World's Best Bacopa with 9 Bioactives for Brain Health

Brain health

A healthy brain allows Brain health is about

us to draw on the making the most of our
strengths of our brain— brain throughout every
information stage of life. A healthy
management, logic, brain allows us to reduce
judgement, perspective some risks to it as we
and wisdom age*

Reference: https://brainhealth.nia.nih.gov/ Accessed 29 March 2018 2

Memory, cognition and brain health at all
stages
Accumulation Accumulation, interpretation, Decline
and application

0 6 65 85

From prenatal period From 6+ years - 65 years 65+ years

up to 6 years • Due to aging
• Due to illness or impaired lifestyle

3
Growth of brain health market in food and
beverage segments
Western &
Central Europe

+22%
+20%
North
Americ +2%
a Asia

+28%
Middle
+8% East/Africa
+14%
South
Australia
Americ
a

Reference: Innova market Insights: https://www.nutritioninsight.com/nutrition-focus/brain-health-on-top-of-consumers-minds-302.html 4

Brain health supplements market potential
The Global Brain Health Supplements Market generated $3,194 million in 2016, and is anticipated to
reach
$5,813 million by 2023, growing at a CAGR of 8.8% from 2017 to 2023

Global brain health supplements market Asia and Europe drive growth in
By application Brain health supplements
2016 2023 2011 2015
20% 19%
18%
18%
16%
16% 15%

% of product launches
14%
14% 13%
12%
12% 11%
10%

8% 7% 7%
6%

4%

2%

0%
Asia Australia North Europe Global
America
Supplements launches tracked with brain health claim

MEMORY ENHANCEMENT segment holds a dominant position in 2016 and would continue to maintain
the lead over the forecast period.
5
References: https://www.alliedmarketresearch.com/brain-health-supplements-market
Supplements available for brain
health
Bacopa

Ginkgo biloba Gotu kola

MEDICINAL
PLANTS

Ashwagandha Ginseng

Others: 1. Fish oils 2. Plant oils 3. Multivitamins 4. Phosphatidylserine 5. New innovations

6
 Traditional use
Natural Remedies
quest for the
world’s best brain
health solution
on the basis of: Literature review

Identified Bacopa / Brahmi as the most suitable alternative

References:
1. https://www.ayurvedacollege.com/articles/students/Brahmi
2. https://www.ncbi.nlm.nih.gov/pubmed/22074576 7
Exploring Bacopa (water
hyssop)
01 Bacopa (Brahmi) is Bacopa monnieri is a
02
used in Ayurveda for short duration annual
its brain health herb, frequent in moist
management habitat and water edges
properties. throughout tropical
and subtropical
India.

Bacopa
(Brahmi)

It can grow in It grows best

a wide range of near flowing
temperatures water and wetlands and
(15–40oc) and is particularly abundant
soil pH (5–7.5). in monsoon, in near-neutral,
clayey loam to clayey soils.
04 03 8
Traditional significance of Bacopa in brain
health
Bacopa monnieri, (Brahmi) is a plant revered in Ayurveda, with an age-old reputation for
being effective for memory and cognition.

Power of differentiation
and identification
0 – VIVECHAN
1
Improves power of
recollection
02 – SMRITI

Improves power of
03 retention
– DHARANA SHAKTI

Reference: http://www.phytojournal.com/archives/2018/vol7issue3/PartC/7-2-458-986.pdf 9
 Journey of
BacoMind®
in pioneering
the world’s best
Bacopa!
Development of BacoMind®
Bacopa
(Brahmi)

Non-
Bacoside bacoside
chemistry chemistry

Soft Unique Preclinical

Biological extraction full spectrum & clinical
action process extract - efficacy
9 bioactives

Safety
studies

11
What is BacoMind® ?

World's best bacopa

with 9 bioactives for
Brain Health.

BacoMind®, the world's best bacopa is a patented, clinically tested,

memory and cognition health supporting full spectrum extract with
9 bioactives and GRAS status.

