Medications for Common URTIs & LRTIS.ppt
- 1. Chapter 35 Lecture 11 Drugs for Common Upper Respiratory Infections
- 2. Respiratory Tract • Upper respiratory tract includes: nares, nasal cavity, pharynx, and larynx. • Lower respiratory tract includes: trachea, bronchi, bronchioles, alveoli, and alveolar- capillary membrane • Air enters the upper resp. tract & travels to the lower tract where gas exchange takes place
- 3. Respiratory Tract • Respiration = the process whereby gas exchange occurs at the alveolar-capillary membrane. 3 phases: 1. Ventilation - movement of air from the atmosphere through the upper & lower airways to the alveoli 2. Perfusion - blood from the pulmonary circulation is adequate at the alveolar-capillary bed 3. Diffusion - molecules move from area of higher concentration to lower concentration of gases - O2 passes into the capillary bed to be circulated & CO2 leaves the capillary bed & diffuses into the alveoli for vent. excretion
- 4. Respiratory Tract • Perfusion - influenced by alveolar pressure. For gas exchange, the perfusion of each alveoli must be matched by adequate ventilation. Mucosal edema, secretions, & bronchospasms increase the resistance to airflow & dec. ventilation & diffusion of gases • Bronchial Smooth Muscle - In the tracheobronchial tube is smooth muscle whose fibers spiral around the tube contraction constriction of airway - Parasympathetic Nervous system releases acetylcholine bronchoconstriction - Sympathetic Nervous system releases epinephrine stimulates beta-2 receptors in bronchial smooth muscle bronchodilation
- 5. Drugs for Upper respiratory Infections • Upper Respiratory Infections (URI’s) = common cold, acute rhinitis, sinusitis, acute tonsillitis, acute laryngitis - The common cold = most expensive > $500 million spent on OTC preparations • Common Cold & Acute Rhinitis - - Common cold caused by the rhinovirus & affects primarily the nasopharyngeal tract. - Acute rhinitis (inflammation of mucus membranes of nose) usually accompanies the common cold - Allergic rhinitis - caused by pollen or a foreign substance
- 6. Drugs for Upper Respiratory Infections • Incubation period of a cold = 1 to 4 days before onset of symptoms & first 3 days of the cold - Home remedies = rest, chicken soup, hot toddies, Vitamins - 4 groups of drugs used to manage symptoms = antihistamins (H-1 blocker), decongestants (sympathomimetic amines), antitussives, expectorants
- 7. Drugs for Upper Respiratory Infections - Antihistamines • Antihistamines or H-1 blockers - compete w/ histamine for receptor sites prevents a histamine response. 2 types of histamine receptors - H-1 & H-2 H-1 stimulation = extravascular smooth muscles (including those lining nasal cavity) are constricted H-2 stimulation = an inc. in gastric secretions = peptic ulcer disease Do not confuse the 2 receptors - antihistamines decrease nasopharyngeal secretions by blocking the H-1 receptor
- 8. Drugs for Upper Respiratory Infections - antihistamines • Histamines - A compound derived from an amino acid histadine. Released in response to an allergic rxn (antigen- antibody rxn) - such as inhaled pollen - When released it reacts w/ H-1 receptors = arterioles & capillaries dialate = inc. in bld flow to the area = capillaries become more permeable = outward passage of fluids into extracellular spaces= edema (congestion) = release of secretions (runny nose & watery eyes) - Large amts. of released histamine in an allergic rxn = extensive arteriolar dilation = dec. BP, skin flushed & edematous = itching, constriction & spasm of bronchioles = SOB & lg. amts. of pulmonary & gastric secretions
