The D-Dimer test measures levels of a protein fragment called D-dimer in the blood. D-dimer is produced when blood clots are broken down in the body. Elevated D-dimer levels can indicate the presence of dangerous blood clots like deep vein thrombosis or pulmonary embolism. Doctors may order a D-dimer test to help rule out blood clot conditions as the cause of a patient's symptoms. The test is useful for quickly determining if conditions involving blood clots like DVT or PE need further testing or treatment.