12
Phytochemistry of BacoMind®
HPLC Profile of Bacopa monnieri Extract

Jujubogenin isomer of Bacopasaponin C

Luteolin

Bacopasaponin C
Bacopaside A3
Bacopaside II
Apigenin

Bacopaside I

Bacosine
Beta-sitosterol is analyzed by HPTLC
(High performance thin layer chromatography)

Every batch of BacoMind® produced is analyzed for the 9 bioactives

13
Phytochemistry of BacoMind®

Bacopasaponin C Bacopaside I Bacopaside II

Reference: Inhouse data 14

Phytochemistry of BacoMind®

Bacoside A3 Beta-sitosterol-D-glucoside Jujubogenin isomer of

Bacopasaponin C

15
Phytochemistry of BacoMind®

Bacosine Apigenin Luteolin

16
Clinical evidence of BacoMind®
Human Clinical Trials

1 2 3 4 5

Efficacy Studies Safety Studies

1 Adult Study 3 Children Study 5 Safety Study

Randomized double- blind Study in children for learning Clinical safety
placebo-controlled study for and memory.
memory in healthy elderly
population, Australia

2 Adult Study 4 Children Study

Randomized double- blind Study in children for attention
placebo- controlled study for and focus
memory in healthy elderly
population, India
17
01A randomized double blind placebo controlled study in elderly Australians for memory

Condition Healthy elderly individuals

Dose 300 mg/day

Participants 98 elderly individuals (Age: ≥55 years)

Duration 12 weeks

Evaluation At 12 weeks

Outcome BacoMind® improved memory acquisition and retention

Reference: Morgan and Stevens. The Journal of Alternative and Complimentary Medicine 2010, 16 : 753-759 18
Effect of BacoMind® in elderly Australians

Immediate recall memory Delayed recall memory

10 10
#9.8
#9.6
9.5 9.5

9 9

8.5 8.5
7.9 7.9
8 8

7.5 7.5 7.8

7.7
7.2
7 7
6.8
6.5 6.5

6 6
Baseline 12 weeks Baseline 12 weeks

#p<0.05 #p<0.05
Placebo BacoMind® Placebo BacoMind®

BacoMind® showed 24% improvement in BacoMind® showed 22%

immediate recall memory compared to improvement in delayed recall
placebo (-7%). memory compared to placebo (-
13%).
19
Effect of BacoMind® in elderly Australians

Impact of memory disturbance Learning

3 45
2.4
#44.3
2.5 44

2.2 43
2
2.2 41.4
42
1.5
41
#1.2
1 41.2
40
39.4
0.5 39

0 38
Baseline 12 weeks Baseline 12 weeks
Placebo BacoMind®
Placebo BacoMind®
#p<0.05 #p<0.05

BacoMind® showed 50% reduction in the impact of BacoMind® showed 7% improvement in

memory disturbance compared to placebo (0%). learning compared to placebo (-4%).

BacoMind® improved memory acquisition and retention

20
02A randomized double blind placebo controlled study in elderly Indians for memory

Condition Healthy elderly individuals

Dose 450 mg/day after breakfast

Participants 65 elderly individuals (Age: 50-75 years)

Duration 12 weeks

Evaluation At 12 weeks and at 24 weeks (BacoMind® administered for 12 weeks only)

Outcome BacoMind® improved verbal memory

Reference: Barbhaiya et al. Journal of Pharmacology and Toxicology 2008, 3: 425-434 21

Effect of BacoMind® in elderly Indians

List Learning Delayed Recall Paired associated dissimilar delayed

recall
3.5

#3.17 3.5
3 #3.26
3 2.74
2.43 2.52
2.24
2.5
2.5
2.19 2.71 2.38
2 2.39
2.14 2

1.5 1.78
1.5

1 1
0 week 12 weeks 24 weeks 0 week 12 weeks 24 weeks

Placebo BacoMind® Placebo BacoMind®

#p<0.05
#p<0.05

BacoMind® showed 78% improvement at 24th BacoMind® showed 36% improvement at 24th
week compared to placebo (-2%) week compared to placebo (-6%).

22
Effect of BacoMind® in elderly Indians

Visual Retention
10

9.5
#9.39

9
8.43
8.5

8 8.38

7.5
7.7
7
0 week 12 weeks

Placebo BacoMind®
#p<0.05

BacoMind® showed 22% improvement at 12th week compared to placebo (0.6%).

