This study examines the impact of cumulative lifetime adversity on depression among U.S. Latinx immigrants, highlighting within-group differences among subgroups such as Puerto Ricans, Cubans, Mexicans, and Dominicans. It found that social support, perceived discrimination, and ethnic identity significantly moderated the relationship between adversity and depression, with variations across these subgroups. The results emphasize the need for tailored mental health interventions addressing the unique experiences and needs of different Latinx immigrant populations.