Nanobiosensors
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This document discusses nanobiosensors, including their classification, working principles, history, and applications. Nanobiosensors combine biological components with nano-scale physicochemical detectors. They are classified based on the type of nanomaterial used, such as nanoparticles, nanotubes, or nanowires. Carbon nanotube-based biosensors that function as field-effect transistors are described. The document also reviews recent developments in electrochemical, fiber-optic, and carbon nanotube biosensors, as well as potential applications in biological and environmental detection.
![ 1962 First description of a biosensor: an amperometric
enzyme electrode for glucose. [Leland Clark, New York
Academy of Sciences Symposium]
1980- first fibre-optic pH sensor for in-vivo blood
gases by Peterson.
1987- Blood Glucose biosensor launched by Medi-
sense Exac Tech.](https://image.slidesharecdn.com/nanobiosensor-140520223906-phpapp01/85/Nanobiosensors-15-320.jpg)
Nanobiosensors
- 1. Graduate Student: Tran Tan Tien Supervisor: Dr. Tran Thi Ngoc Dung
- 3. Nano Scale
- 5. Abstract Introduction Types of Nanobiosensors Working principle of Nanotube Based Biosensors Current Research and Applications of Nanobiosensors
- 6. What is a Nanobiosensor?
- 7. Nanoscience & Nanotechnology Nanoscale Biostructure Smart Materials Optics Fabrication Sensors Energy Capture, Transformation, and Storage Basic concept - 8 major devolpment areas Magnets Electronics Introduction Ratner, Mark A., and Daniel Ratner. Nanotechnology: A gentle introduction to the next big idea. Prentice Hall Professional, 2003.
- 8. I.) Introduction Nano- sensors Deployable nanosensor Biosensors Chemical nanosensors Electrometers Classification based on Applications Agrawal, S., and R. Prajapati. "Nanosensors and their Pharmaceutical Applications: A Review." International Journal of Pharmaceutical Science and Technology 4 (2012): 1528-1535
- 9. What is a Nanobiosensor? A biosensor is a measurement system for the detection of an analyte that combines a biological component with a physicochemical detector, and a nanobiosensor is a biosensor that on the nano-scale size Nanobiosensor Transducer Detector Biological Recognition Element (Bioreceptor) Living biological system (cell, tissue or whole organism) Biological molecular species (antibody, enzyme, protein…)
- 10. Building blocks of life
- 11. WORKING PRINCIPLE OF A BIOSENSOR The interaction of the analyte with the bioreceptor is designed to produce an effect measured by the transducer, which converts the information into a measurable effect, such as an electrical / electronic signal.
- 12. The interaction of the analyte (a) with the bioreceptor, which identifies the stimulus (b) is designed to produce an effect measured by the transducer (c), which converts it to an electrical signal. The output from the transducer is amplified (d), processed (e) and displayed (f). (a) (b ) (c) (d) (e) (f )
- 13. Enzymatic Biosensors - Principles and Applications. D. Grieshaber, R. MacKenzie, J. Vörös, and E. Reimhult, Sensors, 8(3); 1400-1458, 2008.
- 14. HISTORY- Biosensor 1962- first description of a biosensor of : an amperometric enzyme electrode (Glucose sensor) by Clark. 1969- first potentiometric biosensor : urease immobilized on an ammonia electrode to detect urea by Guilbault & Montalva. 1970- ion-selective Field Effect Transistor (ISFET) by Bergveld. 1975- fibre-optic sensor with immobilized indicator to measure carbon-di-oxide or oxygen by Lubbers & Optiz. 1975- first commercial biosensor (Yellow Spring Instrumental Biosensor) . 1975- first microbe based biosensor (first Immunosensor).. 1976- first bedside artificial pancrease. 1980- first fibre-optic pH sensor for in-vivo blood gases by Peterson. 1982- first fibre-optic based biosensor for glucose. 1983- first surface plasmon resonance (SPR) immunosensor. 1984- first mediated Amperometric biosensor. 1987- Blood Glucose biosensor launched by Medi-sense Exac Tech. 1990- SPR based biosensor by Pharmacia BIA Core. 1992- hand-held blood biosensor by i-STAT.. 1996- launching of Gluco-card. 1998- blood glucose biosensor launched by Life-scan Fast Take. 2000- nanotechnology biosensor, chip,quantum dots etc..
