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A Voronoi cell-based simulation is employed to model cell movement, proliferation, and delamination, incorporating biophysical forces acting both within and between cells and across epithelial layers. The simulation demonstrates centripetal growth in the basal (left panel) and second (right panel) layers of the corneal epithelium. Limbal epithelial stem cells (LESCs) are represented by coloured points located at the periphery of the basal layer, while the colors of cells within the domain indicate distinct LESC lineages. Joniani et al. 2026

Image Credit: Neda Khodabakhsh Joniani

Education Articles

Ten quick tips for using the NIH Comparative Genomics Resource

Eric S. Tvedte, Cecilia Arighi, Matthew B. Carson, Luke V. Rasmussen, Kristi Holmes, Terence D. Murphy

PLOS Computational Biology: published February 11, 2026 | https://doi.org/10.1371/journal.pcbi.1013919

Tutorial for variant interrogation in tumor samples

Riley J. Arseneau, Leah K. MacLean, Jeanette E. Boudreau, Daniel Gaston

PLOS Computational Biology: published February 17, 2026 | https://doi.org/10.1371/journal.pcbi.1013924

Ten common misconceptions about Galaxy (and why they are wrong!)

Wendi Anne Bacon, Bérénice Batut, Sanjay Kumar Srikakulam, Paul Zierep, Anthony Bretaudeau, Björn Grüning, Gildas Le Corguillé, Helge Hecht, John Y. Davis, Hans-Rudolf Hotz, Beatriz Serrano-Solano

PLOS Computational Biology: published February 17, 2026 | https://doi.org/10.1371/journal.pcbi.1013869

Ten simple rules for building a collaborative coding culture

Austin L. Zuckerman, Sarah Faber, Kelly Shen, Anthony R. McIntosh, Ashley L. Juavinett

PLOS Computational Biology: published February 23, 2026 | https://doi.org/10.1371/journal.pcbi.1013970

Ten simple rules for coordinating a large digital health project: Perspectives from EU and implications for global contexts

Lucia Sacchi, Blaž Zupan, Silvana Quaglini

PLOS Computational Biology: published February 23, 2026 | https://doi.org/10.1371/journal.pcbi.1013957

Perspective

Towards FAIR and federated data ecosystems for interdisciplinary research

Sebastian Beyvers, Jannis Schlegel, Lukas Brehm, Maria Hansen, Alexander Goesmann, Frank Förster

PLOS Computational Biology: published February 13, 2026 | https://doi.org/10.1371/journal.pcbi.1013806

Research Articles

Multiscale segmentation using hierarchical phase-contrast tomography and deep learning

Yang Zhou, Shahab Aslani, Yousef Javanmardi, Joseph Brunet, David Stansby, Saskia Carroll, Alexandre Bellier, Maximilian Ackermann, Paul Tafforeau, Peter D. Lee, Claire L. Walsh

PLOS Computational Biology: published February 2, 2026 | https://doi.org/10.1371/journal.pcbi.1013923

Cluster dispersal shapes microbial diversity during community assembly

Loïc Marrec, Sonja Lehtinen

PLOS Computational Biology: published February 2, 2026 | https://doi.org/10.1371/journal.pcbi.1013918

A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

Anna Shafer-Skelton, Timothy F. Brady, John T. Serences

PLOS Computational Biology: published February 2, 2026 | https://doi.org/10.1371/journal.pcbi.1013888

Information uncertainty influences learning strategy from sequentially delayed rewards

Sean R. Maulhardt, Alec Solway, Caroline J. Charpentier

PLOS Computational Biology: published February 2, 2026 | https://doi.org/10.1371/journal.pcbi.1013879

BiCLUM: Bilateral contrastive learning for unpaired single-cell multi-omics integration

Yin Guo, Izaskun Mallona, Mark D. Robinson, Limin Li

PLOS Computational Biology: published February 3, 2026 | https://doi.org/10.1371/journal.pcbi.1013932

Modelling chemotaxis of branched cells in complex environments provides insights into immune cell navigation

Jiayi Liu, Jonathan E. Ron, Giulia Rinaldi, Ivanna Williantarra, Antonios Georgantzoglou, Ingrid de Vries, Michael Sixt, Milka Sarris, Nir S. Gov

PLOS Computational Biology: published February 3, 2026 | https://doi.org/10.1371/journal.pcbi.1013934

Modeling human visuomotor adaptation with a disturbance observer framework

Gaurav Sharma, Bernard Marius ’t Hart, Jean-Jacques Orban de Xivry, Denise Y.P. Henriques, Mireille E. Broucke