BacoMind® improved verbal

memory

23
03 An open labeled clinical study in children for learning and memory

Condition School children facing difficulties in learning

Dose 225 mg/day

Participants 24 children (Age: 4-18 years)

Duration 4 months

Evaluation At 4 months

Outcome Children showed improvement in the battery of memory tests.

Reference: Usha et al. Journal of Pharmacology and Toxicology 2008, 3(4): 302-310 24
Memory improvement in children

Memory tests Meaning % over baseline

Repeating sentences Gives idea about logical memory for verbal material 26

Repeating words Checks the short term memory for verbal material 23

Repeating digits forward: subtest checks immediate memory;

Digit span 22
Repeating digits backward: subtest checks working memory

Mental control Checks child’s working memory 20

Conveys about short term memory for non-verbal (graphic)
Visual reproduction 17
material
Verbal retention of
Gives idea about auditory memory for similar pairs 9
similar word pairs

Verbal retention of Conveys about visual as well as auditory memory for dissimilar
9
dissimilar word pairs pairs of words

Assess the awareness of the child about self and the memory
Information 5
related to personal life

25
Effects of BacoMind® in children

Memory improvement in children % of children showed improvement in memory tests

30 8.33; 8%
26 16.67; 17%
25 23 22
20
20
17
Percentage over baseline

15 20.83; 21%

10 9 9
5
5

0
y y y o l y r) r) e
or or or tr or ila il a l lif
em em em c on em i m im na
l m l m m al l m (s i ss r so
ba ba i ng e nt ua or
y (d pe
y
v er ve
r
o rk M vi
s
em or to
al m W rm m em ed
ic er e r y m at
g
tt tt to re
l
54.17; 54%
Lo r r i r y
ho S ho ud ito ry
S A
ud
o 0% improvement 1 to 20% improvement
A em
M
21 to 50% improvement 51 to 75% improvement

BacoMind® showed significant (p<0.05) Overall, BacoMind® showed improvement in 83% of

improvement the
in children children based on the total score of memory tests.

26
04 Open labeled study in children for attention and calmness

Condition Children facing difficulties in maintaining attention and calmness

Dose 225 mg/day

Participants 27 children (Age: 6-12 years)

Duration 6 months

Evaluation At 6 months

BacoMind® significantly (p<0.05) supported children in

Outcome
maintaining attention and calmness

Reference: Dave et al. Advances in Mind-Body Medicine 2014, 28(2):10-5 27

Effects of BacoMind® in children
Children responded with
BacoMind® reduced the overall symptom score 93 reduction in restlessness
%
80 74
70
60 Children Showed
% of children

89 improvement in self control

50 %
40
30 26
Children Showed
20
85 improvement in attention
10 % deficit attribute
0 0
0
0% 0 to 20% 21 to 50% 51 to 75%

% reduction in the total subtests of symptoms

Open labelled clinical studies with BacoMind ® on
% of children showed improvement children – for attention and calmness

BacoMind® supported children in maintaining Additionally, BacoMind® reduced

attention and calmness
• learning problems in 78% of the children
• 74% of the children showed up to a 20%
reduction • impulsivity in 67% of the children

• 26% showed between 21% and 50% reduction in • psychiatric problems in 52% of the children
the total subtests scores
28
05A randomized, open label, dose escalation safety study in healthy adults

Condition Healthy adults

Dose 300 mg/day for 15 days continued with 450 mg/day for next 15 days

Participants 23 elderly individuals (Age: 18-45 years)

Duration 30 days

Evaluation Pre and post treatment

Outcome BacoMind® was found to be safe for human consumption

29
Mechanisms of action of BacoMind®

Dendrite number
Inhibits Antagonizes Inhibits
Dendrite Inhibits PEP Inhibits ROS
COMT 5HT6 PARP
branching

Catecholamines Neuropeptides Cholinergic and

(Dopamine, (Substance P etc) glutaminergic
Norepinephrine) spared transmission
spared enhanced

Neuronal
morphological Neurotransmission Neuro-Protection
changes

Improved memory, learning, attention in aged population

Reference: Dethe et al. Pharmacognosy Magazine 2016, 12: 482-487. 30

Uses of BacoMind®

Supports Suitable for both

learning, memory adults and
and focus* children*

Adults Children
DOSE: 300 to 450 mg/day 225 mg/day

These statements have not been evaluated by the FDA.

