Layout of Tablet Manufacturing Section
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The document discusses the layout and design requirements for a pharmaceutical manufacturing facility. It outlines three main types of layouts - circular flow, parallel flow, and crossover traffic. It emphasizes the importance of proper airflow, temperature control, humidity control, and negative pressure differentials between areas to prevent cross-contamination. It also lists key equipment needed for mixing, granulating, drying, compression, coating, and packaging operations.
![By , Mr. Nitin M. Kadam [email_address]](https://image.slidesharecdn.com/tabletmfglayout-100901052450-phpapp01/85/Layout-of-Tablet-Manufacturing-Section-1-320.jpg)
![[email_address]](https://image.slidesharecdn.com/tabletmfglayout-100901052450-phpapp01/85/Layout-of-Tablet-Manufacturing-Section-16-320.jpg)
Layout of Tablet Manufacturing Section
- 1. By , Mr. Nitin M. Kadam [email_address]
- 2. BUILDING & FACILITIES Designed according to cGMP practices which ensures ; Prevention of cross contamination Proper air handling systems. Proper cleaning & sanitary facilities. Proper Lighting Proper Plumbing Proper washing .etc.
- 3. LAYOUT It is the organized properly planned Interdepartment and Intradepartment arrangements. Proper layout Increases productivity Helps in proper utilization of MAN MATERIAL MONEY MACHINES
- 4. TYPES OF LAYOUT Three Types of layout With 1) Circular Flow 2) Parallel Flow 3) Crossover Traffic
- 5. layout with Central warehouse (crossover traffic)
- 8. Environmental Requirements Proper maintenance is required for Product Protection Employee Comfort Controlled Process Parameters
- 9. Name of area Pressure maintained In pascals Warehouse 10 Weighing area 20 Tableting area 15 Central corridor 30
- 10. Some Important Aspects low Humidity for Effervescent tablets & moisture sensitive drugs. Pressure within areas like mixing & tableting area should remain on negative side than central corridor All areas should be free from dust & floating particles , if possible air conditioned. In coating section suitable exhaust systems There should be properly organized & working air handling system to supply purified air.
- 11. Temp control & Air control should be such that there should be comfortable working environment. And no impact on characteristics of in-process materials such as granulations, raw materials. All areas should be properly ventilated.
- 12. LIST OF EQUIPMENTS MIXING, GRANULATION & DRYING AREA Powder mixer Mass mixer / Planetary mixer / Rapid mixer granulator Sifter Granulators (High shear granulator, chilsonator, ) Tray dryer / FBD Weighing Machines
- 13. COMPRESSION AREA Tablet compression machine Single punch / Multipunch / Rotary Punch & Die storage cabinet Tablet deduster Tablet inspection unit or belt. Dissolution testing apparatus IPQC instruments
- 14. COATING AREA Jacketed kettle (steam, gas, Electrically heated) Coating pans Polishing pans Exhaust system Air conditioning & Dehumidification equipment Weighing balance.
- 15. PACKAGING AREA Strip or Blister packaging Machine. Tablet counter Leak tester Air conditioning & Dehumidification equipment
- 16. [email_address]