- 9. Drugs for Upper Respiratory Infections - Antihistamines • Astemizole (Hismanal), Cetirizine (Zertec), Loratadine (Claritin), Chlorpheniramine (Chlortrimeton), Diphenhydramine (Benadryl) • Actions = competitive antagonist at the histamine receptor; some also have anticholinergic properties • Uses = Treat colds; perennial/seasonal allergic rhinitis (sneezing, runny nose); allergic activity (drying & sedation); some are also antiemetic • SE = Drowsiness, dizziness, sedation, drying effects • CI = glaucoma, acute asthma
- 10. Drugs for Upper Respiratory Infections - Decongestants • Nasal congestion results from dilation of nasal bld. vessels d/t infection, inflammation, or allergy. With dilation there’s transudation of fluid into tissue spaces swelling of the nasal cavity • Decongestants (sympathomimetic amines) - stimulate alpha-adrenergic receptor vasoconstriction of capillaries w/in nasal mucosa shrinking of the nasal mucus membranes & reduction in fluid secretion (runny nose)
- 11. Drugs for Upper Respiratory Infections - Decongestants • Naphazoline HCL (Allerest), Pseudoephedrine (Actifed, Sudafed), Oxymetolazone (Afrin), Phenylpropanolamine HCL (Allerest, Dimetapp) • Use - Congestion d/t common cold, hayfever, upper resp. allergies, sinusitis • SE = Jittery,nervous,restless, Inc BP, inc. bld. sugar • CI = Hypertension, cardiac disease, diabetes • Preparations = nasal spray, tablets, capsules, or liquid • Frequent use, esp. nasal spray, can result in tolerance & rebound nasal congestion - d/t irritation of nasal mucosa
- 12. Drugs for Upper Respiratory Infections - Intranasal Glucocorticoids • Beclomethasone (Beconase, Vancenase, Vanceril), Budesonide (Rhinocort), Dexamethasone (Decadron)fluticasone (Flonase) - Action - steroids used to dec. inflammation locally in the nose - Use - Perennial/seasonal allergic rhinitis (sneezing, runny nose) - May be used alone or w/ antihistamines - SE - rare, but w/ continuous use dryness of the nasal mucosa may occur
- 13. Drugs for Upper Respiratory Infections - Antitussives • Action - Acts on the cough control center in the medulla to suppress the cough reflex • Use - Cough suppression for non-productive irritating coughs * Codeine - Narcotic analgesic to control a cough d/t the common cold or bronchitis * Dextromethorphan - nonnarcotic antitussive that suppresses the cough center in the medulla, widely used - syrup, liquid, chewable & lozenges - SE = drowsiness, sedation
- 14. Drugs for Upper Respiratory infections - Expectorants • Action - Loosens bronchial secretions so they can be eliminated w/ coughing * A nonproductive cough becomes more productive and less frequent • Uses - Nonproductive coughs • Guaifenesin (Robitussin) = Most common * Use alone or in combo w/ other resp. drugs • Hydration is the best expectorant
- 15. Chapter 36 Drugs for Acute and Chronic Lower Respiratory Disorders
- 16. Drugs for Lower Respiratory Disorders • Lung Compliance - Lung volume based on the unit of pressure in the alveoli * Determines the lung’s ability to stretch (tissue elasticity) * Determined by: connective tissue; surface tension in the alveoli controlled by surfactant - surfactant lowers surface tension in alveoli & prevents interstitial fluid from entering * Inc. (high) lung compliance in COPD * Dec. (low) lung compliance in restrictive pulmonary disease = lungs become “stiff” & need more pressure
- 17. Drugs for Lower Respiratory Disorders • Chronic obstructed pulmonary disease (COPD) & restrictive pulmonary disease = 2 major lower resp. tract diseases • COPD = airway obstruction w/ inc. airway resistance to airflow to lung tissues - 4 causes - Chronic bronchitis - emphysema - Bronchiectasis - asthma * Above frequently result in irreversible lung tissue damage. Asthma reversible unless frequent attacks and becomes chronic.