PLOS Computational Biology: published February 4, 2026 | https://doi.org/10.1371/journal.pcbi.1013937

Phase resetting in human stem cell derived cardiomyocytes explains complex cardiac arrhythmias

Khady Diagne, Thomas M. Bury, Morgan E. Pettebone, Marc W. Deyell, Zachary Laksman, Alvin Shrier, Leon Glass, Gil Bub, Emilia Entcheva

PLOS Computational Biology: published February 4, 2026 | https://doi.org/10.1371/journal.pcbi.1013935

FKSUDDAPre: A drug–disease association prediction framework based on F-TEST feature selection and AMDKSU resampling with interpretability analysis

Yun Zuo, Chenyi Zhang, Ge Hua, Qiao Ning, Xiangrong Liu, Xiangxiang Zeng, Zhaohong Deng

PLOS Computational Biology: published February 5, 2026 | https://doi.org/10.1371/journal.pcbi.1013947

Transcriptomic-guided whole-slide image classification for molecular subtype identification

Weiwen Wang, Xiwen Zhang, Yuanyan Xiong

PLOS Computational Biology: published February 9, 2026 | https://doi.org/10.1371/journal.pcbi.1013950

Introducing gold-standard essential gene datasets for Pseudomonas aeruginosa to enhance Tn-Seq analyses

Cléophée Van Maele, Ségolène Caboche, Nathan Nicolau-Guillaumet, Anaëlle Muggeo, Thomas Guillard

PLOS Computational Biology: published February 9, 2026 | https://doi.org/10.1371/journal.pcbi.1013945

Zimin patterns in genomes

Nikol Chantzi, Ioannis Mouratidis, Ilias Georgakopoulos-Soares

PLOS Computational Biology: published February 9, 2026 | https://doi.org/10.1371/journal.pcbi.1013909

Trainable subnetworks reveal insights into structure knowledge organization in protein language models

Ria Vinod, Ava P. Amini, Lorin Crawford, Kevin K. Yang

PLOS Computational Biology: published February 9, 2026 | https://doi.org/10.1371/journal.pcbi.1013925

Cell atlases and the developmental foundations of the phenotype

Alicia Lou, Mónica Chagoyen, Juan F. Poyatos

PLOS Computational Biology: published February 9, 2026 | https://doi.org/10.1371/journal.pcbi.1013944

A framework for evaluating predicted sperm trajectories in crowded microscopy videos

David Hart, Kylie Cashwell, Anita Bhandari, Jayath Premasinghe, Cameron Schmidt

PLOS Computational Biology: published February 10, 2026 | https://doi.org/10.1371/journal.pcbi.1013955

A pre-trained language model-based cross-modal fusion framework for predicting miRNA-drug resistance and sensitivity associations

Nan Sheng, Yunzhi Liu, Ling Gao, Wenju Hou, Lan Huang, Yan Wang

PLOS Computational Biology: published February 10, 2026 | https://doi.org/10.1371/journal.pcbi.1013968

SpaLSTF: Diffusion-based generative model with BiLSTM and XCA-Transformer for spatial transcriptomics imputation

Lin Yuan, Yufeng Jiang, Boyuan Meng, Qingxiang Wang, Cuihong Wang, De-Shuang Huang

PLOS Computational Biology: published February 10, 2026 | https://doi.org/10.1371/journal.pcbi.1013954

Invariant visual object and face learning in the ventral cortical visual pathway: A biologically plausible model

Chenfei Zhang, Edmund T. Rolls, Jianfeng Feng

PLOS Computational Biology: published February 11, 2026 | https://doi.org/10.1371/journal.pcbi.1013959

In silico model of basal ganglia deep brain stimulation in Parkinson’s disease captures range of effective parameters for pathological beta power suppression

Mahboubeh Ahmadipour, Federico Fattorini, Nicolò Meneghetti, Alberto Mazzoni

PLOS Computational Biology: published February 11, 2026 | https://doi.org/10.1371/journal.pcbi.1013280

A theory for self-sustained balanced states in absence of strong external currents

David Angulo-Garcia, Alessandro Torcini

PLOS Computational Biology: published February 12, 2026 | https://doi.org/10.1371/journal.pcbi.1013465

Start small: A model for tissue-wide planar cell polarity without morphogens

Abhisha Thayambath, Julio M. Belmonte

PLOS Computational Biology: published February 12, 2026 | https://doi.org/10.1371/journal.pcbi.1013938

Efficient Gaussian process-based motor hotspot hunting with concurrent optimization of TMS coil location and orientation

