Standardization is a process that puts different variables on the same scale to allow for comparison. There are two main methods: direct and indirect. Indirect standardization is used when the number of deaths for each age group is unknown. It involves choosing a reference population, calculating observed deaths in the population of interest, and applying age-specific mortality rates from the reference population to calculate expected deaths. The standardized mortality ratio is then calculated by dividing observed deaths by expected deaths. Issues in using standardization include requiring total case numbers and the need to clearly state the reference population used.