Django is a Python web framework that allows for rapid development of web applications. It includes features like an object relational mapper, template language, form handling, and more. To use Django, you create models to define the application's data structures, views to handle requests and return responses, and URLs to map requests to views. The Django admin interface provides a quick way to manage models in the database. Overall, Django aims to relieve web developers of low-level tasks so they can focus on writing application logic.