David Luis Schultheiss, Zsolt Turi, Joschka Boedecker, Andreas Vlachos

PLOS Computational Biology: published February 17, 2026 | https://doi.org/10.1371/journal.pcbi.1013994

Information theoretic measures of neural and behavioural coupling predict representational drift

Kristine Heiney, Mónika Józsa, Michael E. Rule, Henning Sprekeler, Stefano Nichele, Timothy O’Leary

PLOS Computational Biology: published February 17, 2026 | https://doi.org/10.1371/journal.pcbi.1013130

An age-structured spatially varying coefficient model for high-resolution mapping of vaccination coverage

C. Edson Utazi, Somnath Chaudhuri, Oghenebrume Wariri, Iyanuloluwa D. Olowe, Mohamed Megheib, Andrew J. Tatem

PLOS Computational Biology: published February 17, 2026 | https://doi.org/10.1371/journal.pcbi.1013989

MENDELSEEK: An algorithm that predicts mendelian genes and elucidates what makes them special

Hongyi Zhou, Brice Edelman, Jeffrey Skolnick

PLOS Computational Biology: published February 17, 2026 | https://doi.org/10.1371/journal.pcbi.1013992

Quantifying the population-level impact of expanded antibiotic treatment for cholera outbreak management

Sharia M. Ahmed, Cormac R. LaPrete, Iza Ciglenecki, Andrew Azman, Daniel T. Leung, Lindsay T. Keegan

PLOS Computational Biology: published February 18, 2026 | https://doi.org/10.1371/journal.pcbi.1013980

Paraplume: A fast and accurate antibody paratope prediction method provides insights into repertoire-scale binding dynamics

Gabriel Athènes, Adam Woolfe, Thierry Mora, Aleksandra M. Walczak

PLOS Computational Biology: published February 18, 2026 | https://doi.org/10.1371/journal.pcbi.1013981

Fitting a lattice model with local and global transmission to spread of a plant disease

Alex Best, Nik Cunniffe

PLOS Computational Biology: published February 18, 2026 | https://doi.org/10.1371/journal.pcbi.1013404

Controllable protein design via autoregressive direct coupling analysis conditioned on principal components

Francesco Caredda, Lisa Gennai, Paolo De Los Rios, Andrea Pagnani

PLOS Computational Biology: published February 19, 2026 | https://doi.org/10.1371/journal.pcbi.1013996

PAIRNet: Predicting PIWI cleavage specificity via position-aware RNA interaction modeling

Lin Zeng, Zhenzhen Li, Enzhi Shen, Shikui Tu, Lei Xu

PLOS Computational Biology: published February 19, 2026 | https://doi.org/10.1371/journal.pcbi.1013936

A dynamical anthrax toxin nanopore biosensor for high-fidelity single-peptide classification

Jennifer M. Colby, Bryan A. Krantz

PLOS Computational Biology: published February 19, 2026 | https://doi.org/10.1371/journal.pcbi.1014019

Intercellular forces driving stratification in a two-layer corneal epithelium: Insight from a Voronoi cell-based simulation model

Neda Khodabakhsh Joniani, David Martinez-Martin, Peter S. Kim, James Guy Lyons

PLOS Computational Biology: published February 20, 2026 | https://doi.org/10.1371/journal.pcbi.1013279

Coevolutionary dynamics of cooperation, risk, and cost in collective risk games

Lichen Wang, Shijia Hua, Yuyuan Liu, Liang Zhang, Linjie Liu, Attila Szolnoki

PLOS Computational Biology: published February 20, 2026 | https://doi.org/10.1371/journal.pcbi.1013512

Attractor dynamics of a whole-cortex network model predicts emergence and structure of fMRI co-activation patterns in the mouse brain

Diego Fasoli, Ludovico Coletta, Daniel Gutierrez-Barragan, Silvia Gini, Alessandro Gozzi, Stefano Panzeri

PLOS Computational Biology: published February 20, 2026 | https://doi.org/10.1371/journal.pcbi.1013995

CA-CAE: A deep learning-based multi-omics model for pan-cancer subtype classification and prognosis prediction

Shumei Zhang, Yicheng Lu, Peixian Li, Junxuan Wu, Guohua Wang, Wen Yang

PLOS Computational Biology: published February 20, 2026 | https://doi.org/10.1371/journal.pcbi.1014015

Degradation graphs reveal hidden proteolytic activity in peptidomes

Erik Hartman, Johan Malmström, Jonas Wallin

PLOS Computational Biology: published February 20, 2026 | https://doi.org/10.1371/journal.pcbi.1013972

A topological map of the genetic components of grapevine—Admixture meets SOMmelier machine learning