- 15. 1962 First description of a biosensor: an amperometric enzyme electrode for glucose. [Leland Clark, New York Academy of Sciences Symposium] 1980- first fibre-optic pH sensor for in-vivo blood gases by Peterson. 1987- Blood Glucose biosensor launched by Medi- sense Exac Tech.
- 16. 2000-nanotechnology biosensor, chip,quantum dots etc..
- 17. Classification
- 18. Nanobiosensors: The Merging of Nanotechnology with Biosensors
- 19. Classification of nanobiosensors Nanobiosensors Nanoparticle based sensors Nanotube based sensors Nanowire Based Sensors Acoustic Wave Biosensors Magnetic Biosensors. Electrochemical Biosensors Malik, P., Katyal, V., Malik, V., Asatkar, A., Inwati, G., & Mukherjee, T. K.. Nanobiosensors: Concepts and Variations. (2013) ISRN Nanomaterials, 2013.
- 21. Balasubramanian, Kannan, and Marko Burghard. "Biosensors based on carbon nanotubes." Analytical and bioanalytical chemistry 385.3 (2006): 452-468. Single-wall carbon nanotubebased field-effect transistors(FETs)
- 23. Interaction DNA
- 24. Balasubramanian, Kannan, and Marko Burghard. "Biosensors based on carbon nanotubes." Analytical and bioanalytical chemistry 385.3 (2006): 452-468.
- 26. Experiment method Nanomaterials and nanofabrication technologies are increasingly being used to design novel biosensors. Investigate important fundamental to develop nanobiosensors.
- 27. Computer modeling of nanoscale and biophysical systems Structure of DNA-Carbon Nanotube Hybrids http://www.physics.upenn.edu/~robertjo/research/
- 29. Computer modeling of nanoscale and biophysical systems Free Energy Landscape of a DNA-Carbon Nanotube Hybrid
- 30. Recent development topics on biosensors Electrochemical biosensor Fiber-optic biosensor Carbon Nanotube biosensor Protein Engineering for biosensors Wireless Biosensors Networks
- 31. Applications of Nanobiosensors Biological Applications DNA Sensors; Genetic monitoring, disease Immunosensors; HIV, Hepatitis,other viral diseas, drug testing, environmental monitoring… Cell-based Sensors; functional sensors, drug testing… Point-of-care sensors; blood, urine, electrolytes, gases, steroids, drugs, hormones, proteins, other… Bacteria Sensors; (E-coli, streptococcus, other): food industry, medicine, environmental, other. Enzyme sensors; diabetics, drug testing, other. Environmental Applications Detection of environmental pollution and toxicity Agricultural monitoring Ground water screening Ocean monitoring
- 34. Reference Ratner, Mark A., and Daniel Ratner. Nanotechnology: A gentle introduction to the next big idea. Prentice Hall Professional, 2003. Agrawal, S., and R. Prajapati. Nanosensors and their Pharmaceutical Applications: A Review." International Journal of Pharmaceutical Science and Technology” 4 (2012): 1528-1535 Zhang, X.; Guo, Q.; Cui, D. Recent Advances in Nanotechnology Applied to Biosensors. Sensors 2009, 9, 1033-1053. Jianrong C, Yuqing M, Nongyue H, Xiaohua W, Sijiao L. Nanotechnology and biosensors. Biotechnol Adv. 2004 Sep;22(7):505-18. Malik, P., Katyal, V., Malik, V., Asatkar, A., Inwati, G., & Mukherjee, T. K.. Nanobiosensors: Concepts and Variations. (2013) ISRN Nanomaterials, 2013. Balasubramanian, Kannan, and Marko Burghard. "Biosensors based on carbon nanotubes." Analytical and bioanalytical chemistry 385.3 (2006): 452-468.