31
This ingredient is not intended to diagnose, treat, cure or prevent any
disease.
BcoMind ® Health Canada Claims

BacoMind® for Adults BacoMind® for Children

• Helps to support
• Supports brain health cognitive function in
• Helps to support cognitive children.
health and brain performance • Helps to support brain
• Helps to support memory health in children
 Making a
difference with
The World’s
Best Bacopa
Challenges in sourcing

Unavailability of Low yield

ORGANIC variants per harvest

Few suppliers of No companies with Unavailability of contamination

good quality Bacopa full control over free material like
sourcing pesticides and ochratoxins

34
Natural Remedies has
solved these challenges

Full control over sourcing: seed-to-shelf

35
Sustainability through win-win
Collaborating with the farmers through a local NGO organizing
training programs on cultivation of Bacopa.

Classroom Training in the Training on safe

training field use of
Agrochemicals

36
Sustainability through win-win

Cultivating Bacopa as a pure crop – ENSURES QUALITY AND BIOMASS SECURITY

37
Sustainability through win-win

Improving the livelihood of the farmers creating WIN- WIN for everyone.

38
New advances of BacoMind®

BacoMind® is
the first ever
100% Herbal Extract Bacopa Brand
with GRAS for Brain to have GRAS
Health

BacoMind® can be used safely used in the following foods at a maximum level of 50 mg per
serving.

Beverages Candies Bakery products

(non-alcoholic) (including gummies, chews, etc) (includes breakfast bars)

39
Brands that contain BacoMind®

AUSTRALIA

40
Brands that contain BacoMind®

AUSTRALIA

41
Brands that contain BacoMind®

USA

42
Brands that contain BacoMind®

New Zealand Netherlands Malaysia Brazil Vietnam

43
Cost per Dose and Million doses sold of
BacoMind®

Cost per dose: 0.03-0.06 USD

1 Million doses sold

till date
44
Accreditations, Certifications & Registrations
for BacoMind®

Quality Manufacturing Product Other

Product
Facility Registrations Credentials

Certificate No. : TC-

5527

45
Why choose BacoMind®?

Only brand with 9 different

bioactives offering holistic benefit

20 years of pioneering work in Only brand with a human

Bacopa chemistry, pre-clinicals, safety clinical study
clinicals, and agronomy

Why is

BacoMind® is developed from

the best Bacopa cultivated in BacoMind® is the 1st
collaboration with our farming
World’s best
Bacopa extract to
partners by sustainable supply Bacopa? receive GRAS status
chain practices

Winning together through

micro financing & buy back High-quality standards compliant to
guarantees ensuring livelihood stringent European, and other global
of our farmer partners regulatory standards

46
Key Publications

1. Barbhaiya et al. Journal of Pharmacology and Toxicology 2008, 3(6): 425-434.

2. Morgan and Stevens. The Journal of Alternative and Complimentary Medicine 2010, 16(7): 753-759.
3. Dave et al. Advances in Mind-Body Medicine 2014, 28(2):10-15.
4. Usha et al. Journal of Pharmacology and Toxicology 2008, 3(4): 302-310.
5. Kasture et al. Journal of Natural Remedies 2007, 7(1): 166-173.
6. Dethe et al. Pharmacognosy Magazine 2016, 12: 482-487.
7. Deepak and Amit. Fitoterapia 2013, 87: 7-10.
8. Deepak et al. Phytochemical analysis 2005, 16(1): 24-29.
9. Deepak and Amit. Phytomedicine 2004, 11(2-3): 264-268.
10. Pravina et al. Phytomedicine 2007, 14: 301-308.
11. Allan et al. Food and Chemical Toxicology 2007, 45: 1928-1937.
12. Deb et al. Biomedical and Environmental Sciences 2008, 21: 7-23.
13. D'Souza et al. Phytotherapy Research 2002, 16(2): 197-198.

47
 THANK YOU!

This is a business to business communication material and the statements used here have not been evaluated by
any regulatory authorities. The ingredients mentioned here are not intended to diagnose, treat, cure or prevent
any disease.