Anush Baloyan, Tomas Konecny, Emma Hovhannisyan, Nate Zadirako, Maria Nikoghosyan, Hans Binder

PLOS Computational Biology: published February 20, 2026 | https://doi.org/10.1371/journal.pcbi.1013882

Carba-NAD binding activates SIR2 by reshaping conformational plasticity and rewiring long-range allosteric networks

Bao-Dan Zhang, De-Rui Zhao, Meng-Ting Liu, Li-Quan Yang, Peng Sang

PLOS Computational Biology: published February 20, 2026 | https://doi.org/10.1371/journal.pcbi.1013966

How sleeping minds decide: State-specific reconfigurations of lexical decision-making

Tao Xia, Chuan-Peng Hu, Başak Türker, Esteban Munoz Musat, Lionel Naccache, Isabelle Arnulf, Delphine Oudiette, Xiaoqing Hu

PLOS Computational Biology: published February 23, 2026 | https://doi.org/10.1371/journal.pcbi.1014007

A novel transformer-based platform for the prediction and design of biosynthetic gene clusters for (un)natural products

Tomoki Kawano, Taro Shiraishi, Tomohisa Kuzuyama, Maiko Umemura

PLOS Computational Biology: published February 23, 2026 | https://doi.org/10.1371/journal.pcbi.1013181

Hemodynamic impact of acute liver injury on cardiac function: An in silico study via a closed-loop cardiovascular model

Jiyang Zhang, Zhongyou Li, Lin Feng, Jialu Zhang, Taoping Bai, Wentao Jiang

PLOS Computational Biology: published February 24, 2026 | https://doi.org/10.1371/journal.pcbi.1014006

Viral evolution during primary infection in immunocompromised hosts

Morgan Craig, Xiaoyan Deng, David V. McLeod

PLOS Computational Biology: published February 25, 2026 | https://doi.org/10.1371/journal.pcbi.1013967

Combining seasonal malaria chemoprevention with novel therapeutics for malaria prevention: a mathematical modelling study

Lydia Braunack-Mayer, Josephine Malinga, Narimane Nekkab, Sherrie L. Kelly, Jörg J. Möhrle, Melissa A. Penny

PLOS Computational Biology: published February 26, 2026 | https://doi.org/10.1371/journal.pcbi.1014021

Corrections

Correction: WormSNAP: A software for fast, accurate, and unbiased detection of fluorescent puncta in C. elegans

Araven Tiroumalechetty, Elisa B. Frankel, Peri T. Kurshan

PLOS Computational Biology: published February 10, 2026 | https://doi.org/10.1371/journal.pcbi.1013953

Correction: Nash equilibrium of attack and defense behaviors between predators and prey

The PLOS Computational Biology Staff

PLOS Computational Biology: published February 13, 2026 | https://doi.org/10.1371/journal.pcbi.1013969

Correction: Correction: Quantifying microbial interactions based on compositional data using an iterative approach for solving generalized Lotka-Volterra equations

The PLOS Computational Biology Staff

PLOS Computational Biology: published February 13, 2026 | https://doi.org/10.1371/journal.pcbi.1013971

Correction: BMDD: A probabilistic framework for accurate imputation of zero-inflated microbiome sequencing data

Huijuan Zhou, Jun Chen, Xianyang Zhang

PLOS Computational Biology: published February 17, 2026 | https://doi.org/10.1371/journal.pcbi.1013974

Correction: Transcriptome-wide root causal inference

The PLOS Computational Biology Staff

PLOS Computational Biology: published February 18, 2026 | https://doi.org/10.1371/journal.pcbi.1013979

Software

TARPON—A Telomere Analysis and Research Pipeline Optimized for Nanopore

Nathaniel Deimler, David V. Ho, Norbert Paul, Zoë Gill, Peter Baumann

PLOS Computational Biology: published February 4, 2026 | https://doi.org/10.1371/journal.pcbi.1013915

Plastic Arbor: A modern simulation framework for synaptic plasticity—From single synapses to networks of morphological neurons

Jannik Luboeinski, Sebastian Schmitt, Shirin Shafiee, Thorsten Hater, Fabian Bösch, Christian Tetzlaff

PLOS Computational Biology: published February 12, 2026 | https://doi.org/10.1371/journal.pcbi.1013926

PON-Del predictor for sequence retaining protein deletions

Haoyang Zhang, Muhammad Kabir, Mauno Vihinen

PLOS Computational Biology: published February 25, 2026 | https://doi.org/10.1371/journal.pcbi.1014020

February 2026

Cover

Centripetal growth in the basal and the second layers in the corneal epithelium

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