This document discusses how using advanced data analytics and a metric called "profit per hour" can help companies optimize manufacturing productivity and eliminate profit-draining variations. It provides two examples of companies that were able to significantly improve performance and increase profits by precisely measuring real-time data on processes and implementing adjustments in response to deviations. Going forward, the use of sensors, wireless connectivity, cloud computing and artificial intelligence could further expand the ability to apply profit per hour analysis across entire facilities, supply chains and other business operations to drive new levels of productivity.