Enzyme
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The document discusses various drugs and their interactions with cytochrome P450 enzymes, highlighting the impact of inhibitors and inducers on drug metabolism. It lists several substances, including sodium valproate and alcohol, categorizing them based on their effects on different CYP enzymes. The implications of these interactions on therapeutic effectiveness and toxicity are emphasized.
Enzyme
- 1. P450 Inhibitors Don't join this group it will make your spirit go down... SICKFACES.COM Group Sodium valproate Isoniazid Cimetidine Ketoconazole Fluconazole Alcohol..binge drinking Chloramphenicol Erythromycin Sulfonamides Ciprofloxacin Omeprazole Metronidazole Grapefruit juice P450 Inducers CRAP GPS induce me to madness!! Carbemazepines Rifampicin Alcohol (chronic) Phenytoin Griseofulvin Phenobarbitone Sulphonylureas
- 2. Cyp 3a4 M.C. ENZYME METABOLISM Cyp 2D6 NERUROLEPTIC (TYPICALANTIPSY) TCA SSRI ABC ---ANTIARRHYTHIC ,,,,,,BBLOCKER,,,,,,,,,CODEIN Cyp 2C8/9 PHENYTOIN WARFARIN Cyp 2C19 CLOPIDOGREL (ACTIVATION) PPI (INHIBITION )
- 3. ACETYLATION –SHIPP C SULFONAMIDE HYDRALAZINE ISONIAZIDE PROCAINAMIDE PAS CONAZPAM STOMACH Absorption SULFONAMIDE ALCOHOL BARBITURATES NSAIDS HISTAMINE RELEASE –PADMAVATI S POLYMIXIN AMPHETAMINE D TUBOCURARINE (CURIUMS ) ( CURONIUMS NO BASIC –NO HISTAMINE) MORPHINE VANCOMYCIN
- 4. ACTIVE – INACTIVE MOST COMMON ACTIVE –ACTIVE FLUOXETINE – NOR FLEUOXETINE CODEIN – MORPHINE DIAZEPAM– DES METHYL DIAZEPAM, OXAZEPAM INACTIVE -- ACTIVE ACYCLOVIR VALCYCLOVIR CYCLOPHOSPHAMIDE ACE I ( ESCEPT CAPTOPRIL/LISINOPRIL)
- 5. ZERO ORDER KINETIC ALCOHOL PHENYTOIN THEOPHYLINE TOLBUTAMIDE WARFARIN CETUXIMAB NARROW THERAPEUTIC INTEX – DAT LAAT MC DIGITALIS ANTIARRHYTHMICS LETHIUM ‘ AMINOGLYCOSIDE ANTIPSYCHOTIC TCA METHOTREXATE CALCENEURIUMINHIBITORS