CHEM 2P21 Reaxys SciFinder Espacenet eCPS ChemDraw Exercise Presentation ppt slides
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This document outlines an exercise to help students explore chemical literature and databases. It asks students to select an antibiotic or drug to research using tools like Reaxys, SciFinder, eCPS and ChemDraw. For the selected drug, students are asked to summarize its importance and bioactivity, identify a reaction that could be reproduced in the lab, discuss if a referenced reaction demonstrates green chemistry principles, and summarize a cited patent using one or two sentences. The exercise aims to help students learn search strategies and skills for exploring chemical properties, reactions, and scholarly information on small molecule drugs.
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CHEM 2P21 Reaxys SciFinder Espacenet eCPS ChemDraw Exercise Presentation ppt slides
- 1. + Ian Gordon CHEM 2P21 SciFinder Reaxys SciFinder, Espacenet eCPS ChemDraw Exercise Happy Pearl Jacobson, Science Librarian, Carleton University
- 2. The objective of this exercise is to: • assist you with exploring the chemical literature • know where, how and why to use the Reaxys, SciFinder, Espacenet, eCPS, ChemSpider, etc. databases and ChemDraw software • learn how to create citations using a citation management system e.g. Zotero using ACS Style • explore chemical naming conventions and reaction sequences, and, • be better informed of small molecule drugs, antibiotics, their chemical properties, reactions, regulatory and scholarly information.
- 10. Select one of the following antibiotics / antibacterial drugs list below, a Drugs.com compound on the Medications for Bacterial Infection list or pick a different drug / chemical of your choice. Remember that you need to pick a drug that allows you to complete all the elements of this assignment: Amoxicillin, Ampicillin, Azithromycin, Cefaclor, Cefzil, Cefoxitin, Cefprozil, Ceftin, Cefuroxime, Cephalexin, Chloramphenicol, Ciprofloxacin, Clarithromycin, Doxycycline, Erythromycin, Flagyl, Invanz, Merrem, Nitrofurantoin, Free penicillin G, Rifampin, Streptomycin, Tetracycline, Tigecycline, Trimethoprim, Tyrothricin, or Zymar.
- 11. Why is this drug important/unique summarizing its bioactivity, uniqueness, target indicator or mode of chemical action. Which reaction is easiest to reproduce at Brock and why? Is this paper’s reaction indicative of green chemistry and why? Summarize, what is unique about this patent? Using ChemDraw, create/copy a reaction sequence or a single compound structure, insert name(s) and citation. One thing you learned about Reaxys through this exercise! Complete the following, where asked, in your own words, using one or two sentence:
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- 24. Williams, J. M.; Brands, K. M. J.; Skerlj, R. T.; Jobson, R. B.; P. G.; et al. Practical Synthesis of the New Carbapenem Antibiotic Ertapenem Sodium. J. Org. Chem. 2005, 44, 7479–7487.
- 38. Junker, T.; Alexy, R.; Knacker, T.; Kümmerer, K. Environ. Sci. Technol. 2006, 40, 318–324.
- 44. + Ian Gordon CHEM 2P21 SciFinder Reaxys SciFinder, Espacenet eCPS ChemDraw Exercise Happy Pearl Jacobson, Science Librarian, Carleton University