Best e-Prescribing Software

Compare the Top e-Prescribing Software as of December 2025

What is e-Prescribing Software?

e-Prescribing software provides physicians and medical professionals with a platform to generate and send electronic prescription orders to pharmacies and their clients. Compare and read user reviews of the best e-Prescribing software currently available using the table below. This list is updated regularly.

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    RXNT

    RXNT

    RXNT

    RXNT is an ambulatory healthcare technology pioneer that empowers medical practices and healthcare organizations to succeed and scale through innovative, data-backed, AI-powered software. Our fully-integrated, ONC-certified suite of medical software—like Clinical EHRs, Practice Management, Medical Billing and RCM, E-Prescribing, Practice Scheduling, Patient Portal, and more—optimizes clinical outcomes and RCM for your practice. Used by tens of thousands of medical professionals—from large physician practices to medical billing companies—to drive growth, streamline business operations, and improve patient care across all 50 U.S. states. Our unified “Full Suite” system employs a secure, central database so your data passes through every product in real-time from anywhere, and more than 125 million prescriptions have been transmitted and over $7 billion in claims have been processed using RXNT.
    Starting Price: $118/month
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  • 2
    ScriptSure

    ScriptSure

    DAW Systems, Inc.

    Discover the pinnacle of E-Prescribing solutions with ScriptSure Cloud ERX – the unparalleled winner of the esteemed White Coat Award for Most Accurate Prescriptions in 2021, 2022, and 2023, securing its position as an 11-time recipient of this prestigious accolade. ScriptSure Cloud ERX seamlessly integrates full e-prescribing capabilities, EPCS (controlled substance prescribing) and weekly updates to medications and daily updates to pharmacy lists. With ScriptSure you get price transparency as well; detailed costs, alternatives and ePA requirement indicators for most medications. Enjoy a user-friendly interface and streamlined workflow methods for electronic refills, order sets, compound medication ordering, prescription printing, patient reports and comprehensive audit logs. Security and compliance are paramount, with ScriptSure being fully HIPAA compliant, ensuring the confidentiality and privacy of patient data. ScriptSure is fast, accurate and built for patient safety.
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  • 3
    MedRight

    MedRight

    CareRight Technologies, LLC

    MedRight is a dynamic, user friendly, secure, cost effective software platform for use in Assisted Living communities, Residential Treatment Centers, IDD facilities, and Group Homes. MedRight improves patient safety, reduces medication errors, and is fully HIPAA compliant. Years of product enhancements and new features based on actual community use have resulted in a powerful, fully integrated software suite that users love. MedRight has it all to manage any senior living community, including the ability to work without a network connection in case the internet is down. Modules include marketing (CRM), e-prescribing, inventory, pharmacy integration, care plans, assessments, e-Narcotic logs, ADLs, billing, and resident and staff management. Let MedRight reduce your risk, improve your bottom line, and streamline your operations, while you spend more time with your residents!
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    Starting Price: $5.50/month/resident
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  • 4
    AestheticsPro

    AestheticsPro

    AestheticsPro

    AestheticsPro is the most complete aesthetics software on the market today. Built in HIPAA-compliance with electronic charting, integrated POS, targeted marketing, and results driven reporting. Our mobile app allows you to power your practice from anywhere, with any device. Our comprehensive Client Portal give your clients full access to view their records and treatment plans, before and after photos, and the ability to instantly book future appointments. AestheticsPro delivers all of the tools you need to manage your medical spa business. Maximize your medical spa's potential and propel your practice forward with the power of AestheticsPro.
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    Starting Price: $59 per month
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  • 5
    Sevocity EHR
    If you're looking for a long-term, stable EHR company that gets to know and serve you and your practice, you've come to the right place. #1 rated implementation and the only EHR that offers free ongoing customization and personalized training by practice and provider, live US-based support 24/7/365 and affordable all-inclusive pricing.
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    Starting Price: $379.00/month
  • 6
    Valant Behavioral Health EHR

    Valant Behavioral Health EHR

    Valant Medical Solutions

    Provide exceptional, data-driven care from anywhere with Valant, the all-in-one EHR and practice management software designed exclusively for behavioral health practices of all sizes. - Focus the efforts of your entire workflow in one system built for individual psychotherapy, medication management, group counseling and more, whether delivered in person or virtually. - Speed your documentation process with 100+ clinical templates for evidence-based and specialized therapies, such as DBT, CBT, MFT, TMS, and weight and eating disorders. - Track your progress with 100+ comprehensive reports on patient retention, compliance, productivity, and financial performance. Demonstrate the value of your care to payers with 80+ reportable outcome measures you can schedule send to patients, auto-score, document, and track progress.
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    AZZLY