- 18. Drugs for Lower Respiratory Disorders • Restrictive lung disease = a dec. in total lung capacity as a result of fluid accumulation or loss of elasticity of the lung. * Causes: Pulmonary edema, pulmonary fibrosis, pneumonitis, lung tumors, scoliosis • Bronchial Asthma = 10-12 million people of all ages affected - a chronic obstructive pulmonary disease characterized by periods of bronchospasm resulting in wheezing & difficulty in breathing
- 19. Drugs for Lower Respiratory Disorders • Asthma - Bronchospasm or bronchoconstriction results when the lung tissue is exposed to extrinsic or intrinsic factors that stimulate a bronchoconstrictive response - Causes: humidity, air pressure changes, temp. changes, smoke, fumes, stress, emotional upset, allergies, dust, food, some drugs * Pathophys = Mast cells (found in connective tissue throughout the body) are directly involved in the asthmatic response - esp. to extrinsic factors - allergens attach themselves to mast cells & basophils = antigen-antibody rxn
- 20. Drugs for Lower Respiratory Disorders - Asthma • Mast cells stimulate release of chemical mediators (histamines, cytokines, serotonin, ECF-A (eosinophils)) • These chemical mediators stimulate bronchial constriction, mucous secretions, inflammation, pulmonary congestion • Cyclic adenosine monophosphate (cAMP) - a cellular substance responsible for maintaining bronchodilation - When inhibited by histamines & ECF-A bronchoconst. • Sympathomimetic (adrenergic) bronchodilators inc. amt. of cAMP & promote dilation first line drugs used
- 21. Drugs for Lower Respiratory Disorders • Sympathomimetics: Alpha & Beta-2 Adrenergic Agonists • Increase cAMP dilation of bronchioles in acute bronchospasm caused by anaphylaxis from allergic rxn give nonselective epinephrine (Adrenalin) - SQ in an emergency to promote bronchodilation & inc. BP SE = tremors, dizziness, HTN, tachycardia, heart palpitations, angina • For bronchospasm d/t COPD - selective beta-2 adrenergic agonists are given via aerosol or tablet
- 22. Drugs for Lower Respiratory Disorders • Metaproterenol (Alupent, Metaprel) - some beta-1, but primarily used as a beta-2 agent - PO or inhaler/nebulizer - For long-term asthma Rx beta-2 adrenergic agonists frequently given by inhalation * more drug delivered directly to constricted bronchial site * Effective dose less than PO dose & less side effects - Action = relaxes bronchial smooth muscle - onset = fast - SE = Nervousness, tremors, restlessness, insomnia & inc. HR
- 23. Drugs for Lower Respiratory Disorders • Albuterol (Proventil, Ventolin) - More beta-2 selective - PO or inhaler - Used for acute/chronic asthma - Rapid onset of action & longer duration than Metaproterenol - Fewer SE because more beta-2 specific, but high doses can still effect beta-1 receptors & cause nervousness, tremors & inc. pulse rate
- 24. Drugs for Lower Respiratory Disorders - Anticholinergics • Ipratropium bromide (Atrovent) - - Action - competitive antagonist (inhibits) of cholinergic receptors in bronchial smooth muscle = bronchiole dilation - Inhaler - Use - In combination w/ beta agonist for asthma & for bronchospasm associated w/ COPD - Need to teach clients how to use properly: If using Atrovent w/ a beta-agonist, use beta-agonist 5 min. before Atrovent; If using Atrovent w/ an inhaled steroid or cromolyn, use Atrovent 5 min. before the steroid or cromolyn - bronchioles dilate & drugs more effective
- 25. Drugs for Lower Respiratory Disorders - Methylxanthine derivatives • Aminophylline, Theophylline (TheoDur), Caffeine – * PO or IV - * Use - Treatment of asthma & COPD * Action - Inc. cAMP bronchodilation; also - diuresis, cardiac, CNS & gastric acid stimulation * When given IV a low therapeutic index & range - Monitor levels frequently * PO doses can be given in standard dosages * Avoid smoking, caffeine & inc. fluid intake
