Blend V: Inulin, Green Banana flour, apple fiber,
bacillus coagulans, spirulina, wheat grass, barley grass, alfalfa
• Proprietary blend IV: 1/2 teaspoon in the leaf, flax seed, psyllium husk powder, chlorella, broccoli, kale,
morning for 7 days, then 1 teaspoon in the spinach, green cabbage, parsley, aloe vera, cayenne pepper,
morning blueberry powder, pomegranate seed powder, and MCT coconut
oil powder
• Proprietary blend V: 1 teaspoon in the
in the evening Proprietary Blend VI: Vitamin K2, Vitamin D3, Vitamin C,
Magnesium oxide, OmniMin AC (trace mineral blend) Quercetin,
• Proprietary blend VI: 1 in the and NAD
morning for 7 days then 1 in the morning and 1 in
the evening Proprietary Blend VII: Bovine collagen and hydrolyzed bovine
colostrum
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
Additional Treatment
Physical therapy and exercise programs can help improve mobility, balance, and strength.
Speech therapy and occupational therapy may also be beneficial in managing speech and fine
motor difficulties.
A special diet based on my personal experience.
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
Results
After 1 month :
Reduced stiffness, tremors in the hand.
His sense of smell improved and he became a little more lively.
After 3 month:
The difficulty starting movement decreased, coordination improved.
The stiffness and tremor in the hand improved further.
His facial expressions became more animated again
His communication has been restored. His mood improved.
And not only the family, but also the patient could report on the
improvement.
Based on these, the patient's quality of life improved!!
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
Research
Studies
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
Mucuna Pruriens in Parkinson’s Disease
By Roberto Cilia, MD,corresponding author Janeth Laguna, MD, Erica Cassani, MD, Emanuele Cereda, MD, PhD, Nicolò G. Pozzi, MD, Ioannis U. Isaias, MD, PhD, Manuela Contin, PharmD, Michela
Barichella, MD, and Gianni Pezzoli, MD
• Objective: In this study, it was investigated whether Mucuna pruriens may be used as an alternative
source of L-DOPA for individuals with Parkinson’s Disease who can not afford long-term therapy.
• Method: Eighteen patients with advanced PD received the following treatments, whose sequence was
randomized: (1) dispersible levodopa at 3.5 mg/kg combined with the dopa-decarboxylase inhibitor
benserazide (LD+DDCI; the reference treatment); (2) high-dose Mucuna pruriens (MP-Hd; 17.5 mg/kg);
(3) low-dose Mucuna pruriens (MP-Ld; 12.5 mg/kg); (4) pharmaceutical preparation of LD without DDCI
(LD−DDCI; 17.5 mg/kg); (5) Mucuna pruriens plus benserazide (MP+DDCI; 3.5 mg/kg); (6) placebo.
• Results: When compared to LD+DDCI, Mucuna pruriens-levodopa showed similar motor response with
fewer dyskinesias and AEs, while Mucuna pruriens-high dose induced greater motor improvement at
90 and 180 minutes, longer ON duration, and fewer dyskinesias.
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5539737/
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the
Literature
Eslam El Nebrisi
• In this context, this review focuses on the neuroprotective activities of curcumin in PD and the various
mechanisms involved. Curcumin’s pharmacokinetics, pharmacodynamics, biological, cellular, and molecular
properties are all addressed. A special emphasis is given to curcumin’s neuroprotective activities via a α7-
nAChR-mediated mechanism, safety profile, and current and upcoming clinical trials for clinical application.
• Overall, the current findings of the clinical trial on nicotinic receptors and PD or curcumin and
neurodegenerative disorders such as PD are very promising, but more pre-clinical studies and clinical trials
are needed to improve curcumin’s bioavailability and define its hidden targets.
• The interaction of curcumin with α7-nACh receptors provides further evidence for a potential neuroprotective
role for curcumin in PD. Additionally, curcumin and derivatives show a high safety profile with minimal
reported toxicity as demonstrated both in in vitro and in in vivo studies in PD models. The evidence reviewed
supports curcumin’s powerful molecular and cellular effects in neurodegenerative disorders as an appealing
strategy for improving PD management and prognosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537234/
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
Vitamin D and Parkinson’s Disease
Antonia Pignolo, Sergio Mastrilli, Chiara Davi, Valentina Arnao, Paolo Aridon, Felipe Augusto dos Santos Mendes, Cesare
Gagliardo, and Marco D’Amelio
• Vitamin D is important for brain development, mature brain activity and associated
with many neurological diseases, including Parkinson’s disease (PD).
• High frequency of vitamin D deficiency in patients with Parkinson’s disease
compared to control population was noted nearly twenty years ago.
• Vitamin D deficiency seems to be related to disease severity and disease
progression, evaluated by Unified Parkinson’s Disease Rating Scale (UPDRS) and
Hoehn and Yahr (H&Y) scale, but not with age of PD onset and duration of disease.
• In summary, as low serum 25(OH)D levels might be correlated with an increased
risk of developing PD, higher 25(OH)D levels seems to be associated with better
motor symptoms, especially with improved balance control.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953648/
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
References
• https://www.nia.nih.gov/health/parkinsons-disease
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539737/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537234/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953648/
International Science Nutrition Society – CURARE CAUSAM - ISNS 2023
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