    AZZLY

    AZZLY

    AZZLY Rize is the premier clinical and business platform for addiction treatment and mental health organizations. As an all-in-one substance use disorder and mental health specific EHR, Patient Engagement and RCM platform, we serve small, medium, and large clinics. Key features for OUTPATIENT Programs include: scheduling, appointment reminder, Zoom telehealth, treatment plans, progress notes, assessments and surveys. For RESIDENTIAL programs: census, medication management, bed board, withdrawal management, DrFirst e-prescribing, EPCS, PDMP, labs. For all levels of care: alerts, patient engagement portal, electronic billing and claims submission built in. AZZLY Rize empowers your staff through its 5 star training and support services, its simplicity and automation. As a true all-in-one EHR/PM/RCM platform, improved compliance, workflow and accurate billing are achieved real-time. We proudly serve programs in over 33 states and are hosted in Microsoft Azure's private cloud network.
    Starting Price: $50/user/month
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    Foothold

    Foothold

    Foothold Technology

    Our human services software offers full functionality for case management, client tracking, electronic health record (EHR), and homeless information management (HMIS) all under one roof. We work with agencies across the spectrum of human services: including developmental disabilities, mental health, substance use disorder, homelessness, supportive housing, HCBS, and much more. Foothold is HIPAA-compliant mental health software, federally certified as an EHR, and offers full interoperability as you navigate the new landscape of care coordination and value-based care. Transform the way you provide care with nimble software and a partnership guided by experience.
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    OptiMantra

    OptiMantra

    OptiMantra

    OptiMantra is an EMR and practice management platform focused on helping integrative and wellness practices. It serves individual and multi-modality group practices of direct and primary care providers, acupuncturists, nurse practitioners, naturopaths, chiropractors, massage therapists, PTs, dieticians and nutritionists, aesthetics, and others across the US and Canada. It is a HIPAA and PHIPA-compliant platform and is highly adaptable and robust - it includes online appointment booking, patient messaging and email reminders, a patient portal, intake forms and customizable charting, integrated payment processing, integrated labs and imaging, insurance billing, in-program tele-health, inventory management, and more. The platform is cloud-based and accessible and usable via any desktop, laptop, tablet or phone with internet access.
    Starting Price: $99 per month
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    PracticeHarmony

    PracticeHarmony

    Mahler Health

    Practice Harmony is the premier practice management tool for running your healthcare practice. Our cloud-based practice management software solution streamlines your practice's operations and optimizes your workflow. Robust scheduling, advanced EHR, customized forms, patient dashboard, optimized voice-to-text, full RCM, TeleMedicine, TelePsychiatry, eRx, HIPAA Compliant CRM, and so much more. Streamlined operations require the perfect orchestration of efficient patient scheduling, proper documentation, and successful billing. Run your entire practice from scheduling to billing with just one log-in. Schedule a demo today to learn how you can bring Harmony to your Practice.
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    iPrescribe

    iPrescribe

    DrFirst

    Toss your prescription pad. iPrescribe enables you to prescribe any drug from your smartphone. It’s safer and faster than your other prescribing options when you’re out of the office. The app includes access to your patient’s medication history, state PDMPs, clinical alerts, and more. Our time-tested process makes it easy to select a medication, write a prescription, sign, and send. We’ll surface popular medications and common prescriptions to get you done faster. By tapping into our network of millions of patient-prescriber relationships, iPrescribe can often automatically import your existing patients. We’ll run a check when you sign up. iPrescribe can pull a patient’s medication history from Surescripts, America’s primary e-prescribing network, and other proprietary sources at DrFirst to surface the most robust history. Just tap the Med History button in a patient’s profile.
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    CarePaths EHR

    CarePaths EHR

    CarePaths

    We built CarePaths EHR for psychiatrists, psychologists, social workers, and counselors to affordably manage practices of all sizes. We are a HIPAA Compliant and ONC-Certified, fully integrated cloud-based behavioral electronic health record and practice management platform. Our system also includes online therapy with secure texting, teletherapy, and outcomes monitoring. With the free upgrade to CarePaths Connect, clinicians can also create a Digital Front Door, allowing patients to effortlessly sign up for services and book appointments with the CarePaths Connect mobile app for patients. Patients can also use the app to engage in teletherapy, message their therapist, and complete assessments. The Automated Measurement-Based Care (MBC) feature streamlines the process of outcomes monitoring so clinicians can tailor their approach based on patient feedback for better therapy outcomes.
    Starting Price: $49 per user per month
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    DrChrono

    DrChrono

    DrChrono

    Increase the efficiency of your medical practice with an all-in-one practice management, electronic health records, and medical billing platform from DrChrono. With its modern and simple interface and dozens of advanced features, DrChrono empowers medical practitioners to better serve their patients. Users can easily schedule patient appointments, check and edit patient charts, and manage billing with ease.
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    Treat

