Piriformis syndrome is a clinical condition caused by the entrapment of the sciatic nerve due to irritation or inflammation of the piriformis muscle, commonly seen in middle-aged individuals. Patients typically experience pain and numbness in the gluteal region that mimics sciatic pain, with potential triggers including trauma, prolonged sitting, and anatomical anomalies. Management includes rest, muscle relaxants, NSAIDs, and physical therapy focusing on stretching and strengthening exercises.