This document provides tips for tuning a MySQL database to optimize performance. It discusses why tuning is important for cost effectiveness, performance, and competitive advantage. It outlines who should be involved in tuning including application designers, developers, DBAs and system administrators. The document covers what can be tuned such as applications, databases structures, and hardware. It provides best practices for when and how much to tune a database. Specific tuning techniques are discussed for various areas including application development, database design, server configuration, and storage engine optimizations.