- 26. Methylxanthine derivatives • Drug Interactions: Inc the risk of dig toxicity, decreases the effects to lithium,dec theophyllin levels with Dilantin, theophyllin and beta-adrenergic agonist given together - synergistic effect can occurcardiac dysrhythmias. Beta blockers, Tagamet, Inderal and e-mycin decrease the liver metabolism rate and inc. the half-life and effects of theophyllin • SE : Anorexia, N&V, nervousness, dizziness, palpitations, GI upset & bleeding, HA, restlessness, flushing, irritability, marked hypotension, hyper-reflexia and seizures. • CI: Severe cardiac dysrhythmias, hyperthyroidism, peptic ulcer disease (increases gastric secretions)
- 27. Drugs for Lower Respiratory Disorders - Leukotrine Receptor Antagonists & Synthesis Inhibitors • Leukotriene (LT) a chemical mediator that can cause inflammatory changes in the lung. The group cysteinyl leukotrienes promotes and inc in eosinophil migration, mucus production, and airway wall edema, which result in broncho-constriction. • LT receptor antagonists & LT synthesis inhibitors (Leukotriene modifiers) effective in reducing the inflammatory symptoms of asthma triggered by allergic & environmental stimuli - Not for acute asthma
- 28. Leucotriene receptor antagonist and synthesis inhibitors •Zafirlukast (Accolate), Zileuton (Zyflo), Montelukast sodium (Singulair) – PO • Action - Decreases the inflammatory process Use - prophylactic & maintenance drug therapy for asthma •Accolate – 1st in group, leukotriene receptor antagonist reduce inflammation & dec bronchoconstriction, PO- BID-rapidly absorbed •Singulair –New leukotriene receptor antagonist, short t1/2 (2.5-5.5) Safe for children under 6yo.
- 29. Drugs for Lower Respiratory Disorders - Glucocorticoids (Steroids) • Glococorticoids have an anti-inflammatory action and are used if asthma is unresponsive to bronchodilator therapy • Given: inhaler- beclomethasone (Vanceril, Beclovent); tablet - triamcinolone (Amcort, Aristocory), dexamethasone (Decadron), prednisone; injection - dexamethasone, hydrocortisone • SE significant w/ long-term oral use - fluid retention, hyperglycemia, impaired immune response • Irritating to the gastric mucosa - take w/ food • When d/c’ing taper the dosage slowly
- 30. Drugs for Lower Respiratory Disorders - Cromolyn & Nedocromil • Cromolyn (Intal) - for prophylactic Rx of bronchial asthma & must be taken on a daily basis - NOT used for acute asthma - Inhaler * Action - inhibits the release of histamine that can cause an asthma rxn * SE - mouth irritation, cough & a bad taste in the mouth ** Caution - rebound bronchospasm is a serious side effect do not d/c the drug abruptly • Nedocromil sodium - action & uses similar to Intal - prophylactic usage - inhalation therapy - may be more effective than Intal
- 31. Drugs for Lower Respiratory Disorders - Mucolytics • Acetylcysteine (Mucomyst) - nebulization * Action - liquefies & loosens thick mucous secretions so they can be expectorated * Use - dissolves thick mucous, acetaminophen overdose (bonds chemically to reduce liver damage) * SE - N & V, chest tightness, bronchoconstriction * Use w/ a bronchodilator • Dornase alfa (Pulmozyme) - an enzyme that digests the DNA in thick sputum of cystic fibrosis (CF) clients
- 32. MATH NDC 000w-7293-01 VIAL No. 7293 R/X Lilly ADD-Vantage Vial NEBCIN Tobramycin sulfate injection, usp 60 Mg per 6ml You need to prepare 30 mg. How much solution will you need? 30 mg X 6 ml = 60 mg 1 X 6 ml = 2 6 = 3 ml 2