    Treat

    DoseSpot

    Treat 4 advances e-prescribing to a new level of power and convenience. Experience Treat on any device with a refined mobile experience. Discover new features like Real-Time Prescription Benefits and Eligibility. Send prescriptions from your desktop or mobile device with Treat 4, giving you the power and flexibility to care for your patients, wherever they may be. It’s never been easier to send and manage electronic prescriptions. Treat 4 offers a robust set of e‑prescribing features to accelerate your workflow. All accessible from your favorite device. Treat 4’s intuitive workflow makes electronic prescribing an asset instead of a distraction. A streamlined design is informed by a sharpened focus on efficiency when writing prescriptions. Your most frequently prescribed medications can be saved as favorites, accessible when and where you need them. Treat 4 is accessible from any web browser as a standalone e‑prescribing app.
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    ChartLogic

    ChartLogic

    Medsphere Systems

    Enhance patient care, office efficiency, and profitability with ChartLogic, an integrated Electronic Health Record (EHR) software suite for private physician practices. Designed to intuitively match a practice's workflow, as well as its specialty and personal preferences, ChartLogic EHR helps physicians document patient encounters and store information securely and cost-effectively. ChartLogic EHR suite includes Electronic Medical Record (EMR) tools, practice management, and medical billing services.
  • 16
    OrderConnect

    OrderConnect

    Netsmart Technologies

    OrderConnect™ is a web-based electronic prescribing and medication management tool that allows providers to prescribe, review and order tests electronically. While integrated with Netsmart electronic health records (EHRs), it can be used as a stand-alone solution as well. OrderConnect is an Electronic Prescribing of Controlled Substances (EPCS) certified solution that supports prescribers in states that mandate EPCS when prescribing opioids and other controlled substances. Access Prescription Drug Monitoring Programs (PDMPs) during the prescribing process. The tool provides support to prescribers in many states that mandate PDMP checking before prescribing opioids and other controlled substances.
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    Nexus EHR

    Nexus EHR

    Nexus Clinical

    Nexus EHR is a cloud-based EHR and PM platform for clinical healthcare providers. Our EHR works with your clinical workflow and maximizes the physician-patient encounter. Access anywhere, any time, and with any device (PC, Tablet, Mobile). Breeze through encounters via our intuitive, easy-to-use interface that allows you to practice naturally. Multi-modal data input allows for maximum flexibility. Nexus Practice Management systems help you manage all billing activities, claims, and ERAs to maximize your revenues. Nexus EHR offers telemedicine to connect with your patients remotely. Nexus's Patient portal offers great flexibility to patients to fill all the demographics, insurance information, and histories online at their convenience.
  • 18
    MDToolbox e-Prescribing
    MDToolbox-Rx is a Certified, Award-Winning, complete electronic prescription writer that can run stand-alone or synced with your other office software. The e-Prescribing Software is a highly customizable, simple to use e-prescribing system that allows you to easily select drugs, find drug information, and create and electronically send a prescription quickly and efficiently. MDToolbox-Rx is Certified for e-Prescribing, Eligibility, Formulary, EPCS (e-Prescribing of Controlled Substances), and Electronic Prior Authorization. Search for drugs by name, nickname, generic, brand, rx, OTC, class or indication in the most comprehensive drug database available. Higher productivity due to less pharmacy calls and time spent for renewal requests.
  • 19
    iCare

    iCare

    iCare.com

    Finally, an Electronic Health Record system for hospitals, clinics, and practices that is flexible enough to change as healthcare evolves yet doesn’t cost a fortune to implement and operate. Delivered in the cloud, the iCare Enterprise Cloud EHR is a fully integrated system which includes a full range of administrative, clinical and revenue cycle management capabilities. iCare provides a complete solution for clinical, billing and administrative functionality at a fraction of the cost of legacy software. A web-based user interface not only gives your users access to iCare from any device but it also allows the workflows to be configured to the way clinicians work. Legacy EHR systems are built on outdated client-server systems that are costly, closed, inflexible and slow to innovate. iCare is built with the future in mind. The industry’s most modern architecture, intuitive user interfaces, and rock solid performance – no other EHR comes close to iCare.
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    Benchmark EHR

    Benchmark EHR

    Benchmark Solutions

    Benchmark EHR is a customizable system designed to save clinicians time and enhance patient care. It features configurable workflows, real-time coding recommendations, and ePrescriptions. Clinicians can generate and dictate progress notes during appointments, automatically updating patient records. The user-friendly patient portal allows patients to access lab results, refill prescriptions, message providers, check appointments, complete forms online, and more. Benchmark Solutions operates as healthcare practices’ one-stop management solution, comprising of Benchmark EHR software, Benchmark PM software, and Benchmark RCM services. Benchmark Solutions' offerings come together to form a comprehensive electronic toolset that can streamline daily internal operations and increase revenue earned all while improving the overall patient experience. Each piece of the Benchmark Solutions suite is modular so it can easily integrate with other technologies already in place.
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